Gene Symbol: Rgs7
Description: regulator of G-protein signaling 7
Alias: regulator of G-protein signaling 7
Species: rat
Products:     Rgs7

Top Publications

  1. Gold S, Ni Y, Dohlman H, Nestler E. Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. J Neurosci. 1997;17:8024-37 pubmed
    ..Striking region-specific patterns of expression were observed. Five subtypes, RGS4, RGS7, RGS8, RGS9, and RGS10 mRNAs, are densely expressed in brain, whereas the other subtypes (RGS3, RGS5, RGS6, and ..
  2. Posner B, Gilman A, Harris B. Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. J Biol Chem. 1999;274:31087-93 pubmed
    ..and GGL (G protein gamma subunit-like) domains form a subfamily that includes the mammalian RGS proteins RGS6, RGS7, RGS9, and RGS11...
  3. Drenan R, Doupnik C, Boyle M, Muglia L, Huettner J, Linder M, et al. Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. J Cell Biol. 2005;169:623-33 pubmed
    The RGS7 (R7) family of RGS proteins bound to the divergent Gbeta subunit Gbeta5 is a crucial regulator of G protein-coupled receptor (GPCR) signaling in the visual and nervous systems...
  4. Ingi T, Aoki Y. Expression of RGS2, RGS4 and RGS7 in the developing postnatal brain. Eur J Neurosci. 2002;15:929-36 pubmed
    ..we performed a systematic survey of the localization of mRNAs encoding three subtypes of the RGSs (RGS2, RGS4 and RGS7) in developing rat brains by in situ hybridization through postnatal day 2 (P2), P10 and P18 to adult...
  5. Carrasco G, Zhang Y, Damjanoska K, D Souza D, Garcia F, Battaglia G, et al. A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. J Pharmacol Exp Ther. 2003;307:1012-9 pubmed
    ..membrane and cytosol-associated 5-HT2A receptors, Galphaq, Galpha11, regulators of G protein signaling (RGS)4, and RGS7 proteins were assayed in the hypothalamic paraventricular nucleus, amygdala, and frontal cortex using Western blot ..
  6. Beaulieu J, Gainetdinov R. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev. 2011;63:182-217 pubmed publisher
  7. Jia L, Linder M, Blumer K. Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein. J Biol Chem. 2011;286:13695-703 pubmed publisher
    R7BP (RGS7 family-binding protein) has been proposed to function in neurons as a palmitoylation-regulated protein that shuttles heterodimeric, G(i/o)?-specific GTPase-activating protein (GAP) complexes composed of G?5 and RGS7 (R7) ..
  8. Luessen D, Sun H, McGinnis M, McCool B, Chen R. Chronic intermittent ethanol exposure selectively alters the expression of G? subunit isoforms and RGS subtypes in rat prefrontal cortex. Brain Res. 2017;1672:106-112 pubmed publisher
    ..Interestingly, we found that CIE increased mRNA and protein levels of RGS2, RGS4, RGS7 and RGS19 but had no effect on the expression of RGS5, RGS6, RGS8, RGS12 or RGS17...
  9. Witherow D, Wang Q, Levay K, Cabrera J, Chen J, Willars G, et al. Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells. J Biol Chem. 2000;275:24872-80 pubmed
    ..Here, we examined the behavior of Gbeta(5), RGS7, RGS9, and Galpha in tissue extracts using immunoprecipitation and conventional chromatography...

More Information


  1. Gold S, Heifets B, Pudiak C, Potts B, Nestler E. Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures. J Neurochem. 2002;82:828-38 pubmed
    ..At 24 h following chronic ECS, RGS7, -8 and -10 mRNA levels were decreased in the granule cell layer, and RGS7 and -8 mRNA levels were decreased in the ..
  2. Howlett A, Gray A, Hunter J, Willardson B. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. J Biol Chem. 2009;284:16386-99 pubmed publisher
    ..The results also show that Gbeta5-RGS7 assembly is dependent on CCT and PhLP1, but the apparent mechanism is different from that of Gbetagamma...
  3. Orlandi C, Posokhova E, Masuho I, Ray T, Hasan N, Gregg R, et al. GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J Cell Biol. 2012;197:711-9 pubmed publisher
    ..We propose that the interaction of RGS proteins with orphan GPCRs promotes signaling selectivity in G protein pathways. ..
  4. Koelle M, Horvitz H. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Cell. 1996;84:115-25 pubmed
    ..Two previously known and 13 newly identified mammalian genes have similarity to egl-10 and SST2, and we propose that members of this family regulate many G protein signaling pathways. ..
  5. Saitoh O, Kubo Y, Odagiri M, Ichikawa M, Yamagata K, Sekine T. RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents. J Biol Chem. 1999;274:9899-904 pubmed
    ..1997) Nature 390, 525-529). Here we report the isolation of a full-length rat cDNA of another brain-specific RGS, RGS7. In situ hybridization study revealed that RGS7 mRNA is predominantly expressed in Golgi cells within granule cell ..
  6. Jedema H, Gold S, Gonzalez Burgos G, Sved A, Tobe B, Wensel T, et al. Chronic cold exposure increases RGS7 expression and decreases alpha(2)-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neurons. Eur J Neurosci. 2008;27:2433-43 pubmed
    ..We observed that the alpha(2)-autoreceptor-evoked inhibition of LC neurons was reduced and that the expression of RGS7 was increased following chronic stress exposure...
  7. Sun H, Calipari E, Beveridge T, Jones S, Chen R. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Neuroscience. 2015;307:253-61 pubmed publisher
    ..AMPH self-administration also produced a negative correlation of the mRNA levels of RGS7 and RGS19 between the two brain regions, which was not present in the control group...