Rbp4

Summary

Gene Symbol: Rbp4
Description: retinol binding protein 4
Alias: RBPA, retinol-binding protein 4, PRBP, RBP, plasma retinol-binding protein, retinol binding protein 4, plasma
Species: rat
Products:     Rbp4

Top Publications

  1. Yang Q, Graham T, Mody N, Preitner F, Peroni O, Zabolotny J, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356-62 pubmed
    ..Here we show, using DNA arrays, that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4(-/-) mice...
  2. Wu Q. [Amplification and desensitization in platelet activation]. Sheng Li Ke Xue Jin Zhan. 1992;23:199-203 pubmed
  3. Li F, Xia K, Sheikh S, Cheng J, Li C, Yang T. Involvement of RBP4 in hyperinsulinism-induced vascular smooth muscle cell proliferation. Endocrine. 2015;48:472-82 pubmed publisher
    Retinol-binding protein 4 (RBP4) is a newly discovered adipocytokine related to insulin resistance (IR). Hyperinsulinemia and IR are the major risk factors for cardiovascular diseases (CVD)...
  4. Li F, Xia K, Sheikh M, Cheng J, Li C, Yang T. Retinol binding protein 4 promotes hyperinsulinism?induced proliferation of rat aortic smooth muscle cells. Mol Med Rep. 2014;9:1634-40 pubmed publisher
    Recent studies have suggested that retinol binding protein 4 (RBP4), an adipocytokine related to insulin resistance (IR), may play an important role in the development of atherosclerosis and cardiovascular diseases (CVD)...
  5. Yamamoto Y, Yoshizawa T, Kamio S, Aoki O, Kawamata Y, Masushige S, et al. Interactions of transthyretin (TTR) and retinol-binding protein (RBP) in the uptake of retinol by primary rat hepatocytes. Exp Cell Res. 1997;234:373-8 pubmed
    The mechanism by which cells take up retinol from retinol-binding protein (RBP) and the role of the RBP-transthyretin (TTR) complex remain unclear...
  6. Seeliger M, Biesalski H, Wissinger B, Gollnick H, Gielen S, Frank J, et al. Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. Invest Ophthalmol Vis Sci. 1999;40:3-11 pubmed
    ..compound heterozygous missense mutations (Ile41Asn and Gly75Asp) in the gene for serum retinol binding protein (RBP)...
  7. Kiernan U, Tubbs K, Nedelkov D, Niederkofler E, Nelson R. Comparative phenotypic analyses of human plasma and urinary retinol binding protein using mass spectrometric immunoassay. Biochem Biophys Res Commun. 2002;297:401-5 pubmed
    ..In this work, MSIA is used in the comparative analyses of retinol binding protein (RBP) from the plasma and urine of a small study population...
  8. Quadro L, Blaner W, Hamberger L, Novikoff P, Vogel S, Piantedosi R, et al. The role of extrahepatic retinol binding protein in the mobilization of retinoid stores. J Lipid Res. 2004;45:1975-82 pubmed
    Although the major tissue site of retinol binding protein (RBP) synthesis in the body is the liver, other sites of synthesis have been reported...
  9. Mercader J, Granados N, Caimari A, Oliver P, Bonet M, Palou A. Retinol-binding protein 4 and nicotinamide phosphoribosyltransferase/visfatin in rat obesity models. Horm Metab Res. 2008;40:467-72 pubmed publisher
    Retinol-binding protein 4 (RBP4) and nicotinamide phosphoribosyltransferase/visfatin (Nampt/visfatin) are adipocyte-secreted proteins (adipokines) whose relevance to the metabolic syndrome and regulation in obesity remain controversial...

Scientific Experts

More Information

Publications37

  1. Henze A, Rohn S, Gericke B, Raila J, Schweigert F. Structural modifications of serum transthyretin in rats during protein-energy malnutrition. Rapid Commun Mass Spectrom. 2008;22:3270-4 pubmed publisher
    ..as well as other markers of nutritional status as body weight, food consumption, total serum protein and serum RBP4 levels as well as antioxidative capacity were determined...
  2. Kutasy B, Gosemann J, Doi T, Fujiwara N, Friedmacher F, Puri P. Nitrofen interferes with trophoblastic expression of retinol-binding protein and transthyretin during lung morphogenesis in the nitrofen-induced congenital diaphragmatic hernia model. Pediatr Surg Int. 2012;28:143-8 pubmed publisher
    ..Retinol-binding protein (RBP) and transthyretin (TTR) are transport proteins for delivery of retinol to the tissues via circulation...
  3. Zhang W, Xu Y, Guo F, Meng Y, Li M. Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus. Chin Med J (Engl). 2008;121:2124-8 pubmed
    b>Retinol binding protein 4 (RBP4), as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 (GLUT4) in insulin resistance (IR) state and to have an intimate relationship ..
  4. Kim Y, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner W, et al. Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem. 2008;283:5611-21 pubmed
    ..Dams lacking both LRAT and retinol-binding protein (RBP), the sole specific carrier for retinol in serum, were maintained on diets containing different amounts of vitamin ..
  5. Bahr M, Boeker K, Manns M, Tietge U. Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis. Clin Endocrinol (Oxf). 2009;70:60-5 pubmed publisher
    ..This study was designed to determine circulating levels and hepatic production of retinol-binding protein 4 (RBP4) in relation to parameters of hepatic and systemic metabolism in patients with liver cirrhosis...
  6. Xu M, Li X, Wang J, Wang X, Huang Y, Cheng Q, et al. Retinol-binding protein 4 is associated with impaired glucose regulation and microalbuminuria in a Chinese population. Diabetologia. 2009;52:1511-9 pubmed publisher
    Increased retinol-binding protein 4 (RBP4) has been reported in association with insulin resistance and type 2 diabetes...
  7. Quadro L, Blaner W, Salchow D, Vogel S, Piantedosi R, Gouras P, et al. Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO J. 1999;18:4633-44 pubmed
    Retinol-binding protein (RBP) is the sole specific transport protein for retinol (vitamin A) in the circulation, and its single known function is to deliver retinol to tissues...
  8. Rask L, Vahlquist A, Peterson P. Studies on two physiological forms of the human retinol-binding protein differing in vitamin A and arginine content. J Biol Chem. 1971;246:6638-46 pubmed
  9. Berry D, Noy N. Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis. Biochim Biophys Acta. 2012;1821:168-76 pubmed publisher
    Vitamin A, retinol, circulates in blood bound to serum retinol binding protein (RBP) and is transported into cells by a membrane protein termed stimulated by retinoic acid 6 (STRA6)...
  10. Quadro L, Gamble M, Vogel S, Lima A, Piantedosi R, Moore S, et al. Retinol and retinol-binding protein: gut integrity and circulating immunoglobulins. J Infect Dis. 2000;182 Suppl 1:S97-S102 pubmed
    ..No differences were observed in B and T cell populations present in spleen, thymus, and bone marrow. ..
  11. Laurent B, Nilsson M, Båvik C, Jones T, Sundelin J, Peterson P. Characterization of the rat retinol-binding protein gene and its comparison to the three-dimensional structure of the protein. J Biol Chem. 1985;260:11476-80 pubmed
    Rat genomic DNA fragments bearing the retinol-binding protein (RBP) gene have been isolated and characterized. The gene spans 6.9 kilobases and contains six exons. The five intervening sequences range in size from 78 base pairs to 4...
  12. Napoli J. Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta. 2012;1821:152-67 pubmed publisher
    ..This article is part of a Special Issue entitled: Retinoid and Lipid Metabolism. ..
  13. Shirai T, Shichi Y, Sato M, Tanioka Y, Furusho T, Ota T, et al. High dietary fat-induced obesity in Wistar rats and type 2 diabetes in nonobese Goto-Kakizaki rats differentially affect retinol binding protein 4 expression and vitamin A metabolism. Nutr Res. 2016;36:262-70 pubmed publisher
    Obesity is a major risk factor for type 2 diabetes, which is caused mainly by insulin resistance. Retinol binding protein 4 (RBP4) is the only specific transport protein for retinol in the serum...
  14. Craig R, Chu W, Elbein S. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Mol Genet Metab. 2007;90:338-44 pubmed
    Serum retinol binding protein 4 (RBP4) was recently described as a new adipokine that reduced peripheral and hepatic insulin sensitivity and increased hepatic gluconeogenesis...
  15. Ghyselinck N, Vernet N, Dennefeld C, Giese N, Nau H, Chambon P, et al. Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein. Dev Dyn. 2006;235:1608-22 pubmed
    Using Rbp4-null mice as models, we have established for the first time the kinetics of the spermatogenetic alterations during vitamin A deficiency (VAD)...
  16. Quadro L, Hamberger L, Gottesman M, Wang F, Colantuoni V, Blaner W, et al. Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency. Endocrinology. 2005;146:4479-90 pubmed
    ..retinoids (vitamin A and its derivatives) are found predominantly as retinol bound to retinol-binding protein (RBP), which transports retinol from liver stores to target tissues, or as retinyl ester incorporated in lipoproteins of ..
  17. Casillas Ramirez A, Alfany Fernandez I, Massip Salcedo M, Juan M, Planas J, Serafin A, et al. Retinol-binding protein 4 and peroxisome proliferator-activated receptor-? in steatotic liver transplantation. J Pharmacol Exp Ther. 2011;338:143-53 pubmed publisher
    ..The injurious effects of retinol-binding protein 4 (RBP4) in various pathologies are well documented...
  18. Peterson P, Rask L, Ostberg L, Andersson L, Kamwendo F, Pertoft H. Studies on the transport and cellular distribution of vitamin A in normal and vitamin A-deficient rats with special reference to the vitamin A-binding plasma protein. J Biol Chem. 1973;248:4009-22 pubmed
  19. Sundelin J, Laurent B, Anundi H, Trägårdh L, Larhammar D, Bjorck L, et al. Amino acid sequence homologies between rabbit, rat, and human serum retinol-binding proteins. J Biol Chem. 1985;260:6472-80 pubmed
    The main transporting protein for vitamin A in rabbit serum, the retinol-binding protein (RBP), was isolated and its amino acid sequence determined...
  20. Janke J, Engeli S, Boschmann M, Adams F, Böhnke J, Luft F, et al. Retinol-binding protein 4 in human obesity. Diabetes. 2006;55:2805-10 pubmed
    ..as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans...
  21. Wendler C, Schmoldt A, Flentke G, Case L, Quadro L, Blaner W, et al. Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice. Circ Res. 2003;92:920-8 pubmed
    Precise regulation of retinoid levels is critical for normal heart development. Retinol-binding protein (RBP), an extracellular retinol transporter, is strongly secreted by cardiogenic endoderm...
  22. Ou H, Wu H, Yang Y, Wu J, Cheng J, Chang C. Elevated retinol binding protein 4 contributes to insulin resistance in spontaneously hypertensive rats. Horm Metab Res. 2011;43:312-8 pubmed publisher
    b>Retinol binding protein 4 (RBP4) is an adipokine secreted by adipose tissue and liver and contributes to insulin resistance (IR) in animals...
  23. Biesalski H, Frank J, Beck S, Heinrich F, Illek B, Reifen R, et al. Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. Am J Clin Nutr. 1999;69:931-6 pubmed
    ..In both siblings, plasma retinol binding protein (RBP) concentrations were below the limit of detection (<0...
  24. Alapatt P, Guo F, Komanetsky S, Wang S, Cai J, Sargsyan A, et al. Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). J Biol Chem. 2013;288:1250-65 pubmed publisher
    ..in the small intestine, stored in liver, and secreted into circulation bound to serum retinol-binding protein (RBP4)...
  25. Kang L, Sebastian B, Pritchard M, Pratt B, Previs S, Nagy L. Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol Clin Exp Res. 2007;31:1581-8 pubmed
    ..protein 1, tumor necrosis factor alpha, and interleukin-6 were increased, while expression of mRNA for retinol binding protein 4 and adiponectin were decreased in epididymal adipose tissue...
  26. Vogel S, Piantedosi R, O Byrne S, Kako Y, Quadro L, Gottesman M, et al. Retinol-binding protein-deficient mice: biochemical basis for impaired vision. Biochemistry. 2002;41:15360-8 pubmed
    We reported previously that mice lacking plasma retinol-binding protein (RBP) are phenotypically normal except that they display impaired vision at the time of weaning...
  27. Thompson C, Blaner W, Van Gelder R, Lai K, Quadro L, Colantuoni V, et al. Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice. Proc Natl Acad Sci U S A. 2001;98:11708-13 pubmed
    ..the role of retinal-based pigments (opsins) in circadian photoreception in mice, animals mutated in plasma retinol binding protein were placed on a vitamin A-free diet and tested for photic induction of gene expression in the ..
  28. Fex G, Hansson B. Retinol-binding protein from human urine and its interaction with retinol and prealbumin. Eur J Biochem. 1979;94:307-13 pubmed
    ..This sequence and the amino acid composition are compatible with the view that the retinol-binding protein in urine is the same as in plasma. ..