Gene Symbol: Rps6kb2
Description: ribosomal protein S6 kinase B2
Alias: ribosomal protein S6 kinase beta-2, ribosomal protein S6 kinase, 70kDa, polypeptide 2, ribosomal protein S6 kinase, polypeptide 2
Species: rat
Products:     Rps6kb2

Top Publications

  1. Harrington L, Findlay G, Gray A, Tolkacheva T, Wigfield S, Rebholz H, et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol. 2004;166:213-23 pubmed
    ..Our results argue that the low malignant potential of tumors arising from TSC1-2 dysfunction may be explained by the failure of TSC mutant cells to activate PI3K and its downstream effectors. ..
  2. Xu T, Shen Y, Pink H, Triantafillou J, Stimpson S, Turnbull P, et al. Phosphorylation of p70s6 kinase is implicated in androgen-induced levator ani muscle anabolism in castrated rats. J Steroid Biochem Mol Biol. 2004;92:447-54 pubmed
    ..These results suggest that the phosphorylation of p70(s6k), likely via the IGF-I pathway, may play an important role in androgen-induced skeletal muscle hypertrophy. ..
  3. Yutsudo Y, Kido Y, Okabayashi Y, Matsumoto M, Ogawa W, Ohba M, et al. Protein kinase Calpha is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells. Pancreas. 2005;30:50-3 pubmed
    ..PKCalpha is implicated in CCK-induced activation of p70 S6 kinase in AR42J cells. ..
  4. Hers I, Wherlock M, Homma Y, Yagisawa H, Tavare J. Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells. J Biol Chem. 2006;281:4762-70 pubmed
    ..These results demonstrate that p122RhoGAP Ser-322 acts as an integrator of signal transduction in a manner dependent on the cellular context. ..
  5. Shahbazian D, Roux P, Mieulet V, Cohen M, Raught B, Taunton J, et al. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 2006;25:2781-91 pubmed
    ..Phosphorylation of eIF4B on Ser422 by RSK and S6K is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3. ..
  6. Marshall S. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Sci STKE. 2006;2006:re7 pubmed
  7. Yoon S, Seo M, Kim S, Jeon W, Ahn Y, Kang U, et al. The effect of MK-801 on mTOR/p70S6K and translation-related proteins in rat frontal cortex. Neurosci Lett. 2008;434:23-8 pubmed publisher
    ..These findings may suggest that repeated MK-801 treatment activates the signal transduction pathways involved in the initiation of protein synthesis in the rat frontal cortex. ..
  8. Zeniou Meyer M, Liu Y, Béglé A, Olanich M, Olanish M, Hanauer A, et al. The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1. Proc Natl Acad Sci U S A. 2008;105:8434-9 pubmed publisher
  9. Zeniou Meyer M, Béglé A, Bader M, Vitale N. The Coffin-Lowry syndrome-associated protein RSK2 controls neuroendocrine secretion through the regulation of phospholipase D1 at the exocytotic sites. Ann N Y Acad Sci. 2009;1152:201-8 pubmed publisher
    ..Expression of PLD1 phosphomimetic mutants fully restores secretion in cells depleted of RSK2, suggesting that RSK2 is a critical upstream signaling element in the activation of PLD1 to produce the lipids required for exocytosis...

More Information


  1. Katta A, Karkala S, Wu M, Meduru S, Desai D, Rice K, et al. Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction. Muscle Nerve. 2009;39:503-11 pubmed publisher
    ..These results suggest that insulin resistance is associated with alterations in the ability of muscle to activate p70S6k signaling following an acute bout of exercise. ..
  2. Ma X, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol. 2009;10:307-18 pubmed publisher
    ..Here, we highlight recent findings on the regulators and effectors of mTOR and discuss specific cases that serve as paradigms for the different modes of mTOR regulation and its control of translation. ..
  3. Wang L, Gout I, Proud C. Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways. MEK-dependent activation of S6K2 in cardiomyocytes. J Biol Chem. 2001;276:32670-7 pubmed
    ..Another hypertrophic agent, endothelin 1, also activated S6K2 in a MEK-dependent manner. Our findings provide strong evidence for novel signaling connections between MEK/ERK and S6K2. ..
  4. Boylan J, Anand P, Gruppuso P. Ribosomal protein S6 phosphorylation and function during late gestation liver development in the rat. J Biol Chem. 2001;276:44457-63 pubmed
    ..We conclude that hepatocyte proliferation in the late gestation fetus is supported by a rapamycin-resistant mechanism that can function independently of ribosomal protein S6 phosphorylation. ..