Gene Symbol: Scly
Description: selenocysteine lyase
Alias: selenocysteine lyase
Species: rat
Products:     Scly

Top Publications

  1. Mihara H, Kurihara T, Watanabe T, Yoshimura T, Esaki N. cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase. Candidate for selenium delivery protein in selenoprotein synthesis. J Biol Chem. 2000;275:6195-200 pubmed
    b>Selenocysteine lyase (SCL) (EC is a pyridoxal 5'-phosphate-dependent enzyme that specifically catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium...
  2. Jafari C, Panzer U, Steinmetz O, Zahner G, Stahl R, Harendza S. Enhanced expression of selenocysteine lyase in acute glomerulonephritis and its regulation by AP-1. Cell Mol Biol Lett. 2006;11:424-37 pubmed
    ..One of the differentially expressed genes was identified as SCL, encoding selenocysteine lyase. Its expression was higher in acute glomerulonephritis and lower in chronic glomerulonephritis...
  3. Omi R, Kurokawa S, Mihara H, Hayashi H, Goto M, Miyahara I, et al. Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase. J Biol Chem. 2010;285:12133-9 pubmed publisher
    b>Selenocysteine lyase (SCL) catalyzes the pyridoxal 5'-phosphate-dependent removal of selenium from l-selenocysteine to yield l-alanine...
  4. Seale L, Hashimoto A, Kurokawa S, Gilman C, Seyedali A, Bellinger F, et al. Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Mol Cell Biol. 2012;32:4141-54 pubmed
    ..b>Selenocysteine lyase (Scly) is the enzyme that supplies Se for selenoprotein biosynthesis via decomposition of the amino acid ..