Ren

Summary

Gene Symbol: Ren
Description: renin
Alias: RATRENAA, RENAA, Ren1, angiotensinogenase, renin 1 structural
Species: rat

Top Publications

  1. doi Congenic strains reveal the effect of the renin gene on skeletal muscle angiogenesis induced by electrical stimulation
    Micheline M de Resende
    Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 33:33-40. 2008
  2. pmc Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats
    Liu Liu
    Dept of Physiology, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA, USA
    Am J Physiol Renal Physiol 301:F1195-201. 2011
  3. ncbi Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems
    Wei Xiang
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 288:E125-32. 2005
  4. doi Expression and nutritional regulation of the (pro)renin receptor in rat visceral adipose tissue
    V Achard
    Aix Marseille University, Laboratoire d Histologie Embryologie, Marseille, France
    J Endocrinol Invest 34:840-6. 2011
  5. doi Accumulation of renin and imidazolone in peritubular capillary endothelial cells in insulin-resistant hypertensive rats
    Zoltan Wagner
    Second Department of Medicine and Nephrological Center, University of Pecs, Pacsirta Street 1, Pecs, Hungary
    J Nephrol 24:656-64. 2011
  6. doi Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats
    Hyung Eun Yim
    Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
    J Nutr Biochem 23:937-45. 2012
  7. doi The increase in sympathetic nerve density in the atrium facilitates atrial fibrillation in patients with rheumatic heart disease
    Yuanhong Li
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People s Republic of China
    Int J Cardiol 165:174-8. 2013
  8. pmc Pharmacogenomic strain differences in cardiovascular sensitivity to propofol
    Thomas A Stekiel
    Anesthesia Research, The Medical College of Wisconsin and The Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 115:1192-200. 2011
  9. pmc TASK-3 channel deletion in mice recapitulates low-renin essential hypertension
    Nick A Guagliardo
    Department of Pharmacology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    Hypertension 59:999-1005. 2012
  10. doi [Hypertension-induced fibrosis: a balance story]
    F Azibani
    INSERM U942, Universite Paris Diderot, Hopital Lariboisiere, 41, boulevard de la Chapelle, 75475 Paris Cedex 10, France
    Ann Cardiol Angeiol (Paris) 61:150-5. 2012

Scientific Experts

  • Helmy Siragy
  • Patrick J Mueller
  • M Filipenko
  • Genevieve Nguyen
  • Randi B Silver
  • Minolfa C Prieto
  • Adam Whaley-Connell
  • THOMAS STEKIEL
  • Xue Qin Hao
  • F Azibani
  • Jorg Peters
  • Martin C Kammerl
  • Brenda J Leckie
  • D J Campbell
  • J F Giudicelli
  • Atsuhiro Ichihara
  • Carol Moreno
  • Matthew J Durand
  • Minolfa C Prieto-Carrasquero
  • Alexis A Gonzalez
  • Dale M Seth
  • Andrew S Greene
  • Heike Wanka
  • Hiroyuki Kobori
  • L Gabriel Navar
  • Michael J Flister
  • Yuanhong Li
  • Hyung Eun Yim
  • Howard J Jacob
  • Naina Shah
  • Nick A Guagliardo
  • Gina M Warner
  • V Achard
  • Zoltan Wagner
  • Liu Liu
  • Julian H Lombard
  • Torsten Schlüter
  • Ming Zhi Zhang
  • Jiqian Huang
  • Petra Gratze
  • Jason D Fowler
  • Javad Habibi
  • Arul Veerappan
  • Jung J Kang
  • Micheline M de Resende
  • A Paliege
  • Wei Xiang
  • Olivier Gribouval
  • Usman Ahmad
  • Li Pan
  • Li Zhang
  • Tatsuya Nakatani
  • Jane Stubbe
  • R Tamura
  • Jennifer L Wilkinson-Berka
  • Zhibing Lu
  • Qizhu Tang
  • Jinqi Huang
  • Hongli Wang
  • Matthew J Hoffman
  • Congxin Huang
  • Bo He
  • Prajwal Reddy
  • Xiaorong Hu
  • Xiaoqing Zhu
  • Hong Jiang
  • C Richer
  • Joseph P Grande
  • Abeba Habtesion
  • Dipok Dhar
  • Douglas A Bayliss
  • David A Tyson
  • Elaine M Schertz
  • Vikram Sharma
  • Robert M Carey
  • J J Saris
  • Justin E Juskewitch
  • In Sun Bae
  • Paula Q Barrett
  • Catherine E Gray
  • Stephen C Textor
  • ChangLong Hu
  • Fatma El Zahraa Mohammed
  • Nathan A Davies
  • Bruce E Knudsen
  • Lilach O Lerman
  • Jane Macnaughtan
  • O Krizanova
  • Ansgar Deibel
  • Rajeshwar P Mookerjee

Detail Information

Publications70

  1. doi Congenic strains reveal the effect of the renin gene on skeletal muscle angiogenesis induced by electrical stimulation
    Micheline M de Resende
    Biotechnology and Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Genomics 33:33-40. 2008
    ..The present study emphasizes the importance of maintaining normal renin regulation as well as ANG II levels during the angiogenesis process with a combination of physiological, genetic, and pharmacological manipulation of the RAS...
  2. pmc Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats
    Liu Liu
    Dept of Physiology, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA, USA
    Am J Physiol Renal Physiol 301:F1195-201. 2011
    ..The greater availability of renin and AGT in the urine reflects the capability for intratubular ANG II formation which stimulates sodium reabsorption in distal nephron segments...
  3. ncbi Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems
    Wei Xiang
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 288:E125-32. 2005
    ....
  4. doi Expression and nutritional regulation of the (pro)renin receptor in rat visceral adipose tissue
    V Achard
    Aix Marseille University, Laboratoire d Histologie Embryologie, Marseille, France
    J Endocrinol Invest 34:840-6. 2011
    ..Early life nutritional environment plays an important role in the development of visceral adipose tissue and interacts with nutritional regulations in adulthood, leading to metabolic dysregulations...
  5. doi Accumulation of renin and imidazolone in peritubular capillary endothelial cells in insulin-resistant hypertensive rats
    Zoltan Wagner
    Second Department of Medicine and Nephrological Center, University of Pecs, Pacsirta Street 1, Pecs, Hungary
    J Nephrol 24:656-64. 2011
    ..The aim of our study was to investigate renal histology in rats with hypertension and IGT, with special emphasis on the peritubular endothelium...
  6. doi Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats
    Hyung Eun Yim
    Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
    J Nutr Biochem 23:937-45. 2012
    ..Up-regulation of renin and AT2 and down-regulation of PAI-1 and MMP-9 might contribute to abnormal programming of renal growth in rats exposed to postnatal early overnutrition...
  7. doi The increase in sympathetic nerve density in the atrium facilitates atrial fibrillation in patients with rheumatic heart disease
    Yuanhong Li
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People s Republic of China
    Int J Cardiol 165:174-8. 2013
    ..The hyperactivity of autonomic nervous system is known to contribute to the occurrence of Af in RHD patients. This study investigated the association between the autonomic density and the risk of Af in RHD patients...
  8. pmc Pharmacogenomic strain differences in cardiovascular sensitivity to propofol
    Thomas A Stekiel
    Anesthesia Research, The Medical College of Wisconsin and The Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 115:1192-200. 2011
    ..A pharmacogenomic approach was used to further localize the genetic region responsible for previously observed enhanced cardiovascular sensitivity to propofol in Dahl Salt Sensitive (SS) versus control Brown Norway (BN) rats...
  9. pmc TASK-3 channel deletion in mice recapitulates low-renin essential hypertension
    Nick A Guagliardo
    Department of Pharmacology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    Hypertension 59:999-1005. 2012
    ..Our studies establish a model of LREH and suggest that loss of TASK channel activity may be one mechanism that advances the syndrome of low renin hypertension...
  10. doi [Hypertension-induced fibrosis: a balance story]
    F Azibani
    INSERM U942, Universite Paris Diderot, Hopital Lariboisiere, 41, boulevard de la Chapelle, 75475 Paris Cedex 10, France
    Ann Cardiol Angeiol (Paris) 61:150-5. 2012
    ..It is shown that angiotensin II induces the expression of BNP and BMPs which ultimately slows the progression of myocardial fibrosis, and that aldosterone inhibits the expression of these factors and thus worsens the fibrosis...
  11. ncbi Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension
    M H Alderman
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, N Y 10461 1602
    N Engl J Med 324:1098-104. 1991
    ....
  12. pmc Genetic deficiency of Smad3 protects the kidneys from atrophy and interstitial fibrosis in 2K1C hypertension
    Gina M Warner
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Renal Physiol 302:F1455-64. 2012
    ..We conclude that abrogation of TGF-β/Smad3 signaling confers protection against the development of fibrosis and atrophy in RAS...
  13. doi Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression
    Naina Shah
    UCL Institute of Hepatology, UCL Medical School, Royal Free Hospital, London, UK
    J Hepatol 56:1047-53. 2012
    ....
  14. doi Alteration of embryonic AT(2)-R and inflammatory cytokines gene expression induced by prenatal exposure to lipopolysaccharide affects renal development
    Xue Qin Hao
    Department of Pharmacology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, China
    Exp Toxicol Pathol 65:433-9. 2013
    ..Prenatal LPS also increased TUNEL-positive cells and collagen I expressions in newborn rats and 7-week-old offspring rats...
  15. pmc Congenic mapping and sequence analysis of the Renin locus
    Michael J Flister
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 61:850-6. 2013
    ..Combined with previous studies, these data suggest that at least 4 BP loci reside within the 30-cM chromosome 13 BP quantitative trait locus that includes Renin...
  16. doi A renin transcript lacking exon 1 encodes for a non-secretory intracellular renin that increases aldosterone production in transgenic rats
    Jorg Peters
    Department of Cardiovascular Medicine, University of Greifswald, Greifswald, Germany
    J Cell Mol Med 12:1229-37. 2008
    ..The CX-(exon2-9)renin transgenic rat appears to be a useful model to study the role and the mechanisms of action of cytoplasmatic renin derived from exon(1A-9) transcripts...
  17. doi Cytosolic renin is targeted to mitochondria and induces apoptosis in H9c2 rat cardiomyoblasts
    Heike Wanka
    Institute of Physiology, University of Greifswald, Karlsburg, Germany
    J Cell Mol Med 13:2926-37. 2009
    ..Non-secretory cytosolic renin can be considered as a new target for cardiac failure...
  18. pmc Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat
    Javad Habibi
    Departments of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Endocrinology 149:5643-53. 2008
    ....
  19. pmc Influence of sedentary versus physically active conditions on regulation of plasma renin activity and vasopressin
    Patrick J Mueller
    Dalton Cardiovascular Research Center and Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri, USA
    Am J Physiol Regul Integr Comp Physiol 295:R727-32. 2008
    ....
  20. pmc Collecting duct renin is upregulated in both kidneys of 2-kidney, 1-clip goldblatt hypertensive rats
    Minolfa C Prieto-Carrasquero
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Hypertension 51:1590-6. 2008
    ....
  21. pmc The collecting duct is the major source of prorenin in diabetes
    Jung J Kang
    Department of Physiology, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hypertension 51:1597-604. 2008
    ..These novel findings suggest that, in a rat model of diabetes, prorenin content and release from the CD may be more important than the juxtaglomerular apparatus in contrast to the existing paradigm...
  22. pmc Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction
    Arul Veerappan
    Department of Physiology and Biophysics, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:1315-20. 2008
    ..The data show that locally produced ANG II is a critical factor governing BC, opening the possibility for novel therapeutic targets in the management of airway disease...
  23. ncbi NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats
    Helmy M Siragy
    Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 1409, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1461-7. 2007
    ..Reversal of the PD effects by SNAP and SNAP effects by ODQ confirms that NO and cGMP mediate the AT(2) receptor inhibition of renal renin production...
  24. doi Renin dynamics in adipose tissue: adipose tissue control of local renin concentrations
    Jason D Fowler
    Dept of Integrative Biology and Physiology, 6 125 Jackson Hall, 321 Church St S E, Univ of Minnesota Medical School, Minneapolis, MN 55455, USA
    Am J Physiol Endocrinol Metab 296:E343-50. 2009
    ..These results suggest that adipose tissue may control its own local renin concentration independently of plasma renin as a potential mechanism for maintaining a functional local adipose RAS...
  25. pmc Intrarenal dopaminergic system regulates renin expression
    Ming Zhi Zhang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 53:564-70. 2009
    ....
  26. pmc Introgression of the Brown Norway renin allele onto the Dahl salt-sensitive genetic background increases Cu/Zn SOD expression in cerebral arteries
    Matthew J Durand
    Department of Physiology, Medical College of Wisconsin, Milwaukee, USA
    Am J Hypertens 24:563-8. 2011
    ..NO-dependent vasodilator responses are rescued in MCAs from Ren1-BN congenic rats, which have a 2...
  27. pmc Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats
    Alexis A Gonzalez
    Department of Physiology, Tulane University, School of Medicine, 1430 Tulane Ave, SL39, New Orleans, LA 70112, USA
    Hypertension 57:859-64. 2011
    ....
  28. pmc Creation and characterization of a renin knockout rat
    Carol Moreno
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 57:614-9. 2011
    ..Plasma renin activity was undetectable in the Ren-/- rat, and renin protein was absent from the juxtaglomerular cells in the kidney...
  29. pmc Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene
    Matthew J Durand
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 299:H1865-74. 2010
    ....
  30. doi Amiloride lowers arterial pressure in cyp1a1ren-2 transgenic rats without affecting renal vascular function
    Torsten Schlüter
    Institute of Physiology, University of Greifswald, Karlsburg, Germany
    J Hypertens 28:2267-77. 2010
    ....
  31. pmc Glucose promotes the production of interleukine-1beta and cyclooxygenase-2 in mesangial cells via enhanced (Pro)renin receptor expression
    Jiqian Huang
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 1409, USA
    Endocrinology 150:5557-65. 2009
    ..It is also possible that PRR could enhance the production of these inflammatory cytokines through direct stimulation of ERK1/2-NF-kappaB signaling cascade...
  32. doi Prorenin contributes to angiotensin peptide formation in transgenic rats with rat prorenin expression targeted to the liver
    Duncan J Campbell
    St Vincent s Institute of Medical Research and the Department of Medicine, University of Melbourne, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Hypertension 54:1248-53. 2009
    ....
  33. pmc Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat
    Adam Whaley-Connell
    Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Am J Physiol Renal Physiol 296:F1013-22. 2009
    ..Thus, in this model of RAAS activation, MR antagonism attenuates glomerular/podocyte remodeling and albuminuria, in part through reductions in redox-mediated impairment of insulin metabolic signaling...
  34. doi Energy metabolism in human renin-gene transgenic rats: does renin contribute to obesity?
    Petra Gratze
    Franz Volhard Clinical Research Center, Helios Klinikum Berlin Buch, Berlin Buch, Germany
    Hypertension 53:516-23. 2009
    ..The mechanisms are independent of any currently known renin-related effects...
  35. ncbi Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat
    Adam Whaley-Connell
    University of Missouri Columbia School of Medicine, Division of Nephrology, MA436, DC043 0, One Hospital Dr, Columbia, MO 65212, USA
    Am J Physiol Endocrinol Metab 293:E355-63. 2007
    ..05). Collectively, these data suggest cardiac oxidative stress-induced structural and functional changes are driven, in part, by AT(1)R-mediated increases in NADPH oxidase activity...
  36. ncbi Renin/prorenin receptors
    G Nguyen
    Institut National de la Sante et de la Recherche Medicale, INSERM Unit 36, College de France, Unit of Experimental Medicine, Paris, France
    Kidney Int 69:1503-6. 2006
    ....
  37. ncbi Effect of apocynin treatment on renal expression of COX-2, NOS1, and renin in Wistar-Kyoto and spontaneously hypertensive rats
    A Paliege
    Medical Faculty of the Charite, Department of Vegetative Anatomy, Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R694-700. 2006
    ..Downregulated COX-2 and renin levels in SHR are apparently unrelated to oxidative stress, since apocynin treatment had no effect on these parameters...
  38. ncbi An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria
    S Clausmeyer
    Department of Pharmacology, University of Heidelberg, Germany
    Circ Res 84:337-44. 1999
    ..This truncated prorenin corresponds exactly to the deletion variant being imported into mitochondria in vitro...
  39. ncbi Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing
    M A Lee-Kirsch
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circ Res 84:240-6. 1999
    ..These findings provide evidence for a novel pathway of intracellular angiotensin generation that occurs exclusively in the brain...
  40. pmc Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells
    S Gambaryan
    Medizinische Universitäts Klinik, Institut für Klinische Biochemie und Pathobiochemie, 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 95:9003-8. 1998
    ..Our results indicate that cGK II, and possibly cGK I, can mediate cGMP inhibitory effects on renin release and are physiological components of the cGMP signal transduction system which opposes the RAAS...
  41. pmc Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats
    E M St Lezin
    Department of Laboratory Medicine, University of California, San Francisco 94143, USA
    J Clin Invest 97:522-7. 1996
    ....
  42. ncbi Renin gene nucleotide sequence of coding and regulatory regions in Dahl rats
    K Y Alam
    Department of Medicine, Medical College of Ohio, Toledo 43699
    Clin Exp Hypertens 15:599-614. 1993
    ....
  43. ncbi Assignment of 22 loci in the rat by somatic hybrid and linkage analysis
    R S Yeung
    Fox Chase Cancer Center, Department of Surgical Oncology, Philadelphia, Pennsylvania 19111
    Mamm Genome 4:585-8. 1993
    ..Results of this study further support the extensive conservation of synteny between the rat and mouse and, to a lesser degree, between rat and human...
  44. ncbi Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats
    C Dubay
    INSERM U 358, Centre d Etude du Polymorphisme Humain, Paris, France
    Nat Genet 3:354-7. 1993
    ..Significant linkage was established between diastolic blood pressure and a microsatellite marker of the renin gene (REN) on rat chromosome 13, and between pulse pressure and the carboxypeptidase B gene (CPB) on chromosome 2...
  45. ncbi Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat
    E L Harris
    Department of Biochemistry, University of Otago, Dunedin, New Zealand
    J Hypertens 13:397-404. 1995
    ..To determine associations between cardiovascular parameters and genotype in 205 F2 rats of both sexes and lineages from reciprocal crosses made between rats of the New Zealand genetically hypertensive (GH) and Brown Norway (BN) rat strains...
  46. pmc Nucleotide sequence of rat renin cDNA
    M Tada
    Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan
    Nucleic Acids Res 16:3576. 1988
  47. ncbi Structure of the rat renin gene
    A Fukamizu
    Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan
    J Mol Biol 201:443-50. 1988
    ..that the rat renin precursor consists of 402 amino acid residues, and shows 85%, 82% and 68% homology to the mouse Ren-1 and Ren-2, and human renins, respectively...
  48. pmc Molecular cloning of rat renin cDNA and its gene
    C E Burnham
    Proc Natl Acad Sci U S A 84:5605-9. 1987
    ....
  49. ncbi Structural analysis of 5'-flanking regions of rat, mouse and human renin genes reveals the presence of a transposable-like element in the two mouse genes
    D Tronik
    LA CNRS 361, Departement d Immunologie, Institut Pasteur, Paris, France
    Gene 69:71-80. 1988
    The two renin genes of the mouse (Ren1 and Ren2) are expressed at different levels in the submaxillary gland (SMG). In contrast to mice, there is no detectable renin gene expression in the rat SMG...
  50. ncbi Similarities and differences in the subcellular localization of hamartin and tuberin in the kidney
    V Murthy
    Molecular Neurogenetics Unit, Charlestown, Massachusetts 02129, USA
    Am J Physiol Renal Physiol 278:F737-46. 2000
    ..The cell-specific expression of tuberin and hamartin described here will provide critical insight into the cell types that give rise to kidney lesions, and the tumor suppressor role of these proteins in TSC...
  51. ncbi High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin
    J J Saris
    Department of Pharmacology, Cardiovascular Research Institute COEUR, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 280:H1706-15. 2001
    ..Binding precedes internalization and proteolytic activation to renin thereby supporting the concept of cardiac angiotensin formation by renal prorenin...
  52. ncbi Nitric oxide synthase mRNA levels correlate with gene expression of angiotensin II type-1 but not type-2 receptors, renin or angiotensin converting enzyme in selected brain areas
    O Krizanova
    Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava
    Physiol Res 50:473-80. 2001
    ....
  53. ncbi Strong association of a renin intronic dimorphism with essential hypertension
    Usman Ahmad
    Department of Biological and Biomedical Sciences, Faculty of Health Sciences, Medical College, Aga Khan University, Karachi, Pakistan
    Hypertens Res 28:339-44. 2005
    ..to identify the genetic mutation that has been detected as an MboI dimorphism in intron 9 of the human renin (REN) gene and to confirm a previously reported, putative association between the REN MboI dimorphism and clinical ..
  54. ncbi Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis
    Olivier Gribouval
    Inserm U574, Hopital Necker Enfants Malades, Universite Rene Descartes, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Nat Genet 37:964-8. 2005
    ..This is the first identification to our knowledge of a renal mendelian disorder linked to genetic defects in the renin-angiotensin system, highlighting the crucial role of the renin-angiotensin system in human kidney development...
  55. pmc AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats
    Minolfa C Prieto-Carrasquero
    Dept of Physiology and Hypertension, Tulane Univ Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112 2699, USA
    Am J Physiol Renal Physiol 289:F632-7. 2005
    ..The augmented distal tubular renin may contribute to increased intratubular ANG II levels and distal nephron sodium reabsorption in ANG II-dependent hypertension...
  56. ncbi Activation of the rat renin promoter by HOXD10.PBX1b.PREP1, Ets-1, and the intracellular domain of notch
    Li Pan
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263 0001, USA
    J Biol Chem 280:20860-6. 2005
    ..PBX1b.PREP1 activate the rat renin promoter cooperatively in COS-7 cells. These results strongly suggest that the renin gene is a downstream target of the Notch signaling pathway...
  57. ncbi Targeting the renin-angiotensin system: what's new?
    B J Leckie
    Department of Cardiovascular Sciences, RK Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Curr Med Chem Cardiovasc Hematol Agents 3:23-32. 2005
    ..11 may be of value where there is both sodium retention and increased angiotensin II. Targeting the renin-angiotensin system by gene therapy or antibody treatment may provide a longer-term treatment for hypertension...
  58. pmc Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 114:1128-35. 2004
    ..The mechanism and substances causing nonproteolytic activation of prorenin may serve as important therapeutic targets for the prevention of diabetic organ damage...
  59. pmc Mast cells: a unique source of renin
    Randi B Silver
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:13607-12. 2004
    ..Our findings provide a rationale for targeting mast cells in conjunction with renin-angiotensin system inhibitors in the management of angiotensin II-related dysfunctions...
  60. ncbi Expression of local renin and angiotensinogen mRNA in cirrhotic portal hypertensive patient
    Li Zhang
    Department of General Surgery, Shandong Provincial Hospital, Jinan 250021, Shandong Province, China
    World J Gastroenterol 9:1584-8. 2003
    ..To investigate the expression of local renin and angiotensinogen mRNA in cirrhotic portal hypertensive patients...
  61. ncbi Cyclooxygenase-2 contributes to elevated renin in the early postnatal period in rats
    Jane Stubbe
    Department of Physiology and Pharmacology, University of Southern Denmark, DK 5000 Odense, Denmark
    Am J Physiol Regul Integr Comp Physiol 284:R1179-89. 2003
    ..We suggest that suckling in the rat is correlated to an enhanced, COX-2-mediated, secretory activity of renin-producing juxtaglomerular cells...
  62. ncbi Intracranial renin alters gustatory neural responses in the nucleus of the solitary tract of rats
    R Tamura
    Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930 0194, Japan
    Am J Physiol Regul Integr Comp Physiol 284:R1108-18. 2003
    ..A similar tendency was evident for the subsample of neurons that responded best to NaCl, but the effect was smaller. These data are consistent with, but not as dramatic as, those reported after dietary-induced sodium appetite...
  63. ncbi Renin mRNA expression and renal dysfunction in tacrolimus-induced acute nephrotoxicity
    Tatsuya Nakatani
    Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Int J Mol Med 11:75-8. 2003
    ..The rise in PRA significantly correlated with increase in FENa by liner regression. Therefore, the results indicate that RAS is involved in the tacrolimus-induced acute nephrotoxicity...
  64. ncbi Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 rat
    Jennifer L Wilkinson-Berka
    Department of Physiology, The University of Melbourne, Grattan Street, Parkville 3010, Victoria, Australia
    Mol Cell Endocrinol 194:201-9. 2002
    ..In each rat strain, thymic renin was predominately active and highest in Ren-2 rats (Ren-2, 22.6+/-4.2, SD 0.8+/-0.1 mGoldblatt Units/g, mean+/-SEM)...
  65. ncbi Angiotensin II feedback is a regulator of renocortical renin, COX-2, and nNOS expression
    Martin C Kammerl
    Institut fur Physiologie, Universitat Regensburg, 93040 Regensburg, Germany
    Am J Physiol Regul Integr Comp Physiol 282:R1613-7. 2002
    ..We conclude that the expression of renin, COX-2, and nNOS in the juxtaglomerular apparatus during low-salt diet is markedly limited by a direct feedback inhibition through ANG II...
  66. ncbi Coronary dilatation reserve in experimental hypertension and chronic heart failure: effects of blockade of the renin-angiotensin system
    C Richer
    Département de Pharmacologie et INSERM 00 01, Faculte de Medecine Paris Sud, Le Kremlin Bicetre, France
    Clin Exp Pharmacol Physiol 28:997-1001. 2001
    ..4. In kallikrein-kinin system-deficient mice, CVR was not different from that of wild-type mice, suggesting that this system is not implicated in normal CVR regulation...

Research Grants28

  1. NO AND EICOSANOID MEDIATE RENAL EFFECTS OF AT2 RECEPTORS
    Helmy Siragy; Fiscal Year: 2000
    ..The proposed studies are related to the long term goal of increased understanding of the pathophysiology of body sodium and water excretion abnormalities and hypertension. ..
  2. Renin receptor provoked renal inflammation
    Helmy Siragy; Fiscal Year: 2009
    ..Information gained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  3. Renin receptor provoked renal inflammation
    Helmy M Siragy; Fiscal Year: 2010
    ..Information gained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  4. Prorenin Receptors Mediate Hypertension and Kidney Disease in Diabetes
    Helmy M Siragy; Fiscal Year: 2010
    ....
  5. Renin receptor provoked renal inflammation
    Helmy Siragy; Fiscal Year: 2009
    ..Information gained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  6. Mechanisms of peripheral vascular anesthetic sensitivity
    THOMAS STEKIEL; Fiscal Year: 2007
    ..Additionally, this model also greatly facilitates development of congenic sub strains (partial chromosomal substitutions) for use in subsequent genetic mapping studies. ..
  7. Physical Activity Dependent Plasticity CNS Sympathetic Nervous System Regulation
    Patrick Mueller; Fiscal Year: 2007
    ....
  8. Renin receptor provoked renal inflammation
    Helmy Siragy; Fiscal Year: 2007
    ..Information gained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  9. Prorenin Receptors Mediate Hypertension and Kidney Disease in Diabetes
    Helmy Siragy; Fiscal Year: 2009
    ....
  10. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2007
    ..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
  11. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2003
    ..The proposed studies will help understand the mechanisms that are involved in diabetic nephropathy and could lead to the development of new therapeutic modalities to prevent or slowdown the development of this disease. ..
  12. AT2 Receptor Modulates Renal Angiotensin II Levels
    Helmy Siragy; Fiscal Year: 2005
    ..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  13. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2006
    ..The proposed studies will help understand the mechanisms that are involved in diabetic nephropathy and could lead to the development of new therapeutic modalities to prevent or slowdown the development of this disease. ..
  14. Inactivity and Enhanced Sympathoexcitation: Role of Neuroplasticity in the RVLM
    Patrick J Mueller; Fiscal Year: 2010
    ....