S1pr1

Summary

Gene Symbol: S1pr1
Description: sphingosine-1-phosphate receptor 1
Alias: Edg1, EDG1 (Edg1), S1P receptor 1, S1P receptor Edg-1, S1P1, endothelial differentiation G-protein coupled receptor 1, endothelial differentiation sphingolipid G-protein-coupled receptor 1, sphingosine 1-phosphate receptor 1, sphingosine 1-phosphate receptor Edg-1
Species: rat

Top Publications

  1. ncbi Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions
    D C Lado
    Department of Neuroscience, University of Florida Brain Institute, University of Florida College of Medicine, Gainesville 32610
    Gene 149:331-6. 1994
  2. ncbi Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes
    Alaa S Awad
    Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Kidney Int 79:1090-8. 2011
  3. ncbi The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons
    Xian Xuan Chi
    Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    J Neurophysiol 104:2741-8. 2010
  4. ncbi Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules
    Gengqian Zhang
    Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia 26506 9229, USA
    Am J Physiol Heart Circ Physiol 299:H1494-504. 2010
  5. ncbi Down-regulation of S1P1 receptor surface expression by protein kinase C inhibition
    Sven Christian Sensken
    Institute for Immunology, Hannover Medical School, 30625 Hanover, Germany
    J Biol Chem 285:6298-307. 2010
  6. ncbi Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS
    Laura J Sim-Selley
    Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    J Neurochem 110:1191-202. 2009
  7. ncbi Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype
    Brian R Wamhoff
    Department of Medicine, Cardiovascular Division, University of Virginia, Charlottesville, VA 22901, USA
    Arterioscler Thromb Vasc Biol 28:1454-61. 2008
  8. ncbi Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat: congenic analysis
    Delyth Graham
    BHF Glasgow Cardiovascular Research Centre, 126 University Pl, Glasgow, G12 8TA United Kingdom
    Hypertension 50:1134-41. 2007
  9. ncbi Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury
    Atsushi Kimura
    Department of Orthopedic Surgery, Jichi Medical University School of Medicine, Tochigi, Japan
    Stem Cells 25:115-24. 2007
  10. ncbi Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney
    Alaa S Awad
    Department of Medicine, Univ of Virginia, Charlottesville, VA, USA
    Am J Physiol Renal Physiol 290:F1516-24. 2006

Research Grants

  1. Brain Cannabinoid Signaling: Selectivity and Adaptation
    Laura Sim Selley; Fiscal Year: 2006
  2. Brain Cannabinoid Signaling: Selectivity and Adaptation
    Laura J Sim Selley; Fiscal Year: 2010

Scientific Experts

  • P Robert
  • Laura J Sim-Selley
  • Brian R Wamhoff
  • Laura Sim Selley
  • Laura J Sim Selley
  • Alaa S Awad
  • William J Valentine
  • Gengqian Zhang
  • Xian Xuan Chi
  • Sven Christian Sensken
  • Mark D Okusa
  • Kevin R Lynch
  • Liping Huang
  • H Okamoto
  • Atsushi Kimura
  • Delyth Graham
  • Soichiro Usui
  • M J Kluk
  • W Kline Bolton
  • Konstantine Khutsishvili
  • Daniel A Osborne
  • Jianxiong Liu
  • Michael D Rouse
  • Virginia I Godwin
  • Gabor Tigyi
  • Yuko Fujiwara
  • Robert Bittman
  • Abby L Parrill
  • James Van Brocklyn
  • Markus H Gräler
  • A L Parrill
  • G D Nicol
  • Sulei Xu
  • Pingnian He
  • Yan Qian
  • Y Takuwa
  • H Shigematsu
  • N Takuwa
  • Ryunosuke Ohkawa
  • Yuichi Hoshino
  • Michelle Gaasenbeek
  • John D McClure
  • Takashi Murakami
  • Kirsten Gilday
  • Yutaka Yatomi
  • William H Miller
  • Seiji Madoiwa
  • Anna F Dominiczak
  • Jun Mimuro
  • Eiji Kobayashi
  • Elisabeth Beattie
  • Rhian M Touyz
  • Martin W McBride
  • Tsukasa Ohmori
  • Augusto Montezano
  • Yoichi Sakata
  • James M Polke
  • Frank W Foss
  • Li Li
  • Hong Ye
  • Timothy L Macdonald
  • Naotoshi Sugimoto
  • Shigeo Takata
  • Noriko Takuwa
  • Yoh Takuwa
  • Satoru Sakagami
  • Shuichi Kaneko
  • T Hla
  • J R Van Brocklyn
  • D L Bautista
  • G Tigyi
  • T Yokomizo
  • S Spiegel
  • D Wang
  • Z Lorincz
  • N Sugimoto
  • D J Fischer
  • K Liliom
  • D L Baker
  • S Sakurada
  • Y Yatomi
  • K Gonda
  • D C Lado
  • K Chang
  • H Okazaki
  • J M Borden
  • A J MacLennan
  • C S Browe
  • A A Gaskin

Detail Information

Publications17

  1. ncbi Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions
    D C Lado
    Department of Neuroscience, University of Florida Brain Institute, University of Florida College of Medicine, Gainesville 32610
    Gene 149:331-6. 1994
    ..Therefore, edg-1 may play a cell-type-specific role in differentiation and also participate in neurotransmission...
  2. ncbi Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes
    Alaa S Awad
    Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Kidney Int 79:1090-8. 2011
    ..As S1P1 receptor (S1P1R) activation blocks kidney inflammation in acute renal injury, we tested whether activation of ..
  3. ncbi The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons
    Xian Xuan Chi
    Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    J Neurophysiol 104:2741-8. 2010
    ..These results indicate that S1PR(1) plays a prominent, although not exclusive, role in mediating the enhancement of excitability produced by S1P...
  4. ncbi Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules
    Gengqian Zhang
    Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia 26506 9229, USA
    Am J Physiol Heart Circ Physiol 299:H1494-504. 2010
    ....
  5. ncbi Down-regulation of S1P1 receptor surface expression by protein kinase C inhibition
    Sven Christian Sensken
    Institute for Immunology, Hannover Medical School, 30625 Hanover, Germany
    J Biol Chem 285:6298-307. 2010
    ..3-3 mg/kg/day FTY720 showed increasing concentration-dependent effectiveness. PKC inhibition therefore may contribute to lymphopenia by down-regulating S1P(1) receptor cell surface expression independently from its activation...
  6. ncbi Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS
    Laura J Sim-Selley
    Department of Pharmacology and Toxicology and Institute for Drug and Alcohol Studies, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    J Neurochem 110:1191-202. 2009
    ..These results indicate that CNS S1P receptors are part of a physiologically relevant and widespread neuromodulatory system, and that the S1P(1) receptor contributes to S1P-mediated antinociception...
  7. ncbi Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype
    Brian R Wamhoff
    Department of Medicine, Cardiovascular Division, University of Virginia, Charlottesville, VA 22901, USA
    Arterioscler Thromb Vasc Biol 28:1454-61. 2008
    ..The role of sphingosine-1-phosphate (S1P) receptors in acute vascular injury and smooth muscle cell (SMC) phenotypic modulation is not completely resolved...
  8. ncbi Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat: congenic analysis
    Delyth Graham
    BHF Glasgow Cardiovascular Research Centre, 126 University Pl, Glasgow, G12 8TA United Kingdom
    Hypertension 50:1134-41. 2007
    ..Examination of expression data within the minimal congenic interval identified the positional candidates Edg1 and Vcam1, demonstrating significantly elevated renal RNA expression levels in the SHRSP compared with WKY and SP...
  9. ncbi Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury
    Atsushi Kimura
    Department of Orthopedic Surgery, Jichi Medical University School of Medicine, Tochigi, Japan
    Stem Cells 25:115-24. 2007
    ..This is the first report to identify a physiological role for a lipid mediator in NSPC migration toward a pathological area of the CNS and further indicates that the Sph-1-P/S1P(1) pathway may have therapeutic potential for CNS injuries...
  10. ncbi Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney
    Alaa S Awad
    Department of Medicine, Univ of Virginia, Charlottesville, VA, USA
    Am J Physiol Renal Physiol 290:F1516-24. 2006
    ..Sphingosine 1-phosphate (S1P) induces peripheral T cell depletion. Therefore, we hypothesized that S1P1 receptor activation protects kidney from IRI...
  11. ncbi Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5
    Soichiro Usui
    Department of Molecular and Cellular Physiology, Kanazawa University Graduate School of Medical Sciences, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    J Biol Chem 279:12300-11. 2004
    ..of PDGF mRNA and protein expression was abolished by the small interfering RNA duplexes targeting S1P(1)/Edg1 receptor subtype...
  12. ncbi Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration
    M J Kluk
    Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut, USA
    Circ Res 89:496-502. 2001
    ..Since EDG-1 is expressed in the pup-intimal phenotype of VSMCs, S1P signaling via EDG-1 may play a role in vascular diseases in which the proliferation and migration of VSMCs are dysregulated...
  13. ncbi EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes
    P Robert
    GlaxoSmithKline Laboratoires Pharmaceutiques, 4 rue du Chesnay Beauregard, 35762 Saint Grégoire, PA, BP 58, France
    J Mol Cell Cardiol 33:1589-606. 2001
    ..6 microM). The effect of S1P could be related to a stimulation of the EDG1 receptor since we showed that the EDG1 receptor is predominantly expressed at the mRNA and protein levels in rat ..
  14. ncbi Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3
    H Okamoto
    Department of Physiology, Kanazawa University School of Medicine, Kanazawa, Japan
    Mol Cell Biol 20:9247-61. 2000
    ..responses are mediated by members of the EDG (endothelial differentiation gene) family G protein-coupled receptors EDG1, EDG3, and EDG5 (AGR16)...
  15. ncbi Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate
    A L Parrill
    Department of Chemistry and Computational Research on Materials Institute, University of Memphis, Memphis, Tennessee 38152 6060, USA
    J Biol Chem 275:39379-84. 2000
    Originating from its DNA sequence, a computational model of the Edg1 receptor has been developed that predicts critical interactions with its ligand, sphingosine 1-phosphate...
  16. ncbi EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition
    H Okamoto
    Department of Molecular and Cellular Physiology, University of Tokyo Graduate School of Medicine, Tokyo 113 0033, Japan
    J Biol Chem 273:27104-10. 1998
    In Chinese hamster ovary (CHO) cells transiently transfected with an expression vector for EDG1, but not an empty vector, sphingosine-1-phosphate (SP) at a concentration as low as 10(-10) M caused an increase in the intracellular free Ca2+..
  17. ncbi FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2
    William J Valentine
    Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 286:30513-25. 2011
    ..sequence from the N terminus to transmembrane domain 2 (TM2) was activated by FTY720P, and the S1P(2)(IC1-TM2)(S1P1) domain insertion chimera showed S1P(1)-like activation...

Research Grants7

  1. Brain Cannabinoid Signaling: Selectivity and Adaptation
    Laura Sim Selley; Fiscal Year: 2006
    ..These studies will contribute to elucidation of the mechanisms of action of CB1 receptors in brain, as well as determine the effects of chronic cannabinoid administration on cellular function during tolerance. ..
  2. Brain Cannabinoid Signaling: Selectivity and Adaptation
    Laura J Sim Selley; Fiscal Year: 2010
    ..This project will determine roles of specific signaling proteins in the effects of acute and long-term CB1R activation by THC and are relevant to cannabinoid therapeutics and drug abuse. ..