Rims1

Summary

Gene Symbol: Rims1
Description: regulating synaptic membrane exocytosis 1
Alias: RIM1a, Rim1, RIM 1, Rab3 effector, Rim1b protein, rab-3-interacting molecule 1, rab3-interacting molecule 1, regulating synaptic membrane exocytosis protein 1
Species: rat

Top Publications

  1. ncbi Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
    Y Wang
    Department of Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 75235, USA
    Nature 388:593-8. 1997
  2. pmc Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1
    Toshihisa Ohtsuka
    KAN Research Institute Inc, Kyoto 600 8815, Japan
    J Cell Biol 158:577-90. 2002
  3. ncbi The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins
    Y Wang
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    J Biol Chem 275:20033-44. 2000
  4. ncbi Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin
    T Coppola
    Institut de Biologie Cellulaire et de Morphologie, University of Lausanne, 1005 Lausanne, Switzerland
    J Biol Chem 276:32756-62. 2001
  5. ncbi RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone
    Susanne Schoch
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Nature 415:321-6. 2002
  6. pmc Munc13-1 is required for presynaptic long-term potentiation
    Ying Yang
    Center for Translational Neuroscience, Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 31:12053-7. 2011
  7. ncbi Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide
    Jun Lu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Mol Biol 352:455-66. 2005
  8. pmc Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission
    Samantha A Spangler
    Department of Neuroscience, Erasmus Medical Center, 3015GE Rotterdam, Netherlands
    J Cell Biol 201:915-28. 2013
  9. ncbi Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum
    Fatma Simsek-Duran
    Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    Nat Neurosci 7:1296-8. 2004
  10. ncbi SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release
    Eiji Inoue
    KAN Research Institute, Kyoto 600 8815, Japan
    Neuron 50:261-75. 2006

Scientific Experts

  • Toshihisa Ohtsuka
  • Eiji Inoue
  • Samantha A Spangler
  • Thomas C Sudhof
  • Etsuko Takao-Rikitsu
  • Ying Yang
  • Christoph Limbach
  • Xiaoping Jiang
  • Y Wang
  • Rong Guan
  • Josep Rizo
  • Yaisa S Andrews-Zwilling
  • Jun Lu
  • Yoshimi Takai
  • Sumiko Mochida
  • Marie Inoue
  • Maki Deguchi-Tawarada
  • Fatma Simsek-Duran
  • Yun Wang
  • Susanne Schoch
  • Josta T Kevenaar
  • Jeroen Demmers
  • Ruud F Toonen
  • Heidi de Wit
  • Esther de Graaff
  • Casper C Hoogenraad
  • Sabine K Schmitz
  • T Coppola
  • Xiaolu Wang
  • Bin Hu
  • Greta Hultqvist
  • Manfred W Kilimann
  • Michael M Laue
  • Nadine Thiede
  • Nicole Calakos
  • Patricia E Litkowski
  • Ying Lin
  • B Joy Snider
  • Krista L Moulder
  • Amanda A Taylor
  • Han Dai
  • Irina Dulubova
  • Mischa Machius
  • Diana R Tomchick
  • T C Sudhof
  • Nils Brose
  • Hiroshi Kawabe
  • Ikuko Yao
  • Mitsutoshi Setou
  • Frederique Varoqueaux
  • Kerstin Reim
  • Isao Kitajima
  • Susumu Higa
  • Hiroshi Takagi
  • Kosei Takeuchi
  • Hongmei Li
  • David J Linden
  • GYORGY LONART
  • Konark Mukherjee
  • Frank Schmitz
  • Tobias Jo
  • Martin Geppert
  • Robert C Malenka
  • Pablo E Castillo
  • S Magnin-Luthi
  • R Regazzi
  • S Gattesco
  • G Schiavo
  • V Perret-Menoud
  • S Sugita
  • M Okamoto
  • K Hofmann
  • F Schmitz

Detail Information

Publications15

  1. ncbi Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
    Y Wang
    Department of Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 75235, USA
    Nature 388:593-8. 1997
    ..We propose that Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles...
  2. pmc Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1
    Toshihisa Ohtsuka
    KAN Research Institute Inc, Kyoto 600 8815, Japan
    J Cell Biol 158:577-90. 2002
    ..CAST was localized at the CAZ of conventional synapses of mouse brain. CAST bound directly RIM1 and indirectly Munc13-1, presumably through RIM1, forming a ternary complex...
  3. ncbi The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins
    Y Wang
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    J Biol Chem 275:20033-44. 2000
    b>RIM1 is a putative effector protein for Rab3s, synaptic GTP-binding proteins. RIM1 is localized close to the active zone at the synapse, where it interacts in a GTP-dependent manner with Rab3 located on synaptic vesicles...
  4. ncbi Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin
    T Coppola
    Institut de Biologie Cellulaire et de Morphologie, University of Lausanne, 1005 Lausanne, Switzerland
    J Biol Chem 276:32756-62. 2001
    ..We propose that the Rab3 effector RIM is a scaffold protein that participates through its multiple binding partners in the docking and fusion of ..
  5. ncbi RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone
    Susanne Schoch
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Nature 415:321-6. 2002
    ..These data indicate that RIM1alpha has a central function in integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitter release...
  6. pmc Munc13-1 is required for presynaptic long-term potentiation
    Ying Yang
    Center for Translational Neuroscience, Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 31:12053-7. 2011
    ..Munc13 proteins also interact with RIM1α, an active zone protein required for presynaptic long-term plasticity...
  7. ncbi Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide
    Jun Lu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Mol Biol 352:455-66. 2005
    ..This groove is formed, in part, by a set of side-chains that is conserved selectively in RIM PDZ domains and that hence determines, at least in part, their unique specificity...
  8. pmc Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission
    Samantha A Spangler
    Department of Neuroscience, Erasmus Medical Center, 3015GE Rotterdam, Netherlands
    J Cell Biol 201:915-28. 2013
    ..scaffolding proteins but was critical for recruitment of several components of the release machinery, including RIM1 and CASK...
  9. ncbi Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum
    Fatma Simsek-Duran
    Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    Nat Neurosci 7:1296-8. 2004
    ..Thus, RIM1alpha phosphorylation triggers presynaptic LTP in part through recruitment of 14-3-3 to phospho-Ser413-RIM1alpha...
  10. ncbi SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release
    Eiji Inoue
    KAN Research Institute, Kyoto 600 8815, Japan
    Neuron 50:261-75. 2006
    ..Furthermore, SAD-B phosphorylates the active zone protein RIM1 but not Munc13-1. These results suggest that mammalian SAD kinase presynaptically regulates neurotransmitter release...
  11. ncbi Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2
    Yaisa S Andrews-Zwilling
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    J Biol Chem 281:19720-31. 2006
    ..We conclude that one function of the Munc13/RIM1alpha interaction is the active zone recruitment of Munc13-1 and ubMunc13-2...
  12. pmc Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution
    Rong Guan
    Department of Biochemistry, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Biochemistry 46:8988-98. 2007
    ..Our results provide a structural basis to understand the function of RIM C2B domains and suggest that dimerization may be a crucial aspect of RIM function...
  13. pmc A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing
    Xiaoping Jiang
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:1798-809. 2010
    ..Presynaptic silencing was accompanied by decreases in levels of the priming proteins Munc13-1 and Rim1. Importantly, overexpression of Rim1alpha prevented the induction of persistent presynaptic silencing...
  14. pmc Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site
    Christoph Limbach
    Department of Neuroscience, Uppsala University, S 75124 Uppsala, Sweden
    Proc Natl Acad Sci U S A 108:E392-401. 2011
    ..At both conventional and ribbon synapses, CAST, Munc13, and RIM are segregated from Aczonin, closer to the PM, and Aczonin is positioned such that it may control the access of neurotransmitter vesicles to the fusion site...
  15. pmc Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release
    Etsuko Takao-Rikitsu
    KAN Research Institute, Kyoto Research Park, Shimogyo ku, Kyoto 600 8815, Japan
    J Cell Biol 164:301-11. 2004
    ..novel cytomatrix at the active zone (CAZ)-associated protein, CAST, and found it directly binds another CAZ protein RIM1 and indirectly binds Munc13-1 through RIM1; RIM1 and Munc13-1 directly bind to each other and are implicated in ..