Rhoa

Summary

Gene Symbol: Rhoa
Description: ras homolog family member A
Alias: Arha, Arha2, transforming protein RhoA, plysia ras-related homolog A2, ras homolog gene family, member A
Species: rat
Products:     Rhoa

Top Publications

  1. Zuckerbraun B, Stoyanovsky D, Sengupta R, Shapiro R, Ozanich B, Rao J, et al. Nitric oxide-induced inhibition of smooth muscle cell proliferation involves S-nitrosation and inactivation of RhoA. Am J Physiol Cell Physiol. 2007;292:C824-31 pubmed
    ..can be pro- or antiproliferative, and it has been demonstrated that the activation status of the small GTPase RhoA determines the proliferative fate of ERK signaling, whereby inactivation of RhoA influences ERK signaling to ..
  2. O Kane E, Stone T, Morris B. Activation of Rho GTPases by synaptic transmission in the hippocampus. J Neurochem. 2003;87:1309-12 pubmed
    Ras-related GTPases of the Rho family, such as RhoA and RhoB, are well-characterised mediators of morphological change in peripheral tissues via their effects on the actin cytoskeleton...
  3. Dovas A, Yoneda A, Couchman J. PKCbeta-dependent activation of RhoA by syndecan-4 during focal adhesion formation. J Cell Sci. 2006;119:2837-46 pubmed
    ..Syndecan-4 clustering at the cell surface has also been associated with RhoA-dependent signalling, but the relationship between PKCalpha and RhoA has not been resolved...
  4. Brozzi F, Arcuri C, Giambanco I, Donato R. S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH. J Biol Chem. 2009;284:8797-811 pubmed publisher
    ..are dependent on reduced activation of the phosphatidylinositol 3-kinase (PI3K) downstream effectors, Akt and RhoA, and consequently elevated activity of GSK3beta and Rac1 and decreased activity of the RhoA-associated kinase...
  5. Aghajanian A, Wittchen E, Campbell S, Burridge K. Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif. PLoS ONE. 2009;4:e8045 pubmed publisher
    ..cytoskeletal dynamics, and in this report we conclude this is indeed a novel mechanism of regulating the GTPase RhoA. In this report, we show that RhoA can be directly activated by reactive oxygen species (ROS) in cells, and that ..
  6. Ridley A, Hall A. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992;70:389-99 pubmed
    ..These data imply that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors. ..
  7. Semenova M, Mäki Hokkonen A, Cao J, Komarovski V, Forsberg K, Koistinaho M, et al. Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death. Nat Neurosci. 2007;10:436-43 pubmed
    ..Rho is required for the rapid glutamate-induced activation of p38alpha and ensuing neuronal death. The ability of RhoA to activate p38alpha was not expected, and it was specific to primary neuronal cultures...
  8. Da Silva J, Hasegawa T, Miyagi T, Dotti C, Abad Rodriguez J. Asymmetric membrane ganglioside sialidase activity specifies axonal fate. Nat Neurosci. 2005;8:606-15 pubmed
    ..TrkA activity locally, which triggers phosphatidylinositol-3-kinase (PI3K)- and Rac1-dependent inhibition of RhoA signaling and the consequent actin depolymerization in one neurite only...
  9. Tas P, Gambaryan S, Roewer N. Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation. J Cell Biochem. 2007;102:368-76 pubmed
    ..Central to the effect is most likely a RhoA/Rho-kinase activation, but also the MAPKK/MEK and the Akt/protein kinase B pathway are activated by the anesthetics...

More Information

Publications105 found, 100 shown here

  1. Del Re D, Miyamoto S, Brown J. RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. J Biol Chem. 2007;282:8069-78 pubmed
    The small G-protein RhoA regulates the actin cytoskeleton, and its involvement in cell proliferation has also been established. In contrast, little is known about whether RhoA participates in cell survival or apoptosis...
  2. Yonemura S, Hirao Minakuchi K, Nishimura Y. Rho localization in cells and tissues. Exp Cell Res. 2004;295:300-14 pubmed
    ..Also, Myc- or GFP-tagged RhoA did not always reflect the localization of endogenous Rho, indicating a drawback of protein-tagging methods for ..
  3. Da Silva J, Medina M, Zuliani C, Di Nardo A, Witke W, Dotti C. RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability. J Cell Biol. 2003;162:1267-79 pubmed
    ..Here, we show that RhoA activity plays a decisive role during neuritogenesis of cultured hippocampal neurons by recruiting and activating ..
  4. Yoshimura S, Sakai H, Nakashima S, Nozawa Y, Shinoda J, Sakai N, et al. Differential expression of Rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation. Brain Res Mol Brain Res. 1997;45:90-8 pubmed
    ..In response to dbcAMP/theophylline treatment, RhoA showed increases in the mRNA level followed by the protein level, as inferred by reverse transcriptase-polymerase ..
  5. Klussmann E, Edemir B, Pepperle B, Tamma G, Henn V, Klauschenz E, et al. Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling. FEBS Lett. 2001;507:264-8 pubmed
    ..The Ht31 cDNA includes the estrogen receptor cofactor Brx and the RhoA GDP/GTP exchange factor proto-lymphoid blast crisis (Lbc) sequences...
  6. Wu K, Hengst U, Cox L, Macosko E, Jeromin A, Urquhart E, et al. Local translation of RhoA regulates growth cone collapse. Nature. 2005;436:1020-1024 pubmed publisher
    ..These effects require intra-axonal messenger RNA translation. Here we show that transcripts for RhoA, a small guanosine triphosphatase (GTPase) that regulates the actin cytoskeleton, are localized to developing axons ..
  7. Zhang Z, Fauser U, Schluesener H. Dexamethasone suppresses infiltration of RhoA+ cells into early lesions of rat traumatic brain injury. Acta Neuropathol. 2008;115:335-43 pubmed
    Inflammatory cell infiltration is a major part of secondary tissue damage in traumatic brain injury (TBI). RhoA is an important member of Rho GTPases and is involved in leukocyte migration...
  8. Chockalingam P, Cholera R, Oak S, Zheng Y, Jarrett H, Thomason D. Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy. Am J Physiol Cell Physiol. 2002;283:C500-11 pubmed
    ..Furthermore, H-Ras, RhoA, and Cdc42 decrease in expression levels and activities in muscle atrophy...
  9. Hunter J, Zeidan A, Javadov S, Kilic A, Rajapurohitam V, Karmazyn M. Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway. J Mol Cell Cardiol. 2009;47:810-8 pubmed publisher
    ..Since RhoA has been identified as an important mediator of cardiac hypertrophy and is inhibited by NO in vascular tissue, we ..
  10. El Sibai M, Pertz O, Pang H, Yip S, Lorenz M, Symons M, et al. RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res. 2008;314:1540-52 pubmed publisher
    ..Rac1 and Cdc42 regulate the formation of lamellipodia and filopodia, respectively at the leading edge, whereas RhoA mediates contraction at the rear of moving cells...
  11. Richter K, Brar S, Ray M, Pisitkun P, Bolland S, Verkoczy L, et al. Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells. J Biol Chem. 2009;284:30652-61 pubmed publisher
    ..These results strongly suggest that SLIP-GC is a replication-related protein in germinal center B cells whose reduction is toxic to cells through an AID-dependent mechanism. ..
  12. Miñambres R, Guasch R, Perez Arago A, Guerri C. The RhoA/ROCK-I/MLC pathway is involved in the ethanol-induced apoptosis by anoikis in astrocytes. J Cell Sci. 2006;119:271-82 pubmed
    ..We found that either the small GTPase RhoA or its effector ROCK-I (Rho kinase), promotes membrane blebbing in astrocytes...
  13. Ispanovic E, Serio D, Haas T. Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation. Am J Physiol Cell Physiol. 2008;295:C600-10 pubmed publisher
    ..Activation of Cdc42 was sufficient to decrease RhoA activity...
  14. Derangeon M, Bourmeyster N, Plaisance I, Pinet Charvet C, Chen Q, Duthe F, et al. RhoA GTPase and F-actin dynamically regulate the permeability of Cx43-made channels in rat cardiac myocytes. J Biol Chem. 2008;283:30754-65 pubmed publisher
    ..The activation of RhoA by cytoxic necrotizing factor 1 markedly enhanced GJIC, whereas its specific inhibition by the Clostridium ..
  15. Marshall A, Barrett O, Cullingford T, Shanmugasundram A, Sugden P, Clerk A. ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes. PLoS ONE. 2010;5:e10027 pubmed publisher
    ..Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g...
  16. Pillé J, Li H, Blot E, Bertrand J, Pritchard L, Opolon P, et al. Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer. Hum Gene Ther. 2006;17:1019-26 pubmed
    Overexpression of RhoA in cancer indicates a poor prognosis, because of increased tumor cell proliferation and invasion and tumor angiogenesis...
  17. Chen H, Firestein B. RhoA regulates dendrite branching in hippocampal neurons by decreasing cypin protein levels. J Neurosci. 2007;27:8378-86 pubmed
    ..In the present study, we show that cypin and RhoA are part of a common pathway that regulates dendrite number...
  18. Wang Y, Wang D, Wu N, Wang Y, Yin Z. ?-Crystallin promotes rat axonal regeneration through regulation of RhoA/rock/cofilin/MLC signaling pathways. J Mol Neurosci. 2012;46:138-44 pubmed publisher
    ..And a common crucial signaling event for myelin inhibitory factors is the activation of RhoA. To investigate whether ?-crystallin counteracts the inhibitory effect of myelin inhibitory factors through ..
  19. Jia Y, Yao H, Zhou J, Chen L, Zeng Q, Yuan H, et al. Role of epimorphin in bile duct formation of rat liver epithelial stem-like cells: involvement of small G protein RhoA and C/EBP?. J Cell Physiol. 2011;226:2807-16 pubmed publisher
    ..pathway of EPM was analyzed by focal adhesion kinase (FAK), extracellular regulated kinase 1/2 (ERK1/2), and RhoA Western blot. Also, a dominant negative (DN) RhoA-WB-F344 cell line (WB(RhoA-DN)) was constructed...
  20. Freeman E, Jani P, Millette C. Expression and potential function of Rho family small G proteins in cells of the mammalian seminiferous epithelium. Cell Commun Adhes. 2002;9:189-204 pubmed
    ..Therefore, RhoA and Rac1 were investigated in Sertoli and germ cells...
  21. Wang Y, Wang Y, Wang D, Wu N, Liu D, Yin Z. Distribution and expression of RhoA in rat retina after optic nerve injury. Ophthalmic Res. 2007;39:174-8 pubmed
    b>RhoA is a small guanosine triphosphatase which participates in signaling pathways of axonal repellents or inhibitors. However, the distribution and expression of RhoA in the rat retina after optic nerve injury has not been elucidated yet...
  22. Ning N, Lin G, Lue T, Lin C. Effects of estrogen, raloxifene, and levormeloxifene on the expression of Rho-kinase signaling molecules in urethral smooth muscle cells. Urology. 2010;76:1517.e6-11 pubmed publisher
    ..at 0, 1, 10, and 100 nmol/L for 48 h and then processed for Western blotting with antibodies against RhoA, Rho kinase I and II (Rock-I and Rock-II), myosin light chain (MLC), phosphorylated MLC, and ?-actin...
  23. Cui Q, Feng X, Wang Y, Zhao L. [Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011;27:1308-11 pubmed
    To investigate the expression of RhoA in the lung tissue of acute lung injury (ALI) rats induced by oleic acid (OA) and explore the influence of RhoA on the level of IL-8 and IL-10 in serum...
  24. Wei W, Yu Z, Yang H, Xie M, Wang W, Luo X. Cellular expression profile of RhoA in rats with spinal cord injury. J Huazhong Univ Sci Technolog Med Sci. 2014;34:657-662 pubmed publisher
    b>RhoA, a small GTPase, is involved in a wide array of cellular functions in the central nervous system, such as cell motility, cytoskeleton rearrangement, transcriptional regulation, phagocytosis and cell growth...
  25. Gakidis M, Cullere X, Olson T, Wilsbacher J, Zhang B, Moores S, et al. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004;166:273-82 pubmed
    ..Thus, Vav proteins are specifically required for stable adhesion. beta2-induced activation of Cdc42, Rac1, and RhoA is defective in Vav1/3ko neutrophils, and phosphorylation of Pyk2, paxillin, and Akt is also significantly reduced...
  26. Zamoner A, Funchal C, Jacques Silva M, Gottfried C, Barreto Silva F, Pessoa Pureur R. Thyroid hormones reorganize the cytoskeleton of glial cells through Gfap phosphorylation and Rhoa-dependent mechanisms. Cell Mol Neurobiol. 2007;27:845-65 pubmed
    ..In addition, C6 cells and astrocytes treated with lysophosphatidic acid, an upstream activator of the RhoA GTPase pathway, totally prevented the morphological alterations induced by TH, indicating that this effect could be ..
  27. Zhang Y, Zhang H, Yuan X, Gu X. Differential effects of phenylalanine on Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons. Pediatr Res. 2007;62:8-13 pubmed
    ..We further demonstrated that phenylalanine down-regulated Rac1, Cdc42, and RhoA mRNA and protein expression...
  28. Temporin K, Tanaka H, Kuroda Y, Okada K, Yachi K, Moritomo H, et al. IL-1beta promotes neurite outgrowth by deactivating RhoA via p38 MAPK pathway. Biochem Biophys Res Commun. 2008;365:375-80 pubmed
    ..neurons (CGNs), neurite outgrowth is inhibited by the addition of myelin-associated glycoprotein (MAG), activating RhoA. IL-1beta overcomes MAG-induced neurite outgrowth inhibition, by deactivating RhoA...
  29. Jeon Y, Won H, Moon M, Choi W, Chang C, Lee J, et al. Interaction of microglia and amyloid-beta through beta2-integrin is regulated by RhoA. Neuroreport. 2008;19:1661-5 pubmed publisher
    ..The binding was markedly enhanced by RhoA inactivation using Tat-C3, dominant negative RhoA, and si-RhoA...
  30. Guo M, Daines D, Tang J, Shen Q, Perrin R, Takada Y, et al. Fibrinogen-gamma C-terminal fragments induce endothelial barrier dysfunction and microvascular leak via integrin-mediated and RhoA-dependent mechanism. Arterioscler Thromb Vasc Biol. 2009;29:394-400 pubmed publisher
    ..Depletion of RhoA via siRNA knockdown or pharmacological inhibition of RhoA signaling attenuated gammaC-induced barrier dysfunction...
  31. Mäkitie L, Kanerva K, Andersson L. Ornithine decarboxylase regulates the activity and localization of rhoA via polyamination. Exp Cell Res. 2009;315:1008-14 pubmed publisher
    ..of the rho family are key modulators of the actin cytoskeleton, we investigated the molecular interactions of rhoA with ODC and polyamines...
  32. Suggate E, Ahmed Z, Read M, Eaton Charnock K, Douglas M, Gonzalez A, et al. Optimisation of siRNA-mediated RhoA silencing in neuronal cultures. Mol Cell Neurosci. 2009;40:451-62 pubmed
    ..disinhibition strategies in cultured retinal ganglion cells (RGC), we conducted experiments designed to silence RhoA signalling in PC12 and primary adult rat retinal cell cultures (containing RGC) by siRNA-mediated RhoA mRNA ..
  33. Christen M, Coye L, Hontz J, LaRock D, Pfuetzner R, Megha -, et al. Activation of a bacterial virulence protein by the GTPase RhoA. Sci Signal. 2009;2:ra71 pubmed publisher
    ..we report that the translocated Salmonellae virulence factor SseJ binds to the guanosine triphosphate-bound form of RhoA. This interaction stimulates the lipase activity of SseJ, which results in the esterification of cholesterol in the ..
  34. Pagiatakis C, Gordon J, Ehyai S, McDermott J. A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression. J Biol Chem. 2012;287:8361-70 pubmed publisher
    ..During contraction, VSMCs modulate calcium sensitivity through RhoA/ROCK-mediated inhibition of the myosin light chain phosphatase complex (MLCP)...
  35. Bulhak A, Roy J, Hedin U, Sjöquist P, Pernow J. Cardioprotective effect of rosuvastatin in vivo is dependent on inhibition of geranylgeranyl pyrophosphate and altered RhoA membrane translocation. Am J Physiol Heart Circ Physiol. 2007;292:H3158-63 pubmed
    ..Statins may inhibit isoprenylation and thereby prevent activation of proteins such as RhoA. We hypothesized that statins protect the myocardium against ischemia-reperfusion injury via a mechanism involving ..
  36. Siegert P, Schmidt G, Papatheodorou P, Wieland T, Aktories K, Orth J. Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the G?(q/11)--p63RhoGEF--RhoA axis. PLoS Pathog. 2013;9:e1003385 pubmed publisher
    ..Subsequently, G?(q/11) activates RhoA via p63RhoGEF, which specifically interacts with G?(q/11) but not with other G proteins like G???/?? and G?(i)...
  37. Zeidan A, Gan X, Thomas A, Karmazyn M. Prevention of RhoA activation and cofilin-mediated actin polymerization mediates the antihypertrophic effect of adenosine receptor agonists in angiotensin II- and endothelin-1-treated cardiomyocytes. Mol Cell Biochem. 2014;385:239-48 pubmed publisher
    ..stimuli, angiotensin II (Ang II, 100 nM) and endothelin-1 (ET-1, 10 nM) on Ras homolog gene family, member A (RhoA)/Rho-associated, coiled-coil containing protein kinase (ROCK) activation in cultured neonatal rat ventricular ..
  38. Wu J, Yuan X, Wang Q, Wei W, Xu M. Rho/ROCK acts downstream of lysophosphatidic acid receptor 1 in modulating P2X3 receptor-mediated bone cancer pain in rats. Mol Pain. 2016;12: pubmed publisher
    ..Lysophosphatidic acid and its receptor LPAR1, acting through the Rho-ROCK pathway, regulate P2X3 receptor in the development of both mechanical and spontaneous pain in bone cancer. ..
  39. Li C, Zhen G, Chai Y, Xie L, Crane J, Farber E, et al. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. Nat Commun. 2016;7:11455 pubmed publisher
    ..Here we show that TGF?-activated RhoA/ROCK signalling functions as a molecular switch regarding the fate of MSCs in arterial repair/remodelling after ..
  40. Ge Z, Li B, Zhou X, Yang Y, Zhang J. Basic fibroblast growth factor activates ?-catenin/RhoA signaling in pulmonary fibroblasts with chronic obstructive pulmonary disease in rats. Mol Cell Biochem. 2016;423:165-174 pubmed
    ..Trigger of the ?-catenin/RhoA pathway has been involved in aberrant ECM deposition in several diseases...
  41. Pi M, Spurney R, Tu Q, Hinson T, Quarles L. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Endocrinology. 2002;143:3830-8 pubmed
    ..Our results suggest that the C terminus of CasR may interact with filamin to create a cytoskeletal scaffold necessary for the spatial organization of Galphaq, RhoGEF Lbc, and Rho signaling pathways upstream of SRE activation. ..
  42. Peng F, Zhang B, Wu D, Ingram A, Gao B, Krepinsky J. TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolae. Am J Physiol Renal Physiol. 2008;295:F153-64 pubmed publisher
    ..The GTPase RhoA mediates TGFbeta-induced matrix accumulation in some settings...
  43. Silbert O, Wang Y, Maciejewski B, Lee H, Shaw S, Sanchez Esteban J. Roles of RhoA and Rac1 on actin remodeling and cell alignment and differentiation in fetal type II epithelial cells exposed to cyclic mechanical stretch. Exp Lung Res. 2008;34:663-80 pubmed publisher
    ..The results showed that mechanical strain stimulated RhoA within 5 minutes of initiation of force. Rac1 was also activated, but not Cdc42...
  44. Chevallier J, Koop C, Srivastava A, Petrie R, Lamarche Vane N, Presley J. Rab35 regulates neurite outgrowth and cell shape. FEBS Lett. 2009;583:1096-101 pubmed publisher
    ..Here, we find that Rab35 colocalizes with actin filaments and with Cdc42, Rac1 and RhoA, and that Rab35 can activate Cdc42 both in vivo and in vitro...
  45. Ma T, Xue Y. RhoA-mediated potential regulation of blood-tumor barrier permeability by bradykinin. J Mol Neurosci. 2010;42:67-73 pubmed publisher
    The purpose of this work is to investigate the potential for the small G protein RhoA to play a role in bradykinin (BK)-induced actin cytoskeleton rearrangement, tight junction (TJ) protein disassembly, and an increase in blood-tumor ..
  46. Dang J, Tian F, Li F, Huang W, Song M, Ding D, et al. Roles of Rho guanine nucleotide triphosphatases in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model. Clin Lab. 2014;60:175-84 pubmed
    ..Rho guanine nucleotide triphosphatases (RhoGTP ases) Rac1 and RhoA are important regulators of axon growth and synaptic plasticity and can be blocked by treatment with fasudil...
  47. Jin L, Liu T, Lagoda G, Champion H, Bivalacqua T, Burnett A. Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction. FASEB J. 2006;20:536-8 pubmed
    ..We hypothesized that increased RhoA/Rho-kinase signaling is a major factor in the pathogenesis of age-associated ED and the mechanism involves ..
  48. Lin Y, Chen N, Shih Y, Liao Y, Xue L, Lo S. DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene. 2010;29:3010-6 pubmed publisher
    ..These changes are rescued by silencing of RhoA, suggesting that the process is RhoA pathway dependent...
  49. Xie H, Xue Y, Liu L, Liu Y, Wang P. Role of RhoA/ROCK signaling in endothelial-monocyte-activating polypeptide II opening of the blood-tumor barrier: role of RhoA/ROCK signaling in EMAP II opening of the BTB. J Mol Neurosci. 2012;46:666-76 pubmed publisher
    The purpose of the present study was to determine the potential for RhoA/ROCK signaling to play a role in endothelial-monocyte-activating polypeptide (EMAP) II-induced increase in blood-tumor barrier (BTB) permeability in rat brain ..
  50. Avalos A, Valdivia A, Muñoz N, Herrera Molina R, Tapia J, Lavandero S, et al. Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA. J Cell Sci. 2009;122:3462-71 pubmed publisher
    ..sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation...
  51. Summers S, Nguyen S, Purdy R. Hindlimb unweighting induces changes in the RhoA-Rho-kinase pathway of the rat abdominal aorta. Vascul Pharmacol. 2008;48:208-14 pubmed publisher
    ..The hypothesis of the present study was that decreased activity in the RhoA/Rho-kinase pathway could contribute to that deficit. Wistar rats were subjected to 20 days of HLU treatment...
  52. Haga J, Kaunas R, Radeff Huang J, Weems J, Estrada K, Chien S, et al. Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. Biochem Biophys Res Commun. 2008;372:216-20 pubmed publisher
    This study investigated interactions between the effects of mechanical stretch and thrombin on RhoA activation in rat aortic smooth muscle cells (RASMC)...
  53. Sun J, Yang T, Wang P, Ma S, Zhu Z, Pu Y, et al. Activation of cold-sensing transient receptor potential melastatin subtype 8 antagonizes vasoconstriction and hypertension through attenuating RhoA/Rho kinase pathway. Hypertension. 2014;63:1354-63 pubmed publisher
    ..TRPM8 activation by menthol attenuated vasoconstriction via RhoA/Rho kinase pathway inhibition in wild-type mice, but the effect was absent in TRPM8(-/-) mice...
  54. Chen C, Liao S, Huang Y, Chiang A. RhoA inactivation is crucial to manganese-induced astrocyte stellation. Biochem Biophys Res Commun. 2005;326:873-9 pubmed
    ..The disruption of cytoskeletal architecture by manganese indicated the decreased activity of RhoA. Pharmacological and biochemical approaches revealed the inactivation of RhoA by manganese...
  55. Su Z, Cao L, Zhu Y, Liu X, Huang Z, Huang A, et al. Nogo enhances the adhesion of olfactory ensheathing cells and inhibits their migration. J Cell Sci. 2007;120:1877-87 pubmed
    ..promote the formation of focal adhesion in OECs and inhibited their membrane protrusion through the activation of RhoA. Furthermore, the co-culture migration assay demonstrated that OEC motility was significantly restricted by Nogo-A ..
  56. Huang Z, Wang Y, Yuan X, He C. RhoA-ROCK-Myosin pathway regulates morphological plasticity of cultured olfactory ensheathing cells. Exp Cell Res. 2011;317:2823-34 pubmed publisher
    ..Using RhoA FRET biosensor, we found that the active RhoA signal mainly distributed in the lamellipodia and/or filopodia of ..
  57. Avalos A, Arthur W, Schneider P, Quest A, Burridge K, Leyton L. Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes. J Biol Chem. 2004;279:39139-45 pubmed
    ..DI-TNC(1) astrocytes were stimulated with Thy-1-Fc immobilized on beads, and increased RhoA activity was confirmed using an affinity precipitation assay...
  58. Zhang H, Cybulsky A, Aoudjit L, Zhu J, Li H, Lamarche Vane N, et al. Role of Rho-GTPases in complement-mediated glomerular epithelial cell injury. Am J Physiol Renal Physiol. 2007;293:F148-56 pubmed
    ..When cultured rat GEC were stimulated with complement C5b-9 for 18 h, RhoA activity increased, whereas Rac1/Cdc42 activities decreased, compared with control cells...
  59. Singh J, Rattan S. Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2013;304:G723-31 pubmed publisher
    The role of PKC and RhoA/ROCK pathways in the phasic activities in the rectal smooth muscles (RSM) in the basal state is not known...
  60. Ford Speelman D, Roche J, Bowman A, Bloch R. The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle. Mol Biol Cell. 2009;20:3905-17 pubmed publisher
    ..a combination of in vitro and in vivo approaches, we found that the rhoGEF domain of obscurin binds selectively to rhoA, and that rhoA colocalizes with obscurin at the M-band in skeletal muscle...
  61. Wang J, Wang Y, Hou Y, Xi T, Liu Y, Liu J. The small GTPase RhoA, but not Rac1, is essential for conditioned aversive memory formation through regulation of actin rearrangements in rat dorsal hippocampus. Acta Pharmacol Sin. 2013;34:811-8 pubmed publisher
    ..The RhoA-ROCK pathway inhibitor Y27632 (8...
  62. Xiang S, Li M, Xie X, Xie Z, Zhou Q, Tian Y, et al. Rapamycin inhibits epithelial-to-mesenchymal transition of peritoneal mesothelium cells through regulation of Rho GTPases. FEBS J. 2016;283:2309-25 pubmed publisher
    ..HG increased the phosphorylation of PI3K, Akt, and mTOR. Importantly, rapamycin inhibits the RhoA, Rac1, and Cdc42 activated by HG...
  63. Hoshino M, Nakamura S. Small GTPase Rin induces neurite outgrowth through Rac/Cdc42 and calmodulin in PC12 cells. J Cell Biol. 2003;163:1067-76 pubmed
  64. Sun Q, Yue P, Ying Z, Cardounel A, Brook R, Devlin R, et al. Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. Arterioscler Thromb Vasc Biol. 2008;28:1760-6 pubmed publisher
    ..mediated mechanism for PM(2.5) and UFP effects. Short-term air pollution exaggerates hypertension through O(2)(.-)-mediated upregulation of the Rho/ROCK pathway. ..
  65. Biz M, Marques M, Crema V, Moriscot A, dos Santos M. GTPases RhoA and Rac1 are important for amelogenin and DSPP expression during differentiation of ameloblasts and odontoblasts. Cell Tissue Res. 2010;340:459-70 pubmed publisher
    ..b>RhoA, Rac1, and Cdc42 were strongly expressed during morphogenesis; during cytodifferentiation, RhoA was present in ..
  66. Andresen B, Shome K, Jackson E, Romero G. AT2 receptors cross talk with AT1 receptors through a nitric oxide- and RhoA-dependent mechanism resulting in decreased phospholipase D activity. Am J Physiol Renal Physiol. 2005;288:F763-70 pubmed
    ..Previous findings demonstrate that ANG II stimulates PLD activity through AT(1) receptors in a RhoA-dependent mechanism...
  67. Kamai T, Tsujii T, Arai K, Takagi K, Asami H, Ito Y, et al. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res. 2003;9:2632-41 pubmed
    ..b>RhoA, RhoC, and ROCK were more abundant in tumors and metastatic lymph nodes than in nontumor bladder and uninvolved ..
  68. Xie X, Chang S, Tatsumoto T, Chan A, Miki T. TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner. Cell Signal. 2005;17:461-71 pubmed
    ..Here, we show that, when expressed in cells, TIM was a potent activator of RhoA. Like activated Rho proteins, expression of TIM potentiated the serum response factor (SRF)- and AP-1-regualted ..
  69. Zhang S, Konstantinidis D, Yang J, Mizukawa B, Kalim K, Lang R, et al. Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development. J Immunol. 2014;193:5973-82 pubmed publisher
    ..How these signaling cascades are coordinated remains elusive. RhoA of the Rho family small GTPases plays an important role in actin cytoskeleton organization, cell adhesion, ..
  70. Iftinca M, Hamid J, Chen L, Varela D, Tadayonnejad R, Altier C, et al. Regulation of T-type calcium channels by Rho-associated kinase. Nat Neurosci. 2007;10:854-60 pubmed
    ..1 was dependent on intracellular GTP, and was antagonized by treatment with ROCK and RhoA inhibitors, LPA receptor antagonists or GDPssS. Site-directed mutagenesis of the Ca(v)3...
  71. Peng F, Wu D, Gao B, Ingram A, Zhang B, Chorneyko K, et al. RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease. Diabetes. 2008;57:1683-92 pubmed publisher
    ..Because activation of the GTPase RhoA has been implicated in matrix upregulation, we studied its role in induction of the matrix protein fibronectin in ..
  72. Guilluy C, Sauzeau V, Rolli Derkinderen M, Guerin P, Sagan C, Pacaud P, et al. Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Br J Pharmacol. 2005;146:1010-8 pubmed
    ..Chronic hypoxia-induced PH in rats is associated with an increase in RhoA activity in pulmonary artery that was maximal after 2 days (10.7+/-0.9-fold increase, n=6, P<0.001)...
  73. Shibata K, Sakai H, Huang Q, Kamata H, Chiba Y, Misawa M, et al. Rac1 regulates myosin II phosphorylation through regulation of myosin light chain phosphatase. J Cell Physiol. 2015;230:1352-64 pubmed publisher
    ..that targets MYPT1 (a regulatory subunit of MLCP) and CPI-17 (a MLCP specific inhibitor) rather than through the RhoA-Rho dependent kinase (ROCK) pathway...
  74. Barman S. Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C. Am J Physiol Lung Cell Mol Physiol. 2007;293:L472-9 pubmed
    ..Furthermore, Western blot analysis revealed that ET-1 increased RhoA expression in both normotensive and hypertensive pulmonary arteries, with expression being greater in the ..
  75. Berto G, Camera P, Fusco C, Imarisio S, Ambrogio C, Chiarle R, et al. The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase. J Cell Sci. 2007;120:1859-67 pubmed
    ..DSCR candidate genes, physically interacts with Citron kinase (CIT-K) and Citron N (CIT-N), two effectors of the RhoA small GTPase that have previously been involved in neuronal proliferation and differentiation...
  76. Cheng C, Webber C, Wang J, Xu Y, Martinez J, Liu W, et al. Activated RHOA and peripheral axon regeneration. Exp Neurol. 2008;212:358-69 pubmed publisher
    ..The role of RHOA GTPase has not been examined in this context...
  77. Fisher D, Xing B, Dill J, Li H, Hoang H, Zhao Z, et al. Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors. J Neurosci. 2011;31:14051-66 pubmed publisher
    ..CSPG-LAR interaction mediates axonal growth inhibition of neurons partially via inactivating Akt and activating RhoA signals...
  78. Joshi A, Bobylev I, Zhang G, Sheikh K, Lehmann H. Inhibition of Rho-kinase differentially affects axon regeneration of peripheral motor and sensory nerves. Exp Neurol. 2015;263:28-38 pubmed publisher
    The small GTPase RhoA and its down-stream effector Rho-kinase (ROCK) are important effector molecules of the neuronal cytoskeleton...
  79. Wen J, Qian C, Pan M, Wang X, Li Y, Lu Y, et al. Lentivirus-Mediated RNA Interference Targeting RhoA Slacks the Migration, Proliferation, and Myelin Formation of Schwann Cells. Mol Neurobiol. 2017;54:1229-1239 pubmed publisher
    b>RhoA, a member of Rho GTPases family, is known to play an important role in remodeling actin cytoskeleton...
  80. Bristow J, Sellers M, Majumdar D, Anderson B, Hu L, Webb D. The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. J Cell Sci. 2009;122:4535-46 pubmed publisher
    ..Thus, our results reveal an important new role for Asef2 in promoting cell migration and rapid adhesion turnover by coordinately regulating the activities of Rho-family GTPases. ..
  81. Wan G, Too H. A specific isoform of glial cell line-derived neurotrophic factor family receptor alpha 1 regulates RhoA expression and glioma cell migration. J Neurochem. 2010;115:759-70 pubmed publisher
    ..In addition, GFR?1b was found to regulate the expression of RhoA small GTPase, which was required for migration of C6 cells...
  82. Jiang W, Xia F, Han J, Wang J. Patterns of Nogo-A, NgR, and RhoA expression in the brain tissues of rats with focal cerebral infarction. Transl Res. 2009;154:40-8 pubmed publisher
    ..Therefore, we hypothesized that Nogo-A and its receptor NgR will be upregulated and will activate RhoA, and thus, they play a role in the damage in the infarction developed...
  83. Bordeleau F, Myrand Lapierre M, Sheng Y, Marceau N. Keratin 8/18 regulation of cell stiffness-extracellular matrix interplay through modulation of Rho-mediated actin cytoskeleton dynamics. PLoS ONE. 2012;7:e38780 pubmed publisher
    ..In addition, we find that this K8/K18 IF modulation of cell stiffness and actin fiber organization occurs through RhoA-ROCK signaling...
  84. Doye A, Mettouchi A, Bossis G, Clément R, Buisson Touati C, Flatau G, et al. CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion. Cell. 2002;111:553-64 pubmed
    ..Upon cell binding and introduction into the cytosol, CNF1 deamidates glutamine 63 of RhoA (or 61 of Rac and Cdc42), rendering constitutively active these GTPases...
  85. Zeng L, Xu H, Chew T, Eng E, Sadeghi M, Adler S, et al. HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation. FASEB J. 2005;19:1845-7 pubmed
    ..The signaling pathway that mediates VEGF-induced GEnC hyperpermeability involves RhoA activation leading to actin cytoskeletal remodeling, MLC diphosphorylation, and enhanced paracellular gap formation...
  86. Ying Z, Giachini F, Tostes R, Webb R. PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA. Arterioscler Thromb Vasc Biol. 2009;29:1657-63 pubmed publisher
    Ras homolog gene family member A (RhoA)/Rho-kinase-mediated Ca(2+) sensitization is a critical component of constrictor responses. The present study investigates how angiotensin II activates RhoA...
  87. Peng F, Zhang B, Ingram A, Gao B, Zhang Y, Krepinsky J. Mechanical stretch-induced RhoA activation is mediated by the RhoGEF Vav2 in mesangial cells. Cell Signal. 2010;22:34-40 pubmed publisher
    ..We have previously shown that the GTPase RhoA mediates stretch-induced fibronectin production...
  88. LaRock D, Brzovic P, Levin I, Blanc M, Miller S. A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions. J Biol Chem. 2012;287:29654-63 pubmed publisher
    ..to the cytoplasmic face of the host cell phagosome membrane where it is activated upon binding the small GTPase, RhoA. SseJ is regulated similarly to cognate eukaryotic effectors, as only the GTP-bound form of RhoA family members ..
  89. Wang Y, Teng H, Huang Z. Repulsive migration of Schwann cells induced by Slit-2 through Ca2+-dependent RhoA-myosin signaling. Glia. 2013;61:710-23 pubmed publisher
    ..required the loss of F-actin and focal adhesion, whereas the subsequent reversal of soma translocation depended on RhoA-Rock-Myosin signaling pathways...
  90. Cardozo M, de Conti A, Ong T, Scolastici C, Purgatto E, Horst M, et al. Chemopreventive effects of ?-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA. J Nutr Biochem. 2011;22:130-5 pubmed publisher
    ..05); only the GOH group had lower hepatic membrane RhoA protein levels (P<...
  91. Oishi A, Makita N, Sato J, Iiri T. Regulation of RhoA signaling by the cAMP-dependent phosphorylation of RhoGDI?. J Biol Chem. 2012;287:38705-15 pubmed publisher
    b>RhoA plays a pivotal role in regulating cell shape and movement. Protein kinase A (PKA) inhibits RhoA signaling and thereby induces a characteristic morphological change, cell rounding...
  92. Wingard C, Husain S, Williams J, James S. RhoA-Rho kinase mediates synergistic ET-1 and phenylephrine contraction of rat corpus cavernosum. Am J Physiol Regul Integr Comp Physiol. 2003;285:R1145-52 pubmed
    ..PE) augments the constrictor responses in rat corporal cavernosal tissues by a mechanism involving the RhoA-Rho kinase pathway...