Gene Symbol: Sac1
Description: SAC1 like phosphatidylinositide phosphatase
Alias: Sac1, phosphatidylinositide phosphatase SAC1, SAC1 suppressor of actin mutations 1-like, suppressor of actin mutations 1-like protein
Species: rat
Products:     Sac1

Top Publications

  1. Zhong R, Ye Z. The SAC domain-containing protein gene family in Arabidopsis. Plant Physiol. 2003;132:544-55 pubmed
    ..Moreover, the expression of the AtSAC6 gene was highly induced by salinity. These results provide a foundation for future studies on the elucidation of the cellular functions of SAC domain-containing proteins in Arabidopsis. ..
  2. Mesmin B, Bigay J, Moser von Filseck J, Lacas Gervais S, Drin G, Antonny B. A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP. Cell. 2013;155:830-43 pubmed publisher
    ..Finally, PI(4)P is hydrolyzed in cis by the ER protein Sac1. The energy provided by PI(4)P hydrolysis drives sterol transfer and allows negative feedback when PI(4)P becomes ..
  3. Nemoto Y, Kearns B, Wenk M, Chen H, Mori K, Alb J, et al. Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity. J Biol Chem. 2000;275:34293-305 pubmed
    The Saccharomyces cerevisiae SAC1 gene was identified via independent analyses of mutations that modulate yeast actin function and alleviate the essential requirement for phosphatidylinositol transfer protein (Sec14p) activity in Golgi ..
  4. Thole J, Vermeer J, Zhang Y, Gadella T, Nielsen E. Root hair defective4 encodes a phosphatidylinositol-4-phosphate phosphatase required for proper root hair development in Arabidopsis thaliana. Plant Cell. 2008;20:381-95 pubmed publisher