Runx1

Summary

Gene Symbol: Runx1
Description: runt-related transcription factor 1
Alias: Aml1, Cbfa2, CBF-alpha-2, PEA2-alpha B, PEBP2-alpha B, acute myeloid leukemia 1 protein, core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene), core-binding factor subunit alpha-2, oncogene AML-1, polyomavirus enhancer-binding protein 2 alpha B subunit, runt related transcription factor 1
Species: rat

Top Publications

  1. pmc Runt-related transcription factor 1 regulates luteinized hormone-induced prostaglandin-endoperoxide synthase 2 expression in rat periovulatory granulosa cells
    Jing Liu
    Department of Obstetrics and Gynecology, Chandler Medical Center, 800 Rose Street, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Endocrinology 150:3291-300. 2009
  2. ncbi Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2
    Marie Bertrand-Philippe
    Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Biol Chem 279:24530-9. 2004
  3. ncbi SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population
    Gisela Orozco
    Instituto de Parasitologia y Biomedicina, Granada, Spain
    J Rheumatol 33:1235-9. 2006
  4. pmc RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking
    Kathleen J Haley
    Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, PBB 3, 75 Francis St, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 301:L693-701. 2011
  5. pmc Phenotypic switching of nonpeptidergic cutaneous sensory neurons following peripheral nerve injury
    Ting Wang
    School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 6:e28908. 2011
  6. ncbi Prognostic value of AML 1/ETO fusion transcripts in patients with acute myelogenous leukemia
    Eun Kyung Cho
    Department of Internal Medicine, Gachon Medical School, Gil Medical Center, 1198 Guwol dong, Namdong gu, Incheon 405 760, Korea
    Korean J Intern Med 18:13-20. 2003
  7. doi Pediatric B-lymphoblastic leukemia with RUNX1 amplification: clinicopathologic study of eight cases
    Kaaren K Reichard
    Department of Pathology, University of New Mexico, Health Sciences Center, Albuquerque, NM, USA
    Mod Pathol 24:1606-11. 2011
  8. doi Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells
    Won Fen Wong
    Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Immunol 188:5408-20. 2012
  9. doi Runx1 and C/EBPβ transcription factors directly up-regulate P2X3 gene transcription
    Giorgia D Ugarte
    Faculty of Biological Sciences, Department of Biochemistry and Molecular Biology, Universidad de Concepcion, Santiago, Chile
    J Cell Physiol 227:1645-52. 2012
  10. doi Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome
    Ashok Patel
    Department of Biomolecular and Sport Sciences, Coventry University, West Midlands CV1 5FB, UK
    Neurosci Lett 487:144-8. 2011

Research Grants

  1. The function of Runx1 in the ovary
    Misung Jo; Fiscal Year: 2007
  2. Function of RUNX transcription factors in COCs
    Misung Jo; Fiscal Year: 2010

Scientific Experts

  • Jose Luis Gonzalez de Aguilar
  • Kathleen J Haley
  • JeeSun Jung
  • Ashok Patel
  • S Gattenlohner
  • Ryo Konno
  • Joan Massague
  • Kaaren K Reichard
  • Misung Jo
  • Giorgia D Ugarte
  • Brigitte van Zundert
  • Martin Montecino
  • Won Fen Wong
  • Ting Wang
  • Jing Liu
  • Yoichiro Takata
  • K Komlosi
  • Sarah Ross
  • Gisela Orozco
  • Marie Bertrand-Philippe
  • Sun J Choi
  • Eun Kyung Cho
  • Emilio Diaz
  • Jimmy Stehberg
  • Miguel Biscaia
  • Ryushi Tazawa
  • Sonoko Habu
  • Masahito Ebina
  • Toshiyuki Takai
  • Shunsuke Kon
  • Toshiaki Kikuchi
  • Kazuyoshi Kohu
  • Shota Endo
  • Manabu Fukumoto
  • Francisco Leisewitz
  • Tatiana Opazo
  • Keisuke Tanaka
  • Tomo Funaki
  • Masanobu Satake
  • Akira Nakamura
  • Mineo Kurokawa
  • Chung Yeng Looi
  • Naoto Ishii
  • Koh Nakata
  • Akiko Sugahara-Tobinai
  • Ryo Funayama
  • Qiufu Ma
  • Xiaotang Jing
  • Erica S Schwartz
  • Derek C Molliver
  • Fu Chia Yang
  • Brian M Davis
  • Omar Abdel Samad
  • Eun Sil Park
  • Daisuke Hamada
  • Hiroshi Inoue
  • Katsutoshi Miyatake
  • Toshihito Tanahashi
  • G C Talián
  • B Farago
  • Mitsuo Itakura
  • Aya Sato
  • B Melegh
  • V Cserép
  • Kazue Tsugawa
  • Caroline S Hill
  • J Bene
  • L Magyari
  • C G Kiss
  • Shunji Nakano
  • V Havasi
  • Natsuo Yasui
  • L Czirjak
  • Fumio Shinomiya
  • B Kovacs
  • Dora Pascual-Salcedo
  • Jose L Pablos
  • María Francisca González-Escribano
  • Elena Sanchez
  • Alejandro Balsa
  • Miguel A Lopez-Nevot
  • Javier Martin
  • Antonio Garcia
  • Miguel A Gonzalez-Gay
  • Belen Torres
  • Derek A Mann
  • Richard G Ruddell
  • James Thomas
  • Michael J P Arthur
  • Narendra Mungalsingh

Detail Information

Publications22

  1. pmc Runt-related transcription factor 1 regulates luteinized hormone-induced prostaglandin-endoperoxide synthase 2 expression in rat periovulatory granulosa cells
    Jing Liu
    Department of Obstetrics and Gynecology, Chandler Medical Center, 800 Rose Street, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Endocrinology 150:3291-300. 2009
    Runt-related transcription factor 1 (RUNX1), a transcription factor, is transiently induced by the LH surge and regulates gene expression in periovulatory granulosa cells...
  2. ncbi Regulation of tissue inhibitor of metalloproteinase 1 gene transcription by RUNX1 and RUNX2
    Marie Bertrand-Philippe
    Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Biol Chem 279:24530-9. 2004
    ..In this study we identify RUNX1 and RUNX2 as UTE-1-binding proteins that are induced at the post-transcriptional level during activation of HSC...
  3. ncbi SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population
    Gisela Orozco
    Instituto de Parasitologia y Biomedicina, Granada, Spain
    J Rheumatol 33:1235-9. 2006
    To replicate the association reported in Japanese individuals of functional SLC22A4 and RUNX1 polymorphisms with rheumatoid arthritis (RA), and to test the possible role in this trait of a functional variant of the SUMO4 gene that was ..
  4. pmc RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking
    Kathleen J Haley
    Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, PBB 3, 75 Francis St, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 301:L693-701. 2011
    ..Runt-related transcription factors (RUNX1-3) have critical roles in immune system development and function...
  5. pmc Phenotypic switching of nonpeptidergic cutaneous sensory neurons following peripheral nerve injury
    Ting Wang
    School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 6:e28908. 2011
    ..This switch was correlated with down-regulation of Runt-related transcription factor 1 (Runx1), a transcription factor that controls expression of GFRα2 and TRPV1 during development...
  6. ncbi Prognostic value of AML 1/ETO fusion transcripts in patients with acute myelogenous leukemia
    Eun Kyung Cho
    Department of Internal Medicine, Gachon Medical School, Gil Medical Center, 1198 Guwol dong, Namdong gu, Incheon 405 760, Korea
    Korean J Intern Med 18:13-20. 2003
    The t (8;21) (q22;q22), which produces the fusion gene AML1/ETO, is associated with relatively good prognosis and, in particular, with a good response to cytosine arabinoside...
  7. doi Pediatric B-lymphoblastic leukemia with RUNX1 amplification: clinicopathologic study of eight cases
    Kaaren K Reichard
    Department of Pathology, University of New Mexico, Health Sciences Center, Albuquerque, NM, USA
    Mod Pathol 24:1606-11. 2011
    ..2); bcr-abl1, t(12;21)(p13;q22); etv6-runx1)...
  8. doi Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells
    Won Fen Wong
    Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    J Immunol 188:5408-20. 2012
    The Runx1 transcription factor is abundantly expressed in naive T cells but rapidly downregulated in activated T cells, suggesting that it plays an important role in a naive stage...
  9. doi Runx1 and C/EBPβ transcription factors directly up-regulate P2X3 gene transcription
    Giorgia D Ugarte
    Faculty of Biological Sciences, Department of Biochemistry and Molecular Biology, Universidad de Concepcion, Santiago, Chile
    J Cell Physiol 227:1645-52. 2012
    Recent evidence indicates that transcription factor Runx1 modulates the expression of several phenotypic markers in dorsal root ganglia (DRGs) neurons, including the pain-related P2X3 receptor...
  10. doi Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome
    Ashok Patel
    Department of Biomolecular and Sport Sciences, Coventry University, West Midlands CV1 5FB, UK
    Neurosci Lett 487:144-8. 2011
    ..The majority of these variants, however, have not been investigated in subjects with DS...
  11. pmc Allelic based gene-gene interactions in rheumatoid arthritis
    JeeSun Jung
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 410 West 10th Street, HITS 5000, Indianapolis, Indiana 46202, USA
    BMC Proc 3:S76. 2009
    ..SNP rs2900180 on C5 interacts with rs2242720 on RUNX1, which interacts with rs881375 on TRAF1...
  12. doi Transcription of the pain-related TRPV1 gene requires Runx1 and C/EBPβ factors
    Giorgia D Ugarte
    Center for Biomedical Research, Universidad Andres Bello, Santiago, Chile
    J Cell Physiol 228:860-70. 2013
    ..The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls the expression of several ..
  13. ncbi No influence of SLC22A4 C6607T and RUNX1 G24658C genotypic variants on the circulating carnitine ester profile in patients with rheumatoid arthritis
    K Komlosi
    Department of Medical Genetics and Child Development, University of Pecs, Pecs, Hungary
    Clin Exp Rheumatol 26:61-6. 2008
    ..Similarly, a G24658C transversion in intron 6 of the gene encoding the RUNX1 transcription factor that regulates OCTN1 and also likely OCTN2 expression was also found to confer susceptibility ..
  14. ncbi Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies
    Yoichiro Takata
    Division of Genetic Information, Institute for Genome Research, The University of Tokushima, 3 18 15 Kuramoto cho, Tokushima, Tokushima, 770 8503, Japan
    J Hum Genet 53:163-73. 2008
    ..tests for the four selected SNPs (rs2240340/padi4_94, rs7528684/fcrl3_3, rs3792876/slc2F2 and rs2268277/runx1) previously reported to be associated with rheumatoid arthritis (RA)...
  15. ncbi Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse model
    Jose Luis Gonzalez de Aguilar
    Institut National de la Sante et de la Recherche Medicale, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, France
    Physiol Genomics 32:207-18. 2008
    ..g., ALDH3, metallothionein-2, and thioredoxin-1) and regeneration (e.g., BTG1, RB1, and RUNX1) but also tissue degradation (e.g., C/EBPdelta and DDIT4) and cell death (e.g...
  16. ncbi AML-1A and AML-1B regulation of MIP-1alpha expression in multiple myeloma
    Sun J Choi
    Department of Medicine Hematology Oncology, University of Pittsburgh, PA, USA
    Blood 101:3778-83. 2003
    ..The data suggest that strategies that enhance AML-1B expression or decrease AML-1A in MM cells may be beneficial therapeutically...
  17. ncbi How the Smads regulate transcription
    Sarah Ross
    Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Int J Biochem Cell Biol 40:383-408. 2008
    ..In this review we focus on the mechanisms whereby the Smads are modified and regulated. We then go on to discuss how the activated Smad complexes regulate transcription...
  18. ncbi Gene expression profiling of the rat endometriosis model
    Ryo Konno
    Department of Gynecology, Omiya Medical Center Jichi Medical University, Amanuma cho, Omiya, Saitama, Japan
    Am J Reprod Immunol 58:330-43. 2007
    ..To investigate the molecular mechanism of endometriosis, gene expression profiling was analyzed in a rat endometriosis model...
  19. pmc Luteinizing hormone-induced RUNX1 regulates the expression of genes in granulosa cells of rat periovulatory follicles
    Misung Jo
    Department of Obstetrics and Gynecology, Chandler Medical Center, 800 Rose Street, Room MS 335, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Mol Endocrinol 20:2156-72. 2006
    ..The present study determined 1) the localization of RUNX1, a nuclear transcription factor, 2) regulation of Runx1 mRNA expression, and 3) its potential function in rat ..
  20. ncbi Smad transcription factors
    Joan Massague
    Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 19:2783-810. 2005
    ..Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior...
  21. pmc NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia
    Stefan Gattenlohner
    Institute of Pathology, University of Wurzburg, Josef Schneiderstrasse 2, 97080 Wurzburg, Germany
    Am J Pathol 163:1081-90. 2003
    ..In search of NCAM(CD56)-related transcription factors we found RUNX1(AML1) up-regulation in ICM and detected RUNX1(AML1) binding within the NCAM(CD56) promoter by electromobility ..
  22. pmc AML1 is expressed in skeletal muscle and is regulated by innervation
    X Zhu
    Biology Department, Massachusetts Institute of Technology, Cambridge 02139
    Mol Cell Biol 14:8051-7. 1994
    ..genes which we found to be regulated by electrical activity is the recently discovered acute myeloid leukemia 1 (AML1) gene. Disruption and translocation of the human AML1 gene are responsible for a form of acute myeloid leukemia...

Research Grants2

  1. The function of Runx1 in the ovary
    Misung Jo; Fiscal Year: 2007
    The goal of the present proposal is to elucidate the role of Runx1, a nuclear transcription factor, in the ovary...
  2. Function of RUNX transcription factors in COCs
    Misung Jo; Fiscal Year: 2010
    ..studies by our laboratory and others have begun to shed light on a small family of nuclear transcription factors, RUNX1 and RUNX2, as key transcriptional regulators involved in COC expansion...