Scarb1

Summary

Gene Symbol: Scarb1
Description: scavenger receptor class B, member 1
Alias: Cd36l1, SR-B1, Srb1, scavenger receptor class B member 1, CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1), CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1, SR-BI, scavanger receptor class B type 1, scavenger receptor class B type I
Species: rat
Products:     Scarb1

Top Publications

  1. Wang N, Lan D, Chen W, Matsuura F, Tall A. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A. 2004;101:9774-9 pubmed
    ..ABCG1 is highly expressed in macrophages and probably mediates cholesterol efflux from macrophage foam cells to the major HDL fractions, providing a mechanism to explain the relationship between HDL levels and atherosclerosis risk...
  2. Babitt J, Trigatti B, Rigotti A, Smart E, Anderson R, Xu S, et al. Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae. J Biol Chem. 1997;272:13242-9 pubmed
    ..Thus, mSR-BI colocalizes with caveolae, and this raises the possibility that the unique properties of these specialized cell surface domains may play a critical role in SR-BI-mediated transfer of lipids between lipoproteins and cells. ..
  3. Lu X, He L, Zhou Q, Wang M, Shen W, Azhar S, et al. NHERF1 and NHERF2 regulation of SR-B1 stability via ubiquitination and proteasome degradation. Biochem Biophys Res Commun. 2017;490:1168-1175 pubmed publisher
    ..NHERF1 and NHERF2 promote SR-B1 ubiquitination at sites K508 and K500, respectively. These results suggest that NHERF1 and NHERF2 down-regulated SR-B1 at least in part via the ubiquitin/proteasome pathway. ..
  4. Jeyakumar S, Sheril A, Vajreswari A. Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain. Indian J Med Res. 2016;144:238-244 pubmed publisher
  5. Lee T, Lin C, Tsai J, Wu Y, Su K, Lu K, et al. Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sci. 2009;84:97-104 pubmed publisher
    ..We investigated the mechanisms underlying the dysregulation by resistin of these regulators leading to promotion of lipid accumulation in bone marrow-derived macrophages...
  6. Lopez D, McLean M. Activation of the rat scavenger receptor class B type I gene by PPARalpha. Mol Cell Endocrinol. 2006;251:67-77 pubmed
    ..In addition, mutational analysis studies confirmed that this PPRE motif is responsible for the PPARalpha/RXRalpha-dependent activation of the rat SR-BI promoter in the cell lines examined. ..
  7. de Beer M, Castellani L, Cai L, Stromberg A, de Beer F, van der Westhuyzen D. ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36. J Lipid Res. 2004;45:706-15 pubmed
    ..These results demonstrate that apoA-II exerts a marked effect on HDL binding and selective lipid uptake by the class B scavenger receptors and establishes a potentially important relationship between apoA-II and CD36. ..
  8. Pilon A, Briand O, Lestavel S, Copin C, Majd Z, Fruchart J, et al. Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake. Arterioscler Thromb Vasc Biol. 2000;20:1074-81 pubmed
    ..These results demonstrate that in the human adrenal cell line expressing SR-BI as the major HDL binding protein, efficient apoAII binding has an inhibitory effect on the delivery of cholesteryl esters to cells. ..
  9. Dissen E, Fossum S. Chromosomal localization of the genes encoding rat CD4, CD8alpha, and CD8beta. Immunogenetics. 1996;44:312-4 pubmed

More Information

Publications62

  1. Provost A, Pequignot M, Sainton K, Gadin S, Sallé S, Marchant D, et al. Expression of SR-BI receptor and StAR protein in rat ocular tissues. C R Biol. 2003;326:841-51 pubmed
    ..Our results may suggest a key role of these genes in the ocular cholesterol metabolism for membranes biosynthesis and neurosteroidogenesis. ..
  2. Reaven E, Cortez Y, Leers Sucheta S, Nomoto A, Azhar S. Dimerization of the scavenger receptor class B type I: formation, function, and localization in diverse cells and tissues. J Lipid Res. 2004;45:513-28 pubmed
    This study has examined the dimeric/oligomeric forms of scavenger receptor class B type I (SR-BI) and its alternatively spliced form, SR-BII, in a diverse group of cells and tissues: i.e...
  3. Johnson M, Johansson J, Svensson P, Aberg M, Eriksson P, Carlsson L, et al. Interaction of scavenger receptor class B type I with peroxisomal targeting receptor Pex5p. Biochem Biophys Res Commun. 2003;312:1325-34 pubmed
    b>Scavenger receptor class B type I (SR-BI) is an HDL receptor that mediates selective HDL lipid uptake...
  4. Rhainds D, Brissette L. The role of scavenger receptor class B type I (SR-BI) in lipid trafficking. defining the rules for lipid traders. Int J Biochem Cell Biol. 2004;36:39-77 pubmed
    The scavenger receptor class B type I (SR-BI) is a 509-amino acid, 82 kDa glycoprotein, with two cytoplasmic C- and N-terminal domains separated by a large extracellular domain...
  5. Nakagawa A, Nagaosa K, Hirose T, Tsuda K, Hasegawa K, Shiratsuchi A, et al. Expression and function of class B scavenger receptor type I on both apical and basolateral sides of the plasma membrane of polarized testicular Sertoli cells of the rat. Dev Growth Differ. 2004;46:283-98 pubmed
  6. Wang L, Connelly M, Ostermeyer A, Chen H, Williams D, Brown D. Caveolin-1 does not affect SR-BI-mediated cholesterol efflux or selective uptake of cholesteryl ester in two cell lines. J Lipid Res. 2003;44:807-15 pubmed
    ..We conclude that basal and SR-BI-stimulated FC efflux to HDL and liposomes and SR-BI-mediated selective uptake of HDL CE are not affected by caveolin-1 expression in HEK 293 or FRT cells. ..
  7. Johnson M, Svensson P, Helou K, Billig H, Levan G, Carlsson L, et al. Characterization and chromosomal localization of rat scavenger receptor class B type I, a high density lipoprotein receptor with a putative leucine zipper domain and peroxisomal targeting sequence. Endocrinology. 1998;139:72-80 pubmed
    ..b>Scavenger receptor class B type I (SR-BI) was recently shown to bind HDL and mediate internalization of its cholesterol content...
  8. Towns R, Menon K. The role of cyclic AMP response element binding protein in transactivation of scavenger receptor class B type I promoter in transfected cells and in primary cultures of rat theca-interstitial cells. Mol Cell Endocrinol. 2005;245:23-30 pubmed
    ..selective uptake and transport of cholesterol for steroid biosynthesis from HDL particles via the scavenger receptor class B type I (SR-BI)...
  9. Seetharam D, Mineo C, Gormley A, Gibson L, Vongpatanasin W, Chambliss K, et al. High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I. Circ Res. 2006;98:63-72 pubmed
    ..Furthermore, reendothelialization is impaired in SR-BI(-/-) mice. Thus, HDL stimulates endothelial cell migration via SR-BI-initiated signaling, and these mechanisms promote endothelial monolayer integrity in vivo. ..
  10. Lai W, Yeh Y, Lee M, Wu L, Ke F, Hwang J. Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis. J Lipid Res. 2013;54:365-78 pubmed publisher
    ..Giving cells lipoproteins or 25-hydroxycholesterol downregulated Ldlr but not Scarb1; Scarb1 was ultimately downregulated by excessive sterol accumulation under 25-hydroxycholesterol and ..
  11. Goti D, Hrzenjak A, Levak Frank S, Frank S, van der Westhuyzen D, Malle E, et al. Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E. J Neurochem. 2001;76:498-508 pubmed
    ..The results of this study indicate that SR-BI promotes the uptake of HDL-associated alphaTocH into cells constituting the BBB and plays an important role during the supply of the CNS with this indispensable micronutrient. ..
  12. Hu Z, Hu J, Shen W, Kraemer F, Azhar S. A Novel Role of Salt-Inducible Kinase 1 (SIK1) in the Post-Translational Regulation of Scavenger Receptor Class B Type 1 Activity. Biochemistry. 2015;54:6917-30 pubmed publisher
  13. Mizutani T, Sonoda Y, Minegishi T, Wakabayashi K, Miyamoto K. Cloning, characterization, and cellular distribution of rat scavenger receptor class B type I (SRBI) in the ovary. Biochem Biophys Res Commun. 1997;234:499-505 pubmed
    ..Our data strongly suggest that SRBI may play a significant role in the ovarian steroidogenesis by mediating selective uptake of cholesterol from HDL to ovarian theca interna cells or to corpus luteum. ..
  14. Murao K, Terpstra V, Green S, Kondratenko N, Steinberg D, Quehenberger O. Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes. J Biol Chem. 1997;272:17551-7 pubmed
    ..An additional role in recognition of damaged cells is suggested by these studies. ..
  15. Zhang S, Picard M, Vasile E, Zhu Y, Raffai R, Weisgraber K, et al. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation. 2005;111:3457-64 pubmed
    ..Thus, SR-BI KO/ApoeR61(h/h) mice have the potential to contribute to our understanding of CHD and its prevention and treatment. ..
  16. Ji A, Meyer J, Cai L, Akinmusire A, de Beer M, Webb N, et al. Scavenger receptor SR-BI in macrophage lipid metabolism. Atherosclerosis. 2011;217:106-12 pubmed publisher
    ..Our results suggest that SR-BI plays a significant role in macrophage cholesterol flux that may partly account for its effects on atherogenesis. ..
  17. Harrison E. Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids. Biochim Biophys Acta. 2012;1821:70-7 pubmed publisher
    ..These and other carotenoids are transported into the mucosal cell by scavenger receptor class B type I (SR-BI)...
  18. Thuahnai S, Lund Katz S, Dhanasekaran P, de la Llera Moya M, Connelly M, Williams D, et al. Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure. J Biol Chem. 2004;279:12448-55 pubmed
    ..FC efflux to HDL is affected both by binding of HDL to SR-BI and by the ability of the receptor to perturb the packing of FC molecules in the cell plasma membrane. ..
  19. Ohashi R, Mu H, Wang X, Yao Q, Chen C. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. QJM. 2005;98:845-56 pubmed
    ..Further research on new modifying factors for RCT and cholesterol efflux is warranted...
  20. McLean M, Sandhoff T. Expression and hormonal regulation of the high-density lipoprotein (HDL) receptor scavenger receptor class B type I messenger ribonucleic acid in the rat ovary. Endocrine. 1998;9:243-52 pubmed
    ..delivery to the ovary is an essential regulated step in steroidogenesis, mRNA levels for the Scavenger Receptor Class B Type I (SR-BI), a putative high-density lipoprotein receptor (HDL-R), were examined in response to tropic ..
  21. Yeh Y, Hwang G, Liu I, Yang V. Identification and expression of scavenger receptor SR-BI in endothelial cells and smooth muscle cells of rat aorta in vitro and in vivo. Atherosclerosis. 2002;161:95-103 pubmed
    In this study, we used immunoelectron microscopy to investigate the subcellular localization of scavenger receptor class B type I (SR-BI) in the arterial walls of rats...
  22. Rao R, Jo Y, Leers Sucheta S, Bose H, Miller W, Azhar S, et al. Differential regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of SR-B1-mediated selective cholesteryl ester transport. Biol Reprod. 2003;68:114-21 pubmed
  23. Kawasaki Y, Nakagawa A, Nagaosa K, Shiratsuchi A, Nakanishi Y. Phosphatidylserine binding of class B scavenger receptor type I, a phagocytosis receptor of testicular sertoli cells. J Biol Chem. 2002;277:27559-66 pubmed
    ..These results allowed us to conclude that SR-BI is a phagocytosis-inducing PS receptor of Sertoli cells. ..
  24. Li X, Titlow W, Jackson B, Giltiay N, Nikolova Karakashian M, Uittenbogaard A, et al. High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner. J Biol Chem. 2002;277:11058-63 pubmed
    ..We conclude that HDL binding to SR-BI stimulates eNOS by increasing intracellular ceramide levels and is independent of an increase in intracellular calcium or Akt kinase phosphorylation. ..
  25. Dao Thi V, Granier C, Zeisel M, Guerin M, Mancip J, Granio O, et al. Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps. J Biol Chem. 2012;287:31242-57 pubmed publisher
    ..Finally, our results underscore a third function of SR-BI governed by specific residues in hypervariable region 1 of E2 leading to enhanced cell entry and depending on SR-BI ability to bind to E2. ..
  26. Hu Z, Hu J, Zhang Z, Shen W, Yun C, Berlot C, et al. Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs). J Biol Chem. 2013;288:11416-35 pubmed publisher
    ..Collectively, these data establish NHERF1 and NHERF2 as SR-BI protein binding partners that play a negative role in the regulation of SR-BI expression, selective CE transport, and steroidogenesis. ..
  27. Tachikawa M, Okayasu S, Hosoya K. Functional involvement of scavenger receptor class B, type I, in the uptake of alpha-tocopherol using cultured rat retinal capillary endothelial cells. Mol Vis. 2007;13:2041-7 pubmed
    ..Our findings strongly suggest that SR-BI at the inner blood-retinal barrier is responsible for alpha-tocopherol uptake from the circulating blood and plays a key role in maintaining alpha-tocopherol in the neural retina. ..
  28. Badeau R, Metso J, Tikkanen M, Jauhiainen M. High-density lipoprotein-associated 17beta-estradiol fatty acyl ester uptake by Fu5AH hepatoma cells: implications of the roles of scavenger receptor class B, type I and the low-density lipoprotein receptor. Biochim Biophys Acta. 2007;1771:1329-34 pubmed
    ..HDL-E2-FAE was hydrolyzed into free E2 with the maximum at 24 h. Fu5AH cells facilitate HDL-E2 uptake by at least SR-BI and LDL receptor pathways and intracellular hydrolysis of E2-FAE into free E2 ensues. ..
  29. Sporstøl M, Mousavi S, Eskild W, Roos N, Berg T. ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines. BMC Mol Biol. 2007;8:5 pubmed
    ..Here, the regulation of SR-BI, ABCA1, and ABCG1 by dexamethasone (a synthetic glucocorticoid) and insulin were studied in order to gain more insight into the role of these two hormones in the cholesterol metabolism...
  30. Xu S, Laccotripe M, Huang X, Rigotti A, Zannis V, Krieger M. Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake. J Lipid Res. 1997;38:1289-98 pubmed
  31. Azhar S, Nomoto A, Reaven E. Hormonal regulation of adrenal microvillar channel formation. J Lipid Res. 2002;43:861-71 pubmed
  32. Ikemoto M, Arai H, Feng D, Tanaka K, Aoki J, Dohmae N, et al. Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I. Proc Natl Acad Sci U S A. 2000;97:6538-43 pubmed
    The scavenger receptor class B type I (SR-BI) mediates the selective uptake of cholesteryl esters from high-density lipoprotein (HDL) and cholesterol secretion into bile in the liver...
  33. Morgado N, Rigotti A, Valenzuela A. Comparative effect of fish oil feeding and other dietary fatty acids on plasma lipoproteins, biliary lipids, and hepatic expression of proteins involved in reverse cholesterol transport in the rat. Ann Nutr Metab. 2005;49:397-406 pubmed
    ..cholesterol acyltransferase, hepatic lipase, apo E, and apo A-I, and hepatic protein levels of the scavenger receptor class B type I, caveolin-1, and the ATP binding cassette transporter A1 were analyzed...
  34. Wu Q, Sucheta S, Azhar S, Menon K. Lipoprotein enhancement of ovarian theca-interstitial cell steroidogenesis: relative contribution of scavenger receptor class B (type I) and adenosine 5'-triphosphate- binding cassette (type A1) transporter in high-density lipoprotein-cholesterol tra. Endocrinology. 2003;144:2437-45 pubmed
    ..Furthermore, the present study presents evidence for a crucial role for SR-BI in HDL-mediated androgen production...
  35. Wang Y, Meng C, Wei Q, Shi F, Mao D. Expression and regulation of scavenger receptor class B type 1 in the rat ovary and uterus during the estrous cycle. Acta Histochem. 2015;117:297-304 pubmed publisher
    ..Taken together, SR-B1 expression in the ovary and uterus across the estrous cycle demonstrate that SR-B1 may be involved in uterine function, follicular development as well as luteal function. ..
  36. Zanoni P, Khetarpal S, Larach D, Hancock Cerutti W, Millar J, Cuchel M, et al. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science. 2016;351:1166-71 pubmed publisher
    ..Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C levels but, paradoxically, increased atherosclerosis...
  37. Ha M, Guan X, Wei L, Li P, Yang M, Liu C. Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic-pituitary-testis axis and ERK-mediated 5α-Reductase 2. Sci Total Environ. 2016;563-564:566-75 pubmed publisher
    ..and then induced the ERK pathway, which was required to mediate 5α-Reductase 2 and scavenger receptor class B-1 (SRB1) levels...
  38. Lee M, Appleton K, El Shewy H, Sorci Thomas M, Thomas M, Lopes Virella M, et al. S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization. J Lipid Res. 2017;58:325-338 pubmed publisher
    ..In conclusion, these data suggest that S1P in HDL stimulates the transient interaction between SR-BI and S1PRs that can activate S1PRs and induce an elevation in intracellular calcium concentration. ..
  39. Husemann J, Loike J, Kodama T, Silverstein S. Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid. J Neuroimmunol. 2001;114:142-50 pubmed
    ..Thus SR-BI and SR-A mediate similar effector functions in neonatal microglia, which suggests that SR-BI plays as important a role as SR-A, and can maintain the wildtype phenotype in SR-A-/- microglia. ..
  40. Lopez D, McLean M. Sterol regulatory element-binding protein-1a binds to cis elements in the promoter of the rat high density lipoprotein receptor SR-BI gene. Endocrinology. 1999;140:5669-81 pubmed
    The high density lipoprotein (HDL) receptor, or scavenger receptor class B type I (SR-BI), is critical for cholesterol transport and a potential target for hypercholesterolemic drugs...
  41. Cho K, Kim H, Kamanna V, Vaziri N. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta. 2010;1800:6-15 pubmed publisher
    ..Present study sought to determine efficacy of niacin supplementation on renal tissue lipid metabolism in CRF...
  42. Régeard M, Trotard M, Lepere C, Gripon P, Le Seyec J. Entry of pseudotyped hepatitis C virus into primary human hepatocytes depends on the scavenger class B type I receptor. J Viral Hepat. 2008;15:865-70 pubmed publisher
    ..In this study, we showed that SRBI also plays an essential role in HCV entry into primary human hepatocytes with two distinct approaches: gene extinction and antibodies neutralization assays. ..
  43. Minahk C, Kim K, Nelson R, Trigatti B, Lehner R, Vance D. Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem. 2008;283:6449-58 pubmed publisher
  44. Osada Y, Shiratsuchi A, Nakanishi Y. Involvement of mitogen-activated protein kinases in class B scavenger receptor type I-induced phagocytosis of apoptotic cells. Exp Cell Res. 2006;312:1820-30 pubmed
  45. Ji Y, Wang N, Ramakrishnan R, Sehayek E, Huszar D, Breslow J, et al. Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J Biol Chem. 1999;274:33398-402 pubmed
    ..Thus, in the mouse, a major portion of the clearance of HDL FC from plasma is mediated by SR-BI. ..
  46. Webb N, de Beer M, Asztalos B, Whitaker N, van der Westhuyzen D, de Beer F. Remodeling of HDL remnants generated by scavenger receptor class B type I. J Lipid Res. 2004;45:1666-73 pubmed
    b>Scavenger receptor class B type I (SR-BI) mediates the selective transfer of cholesteryl ester from HDL to cells...
  47. Vishnyakova T, Bocharov A, Baranova I, Chen Z, Remaley A, Csako G, et al. Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1. J Biol Chem. 2003;278:22771-80 pubmed
    ..In summary, Cla-1 was found to bind and internalize monomerized and HDL-associated LPS, indicating that Cla-1 may play important role in septic shock by affecting LPS cellular uptake and clearance. ..
  48. Shiratsuchi A, Kawasaki Y, Ikemoto M, Arai H, Nakanishi Y. Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells. J Biol Chem. 1999;274:5901-8 pubmed
    ..In conclusion, SR-BI functions at least partly as a PS receptor, enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation. ..
  49. Alam K, Meidell R, Spady D. Effect of up-regulating individual steps in the reverse cholesterol transport pathway on reverse cholesterol transport in normolipidemic mice. J Biol Chem. 2001;276:15641-9 pubmed
    ..Thus, although rHDL stimulated cholesterol efflux from most tissues and increased net cholesterol movement from extrahepatic tissues to the liver, cholesterol flux through the entire RCT pathway was not increased. ..
  50. Osada Y, Sunatani T, Kim I, Nakanishi Y, Shiratsuchi A. Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells. J Biochem. 2009;145:387-94 pubmed publisher
  51. Widjaja Adhi M, Lobo G, Golczak M, von Lintig J. A genetic dissection of intestinal fat-soluble vitamin and carotenoid absorption. Hum Mol Genet. 2015;24:3206-19 pubmed publisher
    ..Subsequently, ISX binds to conserved DNA-binding motifs upstream of the BCO1 and SCARB1 genes. SCARB1 encodes a membrane protein that facilitates absorption of fat-soluble vitamins and carotenoids...
  52. Lopez D, McLean M. Estrogen regulation of the scavenger receptor class B gene: Anti-atherogenic or steroidogenic, is there a priority?. Mol Cell Endocrinol. 2006;247:22-33 pubmed
    ..The objective of this manuscript is to summarize the current information related to estrogen regulation of the gene that codes for the SR-BI receptor. ..
  53. Panzenboeck U, Balazs Z, Sovic A, Hrzenjak A, Levak Frank S, Wintersperger A, et al. ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. J Biol Chem. 2002;277:42781-9 pubmed
    ..In conclusion, the apoA-I/ABCA1- and HDL/SR-BI-dependent pathways modulate polarized sterol mobilization at the BBB...