Genomes and Genes
retinoblastoma binding protein 7
Gene Symbol: retinoblastoma binding protein 7
Description: RB binding protein 7, chromatin remodeling factor
Alias: histone-binding protein RBBP7, RBBP-7, nucleosome-remodeling factor subunit RBAP46, retinoblastoma-binding protein 7
Products: retinoblastoma binding protein 7
- Kaji K, Caballero I, MacLeod R, Nichols J, Wilson V, Hendrich B. The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Nat Cell Biol. 2006;8:285-92 pubmed..Our findings define a role for epigenetic silencing in the cell-fate commitment of pluripotent cells. ..
- Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, et al. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009;28:2763-76 pubmed publisher..These findings may shed new light on the EGFR-related breast carcinogenesis and might offer a potential new target for breast cancer therapy. ..
- Shore A, Kabotyanski E, Roarty K, Smith M, Zhang Y, Creighton C, et al. Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation. PLoS Genet. 2012;8:e1002840 pubmed publisher..Additionally, a PRC2 complex that includes mPINC and RbAp46 may confer epigenetic modifications that maintain a population of mammary epithelial cells committed to the alveolar fate in the involuted gland. ..
- Basta J, Rauchman M. The nucleosome remodeling and deacetylase complex in development and disease. Transl Res. 2015;165:36-47 pubmed publisher..Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer. ..