Rnf5

Summary

Gene Symbol: Rnf5
Description: ring finger protein 5
Alias: E3 ubiquitin-protein ligase RNF5, RING-type E3 ubiquitin transferase RNF5, ing finger protein 5 pseudogene, ring finger protein 5, E3 ubiquitin protein ligase
Species: rat
Products:     Rnf5

Top Publications

  1. Tcherpakov M, Delaunay A, Toth J, Kadoya T, Petroski M, Ronai Z. Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP). J Biol Chem. 2009;284:12099-109 pubmed publisher
    ..b>RNF5 is a ubiquitin ligase anchored to the ER membrane implicated in ERAD via ubiquitination of misfolded proteins...
  2. Zhong B, Zhang L, Lei C, Li Y, Mao A, Yang Y, et al. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity. 2009;30:397-407 pubmed publisher
    ..Here, we showed that the E3 ubiquitin ligase RNF5 interacted with MITA in a viral-infection-dependent manner...
  3. Kuang E, Okumura C, Sheffy Levin S, Varsano T, Shu V, Qi J, et al. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet. 2012;8:e1003007 pubmed publisher
    ..Here, we show that the membrane-associated E3 ligase RNF5 regulates basal levels of autophagy by controlling the stability of a select pool of the cysteine protease ATG4B...
  4. El Khouri E, Le Pavec G, Toledano M, Delaunay Moisan A. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). J Biol Chem. 2013;288:31177-91 pubmed publisher
    ..conductance regulator (CFTR) is one ERAD substrate targeted to co-translational degradation by the E3 ligase RNF5/RMA1. RNF185 is a RING domain-containing polypeptide homologous to RNF5...