Ric3

Summary

Gene Symbol: Ric3
Description: RIC3 acetylcholine receptor chaperone
Alias: protein RIC-3, resistance to inhibitors of cholinesterase 3 homolog
Species: rat

Top Publications

  1. Osman A, Schrader A, Hawkes A, Akil O, Bergeron A, Lustig L, et al. Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Mol Cell Neurosci. 2008;38:153-69 pubmed publisher
    ..Our data suggest that RIC-3 facilitates receptor function, while rapsyn enhances receptor clustering at the cell surface. ..
  2. Koperniak T, Garg B, Boltax J, Loring R. Cell-specific effects on surface ?7 nicotinic receptor expression revealed by over-expression and knockdown of rat RIC3 protein. J Neurochem. 2013;124:300-9 pubmed publisher
    ..receptor expression is dependent on an endogenous chaperone named Resistance to Inhibitors of Cholinesterase 3 (RIC3) by comparing RIC3 protein in rat GH4C1 and human SH-EP1 cells, which express strikingly different surface receptor ..
  3. Wang Y, Yao Y, Tang X, Wang Z. Mouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly of the alpha7 acetylcholine receptor through a cytoplasmic coiled-coil domain. J Neurosci. 2009;29:12625-35 pubmed publisher
    ..We suggest that efficient assembly of the homomeric alpha7 nAChR may thus require mRIC-3 self-association through the cytoplasmic coiled-coil domain and suggest a model by which this may occur. ..

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