Scnn1g

Summary

Gene Symbol: Scnn1g
Description: sodium channel epithelial 1 gamma subunit
Alias: ENaC, amiloride-sensitive sodium channel subunit gamma, SCNEG, Sodium channel, nonvoltage-gated 1, gamma (epithelial), amiloride sensitive sodium channel gamma1 subunit, epithelial Na(+) channel subunit gamma, epithelial sodium channel gamma subunit, gamma-ENaC, gamma-NaCH, nonvoltage-gated sodium channel 1 subunit gamma, sodium channel, non-voltage-gated 1, gamma subunit, sodium channel, nonvoltage-gated, type I, gamma
Species: rat
Products:     Scnn1g

Top Publications

  1. Caldwell R, Boucher R, Stutts M. Serine protease activation of near-silent epithelial Na+ channels. Am J Physiol Cell Physiol. 2004;286:C190-4 pubmed
    The regulation of epithelial Na+ channel (ENaC) function is critical for normal salt and water balance...
  2. Canessa C, Schild L, Buell G, Thorens B, Gautschi I, Horisberger J, et al. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature. 1994;367:463-7 pubmed
    ..The ion-selective permeability, the gating properties and the pharmacological profile of the channel formed by coexpressing the three subunits in oocytes are similar to that of the native channel. ..
  3. Hansson J, Nelson Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, et al. Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet. 1995;11:76-82 pubmed
  4. Mazzochi C, Bubien J, Smith P, Benos D. The carboxyl terminus of the alpha-subunit of the amiloride-sensitive epithelial sodium channel binds to F-actin. J Biol Chem. 2006;281:6528-38 pubmed
    The activity of the amiloride-sensitive epithelial sodium channel (ENaC) is modulated by F-actin. However, it is unknown if there is a direct interaction between alpha-ENaC and actin...
  5. Drummond H, Gebremedhin D, Harder D. Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor. Hypertension. 2004;44:643-8 pubmed
    ..Although recent reports suggest degenerin/epithelial Na+ channel (DEG/ENaC) proteins may be mechanosensors in sensory neurons, their role as mechanosensors in vascular tissue has not been ..
  6. Ergonul Z, Frindt G, Palmer L. Regulation of maturation and processing of ENaC subunits in the rat kidney. Am J Physiol Renal Physiol. 2006;291:F683-93 pubmed
    Antibodies directed against subunits of the epithelial Na channel (ENaC) were used together with electrophysiological measurements in the cortical collecting duct to investigate the processing of the proteins in rat kidney with changes in ..
  7. Kim E, Ahn D, Yeon S, Lim M, Lee Y. Epithelial Na+ channel proteins are mechanotransducers of myogenic constriction in rat posterior cerebral arteries. Exp Physiol. 2012;97:544-55 pubmed publisher
    ..Although previous reports have suggested that epithelial Na(+) channel (ENaC) proteins are mechanotransducers in arteries, experimental evidence demonstrating that ENaC proteins are ..
  8. Svenningsen P, Bistrup C, Friis U, Bertog M, Haerteis S, Krueger B, et al. Plasmin in nephrotic urine activates the epithelial sodium channel. J Am Soc Nephrol. 2009;20:299-310 pubmed publisher
    ..urine from nephrotic rats and from patients with nephrotic syndrome activate the epithelial sodium channel (ENaC) in cultured M-1 mouse collecting duct cells and in Xenopus laevis oocytes heterologously expressing ENaC...
  9. Frindt G, Ergonul Z, Palmer L. Surface expression of epithelial Na channel protein in rat kidney. J Gen Physiol. 2008;131:617-27 pubmed publisher
    Expression of epithelial Na channel (ENaC) protein in the apical membrane of rat kidney tubules was assessed by biotinylation of the extracellular surfaces of renal cells and by membrane fractionation...

More Information

Publications80

  1. Collier D, Snyder P. Extracellular protons regulate human ENaC by modulating Na+ self-inhibition. J Biol Chem. 2009;284:792-8 pubmed publisher
    The epithelial Na(+) channel, ENaC, is exposed to a wide range of proton concentrations in the kidney, lung, and sweat duct. We, therefore, tested whether pH alters ENaC activity...
  2. Garcia Caballero A, Ishmael S, Dang Y, Gillie D, Bond J, Milgram S, et al. Activation of the epithelial sodium channel by the metalloprotease meprin ? subunit. Channels (Austin). 2011;5:14-22 pubmed
    The Epithelial Na(+) Channel (ENaC) is an apical heteromeric channel that mediates Na(+) entry into epithelial cells from the luminal cell surface...
  3. Lütken S, Kim S, Jonassen T, Marples D, Knepper M, Kwon T, et al. Changes of renal AQP2, ENaC, and NHE3 in experimentally induced heart failure: response to angiotensin II AT1 receptor blockade. Am J Physiol Renal Physiol. 2009;297:F1678-88 pubmed publisher
    ..The protein abundance of alpha-epithelial sodium channel (alpha-ENaC) was increased while beta-ENaC and gamma-ENaC expression was decreased in the cortex and outer stripe of the outer ..
  4. Xie Y, Schafer J. Inhibition of ENaC by intracellular Cl- in an MDCK clone with high ENaC expression. Am J Physiol Renal Physiol. 2004;287:F722-31 pubmed
    We examined the effects of intracellular Cl- concentration ([Cl-]i) on the epithelial Na channel (ENaC) in a line of Madin-Darby canine kidney (MDCK) cells (FL-MDCK) with a high rate of Na+ transport produced by stable retroviral ..
  5. Chen X, Seth S, Yue G, Kamat P, Compans R, Guidot D, et al. Influenza virus inhibits ENaC and lung fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2004;287:L366-73 pubmed
    ..is incapable of viral replication and productive infection in mammalian epithelia, on epithelial sodium channels (ENaC) in rat alveolar type II (ATII) cells. In parallel, we determined the effects of virus on amiloride-sensitive (i.e...
  6. Auberson M, Hoffmann Pochon N, Vandewalle A, Kellenberger S, Schild L. Epithelial Na+ channel mutants causing Liddle's syndrome retain ability to respond to aldosterone and vasopressin. Am J Physiol Renal Physiol. 2003;285:F459-71 pubmed
    ..of hypertension caused by mutations in the PY motif of the COOH terminus of beta- and gamma-epithelial Na+ channel (ENaC) subunits. These mutations lead to retention of active channels at the cell surface...
  7. Kanelis V, Rotin D, Forman Kay J. Solution structure of a Nedd4 WW domain-ENaC peptide complex. Nat Struct Biol. 2001;8:407-12 pubmed
    ..sodium channel (alphabetagammaENaC), by association of its WW domains with PY motifs (XPPXY) present in each ENaC subunit, and to regulate the cell surface stability of the channel...
  8. Michlig S, Harris M, Loffing J, Rossier B, Firsov D. Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism. J Biol Chem. 2005;280:38264-70 pubmed
    ..by mutating conserved tyrosine residues in the Pro-X-X-Tyr (PY) motif of the C termini of the beta and gamma ENaC subunits (beta(Y618A) and gamma(Y628A)); (iii) the down-regulation of ENaC activity by progesterone was also ..
  9. Yu Z, Serra A, Sauter D, Loffing J, Ackermann D, Frey F, et al. Sodium retention in rats with liver cirrhosis is associated with increased renal abundance of NaCl cotransporter (NCC). Nephrol Dial Transplant. 2005;20:1833-41 pubmed
    ..Liver cirrhosis was induced by bile duct ligation (BDL) in rats. Steady state mRNA of ENaC subunits alpha, beta, gamma serum and glucocorticoid inducible kinase (Sgk1) were measured by TaqMan PCR in kidney ..
  10. Ahn Y, Brooker D, Kosari F, Harte B, Li J, Mackler S, et al. Cloning and functional expression of the mouse epithelial sodium channel. Am J Physiol. 1999;277:F121-9 pubmed
    The epithelial sodium channel (ENaC) plays a major role in the transepithelial reabsorption of sodium in the renal cortical collecting duct, distal colon, and lung...
  11. Shimkets R, Lifton R, Canessa C. In vivo phosphorylation of the epithelial sodium channel. Proc Natl Acad Sci U S A. 1998;95:3301-5 pubmed
    The activity of the epithelial sodium channel (ENaC) in the distal nephron is regulated by an antidiuretic hormone, aldosterone, and insulin, but the molecular mechanisms that mediate these hormonal effects are mostly unknown...
  12. Lee I, Dinudom A, Sanchez Perez A, Kumar S, Cook D. Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. J Biol Chem. 2007;282:29866-73 pubmed
    The epithelial sodium channel (ENaC) plays an important role in transepithelial Na(+) absorption; hence its function is essential for maintaining Na(+) and fluid homeostasis and regulating blood pressure...
  13. Inagaki A, Yamaguchi S, Ishikawa T. Amiloride-sensitive epithelial Na+ channel currents in surface cells of rat rectal colon. Am J Physiol Cell Physiol. 2004;286:C380-90 pubmed
    ..the amiloride-sensitive epithelial Na+ channel composed of three homologous subunits (alpha-, beta-, and gamma-ENaC)...
  14. Amin M, Reza E, El Shahat E, Wang H, Tesson F, Leenen F. Enhanced expression of epithelial sodium channels in the renal medulla of Dahl S rats. Can J Physiol Pharmacol. 2011;89:159-68 pubmed publisher
    ..as cells from salt-resistant (R) rats, possibly related to dysregulation of the renal epithelial sodium channel (ENaC)...
  15. Frateschi S, Keppner A, Malsure S, Iwaszkiewicz J, Sergi C, Mérillat A, et al. Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity. Am J Pathol. 2012;181:605-15 pubmed publisher
    ..serine protease involved in the regulation of several different effectors, such as the epithelial sodium channel ENaC, the protease-activated receptor PAR2, the tight junction proteins, and the profilaggrin polypeptide...
  16. Luo L, Deng J, Wang D, He J, Deng W. Regulation of epithelial sodium channel expression by oestradiol and progestogen in alveolar epithelial cells. Respir Physiol Neurobiol. 2015;216:52-62 pubmed publisher
    Oestrogen (E) and progestogen (P) exert regulatory effects on the epithelial Na(+) channel (ENaC) in the kidneys and the colon...
  17. Leroy C, Privé A, Bourret J, Berthiaume Y, Ferraro P, Brochiero E. Regulation of ENaC and CFTR expression with K+ channel modulators and effect on fluid absorption across alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006;291:L1207-19 pubmed
    ..increased alveolar liquid clearance in human lungs by a mechanism possibly related to epithelial sodium channels (ENaC)...
  18. Kienitz T, Allolio B, Strasburger C, Quinkler M. Sex-specific regulation of ENaC and androgen receptor in female rat kidney. Horm Metab Res. 2009;41:356-62 pubmed publisher
    ..The epithelial sodium channel (ENaC) modulates sodium reabsorption in the kidney, but little is known about sex-specific regulation of ENaC subunit ..
  19. Kreutz R, Struk B, Rubattu S, Hubner N, Szpirer J, Szpirer C, et al. Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension. Hypertension. 1997;29:131-6 pubmed
    ..Our results fail to support a material contribution of the epithelial sodium channel genes to blood pressure regulation in this model of polygenic hypertension. ..
  20. Kakizoe Y, Kitamura K, Ko T, Wakida N, Maekawa A, Miyoshi T, et al. Aberrant ENaC activation in Dahl salt-sensitive rats. J Hypertens. 2009;27:1679-89 pubmed publisher
    The epithelial sodium channel (ENaC) plays an important role in the regulation of blood pressure by modulating Na reabsorption in the kidney...
  21. Xu J, Berret E, Kim J. Activity-dependent formation and location of voltage-gated sodium channel clusters at a CNS nerve terminal during postnatal development. J Neurophysiol. 2017;117:582-593 pubmed publisher
    ..Thus sound-mediated neuronal activity influences the tonotopic organization of Nav channels at the nerve terminal in the auditory brain stem. ..
  22. Wang X, Takeya K, Aaronson P, Loutzenhiser K, Loutzenhiser R. Effects of amiloride, benzamil, and alterations in extracellular Na+ on the rat afferent arteriole and its myogenic response. Am J Physiol Renal Physiol. 2008;295:F272-82 pubmed publisher
    Recent studies have implicated epithelial Na+ channels (ENaC) in myogenic signaling. The present study was undertaken to determine if ENaC and/or Na+ entry are involved in the myogenic response of the rat afferent arteriole...
  23. Malbert Colas L, Nicolas G, Galand C, Lecomte M, Dhermy D. Identification of new partners of the epithelial sodium channel alpha subunit. C R Biol. 2003;326:615-24 pubmed
    A fine regulation of the amiloride-sensitive Epithelial Sodium Channel (ENaC), made of alpha, beta and gamma subunits, is crucial for maintenance of Na+ balance and blood pressure...
  24. Hobbs C, Blanchard M, Alijevic O, Tan C, Kellenberger S, Bencharit S, et al. Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. Am J Physiol Lung Cell Mol Physiol. 2013;305:L990-L1001 pubmed publisher
    The epithelial sodium channel (ENaC) is responsible for Na(+) and fluid absorption across colon, kidney, and airway epithelia...
  25. Konstas A, Koch J, Korbmacher C. cAMP-dependent activation of CFTR inhibits the epithelial sodium channel (ENaC) without affecting its surface expression. Pflugers Arch. 2003;445:513-21 pubmed
    The cystic fibrosis transmembrane conductance regulator (CFTR) is thought to modulate epithelial sodium channel (ENaC) function in various preparations...
  26. Frindt G, Yang L, Uchida S, Weinstein A, Palmer L. Responses of distal nephron Na+ transporters to acute volume depletion and hyperkalemia. Am J Physiol Renal Physiol. 2017;313:F62-F73 pubmed publisher
    ..appeared as alterations in the expression of protein for the distal nephron Na+ transporters NCC and ENaC. Two hours after a single injection of furosemide (6 mg/kg) or hydrochlorothiazide (HCTZ; 30 mg/kg) Na+ ..
  27. Ishikawa T, Jiang C, Stutts M, Marunaka Y, Rotin D. Regulation of the epithelial Na+ channel by cytosolic ATP. J Biol Chem. 2003;278:38276-86 pubmed
    The epithelial Na+ channel (ENaC), composed of three subunits (alphabetagamma), is expressed in various Na(+)-absorbing epithelia and plays a critical role in salt and water balance and in the regulation of blood pressure...
  28. de Seigneux S, Kim S, Hemmingsen S, Frøkiaer J, Nielsen S. Increased expression but not targeting of ENaC in adrenalectomized rats with PAN-induced nephrotic syndrome. Am J Physiol Renal Physiol. 2006;291:F208-17 pubmed
    ..Puromycin aminonucleoside (PAN)-induced NS is associated with high aldosterone levels and increased ENaC expression and apical targeting...
  29. Faroqui S, Sheriff S, Amlal H. Metabolic acidosis has dual effects on sodium handling by rat kidney. Am J Physiol Renal Physiol. 2006;291:F322-31 pubmed
    ..01) after 5d of CMA. The protein abundance of alpha-, beta-, and gamma-subunits of the epithelial Na(+) channel (ENaC) in the cortex decreased sharply during the first 24 h and then returned to baseline levels after 5d of CMA...
  30. Shi H, Asher C, Chigaev A, Yung Y, Reuveny E, Seger R, et al. Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. J Biol Chem. 2002;277:13539-47 pubmed
    Phosphorylation of the epithelial Na(+) channel (ENaC) has been suggested to play a role in its regulation...
  31. Kota P, Buchner G, Chakraborty H, Dang Y, He H, Garcia G, et al. The N-terminal domain allosterically regulates cleavage and activation of the epithelial sodium channel. J Biol Chem. 2014;289:23029-42 pubmed publisher
    The epithelial sodium channel (ENaC) is activated upon endoproteolytic cleavage of specific segments in the extracellular domains of the ?- and ?-subunits...
  32. Gille T, Randrianarison Pellan N, Goolaerts A, Dard N, Uzunhan Y, Ferrary E, et al. Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway. Am J Respir Cell Mol Biol. 2014;50:526-37 pubmed publisher
    Transepithelial sodium transport via alveolar epithelial Na(+) channels (ENaC) and Na(+),K(+)-ATPase constitutes the driving force for removal of alveolar edema fluid...
  33. Takemura Y, Goodson P, Bao H, Jain L, Helms M. Rac1-mediated NADPH oxidase release of O2- regulates epithelial sodium channel activity in the alveolar epithelium. Am J Physiol Lung Cell Mol Physiol. 2010;298:L509-20 pubmed publisher
    ..resides near the apical surface of type 1 cells, whereas NOX2 coimmunoprecipitates with epithelial sodium channel (ENaC)...
  34. Nielsen J, Kwon T, Praetorius J, Kim Y, Frøkiaer J, Knepper M, et al. Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI. Am J Physiol Renal Physiol. 2003;285:F1198-209 pubmed
    ..The amiloride-sensitive sodium channel (ENaC) is expressed in the renal connecting tubule and collecting duct and is essential in renal regulation of body ..
  35. Dagenais A, Frechette R, Yamagata Y, Yamagata T, Carmel J, Clermont M, et al. Downregulation of ENaC activity and expression by TNF-alpha in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2004;286:L301-11 pubmed
    ..that TNF-alpha decreased the expression of the alpha-, beta-, and gamma-subunits of epithelial sodium channel (ENaC) mRNA to 36, 43, and 16% of the controls after 24-h treatment and reduced to 50% the amount of alpha-ENaC protein ..
  36. Lingueglia E, Renard S, Waldmann R, Voilley N, Champigny G, Plass H, et al. Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone. J Biol Chem. 1994;269:13736-9 pubmed
    ..No labeling was observed in colon from control animals. These results suggest that oligomerization is needed for the proper expression of RCNaCh1 at the cell surface. ..
  37. Strautnieks S, Thompson R, Gardiner R, Chung E. A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families. Nat Genet. 1996;13:248-50 pubmed
    ..genes encoding the three subunits of the human amiloride sensitive epithelial sodium channel (hENaC): SCNN1B and SCNN1G on 16p and SCNN1A on 12p...
  38. Nakano M, Hirooka Y, Matsukawa R, Ito K, Sunagawa K. Mineralocorticoid receptors/epithelial Na(+) channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats. Hypertens Res. 2013;36:277-84 pubmed publisher
    ..alterations were attenuated by intracerebroventricular infusion of eplerenone (10??g?kg(-1) per day), except for ?-ENaC and ?-ENaC...
  39. Harvey K, Dinudom A, Komwatana P, Jolliffe C, Day M, Parasivam G, et al. All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+. J Biol Chem. 1999;274:12525-30 pubmed
    The amiloride-sensitive epithelial sodium channel (ENaC) plays a critical role in fluid and electrolyte homeostasis and consists of alpha, beta, and gamma subunits...
  40. Asher C, Chigaev A, Garty H. Characterization of interactions between Nedd4 and beta and gammaENaC using surface plasmon resonance. Biochem Biophys Res Commun. 2001;286:1228-31 pubmed
    Cell surface expression of the epithelial Na(+) channel ENaC is regulated by the ubiquitin ligase Nedd4...
  41. Otulakowski G, Rafii B, O Brodovich H. Differential translational efficiency of ENaC subunits during lung development. Am J Respir Cell Mol Biol. 2004;30:862-70 pubmed
    The amiloride-sensitive epithelial Na(+) channel (ENaC), the rate-limiting step in epithelial Na(+) transport, consists of three subunits: alpha, beta, and gamma...
  42. Plettenberg S, Weiss E, Lemor R, Wehner F. Subunits alpha, beta and gamma of the epithelial Na+ channel (ENaC) are functionally related to the hypertonicity-induced cation channel (HICC) in rat hepatocytes. Pflugers Arch. 2008;455:1089-95 pubmed
    ..were used to test for the functional relation of subunits alpha, beta, and gamma of the epithelial Na(+) channel (ENaC) to the hypertonicity-induced cation channel (HICC) in confluent rat hepatocytes...
  43. Thomas C, Auerbach S, Zhang C, Stokes J. The structure of the rat amiloride-sensitive epithelial sodium channel gamma subunit gene and functional analysis of its promoter. Gene. 1999;228:111-22 pubmed
  44. Farr T, Coddington Lawson S, Snyder P, McDonald F. Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits. Biochem J. 2000;345 Pt 3:503-9 pubmed
    The epithelial Na(+) channel (ENaC) regulates Na(+) absorption in epithelial tissues including the lung, colon and sweat gland, and in the distal nephrons of the kidney...
  45. Wang W, Li C, Nejsum L, Li H, Kim S, Kwon T, et al. Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking. Am J Physiol Renal Physiol. 2006;290:F530-41 pubmed
    ..Renal hemodynamics, water and sodium excretion, and aquaporin-2 (AQP2) and epithelial Na channel (ENaC) subcellular trafficking were determined in response to continuous ANP infusion in conscious rats, where body ..
  46. Kim S, de Seigneux S, Sassen M, Lee J, Kim J, Knepper M, et al. Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats. Am J Physiol Renal Physiol. 2006;290:F674-87 pubmed
    ..We hypothesize that dysregulation of the epithelial sodium channel (ENaC) and/or of sodium (co)transporters may be responsible for the increased sodium retention associated with HgCl(2)-..
  47. Staub O, Gautschi I, Ishikawa T, Breitschopf K, Ciechanover A, Schild L, et al. Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J. 1997;16:6325-36 pubmed
    ..Mutation of a cluster of Lys residues (to Arg) at the N-terminus of gamma ENaC leads to both inhibition of ubiquitination and increased channel activity, an effect augmented by N-terminal Lys ..
  48. Haerteis S, Krappitz M, Bertog M, Krappitz A, Baraznenok V, Henderson I, et al. Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S. Pflugers Arch. 2012;464:353-65 pubmed
    Proteolytic processing of the amiloride-sensitive epithelial sodium channel (ENaC) by serine proteases is known to be important for channel activation...
  49. Grifoni S, Gannon K, Stec D, Drummond H. ENaC proteins contribute to VSMC migration. Am J Physiol Heart Circ Physiol. 2006;291:H3076-86 pubmed
    ..Recently, we showed that epithelial Na(+) channel (ENaC) proteins are expressed in VSMCs and that ENaC inhibition abolishes pressure-induced constriction in isolated ..
  50. Coote K, Atherton H, Young A, Sugar R, Burrows R, Smith N, et al. The guinea-pig tracheal potential difference as an in vivo model for the study of epithelial sodium channel function in the airways. Br J Pharmacol. 2008;155:1025-33 pubmed publisher
    The epithelial sodium channel (ENaC) is a key regulator of airway mucosal hydration and mucus clearance. Negative regulation of airway ENaC function is predicted to be of clinical benefit in the cystic fibrosis lung...
  51. Kim E, Choi S, Lim M, Yeon S, Lee Y. Role of endogenous ENaC and TRP channels in the myogenic response of rat posterior cerebral arteries. PLoS ONE. 2013;8:e84194 pubmed publisher
    ..Recent findings have indicated that transient receptor potential (TRP) channels and epithelial sodium channels (ENaC) are involved in mechanotransduction...
  52. Teruyama R, Sakuraba M, Wilson L, Wandrey N, Armstrong W. Epithelial Na? sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei. Am J Physiol Endocrinol Metab. 2012;302:E273-85 pubmed publisher
    The epithelial Na? channels (ENaCs) are present in kidney and contribute to Na? and water homeostasis. All three ENaC subunits (?, ?, and ?) were demonstrated in the cardiovascular regulatory centers of the rat brain, including the ..
  53. Sun P, Lin D, Yue P, Jiang H, Gotlinger K, Schwartzman M, et al. High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC. J Am Soc Nephrol. 2010;21:1667-77 pubmed publisher
    ..Because the AA metabolite 11,12-epoxyeicosatrienoic acid (11,12-EET) can inhibit the epithelial sodium channel (ENaC) in the cortical collecting duct, we tested whether dietary potassium modulates ENaC function...
  54. Machida K, Nonoguchi H, Wakamatsu S, Inoue H, Yosifovska T, Inoue T, et al. Acute regulation of the epithelial sodium channel gene by vasopressin and hyperosmolality. Hypertens Res. 2003;26:629-34 pubmed
    The amiloride-sensitive epithelial sodium channel (ENaC) plays a key role in sodium reabsorption in the collecting ducts...
  55. Anantharam A, Palmer L. Determination of epithelial Na+ channel subunit stoichiometry from single-channel conductances. J Gen Physiol. 2007;130:55-70 pubmed
    The epithelial Na(+) channel (ENaC) is a multimeric membrane protein consisting of three subunits, alpha, beta, and gamma...
  56. Hanwell D, Ishikawa T, Saleki R, Rotin D. Trafficking and cell surface stability of the epithelial Na+ channel expressed in epithelial Madin-Darby canine kidney cells. J Biol Chem. 2002;277:9772-9 pubmed
    The apically located epithelial Na(+) channel (alphabetagamma-ENaC) plays a key role in the regulation of salt and fluid transport in the kidney and other epithelia, yet its mode of trafficking to the plasma membrane and its cell surface ..
  57. Li T, Koshy S, Folkesson H. RNA interference for CFTR attenuates lung fluid absorption at birth in rats. Respir Res. 2008;9:55 pubmed publisher
    ..of the epithelial Na channel) and CFTR (cystic fibrosis transmembrane conductance regulator) was used to explore ENaC and CTFR function in newborn rat lungs...
  58. Fouladkou F, Alikhani Koopaei R, Vogt B, Flores S, Malbert Colas L, Lecomte M, et al. A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes. Am J Physiol Renal Physiol. 2004;287:F550-61 pubmed
    The epithelial Na(+) channel (ENaC) is regulated by the ubiquitin-protein ligase Nedd4-2 via interaction with ENaC PY-motifs...
  59. Ruete M, Carrizo L, Bocanegra M, Valles P. Altered renal expression of Na(+) transporters and ROMK in protein-deprived rats. Nephron Physiol. 2009;111:p17-29 pubmed publisher
    ..The abundance of the aldosterone-regulated Na(+)-Cl(-) cotransporter (NCC) and epithelial Na(+) channel (ENaC) was higher in the LP group and was associated with higher plasma aldosterone level...
  60. Rauh R, Hoerner C, Korbmacher C. ???-ENaC is inhibited by CFTR but stimulated by cAMP in Xenopus laevis oocytes. Am J Physiol Lung Cell Mol Physiol. 2017;312:L277-L287 pubmed publisher
    The epithelial sodium channel (ENaC) and the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel critically regulate airway surface liquid by driving fluid absorption and secretion, respectively...
  61. Riazi S, Khan O, Tiwari S, Hu X, Ecelbarger C. Rosiglitazone regulates ENaC and Na-K-2Cl cotransporter (NKCC2) abundance in the obese Zucker rat. Am J Nephrol. 2006;26:245-57 pubmed
    ..RGZ normalized NKCC2 abundance and increased the abundance of the alpha-subunit of the epithelial sodium channel (ENaC)...
  62. Planes C, Blot Chabaud M, Matthay M, Couette S, Uchida T, Clerici C. Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. J Biol Chem. 2002;277:47318-24 pubmed
    ..transport under conditions of moderate hypoxia, we examined the effect of terbutaline on epithelial sodium channel (ENaC) expression and activity in cultured rat alveolar epithelial type II cells exposed to 3% O(2) for 24 h...
  63. Amin M, Reza E, Wang H, Leenen F. Sodium transport in the choroid plexus and salt-sensitive hypertension. Hypertension. 2009;54:860-7 pubmed publisher
    ..of epithelial sodium channels (ENaCs) and Na(+)-K(+)-ATPase in Na(+) transport by the choroid plexus, we studied ENaC expression and Na(+) transport in the choroid plexus...
  64. Kim S, Schou U, Peters C, de Seigneux S, Kwon T, Knepper M, et al. Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2 11beta-hydroxysteroid dehydrogenase in rats with CCl4-induced decompensated liver cirrhosis. J Am Soc Nephrol. 2005;16:3196-210 pubmed
    It was hypothesized that dysregulation of renal epithelial sodium channel (ENaC) subunits and/or 11beta-hydroxysteroid dehydrogenase (11betaHSD2) may play a role in the increased sodium retention in liver cirrhosis (LC)...
  65. Li Y, Zhang D, Tu H, Muelleman R. Altered ENaC is Associated With Aortic Baroreceptor Dysfunction in Chronic Heart Failure. Am J Hypertens. 2016;29:582-9 pubmed publisher
    ..As a mechanosensor in mammalian nonepithelium, the epithelial sodium channel (ENaC) is an amiloride-sensitive and voltage-independent ion channel...
  66. Yu Z, Schumacher M, Frey B, Frey F, Vogt B. Regulation of epithelial sodium channel in puromycin aminonucleoside-induced unilateral experimental nephrotic syndrome in normal and analbuminemic Nagase rats. Nephron Physiol. 2005;101:p51-62 pubmed
    ..The epithelial sodium channel (ENaC) is the rate-limiting constituent of sodium transport in CCD...
  67. Wakida N, Kitamura K, Tuyen D, Maekawa A, Miyoshi T, Adachi M, et al. Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone. Kidney Int. 2006;70:1432-8 pubmed
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