Gene Symbol: Rgs14
Description: regulator of G-protein signaling 14
Alias: regulator of G-protein signaling 14
Species: rat
Products:     Rgs14

Top Publications

  1. Traver S, Bidot C, Spassky N, Baltauss T, de Tand M, Thomas J, et al. RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochem J. 2000;350 Pt 1:19-29 pubmed
    ..This protein was identified as RGS14, a member of the recently discovered family of RGS ('regulators of G-protein signalling') proteins that stimulate ..
  2. Cho H, Kehrl J. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007;178:245-55 pubmed
    ..Fluorescence resonance energy transfer analysis confirms a direct interaction between RGS14 and G(ialpha1) in centrosomes...
  3. Martin McCaffrey L, Willard F, Pajak A, Dagnino L, Siderovski D, D Souza S. RGS14 is a microtubule-associated protein. Cell Cycle. 2005;4:953-60 pubmed
    ..elegans, D. melanogaster and mammals. We recently demonstrated that RGS14 is required for completion of the first mitotic division of the mouse embryo, and that it regulates microtubule ..
  4. Cho H, Kim D, Kehrl J. RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock. J Biol Chem. 2005;280:805-14 pubmed
    b>RGS14, a member of the regulator of G-protein signaling (RGS) protein family, possesses an N-terminal RGS domain, two Raf-like Ras-binding domains, and a GoLoco motif, which has GDP dissociation inhibitor activity...
  5. Kimple R, de Vries L, Tronchere H, Behe C, Morris R, Gist Farquhar M, et al. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. J Biol Chem. 2001;276:29275-81 pubmed
    ..RGS12 and RGS14 contain not only the hallmark RGS box responsible for GTPase-accelerating activity but also a single G alpha(i/o)-..
  6. Snow B, Antonio L, Suggs S, Gutstein H, Siderovski D. Molecular cloning and expression analysis of rat Rgs12 and Rgs14. Biochem Biophys Res Commun. 1997;233:770-7 pubmed
    ..We have also identified conserved regions in RGS12 which are similar to protein domains found in mouse rhophilin and coiled-coil proteins suggesting possible interactions with ras-like G-proteins. ..
  7. Mittal V, Linder M. The RGS14 GoLoco domain discriminates among Galphai isoforms. J Biol Chem. 2004;279:46772-8 pubmed
    ..b>RGS14 regulates G protein nucleotide exchange and hydrolysis by acting as a GAP through its RGS domain and as a guanine ..
  8. Martin McCaffrey L, Willard F, Oliveira dos Santos A, Natale D, Snow B, Kimple R, et al. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell. 2004;7:763-9 pubmed
    ..elegans and D. melanogaster. Here we show that "regulator of G protein signaling-14" (RGS14) is expressed by the mouse embryonic genome immediately prior to the first mitosis, where it colocalizes with the ..
  9. Shu F, Ramineni S, Amyot W, Hepler J. Selective interactions between Gi alpha1 and Gi alpha3 and the GoLoco/GPR domain of RGS14 influence its dynamic subcellular localization. Cell Signal. 2007;19:163-76 pubmed
    b>RGS14 is a multifunctional protein that contains an RGS domain, which binds active Gi/o alpha-GTP, a GoLoco/GPR domain, which binds inactive Gi alpha-GDP, and a tandem Rap1/2 binding domain (RBD)...

More Information


  1. Kimple R, Kimple M, Betts L, Sondek J, Siderovski D. Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits. Nature. 2002;416:878-81 pubmed
    ..crystal structure of Galpha(i1) GDP bound to the GoLoco region of the 'regulator of G-protein signalling' protein RGS14. Key contacts are described between the GoLoco motif and Galpha protein, including the extension of GoLoco's ..
  2. Willard F, Willard M, Kimple A, Soundararajan M, Oestreich E, Li X, et al. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PLoS ONE. 2009;4:e4884 pubmed publisher
    ..b>RGS14 contains tandem Ras-binding domains that have been reported to bind to Rap- but not Ras GTPases in vitro, leading ..
  3. Vellano C, Brown N, Blumer J, Hepler J. Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by G?i1 and G?i-linked G protein-coupled receptors. J Biol Chem. 2013;288:3620-31 pubmed publisher
    b>Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates heterotrimeric G protein and H-Ras signaling pathways...
  4. Shu F, Ramineni S, Hepler J. RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. Cell Signal. 2010;22:366-76 pubmed publisher
    ..We report here that RGS14 is an integrator of G protein and MAPKinase signalling pathways...
  5. Vellano C, Maher E, Hepler J, Blumer J. G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·G?i1 complex in live cells. J Biol Chem. 2011;286:38659-69 pubmed publisher
    b>Regulator of G protein Signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates both conventional and unconventional G protein signaling pathways...
  6. Hollinger S, Ramineni S, Hepler J. Phosphorylation of RGS14 by protein kinase A potentiates its activity toward G alpha i. Biochemistry. 2003;42:811-9 pubmed
    ..b>RGS14 and RGS12 are unique among RGS proteins in that they also regulate Galpha(i) signals because of the guanine ..
  7. Vellano C, Shu F, Ramineni S, Yates C, Tall G, Hepler J. Activation of the regulator of G protein signaling 14-G?i1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. Biochemistry. 2011;50:752-62 pubmed publisher
    b>RGS14 is a brain scaffolding protein that integrates G protein and MAP kinase signaling pathways. Like other RGS proteins, RGS14 is a GTPase activating protein (GAP) that terminates G?i/o signaling...
  8. Branch M, Hepler J. Endogenous RGS14 is a cytoplasmic-nuclear shuttling protein that localizes to juxtanuclear membranes and chromatin-rich regions of the nucleus. PLoS ONE. 2017;12:e0184497 pubmed publisher
    b>Regulator of G protein signaling 14 (RGS14) is a multifunctional scaffolding protein that integrates G protein and H-Ras/MAPkinase signaling pathways to regulate synaptic plasticity important for hippocampal learning and memory...
  9. Urabe Y, Tanikawa C, Takahashi A, Okada Y, Morizono T, Tsunoda T, et al. A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. PLoS Genet. 2012;8:e1002541 pubmed publisher
    ..Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P?=?8.51×10?¹², odds ratio (OR)?=?1.19), INMT-FAM188B-AQP1 on 7p14...
  10. Lin Y, Kim K, Yang Y, Ivessa A, Sadoshima J, Park Y. Regulation of longevity by regulator of G-protein signaling protein, Loco. Aging Cell. 2011;10:438-47 pubmed publisher
    ..Consistently, when expression of RGS14, mammalian homologue of Loco, was reduced in rat fibroblast cells, the resistance to oxidative stress increased ..
  11. Lee S, Simons S, Heldt S, Zhao M, Schroeder J, Vellano C, et al. RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. Proc Natl Acad Sci U S A. 2010;107:16994-8 pubmed publisher
    ..Here we demonstrate that the signaling protein RGS14 is highly enriched in CA2 pyramidal neurons and plays a role in suppression of both synaptic plasticity at these ..
  12. López Aranda M, López Téllez J, Navarro Lobato I, Masmudi Martín M, Gutierrez A, Khan Z. Role of layer 6 of V2 visual cortex in object-recognition memory. Science. 2009;325:87-9 pubmed publisher
    ..Furthermore, elimination of the same-layer neurons by means of injection of a selective cytotoxin resulted in the complete loss of normal as well as protein-mediated enhanced ORM. ..
  13. López Aranda M, Acevedo M, Carballo F, Gutierrez A, Khan Z. Localization of the GoLoco motif carrier regulator of G-protein signalling 12 and 14 proteins in monkey and rat brain. Eur J Neurosci. 2006;23:2971-82 pubmed
    ..Here, we have studied the expression pattern of RGS12 and RGS14 proteins in brain at regional, cellular and subcellular levels...