Runx2

Summary

Gene Symbol: Runx2
Description: runt-related transcription factor 2
Alias: Cbfa1, OSF-2, runt-related transcription factor 2, CBF-alpha-1, core-binding factor subunit alpha-1, osteoblast-specific transcription factor 2
Species: rat
Products:     Runx2

Top Publications

  1. Paredes R, Arriagada G, Cruzat F, Villagra A, Olate J, Zaidi K, et al. Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Mol Cell Biol. 2004;24:8847-61 pubmed
    Bone-specific transcription of the osteocalcin (OC) gene is regulated principally by the Runx2 transcription factor and is further stimulated in response to 1alpha,25-dihydroxyvitamin D3 via its specific receptor (VDR)...
  2. Ducy P, Zhang R, Geoffroy V, Ridall A, Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997;89:747-54 pubmed
    ..We have now cloned the cDNA encoding Osf2/Cbfa1, the protein that binds to OSE2...
  3. Kim I, Otto F, Zabel B, Mundlos S. Regulation of chondrocyte differentiation by Cbfa1. Mech Dev. 1999;80:159-70 pubmed
    b>Cbfa1, a developmentally expressed transcription factor of the runt family, was recently shown to be essential for osteoblast differentiation...
  4. Inada M, Yasui T, Nomura S, Miyake S, Deguchi K, Himeno M, et al. Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn. 1999;214:279-90 pubmed
    b>Cbfa1, a transcription factor that belongs to the runt-domain gene family, plays an essential role in osteogenesis...
  5. Yoshida C, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, et al. Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004;18:952-63 pubmed
    ..b>Runx2 is essential for osteoblast differentiation and is involved in chondrocyte maturation...
  6. Young D, Hassan M, Pratap J, Galindo M, Zaidi S, Lee S, et al. Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2. Nature. 2007;445:442-6 pubmed
    ..Runt-related transcription factors Runx1, Runx2 and Runx3 establish and maintain cell identity, and convey phenotypic information through successive cell ..
  7. Shintaku Y, Murakami T, Yanagita T, Kawanabe N, Fukunaga T, Matsuzaki K, et al. Sox9 expression during fracture repair. Cells Tissues Organs. 2011;194:38-48 pubmed publisher
    ..As a result, Sox9- and Runx1-expressing cells were detected in the periosteal callus together with Runx2 expression...
  8. Needham C, Shah S, Dahlin R, Kinard L, Lam J, Watson B, et al. Osteochondral tissue regeneration through polymeric delivery of DNA encoding for the SOX trio and RUNX2. Acta Biomater. 2014;10:4103-12 pubmed publisher
    ..or loaded in a spatial fashion with bPEI-HA and DNA encoding for either Runt-related transcription factor 2 (RUNX2) or SRY (sex determining region Y)-box 5, 6, and 9 (the SOX trio), to generate bone and cartilage tissues ..
  9. Qian G, Zhang X, Lu L, Wu X, Li S, Meng J. Regulation of Cbfa1 expression by total flavonoids of Herba epimedii. Endocr J. 2006;53:87-94 pubmed
    Core binding factor alpha1 (Cbfa1) is a member of the runt family of transcription factors, which appears to play a pivotal role in regulating the differentiation of osteoblastic precursors and the activity of mature osteoblasts...

More Information

Publications62

  1. Vega R, Matsuda K, Oh J, Barbosa A, Yang X, Meadows E, et al. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell. 2004;119:555-66 pubmed
    ..chondrocyte hypertrophy and endochondral bone formation by interacting with and inhibiting the activity of Runx2, a transcription factor necessary for chondrocyte hypertrophy...
  2. Liu L, Chen L, Mai Z, Peng Z, Yu K, Liu G, et al. Cyclical compressive stress induces differentiation of rat primary mandibular condylar chondrocytes through phosphorylated myosin light chain II. Mol Med Rep. 2016;14:4293-4300 pubmed publisher
    ..Furthermore, CUCS promoted runt?related transcription factor?2 (RUNX2) expression at mRNA (P<0.01) and protein levels (P<0...
  3. Shi N, Li C, Cui X, Tomarev S, Chen S. Olfactomedin 2 Regulates Smooth Muscle Phenotypic Modulation and Vascular Remodeling Through Mediating Runt-Related Transcription Factor 2 Binding to Serum Response Factor. Arterioscler Thromb Vasc Biol. 2017;37:446-454 pubmed publisher
    ..Olfm2 is a novel factor mediating SMC phenotypic modulation. Thus, Olfm2 may be a potential target for treating injury-induced proliferative vascular diseases. ..
  4. Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, et al. A twist code determines the onset of osteoblast differentiation. Dev Cell. 2004;6:423-35 pubmed
    b>Runx2 is necessary and sufficient for osteoblast differentiation, yet its expression precedes the appearance of osteoblasts by 4 days. Here we show that Twist proteins transiently inhibit Runx2 function during skeletogenesis...
  5. Ichikawa Y, Sumi M, Ohwatari N, Komori T, Sumi T, Shibata H, et al. Evaluation of 9.4-T MR microimaging in assessing normal and defective fetal bone development: comparison of MR imaging and histological findings. Bone. 2004;34:619-28 pubmed
    ..For this purpose, we performed 9.4-T MR microimaging on developing bones in normal embryos, and also in Runx2/Cbfa1-/- embryos with severely defective bone development...
  6. Takeuchi H, Nagayama M, Imaizumi Y, Tsukahara T, Nakazawa J, Kusaka Y, et al. Immunohistochemical analysis of osteoconductivity of beta-tricalcium phosphate and carbonate apatite applied in femoral and parietal bone defects in rats. Dent Mater J. 2009;28:595-601 pubmed
    The feature of osteoconductivity, and expression of inductive BMP and transcription factors (Runx2 and Osterix) for osteoblast differentiation, which was related to conductive bone formation, were observed in experimentally created ..
  7. Schneider G, Zaharias R, Seabold D, Stanford C. Integrin-associated tyrosine kinase FAK affects Cbfa1 expression. J Orthop Res. 2011;29:1443-7 pubmed publisher
    ..The hypothesis of this study was FAK mediates osteoblast differentiation dependent Cbfa1 expression...
  8. Siddiqui S, Arshad M. Osteogenic potential of punica granatum through matrix mineralization, cell cycle progression and runx2 gene expression in primary rat osteoblasts. Daru. 2014;22:72 pubmed publisher
    ..Cell cycle progression and osteogenic gene Runx2 expression were carried out by flow cytometry and real time PCR, respectively...
  9. Kanno T, Takahashi T, Tsujisawa T, Ariyoshi W, Nishihara T. Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts. J Cell Biochem. 2007;101:1266-77 pubmed
    ..b>Runx2, a transcription factor involved in the control of osteoblast differentiation, has been identified as a target of ..
  10. Chen Z, Huang S, Fan W, Tang W, Liu F, Qiu H. [Effects of high glucose on expression of core binding factor alpha1 and osteocalcin in vascular smooth muscle cells]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2010;41:784-8 pubmed
    ..High glucose decrease the expression of alpha-SMA in VSMCs, which could induce the transdifferentiation from RVSMCs to osteoblast-like cells. ..
  11. San Martin I, Varela N, Gaete M, Villegas K, Osorio M, Tapia J, et al. Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells. J Cell Physiol. 2009;221:560-71 pubmed publisher
    Bone formation and osteoblast differentiation require the functional expression of the Runx2/Cbfbeta heterodimeric transcription factor complex...
  12. Boumah C, Lee M, Selvamurugan N, Shimizu E, Partridge N. Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene. Mol Endocrinol. 2009;23:1255-63 pubmed publisher
    ..Upon PTH treatment, Runx2, already bound to the runt domain site of the MMP-13 promoter, interacted with p300, which then acetylated ..
  13. Drissi H, Pouliot A, Stein J, Van Wijnen A, Stein G, Lian J. Identification of novel protein/DNA interactions within the promoter of the bone-related transcription factor Runx2/Cbfa1. J Cell Biochem. 2002;86:403-12 pubmed
    The runt homology transcription factor Runx2/Cbfa1 is essential for bone development and osteoblast differentiation...
  14. Zhang X, Ma Y, Fu X, Liu Q, Shao Z, Dai L, et al. Runx2-Modified Adipose-Derived Stem Cells Promote Tendon Graft Integration in Anterior Cruciate Ligament Reconstruction. Sci Rep. 2016;6:19073 pubmed publisher
    b>Runx2 is a powerful osteo-inductive factor and adipose-derived stem cells (ADSCs) are multipotent. However, it is unknown whether Runx2-overexpressing ADSCs (Runx2-ADSCs) could promote anterior cruciate ligament (ACL) reconstruction...
  15. Jazayeri M, Shokrgozar M, Haghighipour N, Mahdian R, Farrokhi M, Bonakdar S, et al. Evaluation of Mechanical and Chemical Stimulations on Osteocalcin and Runx2 Expression in Mesenchymal Stem Cells. Mol Cell Biomech. 2015;12:197-213 pubmed
    ..Results indicated that mechanical loading alone caused a phenomenal increase in Runx2 and osteocalcin expression...
  16. Han N, Jiang B, Wang T, Zhang P, Kou Y, Zhang D. [Effect of calcitonin gene-related peptide on RUNX2 expression in primary rat osteoblasts]. Beijing Da Xue Xue Bao Yi Xue Ban. 2011;43:652-6 pubmed
    To investigate the effects of exogenous calcitonin gene-related peptide (CGRP) on RUNX2 expression in primary cultured rat osteoblasts...
  17. Gross S, Krause Y, Wuelling M, Vortkamp A. Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS ONE. 2012;7:e43553 pubmed publisher
    ..Furthermore, we demonstrate that Hoxa11 and Hoxd11 act upstream of Runx2 and Shox2, two key regulators of chondrocyte differentiation...
  18. Xiao Z, Thomas R, Hinson T, Quarles L. Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor. Gene. 1998;214:187-97 pubmed
    Although the CBFA1 gene encodes an osteoblast-specific transcription factor that regulates osteoblast differentiation, uncertainty exists about the organization of its 5' end and the relevance of a novel N-terminal sequence identified in ..
  19. Funato N, Chapman S, McKee M, Funato H, Morris J, Shelton J, et al. Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development. 2009;136:615-25 pubmed publisher
    ..negatively regulates intramembranous ossification of the mandible by directly inhibiting the transcription factor Runx2, a master regulator of osteoblast differentiation...
  20. Park E, Park J, Franceschi R, Jo M. The role for runt related transcription factor 2 (RUNX2) as a transcriptional repressor in luteinizing granulosa cells. Mol Cell Endocrinol. 2012;362:165-75 pubmed publisher
    ..The present study investigated the role of RUNX2 transcription factor in regulating the expression of Runx1, Ptgs2, and Tnfaip6 using cultured granulosa cells ..
  21. Fu Y, Zhang P, Ge J, Cheng J, Dong W, Yuan H, et al. Histone deacetylase 8 suppresses osteogenic differentiation of bone marrow stromal cells by inhibiting histone H3K9 acetylation and RUNX2 activity. Int J Biochem Cell Biol. 2014;54:68-77 pubmed publisher
    ..histone H3 lysine 9 acetylation (H3K9Ac) and significantly enhanced the expression of osteogenesis-related genes Runx2, Osterix, osteocalcin (OCN), osteopontin (OPN) and alkaline phosphatase (ALP)...
  22. Aqeilan R, Hassan M, de Bruin A, Hagan J, Volinia S, Palumbo T, et al. The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem. 2008;283:21629-39 pubmed publisher
    ..Interestingly, we find WWOX physically associates with RUNX2, the principal transcriptional regulator of osteoblast differentiation, and on osteocalcin chromatin...
  23. Shimizu E, Selvamurugan N, Westendorf J, Olson E, Partridge N. HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression. J Biol Chem. 2010;285:9616-26 pubmed publisher
    ..Here, we show that histone deacetylase 4 (HDAC4) interacts with Runx2, binds the MMP-13 promoter, and suppresses MMP-13 gene transcription in the rat osteoblastic cell line, UMR 106-01...
  24. Jia Z, Wang S, He D, Cui L, Lu Y, Hu H, et al. Role of calcium in the regulation of bone morphogenetic protein 2, runt-related transcription factor 2 and Osterix in primary renal tubular epithelial cells by the vitamin D receptor. Mol Med Rep. 2015;12:2082-8 pubmed publisher
    ..The gene and protein levels of bone morphogenetic protein 2 (BMP2), runt-related transcription factor 2 (Runx2) and osterix were detected in the RTECs transduced with Lenti-VDR-sh and were incubated with calcium...
  25. Hu R, Liu W, Li H, Yang L, Chen C, Xia Z, et al. A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J Biol Chem. 2011;286:12328-39 pubmed publisher
    ..differentiation by targeting histone deacetylase 5, resulting in increased runt-related transcription factor 2 (Runx2) protein production...
  26. Massague J, Seoane J, Wotton D. Smad transcription factors. Genes Dev. 2005;19:2783-810 pubmed
    ..Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior. ..
  27. Sun J, Zhou H, Deng Y, Zhang Y, Gu P, Ge S, et al. Conditioned medium from bone marrow mesenchymal stem cells transiently retards osteoblast differentiation by downregulating runx2. Cells Tissues Organs. 2012;196:510-22 pubmed publisher
    ..this suppression, levels of two osteoblastic transcription factors, runt-related transcription factor 2 (Runx2) and osterix (Osx), were detected at both mRNA and protein levels...
  28. Sowa H, Kaji H, Hendy G, Canaff L, Komori T, Sugimoto T, et al. Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2. J Biol Chem. 2004;279:40267-75 pubmed
    ..DNA (AS) antagonized bone morphogenetic protein (BMP)-2-induced alkaline phosphatase activity and osteocalcin and Runx2 mRNA expression...
  29. Hao J, Zhang L, Cong G, Ren L, Hao L. MicroRNA-34b/c inhibits aldosterone-induced vascular smooth muscle cell calcification via a SATB2/Runx2 pathway. Cell Tissue Res. 2016;366:733-746 pubmed
    ..Overexpression of SATB2 induced Runx2 overproduction and VSMC calcification...
  30. Aeimlapa R, Wongdee K, Charoenphandhu N, Suntornsaratoon P, Krishnamra N. Premature chondrocyte apoptosis and compensatory upregulation of chondroregulatory protein expression in the growth plate of Goto-Kakizaki diabetic rats. Biochem Biophys Res Commun. 2014;452:395-401 pubmed publisher
    ..immunohistochemical analysis further confirmed the overexpression of parathyroid hormone-related protein (PTHrP), Runx2 and VEGF, but not Indian hedgehog (Ihh) in the HZ...
  31. Han M, Che X, Cho G, Park H, Lim K, Park N, et al. Functional cooperation between vitamin D receptor and Runx2 in vitamin D-induced vascular calcification. PLoS ONE. 2013;8:e83584 pubmed publisher
    ..We investigated the roles of vitamin D receptor (Vdr) and runt-related transcription factor 2 (Runx2) in the osteoblastic differentiation of VSMCs in response to vitamin D3 using in vitro VSMCs cultures and in vivo ..
  32. Takai H, Mezawa M, Choe J, Nakayama Y, Ogata Y. Osteogenic transcription factors and proto-oncogene regulate bone sialoprotein gene transcription. J Oral Sci. 2013;55:209-15 pubmed
    Runt homeodomain protein 2 (Runx2), distalless 5 (Dlx5) and Smad1 are transcription factors that play critical roles in controlling the differentiation of osteoblasts and mineralization of bone...
  33. He W, Li Z, Cui Y, Yi B, Liang C, Wang X, et al. [Effect of icariin on the mRNA expressions of Cbfalpha1, BMP2, BMP4 in rat osteoblasts]. Beijing Da Xue Xue Bao Yi Xue Ban. 2009;41:669-73 pubmed
    ..The Cbfalpha1, BMP2, BMP4 mRNA were significantly upregulated after icariin treatment. Icariin could promote the differentiation ability of rat osteoblasts through upregulating the Cbfalpha1, BMP2, BMP4 mRNA expressions. ..
  34. Yang C, Wang Y, Xu H. Fluoride Regulate Osteoblastic Transforming Growth Factor-?1 Signaling by Mediating Recycling of the Type I Receptor ALK5. PLoS ONE. 2017;12:e0170674 pubmed publisher
    ..The gene expression of Runx2 and ALK5 in cells increased after low concentration fluoride treatment which was also inhibited by high ..
  35. Hie M, Iitsuka N, Otsuka T, Nakanishi A, Tsukamoto I. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Bone. 2011;49:1152-9 pubmed publisher
    ..The protein level of a transcription factor MITF, but not PU.1, decreased. The expression of Runx2 decreased associated with the decrease in ?-catenin protein and the suppression of glycogen synthase kinase 3? (..
  36. Tanimoto Y, Veistinen L, Alakurtti K, Takatalo M, Rice D. Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2). J Biol Chem. 2012;287:21429-38 pubmed publisher
    ..Here, we show that Gli3 acts as a repressor in the developing murine calvaria and that Dlx5, Runx2 type II isoform (Runx2-II), and Bmp2 are expressed ectopically in the calvarial mesenchyme, which results in ..
  37. Hattori S, Dhar D, Hara N, Tonomoto Y, Onoda T, Ono T, et al. FR-167653, a selective p38 MAPK inhibitor, exerts salutary effect on liver cirrhosis through downregulation of Runx2. Lab Invest. 2007;87:591-601 pubmed
    ..mRNA expression of runt-related protein 2 (Runx2), a profibrogenic transcription factor, was significantly low in FR-treated livers, indicating that Runx2 might be ..
  38. Zhang X, Liu Y, Wang X, Sun X, Zhang C, Zheng S. Analysis of novel RUNX2 mutations in Chinese patients with cleidocranial dysplasia. PLoS ONE. 2017;12:e0181653 pubmed publisher
    ..This disease is mainly caused by heterozygous mutations in RUNX2, a gene that encodes an osteoblast-specific transcription factor...
  39. Fen J, Zhang J, Dallas S, Lu Y, Chen S, Tan X, et al. Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res. 2002;17:1822-31 pubmed
    ..of Dmp1 in bone and cartilage and examined whether Dmp1 expression was regulated by core-binding factor a1 (Cbfa1)...
  40. Kim J, Bae S, Choi J, Kim H, Ryoo H. The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem. 2003;278:319-26 pubmed
    Fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling induces the expression of Runx2, a key transcription factor in osteoblast differentiation, but little is known about the molecular signaling mechanisms that mediate this...
  41. Bertrand Philippe M, Ruddell R, Arthur M, Thomas J, Mungalsingh N, Mann D. Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2. J Biol Chem. 2004;279:24530-9 pubmed
    ..In this study we identify RUNX1 and RUNX2 as UTE-1-binding proteins that are induced at the post-transcriptional level during activation of HSC...
  42. Sun L, Vitolo M, Qiao M, Anglin I, Passaniti A. Regulation of TGFbeta1-mediated growth inhibition and apoptosis by RUNX2 isoforms in endothelial cells. Oncogene. 2004;23:4722-34 pubmed
    ..Vascular endothelial cells (ECs) express RUNX genes that are activated by angiogenic factors. The RUNX2 gene also activates the vascular endothelial growth factor promoter...
  43. Xue T, Mao Z, Lin L, Hou Y, Wei X, Fu X, et al. Non-virus-mediated transfer of siRNAs against Runx2 and Smad4 inhibit heterotopic ossification in rats. Gene Ther. 2010;17:370-9 pubmed publisher
    ..But the existing preventive or therapeutic methods all have disadvantages. Runt-related protein 2 (Runx2) and Smad4 are two regulators that have important roles in the differentiation of osteoblast...
  44. Heilmann A, Schinke T, Bindl R, Wehner T, Rapp A, Haffner Luntzer M, et al. The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing. PLoS ONE. 2013;8:e84232 pubmed publisher
    ..The finding that Fzd9, in addition to its role in physiological bone remodeling, regulates bone repair may have implications for the development of treatments for poorly or non-healing fractures. ..
  45. Park E, Lind A, Dahm Kähler P, Brannstrom M, Carletti M, Christenson L, et al. RUNX2 transcription factor regulates gene expression in luteinizing granulosa cells of rat ovaries. Mol Endocrinol. 2010;24:846-58 pubmed publisher
    The LH surge promotes terminal differentiation of follicular cells to become luteal cells. RUNX2 has been shown to play an important role in cell differentiation, but the regulation of Runx2 expression and its function in the ovary ..
  46. Zhang Y, Xie R, Croce C, Stein J, Lian J, Van Wijnen A, et al. A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci U S A. 2011;108:9863-8 pubmed publisher
    ..in osteoblasts and chondrocytes is stringently controlled by the cell-fate-determining transcription factor Runx2. In this study, we directly addressed whether microRNAs (miRNAs) can control the osteogenic activity of Runx2 and ..
  47. Graciolli F, Neves K, dos Reis L, Graciolli R, Noronha I, Moyses R, et al. Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia. Nephrol Dial Transplant. 2009;24:1416-21 pubmed publisher
    ..cells (VSMCs) into calcifying cells, evidenced by upregulated expression of runt-related transcription factor 2 (Runx2), whereas PTH is protective against VC. In addition, Runx2 has been detected in calcified arteries of CKD patients...
  48. Satake M, Nomura S, Yamaguchi Iwai Y, Takahama Y, Hashimoto Y, Niki M, et al. Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development. Mol Cell Biol. 1995;15:1662-70 pubmed
    ..The implication of mouse AML1/PEBP2 alpha B expression in hematopoietic cells other than those of T-cell lineage is discussed in relation to myeloid leukemogenesis. ..
  49. Wang B, Dai C, Quan J, Zhu Z, Zheng F, Zhang H, et al. Parathyroid hormone regulates osterix and Runx2 mRNA expression predominantly through protein kinase A signaling in osteoblast-like cells. J Endocrinol Invest. 2006;29:101-8 pubmed
    Runt-related transcription factor 2 (Runx2) and osterix are osteoblast-specific transcription factors essential for the development of osteoblastic cells and bone formation...
  50. Smith N, Dong Y, Lian J, Pratap J, Kingsley P, Van Wijnen A, et al. Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol. 2005;203:133-43 pubmed
    ..Initial studies have shown that both Runx1 and Runx2 are expressed in pre-chondrogenic mesenchyme of the developing embryo at E12.5...
  51. Lambertini E, Franceschetti T, Torreggiani E, Penolazzi L, Pastore A, Pelucchi S, et al. SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts. BMC Mol Biol. 2010;11:13 pubmed publisher
    ..We found that SLUG is positively correlated with RUNX2 expression and deposition of mineralized matrix, and is regulated by Lef-1 and beta-catenin...
  52. Aberg T, Cavender A, Gaikwad J, Bronckers A, Wang X, Waltimo Siren J, et al. Phenotypic changes in dentition of Runx2 homozygote-null mutant mice. J Histochem Cytochem. 2004;52:131-9 pubmed
    Genetic and molecular studies in humans and mice indicate that Runx2 (Cbfa1) is a critical transcriptional regulator of bone and tooth formation...
  53. Wen J, Tao R, Ni L, Duan Q, Lu Q. Immunolocalization and expression of Runx2 in tertiary dentinogenesis. Hybridoma (Larchmt). 2010;29:195-9 pubmed publisher
    b>Runx2 is a new transcription factor that takes part in odontoblast differentiation...