Gene Symbol: Rbp3
Description: retinol binding protein 3
Alias: Irbp, retinol-binding protein 3, interphotoreceptor retinoid binding protein, interphotoreceptor retinol- binding protein, retinol binding protein 3, interstitial
Species: rat
Products:     Rbp3

Top Publications

  1. Gonzalez Fernandez F, Healy J. Early expression of the gene for interphotoreceptor retinol-binding protein during photoreceptor differentiation suggests a critical role for the interphotoreceptor matrix in retinal development. J Cell Biol. 1990;111:2775-84 pubmed
    Interphotoreceptor retinol-binding protein (IRBP), the major protein component of the subretinal space, is in a strategic position to mediate cellular interactions between the retinal pigmented epithelium (RPE) and the neural retina...
  2. Huchon D, Madsen O, Sibbald M, Ament K, Stanhope M, Catzeflis F, et al. Rodent phylogeny and a timescale for the evolution of Glires: evidence from an extensive taxon sampling using three nuclear genes. Mol Biol Evol. 2002;19:1053-65 pubmed publisher
    ..The divergence between rodents and lagomorphs is placed just at the K-T boundary and the first splits among placentals in the Late Cretaceous. Our results thus tend to reconcile molecular and morphological-paleontological insights...
  3. Organisciak D, Darrow R, Barsalou L, Kutty R, Wiggert B. Susceptibility to retinal light damage in transgenic rats with rhodopsin mutations. Invest Ophthalmol Vis Sci. 2003;44:486-92 pubmed
    ..and Northern blot analysis of retinal heme oxygenase (HO)-1 and interphotoreceptor retinol binding protein (IRBP)...
  4. Wright A, Chakarova C, Abd El Aziz M, Bhattacharya S. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Nat Rev Genet. 2010;11:273-84 pubmed publisher
    ..Although genetic and mechanistic diversity creates challenges for therapy, some approaches--particularly gene-replacement therapy--are showing considerable promise. ..
  5. Li S, Yang Z, Hu J, Gordon W, Bazan N, Haas A, et al. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). J Biol Chem. 2013;288:11395-406 pubmed publisher
    Interphotoreceptor retinoid-binding protein (IRBP) secreted by photoreceptors plays a pivotal role in photoreceptor survival and function...
  6. Daiger S, Sullivan L, Bowne S. Genes and mutations causing retinitis pigmentosa. Clin Genet. 2013;84:132-41 pubmed publisher
    ..In this review, we summarize the current approaches to gene discovery and mutation detection for RP, and indicate pitfalls and unsolved problems. Similar considerations apply to other forms of inherited retinal disease. ..
  7. Gonzalez Fernandez F, Van Niel E, Edmonds C, Beaver H, Nickerson J, Garcia Fernandez J, et al. Differential expression of interphotoreceptor retinoid-binding protein, opsin, cellular retinaldehyde-binding protein, and basic fibroblastic growth factor. Exp Eye Res. 1993;56:411-27 pubmed
    The mRNA for rat interphotoreceptor retinoid-binding protein (IRBP) consists of 5.2 kb and 6.4 kb transcripts which are expressed early during retinal development...
  8. Katz M, Gao C, Stientjes H. Regulation of the interphotoreceptor retinoid-binding protein content of the retina by vitamin A. Exp Eye Res. 1993;57:393-401 pubmed
    ..This protein (interphotoreceptor retinoid-binding protein, IRBP) appears to be involved in the transport of visual cycle retinoids between the photoreceptors and the RPE...
  9. Suzuki H, Tsuchiya K, Takezaki N. A molecular phylogenetic framework for the Ryukyu endemic rodents Tokudaia osimensis and Diplothrix legata. Mol Phylogenet Evol. 2000;15:15-24 pubmed
    ..and Apodemus, Micromys, Mus, and Rattus, using an analysis of mitochondrial cytochrome b gene (1140 bp) and nuclear IRBP gene (782 bp) sequences...

More Information


  1. Douzery E, Delsuc F, Stanhope M, Huchon D. Local molecular clocks in three nuclear genes: divergence times for rodents and other mammals and incompatibility among fossil calibrations. J Mol Evol. 2003;57 Suppl 1:S201-13 pubmed
    ..We considered 2422 first and second codon positions of the combined ADRA2B, IRBP, and vWF nuclear genes for a well-documented set of placentals including an extensive sampling of rodents...
  2. Poux C, Chevret P, Huchon D, de Jong W, Douzery E. Arrival and diversification of caviomorph rodents and platyrrhine primates in South America. Syst Biol. 2006;55:228-44 pubmed
    ..Using sequences from three nuclear genes (ADRA2B, vWF, and IRBP, both separate and combined) from 60 species, and eight fossil calibration constraints, we estimated the times of ..
  3. Kiser P, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012;1821:137-51 pubmed publisher
    ..This article is part of a Special Issue entitled: Retinoid and Lipid Metabolism. ..
  4. Serizawa K, Suzuki H, Tsuchiya K. A phylogenetic view on species radiation in Apodemus inferred from variation of nuclear and mitochondrial genes. Biochem Genet. 2000;38:27-40 pubmed
    ..We examined the cytochrome b (cyt b) gene in mitochondrial DNA (1140 bp) and the interphotoreceptor retinoid binding protein (IRBP) gene in nuclear DNA (1152 bp) in nine species of Apodemus...