Gene Symbol: Ruvbl1
Description: RuvB-like AAA ATPase 1
Alias: NMP238, Pontin52, Tip49a, ruvB-like 1, 49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP-interacting protein, DNA helicase p50, RuvB-like protein 1, pontin 52
Species: rat
Products:     Ruvbl1

Top Publications

  1. Kanemaki M, Makino Y, Yoshida T, Kishimoto T, Koga A, Yamamoto K, et al. Molecular cloning of a rat 49-kDa TBP-interacting protein (TIP49) that is highly homologous to the bacterial RuvB. Biochem Biophys Res Commun. 1997;235:64-8 pubmed
    ..These findings suggest that TIP49 is a putative ATP-dependent DNA helicase. ..
  2. Bauer A, Huber O, Kemler R. Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein. Proc Natl Acad Sci U S A. 1998;95:14787-92 pubmed
    ..Here we report the identification of an interaction partner of beta-catenin, a nuclear protein designated Pontin52. Pontin52 binds beta-catenin in the region of Armadillo repeats 2-5 and, more importantly, also binds the TATA ..
  3. Makino Y, Kanemaki M, Kurokawa Y, Koji T, Tamura T. A rat RuvB-like protein, TIP49a, is a germ cell-enriched novel DNA helicase. J Biol Chem. 1999;274:15329-35 pubmed
    We have isolated a novel nuclear protein with a molecular mass of 49 kDa (TIP49a) from rat liver. The rat TIP49a showed structural resemblance to several bacterial RuvBs and also displayed Walker A and B motifs...
  4. Kurokawa Y, Kanemaki M, Makino Y, Tamura T. A notable example of an evolutionary conserved gene: studies on a putative DNA helicase TIP49. DNA Seq. 1999;10:37-42 pubmed
    b>TIP49a (just called as simply TIP49 in previous reports [Kanemaki et al., 1997; Makino et al., 1998]) was found in a rat nuclear protein complex that included the TATA-binding protein...
  5. Hawley S, Tamura T, Miles L. Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a. J Biol Chem. 2001;276:179-86 pubmed
    ..Two separate amino acid sequences were obtained and were identical to sequences contained within human and rat TIP49a. The cDNA for the 54-kDa protein matched the human TIP49a sequence, and encoded a COOH-terminal lysine, consistent ..
  6. Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, et al. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat Struct Mol Biol. 2007;14:1165-72 pubmed
    ..Collectively, these observations reveal a link between YY1 and INO80 and roles for both in HRR, providing new insight into mechanisms that control the cellular response to genotoxic stress. ..
  7. Obri A, Ouararhni K, Papin C, Diebold M, Padmanabhan K, Marek M, et al. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Nature. 2014;505:648-53 pubmed publisher
    ..Z at specific chromatin control regions, in particular at enhancers and insulators. ..
  8. Kikuchi N, Gohshi T, Kawahire S, Tachibana T, Yoneda Y, Isobe T, et al. Molecular shape and ATP binding activity of rat p50, a putative mammalian homologue of RuvB DNA helicase. J Biochem. 1999;125:487-94 pubmed
    ..cerevisiae extract. This suggests that this putative DNA helicase is present in a wide variety of species ranging from yeast to mammals. ..
  9. Ikura T, Ogryzko V, Grigoriev M, Groisman R, Wang J, Horikoshi M, et al. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell. 2000;102:463-73 pubmed
    ..These results indicate that the histone acetylase TIP60-containing complex plays a role in DNA repair and apoptosis. ..

More Information


  1. Dugan K, Wood M, Cole M. TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis. Oncogene. 2002;21:5835-43 pubmed
    ..These results indicate that individual cofactors differentially potentiate c-Myc and E2F1 functions. ..
  2. Mir R, Bele A, Mirza S, Srivastava S, Olou A, Ammons S, et al. A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression. Mol Cell Biol. 2015;36:886-99 pubmed publisher
    ..Biochemical analyses demonstrated an additional phosphorylation-independent interaction of ECD with the RUVBL1 component of the R2TP complex, and this interaction is essential for ECD's cell cycle progression function...