Gene Symbol: S1pr2
Description: sphingosine-1-phosphate receptor 2
Alias: Edg5, GPCR18, Gpcr13, H218, snGPCR18, sphingosine 1-phosphate receptor 2, AGR16, G-protein coupled receptor 13, G-protein coupled receptor H218, S1P receptor 2, S1P receptor Edg-5, S1P2, endothelial differentiation G-protein coupled receptor 5, endothelial differentiation, sphingolipid G-protein-coupled receptor, 5, sphingosine 1-phosphate receptor Edg-5
Species: rat
Products:     S1pr2

Top Publications

  1. Studer E, Zhou X, Zhao R, Wang Y, Takabe K, Nagahashi M, et al. Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes. Hepatology. 2012;55:267-76 pubmed publisher
    ..In summary, all these data support the hypothesis that conjugated bile acids activate the ERK1/2 and AKT signaling pathways primarily through S1P(2) in primary rodent hepatocytes. ..
  2. Kageyama Y, Ikeda H, Watanabe N, Nagamine M, Kusumoto Y, Yashiro M, et al. Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents. Hepatology. 2012;56:1427-38 pubmed publisher
    ..of those cells and enhances portal vein pressure in isolated perfused rat livers with Rho activation by way of S1P receptor 2 (S1P(2) )...
  3. An S, Bleu T, Huang W, Hallmark O, Coughlin S, Goetzl E. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett. 1997;417:279-82 pubmed
    ..Two closely related G protein-coupled receptors, rat H218 and human Edg3, are highly similar to Edg2...
  4. Chen T, Huang Z, Liu R, Yang J, Hylemon P, Zhou H. Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. Front Biosci (Landmark Ed). 2017;22:596-608 pubmed
    ..Here, we show that, except for S1PR4, all S1PRs are expressed in normal intestinal epithelial cells with S1PR2 being the most abundant...
  5. Lei S, Wang Q, Lv C, Wu C, Yuan Q, Han J. [Inhibition of S1PR2 activity down-regulates expressions of sphingosine kinase 1 and MCP-1 in rat glomerular mesangial cells under high glucose]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2015;31:36-9 pubmed
    ..investigate the effects of high glucose and the specific antagonist JTE-013 of sphingosine-1-phosphate receptor 2 (S1PR2) on the expressions of sphingosine kinase 1 (Sphk1), S1PR2 and monocyte chemoattractant protein-1 (MCP-1) in rat ..
  6. Björklund S, Palmberg S, Rask S, Westerdahl A, Törnquist K. Effects of sphingosine 1-phosphate on calcium signaling, proliferation and S1P2 receptor expression in PC Cl3 rat thyroid cells. Mol Cell Endocrinol. 2005;231:65-74 pubmed
    ..In summary, S1P modulates central intracellular signaling cascades and is antiproliferative in PC Cl(3) cells. S1P(2) receptor expression is modulated by insulin and TSH, two central growth factors in thyroid cell regulation. ..
  7. Liu W, Lan T, Xie X, Huang K, Peng J, Huang J, et al. S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition. Exp Cell Res. 2012;318:936-43 pubmed publisher
    ..Among five S1P receptors the mRNA level of S1P2 receptor was the most abundant in kidney of diabetic rats and mesangial cells under high glucose condition...
  8. Al Jarallah A, Oriowo M. The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. PLoS ONE. 2017;12:e0170792 pubmed publisher
    ..S1P-induced contraction was mediated by S1PR1 and S1PR2 in control and S1PR2 in inflamed colon segments...
  9. Wamhoff B, Lynch K, Macdonald T, Owens G. Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol. 2008;28:1454-61 pubmed publisher
    ..injury of the rat carotid artery, S1P1/S1P3 receptor mRNA levels were transiently increased at 48 hours whereas S1P2 receptor expression was decreased. S1P2 expression was reinduced and increased at 7 to 10 days postinjury...

More Information


  1. Lu H, Yuan H, Chen S, Huang L, Xiang H, Yang G, et al. Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats. Mol Cell Biochem. 2012;363:217-24 pubmed publisher
    ..These results indicate that the impaired functions (such as chemotactic, wound healing, and morphogenetic responses) in senescent PMECs in vivo are mediated by the S1P(2) receptor. ..
  2. Gandy K, Canals D, Adada M, Wada M, Roddy P, Snider A, et al. Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J. 2013;449:661-72 pubmed publisher
    ..antagonists, along with siRNA (small interfering RNA) techniques and genetic knockout approaches, we identify the S1PR2 as the specific and necessary receptor to induce phosphorylation of ERM proteins and subsequent filopodia ..
  3. MacLennan A, Carney P, Zhu W, Chaves A, Garcia J, Grimes J, et al. An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability. Eur J Neurosci. 2001;14:203-9 pubmed
    A wealth of indirect data suggest that the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate (S1P) receptor plays important roles in development...
  4. Ancellin N, Hla T. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. J Biol Chem. 1999;274:18997-9002 pubmed
    ..Furthermore, because only EDG-3 was antagonized by suramin, variations in receptor structure may determine differences in antagonist selectivity. This property may be exploited to synthesize receptor subtype-specific antagonists. ..
  5. Frias M, James R, Gerber Wicht C, Lang U. Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate. Cardiovasc Res. 2009;82:313-23 pubmed publisher
    ..agonists and antagonists of the S1P receptor subtypes indicate that HDL and S1P activate Stat3 mainly through the S1P2 receptor...
  6. MacLennan A, Browe C, Gaskin A, Lado D, Shaw G. Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. Mol Cell Neurosci. 1994;5:201-9 pubmed
    Polymerase chain reaction techniques and medium stringency library screening were used to isolate a rat cDNA ("H218") which encodes a novel guanine nucleotide-binding protein coupled receptor homolog ("pH218")...
  7. Völzke A, Koch A, Meyer Zu Heringdorf D, Huwiler A, Pfeilschifter J. Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. Biochim Biophys Acta. 2014;1841:11-21 pubmed publisher
    ..revealed that the S1P-dependent increase of COX-2 mRNA and protein expression was mediated via activation of S1P receptor 2 (S1P2)...
  8. Yang Z, Xiong F, Wang Y, Gong W, Huang J, Chen C, et al. TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. Pharmacol Res. 2016;111:226-236 pubmed publisher
    ..As our previous findings confirmed that, sphingosine 1-phosphate (S1P)/sphingosine 1-phosphate receptor 2 (S1P2) signaling activation promoted renal fibrosis in diabetes...
  9. Okazaki H, Ishizaka N, Sakurai T, Kurokawa K, Goto K, Kumada M, et al. Molecular cloning of a novel putative G protein-coupled receptor expressed in the cardiovascular system. Biochem Biophys Res Commun. 1993;190:1104-9 pubmed
    ..Although the ligand for this receptor has yet to be identified, the results suggest the existence of a new receptor subfamily in the cardiovascular system thus far unrecognized. ..
  10. Liu R, Zhao R, Zhou X, Liang X, Campbell D, Zhang X, et al. Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2. Hepatology. 2014;60:908-18 pubmed publisher
    ..kinase B (AKT)-signaling pathways through sphingosine 1-phosphate receptor 2 (S1PR2) in rodent hepatocytes...
  11. Ni X, Epshtein Y, Chen W, Zhou T, Xie L, Garcia J, et al. Interaction of integrin ?4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancement. J Cell Biochem. 2014;115:1187-95 pubmed
    ..In the current study, we investigated the roles of S1PR2 and S1PR3 in S1P/HGF-mediated EC signaling and their associations with ITGB4...
  12. Trifilieff A, Baur F, Fozard J. Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. Naunyn Schmiedebergs Arch Pharmacol. 2009;380:303-9 pubmed publisher
    ..These data demonstrate the importance of S1P and the S1P(2) receptor as regulators of allergen-induced activation of mast cells in their natural environment in the rat lung...