Gene Symbol: Rxrg
Description: retinoid X receptor gamma
Alias: retinoic acid receptor RXR-gamma, RXR gamma-1, nuclear receptor subfamily 2 group B member 3, retinoic X receptor gamma-1
Species: rat
Products:     Rxrg

Top Publications

  1. Mangelsdorf D, Borgmeyer U, Heyman R, Zhou J, Ong E, Oro A, et al. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 1992;6:329-44 pubmed
    ..This study suggests that the RXR family plays critical roles in diverse aspects of development, from embryo implantation to organogenesis and central nervous system differentiation, as well as in adult physiology. ..
  2. Cimini A, Benedetti E, Cristiano L, Sebastiani P, D Amico M, D Angelo B, et al. Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons. Neuroscience. 2005;130:325-37 pubmed
    ..In particular, we point toward the PPARbeta/delta isotype as a key factor in neuronal differentiation. ..
  3. Ravnskjaer K, Boergesen M, Rubi B, Larsen J, Nielsen T, Fridriksson J, et al. Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells. Endocrinology. 2005;146:3266-76 pubmed
    ..These results show a strong subtype specificity of the two PPAR subtypes alpha and gamma on lipid partitioning and insulin secretion when systematically compared in a beta-cell context. ..
  4. Koda T, Imai H, Morita M. Antiestrogenic activity of vitamin A in in vivo uterotrophic assay. Life Sci. 2007;80:945-9 pubmed
    ..The up-regulation of RAR or RXR mRNA expression level was probably responsible for the antiestrogenic activity of ATRA. ..
  5. McGrane M. Vitamin A regulation of gene expression: molecular mechanism of a prototype gene. J Nutr Biochem. 2007;18:497-508 pubmed
  6. Belanger A, Luo Z, Vincent K, Akita G, Cheng S, Gregory R, et al. Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor. Biochem Biophys Res Commun. 2007;364:567-72 pubmed
    ..These results suggest that HIF-1 may be involved in hypoxia-induced suppression of fatty acid metabolism in cardiomyocytes by reducing the DNA binding activity of PPARalpha/RXR. ..
  7. Latasa M, Ituero M, Moran Gonzalez A, Aranda A, Cosgaya J. Retinoic acid regulates myelin formation in the peripheral nervous system. Glia. 2010;58:1451-64 pubmed publisher
    ..At the same time, through a RAR-dependent mechanism, RA downregulates myelin-associated glycoprotein, which also contributes to the dysmyelinating effect of the retinoid. ..
  8. Liu Q, Linney E. The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms. Mol Endocrinol. 1993;7:651-8 pubmed
    ..The results of this study along with those of previously published studies suggest that there may be more than two isoforms of mRXR gamma. ..
  9. Georgiades P, Brickell P. Differential expression of the rat retinoid X receptor gamma gene during skeletal muscle differentiation suggests a role in myogenesis. Dev Dyn. 1997;210:227-35 pubmed
    ..This dynamic expression pattern of RXRgamma during myogenesis suggests its possible involvement in the differentiation of limb myoblasts but excludes a role in the differentiation of early myotomal myoblasts. ..

More Information


  1. Georgiades P, Wood J, Brickell P. Retinoid X receptor-gamma gene expression is developmentally regulated in the embryonic rodent peripheral nervous system. Anat Embryol (Berl). 1998;197:477-84 pubmed
    ..We discuss the possible significance of the timing of RXRgamma expression in the developing PNS and suggest that closer examination of the structure and function of the PNS of RXRgamma null mutant mice would be of interest. ..
  2. Georgiades P, Brickell P. Regulation of retinoid X receptor-gamma gene transcript levels in rat heart cells. Cell Biol Int. 1998;22:457-63 pubmed
    ..It was shown by Northern blot experiments, that in this system, RXRgamma transcript levels are differentially influenced by these two hormones. The significance of these findings in relation to previously published work is discussed. ..
  3. Ryu J, Lee E, Kim T, Lee Y, Lee J, Lee B, et al. Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di(n-butyl) phthalate. J Toxicol Environ Health A. 2008;71:1542-9 pubmed publisher
    ..Data thus provide some insights into the molecular mechanisms underlying DBP-induced testicular dysgenesis. ..
  4. Arfaoui A, Lobo M, Boulbaroud S, Ouichou A, Mesfioui A, Arenas M. Expression of retinoic acid receptors and retinoid X receptors in normal and vitamin A deficient adult rat brain. Ann Anat. 2013;195:111-21 pubmed publisher
    ..These findings indicate that the brain management of retinoic acid differs between males and females, also leading to differences in their response to VAD diet in terms of receptor expression. ..
  5. Lee S, Lee J, Choi J, Lee S, Park J, Kim D. Epigenetic inactivation of retinoid X receptor genes in non-small cell lung cancer and the relationship with clinicopathologic features. Cancer Genet Cytogenet. 2010;197:39-45 pubmed publisher
    ..Methylation in the tumors was detected in all three genes: RXRA, 5.7%; RXRB, 4.3%; RXRG, 23.7%...
  6. Germain P, Chambon P, Eichele G, Evans R, Lazar M, Leid M, et al. International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev. 2006;58:760-72 pubmed
    ..Indeed, multiple questions about the actual biological role of RXRs and the existence of an endogenous ligand have still to be answered. ..
  7. Chen H, Privalsky M. Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition. Proc Natl Acad Sci U S A. 1995;92:422-6 pubmed
    ..Thus, oligomer formation plays an important role in determining the specificity of DNA recognition by nuclear receptors and contributes to isoform-dependent differences in gene regulation. ..
  8. Ben Shushan E, Sharir H, Pikarsky E, Bergman Y. A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol Cell Biol. 1995;15:1034-48 pubmed