Rsad2

Summary

Gene Symbol: Rsad2
Description: radical S-adenosyl methionine domain containing 2
Alias: Best5, Vig1, radical S-adenosyl methionine domain-containing protein 2, bone-expressed sequence tag 5 protein, viperin, virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Species: rat
Products:     Rsad2

Top Publications

  1. Grewal T, Genever P, Brabbs A, Birch M, Skerry T. Best5: a novel interferon-inducible gene expressed during bone formation. FASEB J. 2000;14:523-31 pubmed
    ..We have recently identified a novel rat cDNA (best5) by differential display PCR that is regulated during osteoblast differentiation and bone formation in vitro and ..
  2. Rivieccio M, Suh H, Zhao Y, Zhao M, Chin K, Lee S, et al. TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5. J Immunol. 2006;177:4735-41 pubmed
    ..One of the most highly up-regulated genes on microarray was the protein viperin/cig5...
  3. Zhang Y, Burke C, Ryman K, Klimstra W. Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J Virol. 2007;81:11246-55 pubmed
    ..to affect virus genome translation and included murine ISG20, ISG15, the zinc finger antiviral protein (ZAP), viperin, p56, p54, and p49...
  4. Helbig K, Lau D, Semendric L, Harley H, Beard M. Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology. 2005;42:702-10 pubmed
    ..One ISG significantly elevated in all patients was viperin, an evolutionary conserved ISG that has antiviral activity against human cytomegalovirus...
  5. Chin K, Cresswell P. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proc Natl Acad Sci U S A. 2001;98:15125-30 pubmed
    ..We have named the protein viperin (for virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible)...
  6. Hinson E, Cresswell P. The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion. J Biol Chem. 2009;284:4705-12 pubmed publisher
    b>Viperin is an evolutionarily conserved interferon-inducible protein that localizes to the endoplasmic reticulum (ER) and inhibits a number of DNA and RNA viruses...
  7. Duschene K, Broderick J. The antiviral protein viperin is a radical SAM enzyme. FEBS Lett. 2010;584:1263-7 pubmed publisher
    b>Viperin, an interferon-inducible antiviral protein, is shown to bind an iron-sulfur cluster, based on iron analysis as well as UV-Vis and electron paramagnetic resonance spectroscopic data...
  8. Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, et al. Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. Immunity. 2011;34:352-63 pubmed publisher
    ..We showed that the IFN-inducible antiviral protein Viperin promoted TLR7- and TLR9-mediated production of type I IFN by pDCs...
  9. Szretter K, Brien J, Thackray L, Virgin H, Cresswell P, Diamond M. The interferon-inducible gene viperin restricts West Nile virus pathogenesis. J Virol. 2011;85:11557-66 pubmed publisher
    ..Here, we examined the contribution of the ISG viperin to the control of West Nile virus (WNV) in genetically deficient cells and mice...

More Information

Publications15

  1. Zhu H, Cong J, Shenk T. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc Natl Acad Sci U S A. 1997;94:13985-90 pubmed
    ..These RNAs accumulate after infection with virus that has been inactivated by treatment with UV light, indicating that the inducer is present in virions. We conclude that human cytomegalovirus induces interferon-responsive mRNAs. ..
  2. Qiu L, Cresswell P, Chin K. Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1. Blood. 2009;113:3520-9 pubmed publisher
    b>Viperin (virus inhibitory protein, endoplasmic reticulum [ER]-associated, interferon-inducible) has been identified as a highly inducible ER protein that has antiviral activity...
  3. Hinson E, Cresswell P. The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix. Proc Natl Acad Sci U S A. 2009;106:20452-7 pubmed publisher
    ..Here we show that the IFN-induced antiviral protein viperin, which localizes to the cytosolic face of the ER and inhibits HCV, localizes to lipid droplets...
  4. Seo J, Yaneva R, Hinson E, Cresswell P. Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity. Science. 2011;332:1093-7 pubmed publisher
    b>Viperin is an interferon-inducible protein that is directly induced in cells by human cytomegalovirus (HCMV) infection. Why HCMV would induce viperin, which has antiviral activity, is unknown...
  5. Wang S, Wu X, Pan T, Song W, Wang Y, Zhang F, et al. Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33. J Gen Virol. 2012;93:83-92 pubmed publisher
    b>Viperin is a type-I and -II interferon-inducible intracytoplasmic protein that mediates antiviral activity against several viruses. A previous study has reported that viperin could limit hepatitis C virus (HCV) replication in vitro...
  6. Teng T, Foo S, Simamarta D, Lum F, Teo T, Lulla A, et al. Viperin restricts chikungunya virus replication and pathology. J Clin Invest. 2012;122:4447-60 pubmed publisher
    ..a cohort of CHIKV-infected patients revealed that type I IFNs controlled CHIKV infection via RSAD2 (which encodes viperin), an enigmatic multifunctional IFN-stimulated gene (ISG)...