Gene Symbol: Sdcbp
Description: syndecan binding protein
Alias: TACIP18, mda-9, syntenin-1, syndecan-binding protein 1, syntenin
Species: rat
Products:     Sdcbp

Top Publications

  1. Zimmermann P, Tomatis D, Rosas M, Grootjans J, Leenaerts I, Degeest G, et al. Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments. Mol Biol Cell. 2001;12:339-50 pubmed
    b>Syntenin is a PDZ protein that binds the cytoplasmic C-terminal FYA motif of the syndecans. Syntenin is widely expressed. In cell fractionation experiments, syntenin partitions between the cytosol and microsomes...
  2. Tomoda T, Kim J, Zhan C, Hatten M. Role of Unc51.1 and its binding partners in CNS axon outgrowth. Genes Dev. 2004;18:541-58 pubmed
    ..The second binding partner is a PDZ domain-containing scaffolding protein, Syntenin, that binds Rab5 GTPase, the activity of which is attenuated by SynGAP...
  3. Egea Jimenez A, Gallardo R, Garcia Pino A, Ivarsson Y, Wawrzyniak A, Kashyap R, et al. Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. Nat Commun. 2016;7:12101 pubmed publisher
    ..Here we report a crystal structure of the syntenin PDZ tandem in complex with the carboxy-terminal fragment of Frizzled 7 and phosphatidylinositol 4,5-bisphosphate (..
  4. Luyten A, Mortier E, Van Campenhout C, Taelman V, Degeest G, Wuytens G, et al. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. Mol Biol Cell. 2008;19:1594-604 pubmed publisher
    ..We previously established that the postsynaptic density 95/disc-large/zona occludens (PDZ) protein syntenin binds to syndecans, Wnt coreceptors, and known stimulators of protein kinase C (PKC)alpha and CDC42 activity...
  5. Grootjans J, Zimmermann P, Reekmans G, Smets A, Degeest G, Durr J, et al. Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. Proc Natl Acad Sci U S A. 1997;94:13683-8 pubmed
    ..This protein, syntenin, contains a tandem repeat of PDZ domains that reacts with the FYA C-terminal amino acid sequence of the syndecans...
  6. Iuliano R, Trapasso F, Sama I, Le Pera I, Martelli M, Lembo F, et al. Rat protein tyrosine phosphatase eta physically interacts with the PDZ domains of syntenin. FEBS Lett. 2001;500:41-4 pubmed
    ..interacting proteins, a yeast two-hybrid screening was performed and an insert corresponding to the full-length syntenin cDNA was isolated...
  7. Fernandez Larrea J, Merlos Suarez A, Urena J, Baselga J, Arribas J. A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. Mol Cell. 1999;3:423-33 pubmed
    ..The binding specificity of one of them, TACIP18 (previously identified and named Syntenin or mda-9), coincides with that of the component that possibly mediates the normal trafficking of proTGF-alpha...
  8. Geijsen N, Uings I, Pals C, Armstrong J, McKinnon M, Raaijmakers J, et al. Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. Science. 2001;293:1136-8 pubmed
    ..In this study, we sought to find a role for the cytoplasmic domain of IL-5Ralpha. We show that syntenin, a protein containing PSD-95/Discs large/zO-1 (PDZ) domains, associates with the cytoplasmic tail of the IL-..
  9. Ohno K, Koroll M, El Far O, Scholze P, Gomeza J, Betz H. The neuronal glycine transporter 2 interacts with the PDZ domain protein syntenin-1. Mol Cell Neurosci. 2004;26:518-29 pubmed
    ..Screening of a rat brain cDNA library identified the PDZ domain protein syntenin-1 as an intracellular binding partner of GlyT2...

More Information


  1. Koroll M, Rathjen F, Volkmer H. The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. J Biol Chem. 2001;276:10646-54 pubmed
    ..Here, we demonstrate that rat syntenin-1, previously published as syntenin, mda-9, or TACIP18 in human, is a neurofascin-binding protein that exhibits a ..
  2. Li A, Li H, Jin B, Ye Q, Zhou T, Yu X, et al. A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis. J Biol Chem. 2004;279:49251-8 pubmed
    ..Our results demonstrated that eIF5A and syntenin could engage in a specific interaction both in vitro and in vivo and functioned collaboratively to regulate p53 ..
  3. Kashyap R, Roucourt B, Lembo F, Fares J, Carcavilla A, Restouin A, et al. Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells. Front Pharmacol. 2015;6:241 pubmed publisher
    The scaffold protein syntenin abounds during fetal life where it is important for developmental movements. In human adulthood, syntenin gain-of-function is increasingly associated with various cancers and poor prognosis...
  4. Hwangbo C, Tae N, Lee S, Kim O, Park O, Kim J, et al. Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene. 2016;35:389-401 pubmed publisher
    b>Syntenin, a tandem PDZ domain containing scaffold protein, functions as a positive regulator of cancer cell progression in several human cancers...
  5. Koo T, Lee J, Kim E, Kim K, Kim H, Lee J. Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines. Oncogene. 2002;21:4080-8 pubmed
    ..Of the 17 cDNAs identified as being differentially expressed genes, it was determined that syntenin was overexpressed in metastatic MDA-MB-435 cells...
  6. Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley J, et al. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. J Biol Chem. 2002;277:15221-4 pubmed
    ..a series of glutamate receptor subunits that interact differentially with the PDZ proteins GRIP, PICK1, and syntenin. GST-pull-down experiments identified more interactions than detected by yeast two-hybrid assays...
  7. Hirbec H, Martin S, Henley J. Syntenin is involved in the developmental regulation of neuronal membrane architecture. Mol Cell Neurosci. 2005;28:737-46 pubmed
    b>Syntenin is a approximately 33 kDa scaffolding protein that we have shown previously to bind to kainate receptor subunits via a PDZ interaction...
  8. Ko J, Yoon C, Piccoli G, Chung H, Kim K, Lee J, et al. Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin-1. J Neurosci. 2006;26:963-70 pubmed
    ..large/zona occludens-1] interaction between the CAZ protein ERC2/CAST1 and the tandem PDZ protein syntenin-1, which is known to associate with diverse synaptic proteins, including glutamate receptor subunits, SynCAM, and ..
  9. Wawrzyniak A, Vermeiren E, Zimmermann P, Ivarsson Y. Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1. FEBS Lett. 2012;586:1445-51 pubmed publisher
    b>Syntenin-1 is a PDZ protein involved in receptor recycling and clustering. Its two PDZ domains interact with various receptors and phosphoinositides, and are flanked by N- and C-terminal regions...
  10. Torres R, Firestein B, Dong H, Staudinger J, Olson E, Huganir R, et al. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 1998;21:1453-63 pubmed
    ..Thus, PDZ proteins may play critical roles in localizing vertebrate receptor tyrosine kinases and/or their ligands and may be particularly important for Eph function in guidance or patterning or at the synapse. ..