Gene Symbol: Sav1
Description: salvador family WW domain containing protein 1
Alias: protein salvador homolog 1, 45 kDa WW domain protein, Salvador homolog 1 protein, rWW45
Lee J, Kim T, Yang T, Koo B, Oh S, Lee K, et al
. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008;27:1231-42 pubmed publisher
..Collectively, these data provide compelling evidence that WW45 is a key mediator of MST1 signalling in the coordinate coupling of proliferation arrest with terminal differentiation for proper epithelial tissue development in mammals. ..
Callus B, Verhagen A, Vaux D. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J. 2006;273:4264-76 pubmed
..Together these results show that hSav can bind to, and be phosphorylated by, Mst, and that the stabilizing effect of Mst on hSav requires its interaction with hSav but is probably not due to phosphorylation of hSav by Mst. ..
Hwang E, Ryu K, Pääkkönen K, Güntert P, Cheong H, Lim D, et al
. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proc Natl Acad Sci U S A. 2007;104:9236-41 pubmed
..These results imply a novel mode of interaction with RASSF family proteins and provide insight into the mechanism of apoptosis control by the SARAH domain. ..
Lu L, Li Y, Kim S, Bossuyt W, Liu P, Qiu Q, et al
. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A. 2010;107:1437-42 pubmed publisher
..the role of hippo signaling in regulation of mammalian organ size we have generated conditional alleles of Sav1, mst1, and mst2, orthologs of Drosophila Salvador and hippo, respectively...
Luo X, Li Z, Yan Q, Li X, Tao D, Wang J, et al
. The human WW45 protein enhances MST1-mediated apoptosis in vivo. Int J Mol Med. 2009;23:357-62 pubmed
..These results indicate that hWW45 is required to enhance MST1-mediated apoptosis in vivo and thus is a critical player in an MST1-driven cell death signaling pathway. ..
Park B, Kim D, Won G, Jeon H, Oh B, Lee Y, et al
. Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPAR?. PLoS ONE. 2012;7:e30983 pubmed publisher
..We sought to understand the role of MST2 kinase and Salvador homolog 1 (SAV1), a scaffolding protein that functions in the MST pathway, in adipocyte differentiation...