Reln

Summary

Gene Symbol: Reln
Description: reelin
Alias: Reelen, reeler, reelin
Species: rat
Products:     Reln

Top Publications

  1. Sui L, Li B. Effects of perinatal hypothyroidism on regulation of reelin and brain-derived neurotrophic factor gene expression in rat hippocampus: Role of DNA methylation and histone acetylation. Steroids. 2010;75:988-97 pubmed publisher
    ..the role of DNA methylaion and histone acetylation in the effects of perinatal hypothyroidism on regulation of reelin and brain-derived neurotrophic factor (BDNF) gene expression in rat hippocampus...
  2. Weaver I, Meaney M, Szyf M. Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc Natl Acad Sci U S A. 2006;103:3480-5 pubmed
    ..These results suggest that early-life experience has a stable and broad effect on the hippocampal transcriptome and anxiety-mediated behavior, which is potentially reversible in adulthood. ..
  3. Lussier A, Caruncho H, Kalynchuk L. Repeated exposure to corticosterone, but not restraint, decreases the number of reelin-positive cells in the adult rat hippocampus. Neurosci Lett. 2009;460:170-4 pubmed publisher
    ..Interestingly, recent evidence has described a regulatory role for the extracellular matrix protein reelin in important aspects of neural plasticity within the hippocampus and dentate gyrus...
  4. Pujadas L, Gruart A, Bosch C, Delgado L, Teixeira C, Rossi D, et al. Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation. J Neurosci. 2010;30:4636-49 pubmed publisher
    b>Reelin, an extracellular protein essential for neural migration and lamination, is also expressed in the adult brain...
  5. Fournier N, Andersen D, Botterill J, Sterner E, Lussier A, Caruncho H, et al. The effect of amygdala kindling on hippocampal neurogenesis coincides with decreased reelin and DISC1 expression in the adult dentate gyrus. Hippocampus. 2010;20:659-71 pubmed publisher
    ..b>Reelin and DISC1 (disrupted-in-schizophrenia 1) are proteins that play a regulatory role in the maturation and ..
  6. Lussier A, Lebedeva K, Fenton E, Guskjolen A, Caruncho H, Kalynchuk L. The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus. Neuropharmacology. 2013;71:174-83 pubmed publisher
    We have hypothesized that the extracellular matrix protein reelin is involved in the pathogenesis of major depression...
  7. Fatemi S, Reutiman T, Folsom T. Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats. Schizophr Res. 2009;111:138-52 pubmed publisher
    Disruption of the Reelin and GABAergic signaling systems have been observed in psychiatric disorders including autism, schizophrenia, bipolar disorder, and major depression...
  8. Beffert U, Morfini G, Bock H, Reyna H, Brady S, Herz J. Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J Biol Chem. 2002;277:49958-64 pubmed
    b>Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2, thereby inducing tyrosine phosphorylation of the adaptor protein Disabled-1 ..
  9. Teixeira C, Martin E, Sahún I, Masachs N, Pujadas L, Corvelo A, et al. Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder. Neuropsychopharmacology. 2011;36:2395-405 pubmed publisher
    ..Recent studies have shown that Reelin, an extracellular protein that is critical for neuronal development, is reduced in schizophrenia and bipolar ..

More Information

Publications86

  1. Fatemi S, Earle J, McMenomy T. Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol Psychiatry. 2000;5:654-63, 571 pubmed
    ..Recent landmark postmortem reports implicate Reelin, a secretory glycoprotein responsible for normal lamination of brain, in the pathology of schizophrenia and ..
  2. Niu S, Renfro A, Quattrocchi C, Sheldon M, D ARCANGELO G. Reelin promotes hippocampal dendrite development through the VLDLR/ApoER2-Dab1 pathway. Neuron. 2004;41:71-84 pubmed
    ..In addition to cellular disorganization, dendrite abnormalities are present in the brain of reeler mice lacking Reelin...
  3. Impagnatiello F, Guidotti A, Pesold C, Dwivedi Y, Caruncho H, Pisu M, et al. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc Natl Acad Sci U S A. 1998;95:15718-23 pubmed
    ..nuclei, and cerebella of schizophrenia patients and their matched nonpsychiatric subjects were compared for reelin (RELN) mRNA and reelin (RELN) protein content...
  4. Hartfuss E, Forster E, Bock H, Hack M, Leprince P, Luque J, et al. Reelin signaling directly affects radial glia morphology and biochemical maturation. Development. 2003;130:4597-609 pubmed
    ..We show an important role of the secreted molecule reelin for the establishment of radial glia processes...
  5. Bal M, Leitz J, Reese A, Ramirez D, Durakoglugil M, Herz J, et al. Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission. Neuron. 2013;80:934-46 pubmed publisher
    b>Reelin is a glycoprotein that is critical for proper layering of neocortex during development as well as dynamic regulation of glutamatergic postsynaptic signaling in mature synapses...
  6. Stranahan A, Salas Vega S, Jiam N, Gallagher M. Interference with reelin signaling in the lateral entorhinal cortex impairs spatial memory. Neurobiol Learn Mem. 2011;96:150-5 pubmed publisher
    ..The glutamatergic cells of origin for the perforant pathway are distinguished by their expression of reelin, a glycoprotein involved in learning and synaptic plasticity...
  7. Qiu S, Weeber E. Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J Neurophysiol. 2007;97:2312-21 pubmed
    b>Reelin signaling through the low-density lipoprotein receptor family members, apoliproprotein E receptor 2 (apoER2) and very-low-density lipoprotein receptor (VLDLR), plays a pivotal role in dictating neuronal lamination during embryonic ..
  8. Ballif B, Arnaud L, Arthur W, Guris D, Imamoto A, Cooper J. Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol. 2004;14:606-10 pubmed
    ..These migrations are coordinated to ensure normal development. The secreted protein Reelin controls the locations of many types of neurons, and its absence causes the classic "Reeler" phenotype...
  9. D ARCANGELO G, Miao G, Chen S, Soares H, Morgan J, Curran T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature. 1995;374:719-23 pubmed
    The autosomal recessive mouse mutation reeler leads to impaired motor coordination, tremors and ataxia...
  10. Tinnes S, Schäfer M, Flubacher A, Münzner G, Frotscher M, Haas C. Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning. FASEB J. 2011;25:1002-13 pubmed publisher
    ..Lack of Reelin causes severe disturbances in cerebral layering, such as the reeler phenotype and granule cell dispersion in temporal lobe epilepsy...
  11. Ventruti A, Kazdoba T, Niu S, D ARCANGELO G. Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience. 2011;189:32-42 pubmed publisher
    ..Heterozygous reeler mice expressing reduced levels of Reelin are grossly normal but exhibit behavioral and physiological abnormalities...
  12. Hong S, Shugart Y, Huang D, Shahwan S, Grant P, Hourihane J, et al. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Nat Genet. 2000;26:93-6 pubmed
    ..LCH parallels the reeler mouse mutant (Reln(rl)), in which Reln mutations cause cerebellar hypoplasia, abnormal cerebral cortical neuronal ..
  13. Rogers J, Rusiana I, Trotter J, Zhao L, Donaldson E, Pak D, et al. Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn Mem. 2011;18:558-64 pubmed publisher
    ..The known lipoprotein receptor ligand Reelin is important for normal synaptic plasticity, dendritic morphology, and cognitive function; however, the in vivo ..
  14. Miller C, Sweatt J. Covalent modification of DNA regulates memory formation. Neuron. 2007;53:857-69 pubmed
    ..of the memory suppressor gene PP1 and demethylation and transcriptional activation of the synaptic plasticity gene reelin, indicating both methyltransferase and demethylase activity during consolidation...
  15. Pesold C, Liu W, Guidotti A, Costa E, Caruncho H. Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression. Proc Natl Acad Sci U S A. 1999;96:3217-22 pubmed
    b>Reelin (Reln) is a protein with some structural analogies with other extracellular matrix proteins that functions in the regulation of neuronal migration during the development of cortical laminated structures...
  16. Meyer G, Cabrera Socorro A, Perez Garcia C, Martinez Millan L, Walker N, Caput D. Developmental roles of p73 in Cajal-Retzius cells and cortical patterning. J Neurosci. 2004;24:9878-87 pubmed
    ..p73-expressing CR cells are lost in p73-/- embryos, although Reelin is faintly expressed in the marginal zone...
  17. Nishikawa S, Goto S, Yamada K, Hamasaki T, Ushio Y. Lack of Reelin causes malpositioning of nigral dopaminergic neurons: evidence from comparison of normal and Reln(rl) mutant mice. J Comp Neurol. 2003;461:166-73 pubmed
    The reeler gene (Reln(rl), formerly rl) product Reelin controls neuronal migration and positioning and thereby plays a key role in brain development...
  18. Kobow K, Jeske I, Hildebrandt M, Hauke J, Hahnen E, Buslei R, et al. Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy. J Neuropathol Exp Neurol. 2009;68:356-64 pubmed publisher
    ..b>Reelin, which plays a key role during hippocampal development and maintenance of laminar organization, is synthesized and ..
  19. Ohshima T, Ogawa M, Veeranna -, Hirasawa M, Longenecker G, Ishiguro K, et al. Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain. Proc Natl Acad Sci U S A. 2001;98:2764-9 pubmed
    ..Mutant mice lacking either Cdk5 or p35 exhibit certain similarities with Reelin/Dab1-mutant mice in the disorganization of cortical laminar structure in the brain...
  20. Tan W, Sherman D, Turesson J, Shao X, Janczewski W, Feldman J. Reelin demarcates a subset of pre-Bötzinger complex neurons in adult rat. J Comp Neurol. 2012;520:606-19 pubmed publisher
    ..We identified the glycoprotein reelin as a potentially useful marker, because it is expressed in distinct populations of pre-BötC and inspiratory ..
  21. Ishibashi K, Komeda K, Sekiguchi F, Kanazawa Y. Creeping: a new mutant rat with neurological disease. Lab Anim Sci. 1989;39:132-6 pubmed
    ..The same type of change is also present in the hippocampus and fascia dentata. ..
  22. Britanova O, Alifragis P, Junek S, Jones K, Gruss P, Tarabykin V. A novel mode of tangential migration of cortical projection neurons. Dev Biol. 2006;298:299-311 pubmed
    ..In vitro and in vivo analysis of reeler mutant brains demonstrated that although reeler mutation does not influence tangential migration of interneurons, ..
  23. Ramos Moreno T, Galazo M, Porrero C, Martinez Cerdeno V, Clascá F. Extracellular matrix molecules and synaptic plasticity: immunomapping of intracellular and secreted Reelin in the adult rat brain. Eur J Neurosci. 2006;23:401-22 pubmed
    b>Reelin, a large extracellular matrix glycoprotein, is secreted by several neuron populations in the developing and adult rodent brain...
  24. Grayson D, Jia X, Chen Y, Sharma R, Mitchell C, Guidotti A, et al. Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci U S A. 2005;102:9341-6 pubmed
    b>Reelin mRNA and protein levels are reduced by approximately 50% in various cortical structures of postmortem brain from patients diagnosed with schizophrenia or bipolar illness with psychosis...
  25. Remedios R, Huilgol D, Saha B, Hari P, Bhatnagar L, Kowalczyk T, et al. A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nat Neurosci. 2007;10:1141-50 pubmed
    ..and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin and Cdk5)...
  26. Garcia Miranda P, Peral M, Ilundain A. Rat small intestine expresses the reelin-Disabled-1 signalling pathway. Exp Physiol. 2010;95:498-507 pubmed publisher
    Expression of reelin, reelin receptors [apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VldlR)] and the Disabled-1 (Dab1) protein was investigated in rat intestinal mucosa...
  27. Devlin B, Bennett P, Dawson G, Figlewicz D, Grigorenko E, McMahon W, et al. Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network. Am J Med Genet B Neuropsychiatr Genet. 2004;126B:46-50 pubmed
    ..2001: Mol Psychiatry 6:150-159] suggests alleles of a CGG polymorphism, just 5' of the reelin gene (RELN) initiator codon, confer liability for autism, especially alleles bearing 11 or more CGG repeats (long ..
  28. Stranahan A, Haberman R, Gallagher M. Cognitive decline is associated with reduced reelin expression in the entorhinal cortex of aged rats. Cereb Cortex. 2011;21:392-400 pubmed publisher
    ..form the perforant path input to the hippocampal formation, exhibit early alterations over the course of aging Reelin, a glycoprotein implicated in synaptic plasticity, is expressed by entorhinal cortical layer II neurons...
  29. Cariboni A, Rakic S, Liapi A, Maggi R, Goffinet A, Parnavelas J. Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons. Development. 2005;132:4709-18 pubmed
    ..Here, we show that reelin, which is expressed along the route of the migrating cells, has an inhibitory role in guiding GnRH neurons to the ..
  30. Martinez Galan J, Moncho Bogani J, Caminos E. Expression of calcium-binding proteins in layer 1 reelin-immunoreactive cells during rat and mouse neocortical development. J Histochem Cytochem. 2014;62:60-9 pubmed publisher
    Cajal-Retzius cells in layer 1 of the developing cerebral cortex and their product of secretion, reelin, an extracellular matrix protein, play a crucial role in establishing the correct lamination pattern in this tissue...
  31. Won S, Kim S, Xie L, Wang Y, Mao X, Jin K, et al. Reelin-deficient mice show impaired neurogenesis and increased stroke size. Exp Neurol. 2006;198:250-9 pubmed
    b>Reelin (Reln) is a protein involved in migration of newborn neurons during development...
  32. Hevner R, Daza R, Englund C, Kohtz J, Fink A. Postnatal shifts of interneuron position in the neocortex of normal and reeler mice: evidence for inward radial migration. Neuroscience. 2004;124:605-18 pubmed
    ..To study the effects of reelin deficiency, experiments were performed in reeler mutant mice. In normal P0.5 cortex, interneurons were most abundant in the marginal zone and layer 5. By P7...
  33. Zhao S, Chai X, Forster E, Frotscher M. Reelin is a positional signal for the lamination of dentate granule cells. Development. 2004;131:5117-25 pubmed
    Reelin is required for the proper positioning of neurons in the cerebral cortex. In the reeler mutant lacking reelin, the granule cells of the dentate gyrus fail to form a regular, densely packed cell layer...
  34. Hertel N, Redies C. Absence of layer-specific cadherin expression profiles in the neocortex of the reeler mutant mouse. Cereb Cortex. 2011;21:1105-17 pubmed publisher
    ..One of the animal models used for studying corticogenesis is the reeler mouse...
  35. Sui L, Wang Y, Ju L, Chen M. Epigenetic regulation of reelin and brain-derived neurotrophic factor genes in long-term potentiation in rat medial prefrontal cortex. Neurobiol Learn Mem. 2012;97:425-40 pubmed publisher
    ..The present study investigated the epigenetic regulation of two genes, reelin and brain-derived neurotrophic factor (bdnf), both play important roles in neural plasticity, in the mPFC...
  36. Haas C, Dudeck O, Kirsch M, Huszka C, Kann G, Pollak S, et al. Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. J Neurosci. 2002;22:5797-802 pubmed
    The reelin signaling pathway plays a crucial role during the development of laminated structures in the mammalian brain...
  37. Alvarez Dolado M, Ruiz M, Del Rio J, Alcantara S, Burgaya F, Sheldon M, et al. Thyroid hormone regulates reelin and dab1 expression during brain development. J Neurosci. 1999;19:6979-93 pubmed
    The reelin and dab1 genes are necessary for appropriate neuronal migration and lamination during brain development...
  38. Wang Y, Zhong J, Xu H, Wei W, Dong J, Yu F, et al. Perinatal iodine deficiency and hypothyroidism increase cell apoptosis and alter doublecortin and reelin protein expressions in rat cerebellum. Arch Med Res. 2012;43:255-64 pubmed publisher
    ..effects of perinatal iodine deficiency and hypothyroidism on cerebellar cell apoptosis, doublecortin (Dcx) and reelin. Apoptosis is an essential part of neural development...
  39. Martinez Cerdeno V, Clascá F. Reelin immunoreactivity in the adult neocortex: a comparative study in rodents, carnivores, and non-human primates. Brain Res Bull. 2002;57:485-8 pubmed
    ..addition to playing a crucial role in early cortical development, intercellular signaling mediated by the protein Reelin may be widely active in the adult neocortex...
  40. Bock H, Herz J. Reelin activates SRC family tyrosine kinases in neurons. Curr Biol. 2003;13:18-26 pubmed
    b>Reelin is a large signaling molecule that regulates the positioning of neurons in the mammalian brain...
  41. Roglio I, Bianchi R, Gotti S, Scurati S, Giatti S, Pesaresi M, et al. Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury. Neuroscience. 2008;155:673-85 pubmed publisher
    ..e. myelin proteins and Na(+),K(+)-ATPase pump) and stimulate reelin gene expression...
  42. Brosda J, Dietz F, Koch M. Impairment of cognitive performance after reelin knockdown in the medial prefrontal cortex of pubertal or adult rats. Neurobiol Dis. 2011;44:239-47 pubmed publisher
    The glycoprotein reelin is important for embryonic neuronal migration. During adulthood reelin possibly acts as a modulator of synaptic plasticity...
  43. Phelps P, Rich R, Dupuy Davies S, RIOS Y, Wong T. Evidence for a cell-specific action of Reelin in the spinal cord. Dev Biol. 2002;244:180-98 pubmed
    b>Reelin, the extracellular matrix protein missing in reeler mice, plays an important role in neuronal migration in the central nervous system...
  44. Hu C, Wang P, Zhang S, Ren L, Lv Y, Yin R, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017;39:621-631 pubmed publisher
    ..Melatonin could delay the progress of AD through multiple mechanisms. Reelin-Dab1 signaling plays an important role in AD, including neuronal function and synaptic plasticity...
  45. Tinnes S, Ringwald J, Haas C. TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy. FASEB J. 2013;27:2542-52 pubmed publisher
    ..There is increasing evidence that a loss and the functional inactivation of the positional signal Reelin is involved in GCD formation...
  46. Bartlett C, Gharani N, Millonig J, Brzustowicz L. Three autism candidate genes: a synthesis of human genetic analysis with other disciplines. Int J Dev Neurosci. 2005;23:221-34 pubmed
    ..From this body of work we highlight results from three candidate genes, REELIN (RELN), SEROTONIN TRANSPORTER (5HTT), and ENGRAILED 2 (EN2) and discuss the relevant neuroscience, molecular ..
  47. Villeda S, Akopians A, Babayan A, Basbaum A, Phelps P. Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord. Neuroscience. 2006;139:1385-96 pubmed
    Mutations in reeler, the gene coding for the Reelin protein, result in pronounced motor deficits associated with positioning errors (i.e. ectopic locations) in the cerebral and cerebellar cortices...
  48. Betancourt A, Burgess S, Carr R. Effect of developmental exposure to chlorpyrifos on the expression of neurotrophin growth factors and cell-specific markers in neonatal rat brain. Toxicol Sci. 2006;92:500-6 pubmed
    ..to CPS on the expression of mRNA for two factors critical to brain development, nerve growth factor (NGF) and reelin, were investigated in the forebrain of rats...
  49. Pathak A, Sinha R, Mohan V, Mitra K, Godbole M. Maternal thyroid hormone before the onset of fetal thyroid function regulates reelin and downstream signaling cascade affecting neocortical neuronal migration. Cereb Cortex. 2011;21:11-21 pubmed publisher
    ..b>Reelin downregulation under hypothyroidism is neither due to enhanced apoptosis in Cajal-Retzius cells nor mediated ..
  50. Zhang J, Qin L, Zhao H. Early repeated maternal separation induces alterations of hippocampus reelin expression in rats. J Biosci. 2013;38:27-33 pubmed
    The long-term effects of repeated maternal separation (MS) during early postnatal life on reelin expression in the hippocampus of developing rats were investigated in the present study...
  51. Hoareau C, Hazane F, Le Pen G, Krebs M. Postnatal effect of embryonic neurogenesis disturbance on reelin level in organotypic cultures of rat hippocampus. Brain Res. 2006;1097:43-51 pubmed
    ..Several reports have found decreased levels of reelin in the cortex and the hippocampus of postmortem brains of schizophrenic patients...
  52. Botella Lopez A, Cuchillo Ibanez I, Cotrufo T, Mok S, Li Q, Barquero M, et al. Beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. Neurobiol Dis. 2010;37:682-91 pubmed publisher
    b>Reelin is a glycoprotein that modulates synaptic function and plasticity in the mature brain, thereby favouring memory formation. We recently reported altered cerebral Reelin expression in Alzheimer's disease (AD)...
  53. Palacios García I, Lara Vásquez A, Montiel J, Díaz Véliz G, Sepúlveda H, Utreras E, et al. Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats. PLoS ONE. 2015;10:e0117680 pubmed publisher
    ..The extracellular protein Reelin, expressed by Cajal-Retzius cells during cortical development, plays critical roles on cortical lamination and ..
  54. Botella Lopez A, de Madaria E, Jover R, Bataller R, Sancho Bru P, Candela A, et al. Reelin is overexpressed in the liver and plasma of bile duct ligated rats and its levels and glycosylation are altered in plasma of humans with cirrhosis. Int J Biochem Cell Biol. 2008;40:766-75 pubmed
    b>Reelin is an extracellular matrix protein secreted by a variety of cell types in both embryonic and adult tissues, including the liver...
  55. Bock H, Jossin Y, Liu P, Forster E, May P, Goffinet A, et al. Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. J Biol Chem. 2003;278:38772-9 pubmed
    b>Reelin is a large secreted signaling protein that binds to two members of the low density lipoprotein receptor family, the apolipoprotein E receptor 2 and the very low density lipoprotein receptor, and regulates neuronal positioning ..
  56. Perez Costas E, Fenton E, Caruncho H. Reelin expression in brain endothelial cells: an electron microscopy study. BMC Neurosci. 2015;16:16 pubmed publisher
    b>Reelin expression and function have been extensively studied in the brain, although its expression has been also reported in other tissues including blood...
  57. Yavin E, Himovichi E, Eilam R. Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency. Neuroscience. 2009;162:1011-22 pubmed publisher
    ..in migration in the hippocampus and cortex, after one and two weeks respectively, may be attributed to a temporary reelin disorganization or partial deficiency...
  58. Kikkawa S, Yamamoto T, Misaki K, Ikeda Y, Okado H, Ogawa M, et al. Missplicing resulting from a short deletion in the reelin gene causes reeler-like neuronal disorders in the mutant shaking rat Kawasaki. J Comp Neurol. 2003;463:303-15 pubmed
    The shaking rat Kawasaki (SRK) is an autosomal recessive mutant that exhibits reeler-like abnormal locomotor behaviors...
  59. Yoshihara S, Omichi K, Yanazawa M, Kitamura K, Yoshihara Y. Arx homeobox gene is essential for development of mouse olfactory system. Development. 2005;132:751-62 pubmed
    ..These findings suggest a likely role of Arx in regulating the expression of putative instructive signals produced in the olfactory bulb for the proper innervation of olfactory sensory axons. ..
  60. Lutter S, Xie S, Tatin F, Makinen T. Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. J Cell Biol. 2012;197:837-49 pubmed publisher
    ..Here, we identify Reelin, an extracellular matrix glycoprotein previously implicated in central nervous system development, as an important ..
  61. Ampuero E, Jury N, Hartel S, Marzolo M, van Zundert B. Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons. J Cell Physiol. 2017;232:1187-1199 pubmed publisher
    b>Reelin, an extracellular glycoprotein secreted in embryonic and adult brain, participates in neuronal migration and neuronal plasticity...
  62. Bender R, Zhou L, Wilkars W, Fester L, Lanowski J, Paysen D, et al. Roles of 17ß-estradiol involve regulation of reelin expression and synaptogenesis in the dentate gyrus. Cereb Cortex. 2010;20:2985-95 pubmed publisher
    ..CR) cells, which regulate neuronal migration and synaptogenesis via the extracellular matrix protein reelin. Immunoreactivity of aromatase, the final enzyme of estradiol synthesis, was strongest in mature granule cells...
  63. Jensen P, Zoghbi H, Goldowitz D. Dissection of the cellular and molecular events that position cerebellar Purkinje cells: a study of the math1 null-mutant mouse. J Neurosci. 2002;22:8110-6 pubmed
    ..of Purkinje cells through the expression of the Netrin-like receptor Unc5h3 and the extracellular matrix molecule Reelin. To explore the role of the EGL on these processes, we made use of the math1 null-mutant mouse in which the EGL ..
  64. Lambert de Rouvroit C, Bernier B, Royaux I, de Bergeyck V, Goffinet A. Evolutionarily conserved, alternative splicing of reelin during brain development. Exp Neurol. 1999;156:229-38 pubmed
    b>Reelin is the protein defective in reeler mutant mice and plays a pivotal role in brain development. However, some uncertainties remain about the relationship between reelin and the reeler phenotype...
  65. Mooney S, Siegenthaler J, Miller M. Ethanol induces heterotopias in organotypic cultures of rat cerebral cortex. Cereb Cortex. 2004;14:1071-80 pubmed
    ..Fixed slices were sectioned and immunolabeled with antibodies directed against calretinin, reelin, nestin, GFAP, doublecortin, MAP-2 and NeuN...
  66. D ARCANGELO G, Homayouni R, Keshvara L, Rice D, Sheldon M, Curran T. Reelin is a ligand for lipoprotein receptors. Neuron. 1999;24:471-9 pubmed
    A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development...
  67. Persico A, D Agruma L, Maiorano N, Totaro A, Militerni R, Bravaccio C, et al. Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. Mol Psychiatry. 2001;6:150-9 pubmed
    Autistic disorder (MIM 209850) is currently viewed as a neurodevelopmental disease. Reelin plays a pivotal role in the development of laminar structures including the cerebral cortex, hippocampus, cerebellum and of several brainstem ..
  68. Saegusa Y, Woo G, Fujimoto H, Kemmochi S, Shimamoto K, Hirose M, et al. Sustained production of Reelin-expressing interneurons in the hippocampal dentate hilus after developmental exposure to anti-thyroid agents in rats. Reprod Toxicol. 2010;29:407-14 pubmed publisher
    ..evidence reflecting a permanent disruption of neuronal development due to hypothyroidism, distribution of Reelin-producing cells that function in neuronal migration and positioning was analyzed in the hippocampal dentate hilus ..
  69. HOE H, Lee K, Carney R, Lee J, Markova A, Lee J, et al. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci. 2009;29:7459-73 pubmed publisher
    ..previous work has shown that APP processing and Abeta production are regulated by the extracellular matrix protein Reelin. In the present study, we examined whether Reelin interacts with APP, and the functional consequences of that ..
  70. Rideau Batista Novais A, Guiramand J, Cohen Solal C, Crouzin N, de Jesus Ferreira M, Vignes M, et al. N-acetyl-cysteine prevents pyramidal cell disarray and reelin-immunoreactive neuron deficiency in CA3 after prenatal immune challenge in rats. Pediatr Res. 2013;73:750-5 pubmed publisher
    ..In the present study, we evaluated the occurrence of pyramidal cell disarray and reelin neuronal deficit in the hippocampus, and the protective role of N-acetyl-cysteine (NAC) in a rodent experimental ..
  71. Sui L, Ren W, Li B. Administration of thyroid hormone increases reelin and brain-derived neurotrophic factor expression in rat hippocampus in vivo. Brain Res. 2010;1313:9-24 pubmed publisher
    ..Two genes critical for neuronal plasticity and implicated in psychiatric disorders, reelin and brain-derived neurotrophic factor (BDNF), were investigated in the present study...
  72. Fatemi S, Snow A, Stary J, Araghi Niknam M, Reutiman T, Lee S, et al. Reelin signaling is impaired in autism. Biol Psychiatry. 2005;57:777-87 pubmed
    ..Recent genetic linkage studies implicate Reelin glycoprotein in causation of autism...
  73. Misaki K, Kikkawa S, Terashima T. Reelin-expressing neurons in the anterior commissure and corpus callosum of the rat. Brain Res Dev Brain Res. 2004;148:89-96 pubmed
    b>Reelin is an extracellular matrix protein, which plays a crucial role for the formation of laminated and nonlaminated structures in the central nervous system...
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    Given that suppressed reelin protein synthesis is associated with cognitive dysfunction in both rodents and humans, we examined the ontogeny of these deficits in rats reared in isolation as a basis for understanding developmental ..