Gene Symbol: RT1-Da
Description: RT1 class II, locus Da
Alias: DA1, H2-Ea, RT1-u, RT1 class II, locus Da, MHC RT1.u-D-alpha chain, MHC class II RT1D alpha chain antigen, MHC class II antigen RT1.D alpha chain, RT1-D alpha, RT1-Du alpha, histocompatibility 2, class II antigen E alpha
Species: rat
Products:     RT1-Da

Top Publications

  1. Hoppenbrouwers I, Aulchenko Y, Janssens A, Ramagopalan S, Broer L, Kayser M, et al. Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis. J Hum Genet. 2009;54:676-80 pubmed publisher
    ..Several of these risk genes, including CD58 and CLEC16A, are shared by different autoimmune diseases. Fine mapping studies will be needed to determine the functional contributions to distinct autoimmune phenotypes. ..
  2. de Gassart A, Camosseto V, Thibodeau J, Ceppi M, Catalan N, Pierre P, et al. MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc Natl Acad Sci U S A. 2008;105:3491-6 pubmed publisher
    ..MARCH I is, therefore, a major regulator of HLA-DR traffic, and its loss contributes to the acquisition of the potent immunostimulatory properties of mature human DCs. ..
  3. Yoon T, Macmillan H, Mortimer S, Jiang W, Rinderknecht C, Stern L, et al. Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis. Proc Natl Acad Sci U S A. 2012;109:11276-81 pubmed publisher
    ..Collectively, our data define a putative binding surface and an overall orientation of the szDOv/sDM complex and have implications for the mechanism of DO inhibition of DM. ..
  4. Hamza T, Zabetian C, Tenesa A, Laederach A, Montimurro J, Yearout D, et al. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. Nat Genet. 2010;42:781-5 pubmed publisher
    ..The genetic association with HLA supports the involvement of the immune system in Parkinson's disease and offers new targets for drug development. ..
  5. Denzin L, Cresswell P. HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell. 1995;82:155-65 pubmed
    ..Antibody blocking experiments suggest that a transient interaction between HLA-DM and the MHC class II-CLIP complex is required. ..
  6. Guo Y, Deng X, Zheng W, Xu H, Song Z, Liang H, et al. HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease. Neurosci Lett. 2011;501:185-7 pubmed publisher
    ..446, p=0.040 for genotypic distribution; ?²=5.762, p=0.016 for allele distribution), suggesting this variant is associated with late-onset sporadic PD in Chinese Han population. ..
  7. Lapaque N, Jahnke M, Trowsdale J, Kelly A. The HLA-DRalpha chain is modified by polyubiquitination. J Biol Chem. 2009;284:7007-16 pubmed publisher
    ..In contrast, although lysine 219 is absolutely required for modification of DRalpha, other features of the DRalpha tail act to limit the extent of ubiquitination. ..
  8. Swaminathan S, Huentelman M, Corneveaux J, Myers A, Faber K, Foroud T, et al. Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. PLoS ONE. 2012;7:e50640 pubmed publisher
    ..006, odds ratio = 3.986 (95% confidence interval 1.490-10.667)). A novel APP gene duplication was observed in one case sample. Further investigation of the identified genes in independent and larger samples is warranted. ..
  9. Liljedahl M, Kuwana T, Fung Leung W, Jackson M, Peterson P, Karlsson L. HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. EMBO J. 1996;15:4817-24 pubmed
    ..The DO-DM complexes survive in the lysosomal system suggesting that DO and DM functions may be intertwined. ..

More Information


  1. de Palma J. Cause & effect, or ... there are lies, damn lies, and statistics. Nephrol News Issues. 1992;6:27-8, 30, 57 pubmed
  2. Pachot A, Monneret G, Brion A, Venet F, Bohe J, Bienvenu J, et al. Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients. Crit Care Med. 2005;33:31-8; discussion 236-7 pubmed
    ..These results obtained at the mRNA level support previous reports describing the loss of monocyte HLA-DR at the protein level and thus confirm the potential of measuring monocyte HLA-DR in septic patient followup. ..
  3. Ettinger R, Moustakas A, Lobaton S. Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles. Immunogenetics. 2004;56:585-96 pubmed
    ..These data are important to a comprehensive understanding of MHC class II structure-function and for mechanistic studies of rat models of autoimmunity. ..
  4. Ryan S, Bonomo J, Zhao F, Cobb B. MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation. J Exp Med. 2011;208:1041-53 pubmed publisher
    ..Our findings reveal that MHCII N-glycosylation directly impacts binding and presentation of at least one class of T cell-dependent antigen. ..
  5. Thiessen S, Serra P, Amrani A, Verdaguer J, Santamaria P. T-cell tolerance by dendritic cells and macrophages as a mechanism for the major histocompatibility complex-linked resistance to autoimmune diabetes. Diabetes. 2002;51:325-38 pubmed
  6. Ghosh P, Amaya M, Mellins E, Wiley D. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature. 1995;378:457-62 pubmed
    ..The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM. ..
  7. Holowachuk E. Isolation and characterization of a cDNA clone for the MHC class II chain RT1.Du alpha of the diabetic BB rat. Immunogenetics. 1985;22:665-71 pubmed
  8. Kim J, Park B, Cheong H, Pasaje C, Bae J, Park J, et al. HLA-DRA polymorphisms associated with risk of nasal polyposis in asthmatic patients. Am J Rhinol Allergy. 2012;26:12-7 pubmed publisher
    ..Despite the need for replication in larger cohorts and/or functional evaluations, our findings suggest that HLA-DRA polymorphisms might contribute to nasal polyposis susceptibility in patients with asthma. ..
  9. Ito K, Bian H, Molina M, Han J, Magram J, Saar E, et al. HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J Exp Med. 1996;183:2635-44 pubmed
    ..Non-Tg mice immunized with either PLP175-192 or MBP87-106 did not develop EAE. These results demonstrated that a human MHC class II binding site alone can confer susceptibility to an experimentally induced murine autoimmune disease. ..
  10. Nakatani N, Hattori E, Ohnishi T, Dean B, Iwayama Y, Matsumoto I, et al. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. Hum Mol Genet. 2006;15:1949-62 pubmed
    ..Finally, gene network analysis using the currently obtained expression data highlighted cellular growth and nervous system development pathways as potential targets in the molecular pathophysiology of bipolar disorder. ..
  11. Flynn J, Wan Q, Panos J, McCormick D, Giraldo A, David C, et al. Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. J Autoimmun. 2002;18:213-20 pubmed
    ..Thus, depending on the background strain and the Tg used to induce disease, the presence of the DQ8 transgene can reduce thyroiditis mediated by DR3 molecules. ..
  12. Vestberg M, Brunsberg U, Bergsteinsdottir K, Karlsson M, Gustafsson K, Wedekind D, et al. Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule. Immunogenetics. 1998;48:344-9 pubmed
  13. Matsuoka T, Kohrogi H, Ando M, Nishimura Y, Matsushita S. Dermatophagoides farinae-1-derived peptides and HLA molecules recognized by T cells from atopic individuals. Int Arch Allergy Immunol. 1997;112:365-70 pubmed
    ..Thus, although some peptides have a more potent T cell-stimulatory activity than others, the T cell receptor ligands formed with the Der f 1 molecule are highly heterogeneous. ..
  14. Venet F, Tissot S, Debard A, Faudot C, Crampé C, Pachot A, et al. Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock. Crit Care Med. 2007;35:1910-7 pubmed
    ..Severe burn injury induced a marked reduction in mHLA-DR expression at both protein and messenger RNA levels. Its persistent decrease was associated with mortality and the development of septic complications. ..
  15. Holowachuk E, Greer M, Martin D. The complete sequence of the MHC class II chain RT.1D alpha u of the diabetic BB rat: mRNA levels of RT1.D alpha in lymphocytes. Nucleic Acids Res. 1987;15:10551-67 pubmed
    ..The increased class II gene transcripts found in lymphocytes of young BB rats indicates that they possess a highly activated immune system. ..
  16. Tuncel J, Haag S, Yau A, Norin U, Baud A, Lönnblom E, et al. Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat. PLoS Genet. 2014;10:e1004151 pubmed publisher
    ..To our knowledge, this is the first study showing how a recombination between natural alleles of genes in the MHC influences lineage commitment of T cells. ..
  17. Dessen A, Lawrence C, Cupo S, Zaller D, Wiley D. X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II. Immunity. 1997;7:473-81 pubmed
    ..A model is proposed for the DR4 recognition of collagen II (261-273), an antigen immunodominant in human-transgenic mouse models of RA. ..
  18. Maingat F, Halloran B, Acharjee S, van Marle G, Church D, Gill M, et al. Inflammation and epithelial cell injury in AIDS enteropathy: involvement of endoplasmic reticulum stress. FASEB J. 2011;25:2211-20 pubmed publisher
    ..Lentivirus infections cause gut inflammation and ensuing damage to intestinal epithelial cells, likely through induction of ER stress pathways, resulting in disruption of gut functional integrity...
  19. Holowachuk E, Greer M, Martin D. Elevated mRNA levels of major histocompatibility complex class II genes in lymphocytes of autoimmune BB rats. Diabetes. 1988;37:1637-40 pubmed
    ..D alpha and RT1.D beta genes in the prediabetic BB rats may reflect differences in the proportion of lymphocytes expressing these genes and thus differences in splenic lymphocyte populations.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  20. Li X, Howard T, Zheng S, Haselkorn T, Peters S, Meyers D, et al. Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol. 2010;125:328-335.e11 pubmed publisher
  21. Easterfield A, Bradley J, Bolton E. Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains. Immunogenetics. 2003;55:344-50 pubmed
    ..This information is of considerable value for experimental studies of transplantation immunity and autoimmune disease. ..
  22. Duyar H, Dengjel J, de Graaf K, Wiesmüller K, Stevanovic S, Weissert R. Peptide motif for the rat MHC class II molecule RT1.Da: similarities to the multiple sclerosis-associated HLA-DRB1*1501 molecule. Immunogenetics. 2005;57:69-76 pubmed
    ..Both methods revealed similar binding characteristics for peptides to RT1.Da. This data will allow epitope predictions for analysis of peptides, relevant for experimental autoimmune diseases. ..
  23. Walter L, Hurt P, Himmelbauer H, Sudbrak R, Günther E. Physical mapping of the major histocompatibility complex class II and class III regions of the rat. Immunogenetics. 2002;54:268-75 pubmed
    ..Thus, the MHC of the rat is now completely mapped in a single contig of BAC/PAC clones derived from a single RT1 haplotype and encompasses about 3.7 Mb...
  24. Bennetts B, Teutsch S, Buhler M, Heard R, Stewart G. HLA-DMB gene and HLA-DRA promoter region polymorphisms in Australian multiple sclerosis patients. Hum Immunol. 1999;60:886-93 pubmed
    ..Some interactions between specific TCRBV polymorphisms and the HLA-DRA promoter were observed, which is consistent with other published reports suggesting an epistatic interaction between TCRBV and HLA-DRB1. ..
  25. Kong S, Chui P, Lim B, Salto Tellez M. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Virus Res. 2009;145:260-9 pubmed publisher
    ..Ultimately, this study may serve as a model for future, tissue-based analyses of fibroinflammatory conditions affecting the lung...
  26. Riberdy J, Newcomb J, Surman M, Barbosa J, Cresswell P. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides. Nature. 1992;360:474-7 pubmed
    ..Addition of synthetic CLIP inhibits the loading process, indicating that CLIP may define the region of the invariant chain responsible for obstructing the class II binding site. ..