Rdh5

Summary

Gene Symbol: Rdh5
Description: retinol dehydrogenase 5
Alias: Rdh1, 11-cis retinol dehydrogenase, LOW QUALITY PROTEIN: 11-cis retinol dehydrogenase, 9-cis-retinol dehydrogenase, retinol dehydrogenase 1 (11-cis), retinol dehydrogenase 5 (11-cis/9-cis), retinol dehydrogenase type 5
Species: rat
Products:     Rdh5

Top Publications

  1. Gonzalez Fernandez F, Kurz D, Bao Y, Newman S, Conway B, Young J, et al. 11-cis retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus. Mol Vis. 1999;5:41 pubmed
    ..To elucidate the molecular defect we considered the genes for interphotoreceptor retinoid-binding protein (RBP3) and 11-cis retinol dehydrogenase (RDH5) as candidates for this disease.
  2. Wang J, Bongianni J, Napoli J. The N-terminus of retinol dehydrogenase type 1 signals cytosolic orientation in the microsomal membrane. Biochemistry. 2001;40:12533-40 pubmed
    ..The latter suggests that the SDR core of RoDH1 has marked external hydrophobicity that causes nonspecific membrane association. ..
  3. Lidén M, Tryggvason K, Eriksson U. The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function. Exp Cell Res. 2005;311:205-17 pubmed
  4. Huang J, Possin D, Saari J. Localizations of visual cycle components in retinal pigment epithelium. Mol Vis. 2009;15:223-34 pubmed
    ..Three visual cycle enzymes (RDH5, LRAT, and RPE65) were restricted to the somata of RPE cells and were not detected within apical processes...
  5. Kiser P, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012;1821:137-51 pubmed publisher
    ..This article is part of a Special Issue entitled: Retinoid and Lipid Metabolism. ..