Gene Symbol: Rnd1
Description: Rho family GTPase 1
Alias: rho-related GTP-binding protein Rho6
Species: rat
Products:     Rnd1

Top Publications

  1. Aoki J, Katoh H, Mori K, Negishi M. Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells. Biochem Biophys Res Commun. 2000;278:604-8 pubmed
    ..In this study, we examined the morphological role of Rnd1, a new member of Rho family GTPases, in PC12 cells, and found that expression of Rnd1 by itself caused the ..
  2. Kim Y, Hori M, Yasuda K, Ozaki H. Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria. Comp Biochem Physiol A Mol Integr Physiol. 2005;142:410-5 pubmed
    Uterine myometrial contractility remains a poorly characterized area of research in reproductive physiology. Rnd1, a novel member of the GTP-binding Rho protein family, inhibits Ca(2+)-sensitization by specifically interfering with a RhoA/..
  3. Li Y, Ghavampur S, Bondallaz P, Will L, Grenningloh G, Püschel A. Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10. J Biol Chem. 2009;284:363-71 pubmed publisher
    The GTPase Rnd1 affects actin dynamics antagonistically to Rho and has been implicated in the regulation of neurite outgrowth, dendrite development, and axon guidance. Here we show that Rnd1 interacts with the microtubule regulator SCG10...
  4. de Souza L, Moura Costa M, Bilek E, Lopes M, Martins V, Püschel A, et al. STI1 antagonizes cytoskeleton collapse mediated by small GTPase Rnd1 and regulates neurite growth. Exp Cell Res. 2014;324:84-91 pubmed publisher
    ..We show that cytoplasmic STI1 directly interacts with the GTPase Rnd1. This interaction is specific for the Rnd1 member of the Rnd family...
  5. Nobes C, Lauritzen I, Mattei M, Paris S, Hall A, Chardin P. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol. 1998;141:187-97 pubmed
    ..We have identified three proteins that form a distinct branch of the Rho family: Rnd1, expressed mostly in brain and liver; Rnd2, highly expressed in testis; and Rnd3/RhoE, showing a ubiquitous low ..
  6. Ishikawa Y, Katoh H, Negishi M. A role of Rnd1 GTPase in dendritic spine formation in hippocampal neurons. J Neurosci. 2003;23:11065-72 pubmed
    ..b>Rnd1, a novel member of this family, is predominantly expressed in neurons in brain; however, the neuronal functions of ..
  7. Harada A, Katoh H, Negishi M. Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. J Biol Chem. 2005;280:18418-24 pubmed
    ..b>Rnd1, a member of this family, has a low intrinsic GTPase activity and exerts antagonistic effects on RhoA signaling...
  8. Ishikawa Y, Katoh H, Negishi M. Small GTPase Rnd1 is involved in neuronal activity-dependent dendritic development in hippocampal neurons. Neurosci Lett. 2006;400:218-23 pubmed
    ..We recently have shown that Rnd1, a member of the Rho family, is highly expressed in brain during the synaptogenic stage and is involved in ..
  9. Tong Y, Hota P, Penachioni J, Hamaneh M, Kim S, Alviani R, et al. Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. J Biol Chem. 2009;284:35962-72 pubmed publisher
    ..These findings suggest that the monomeric form of the intracellular region is primed for GAP activity and extend a model for plexin activation. ..

More Information


  1. Kakimoto T, Katoh H, Negishi M. Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching. J Biol Chem. 2004;279:14104-10 pubmed
    ..Therefore, we found that functionally different splicing variants of Rapostlin have different responses to Rnd2 in association with N-WASP. ..