Gene Symbol: Rbp1
Description: retinol binding protein 1
Alias: retinol-binding protein 1, CRBP, CRBP-I, cellular retinol-binding protein I, retinol binding protein 1, cellular
Species: rat
Products:     Rbp1

Top Publications

  1. Farias E, Ong D, Ghyselinck N, Nakajo S, Kuppumbatti Y, Mira y Lopez R. Cellular retinol-binding protein I, a regulator of breast epithelial retinoic acid receptor activity, cell differentiation, and tumorigenicity. J Natl Cancer Inst. 2005;97:21-9 pubmed
    ..Cellular retinol-binding protein I (CRBP-I) functions in retinol storage and its expression is lower in human cancers than in normal cells...
  2. Noy N, Blaner W. Interactions of retinol with binding proteins: studies with rat cellular retinol-binding protein and with rat retinol-binding protein. Biochemistry. 1991;30:6380-6 pubmed
    The interactions of retinol with rat cellular retinol-binding protein (CRBP) and with rat serum retinol-binding protein (RBP) were studied...
  3. Molotkov A, Ghyselinck N, Chambon P, Duester G. Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation. Biochem J. 2004;383:295-302 pubmed
  4. Menozzi I, Vallese F, Polverini E, Folli C, Berni R, Zanotti G. Structural and molecular determinants affecting the interaction of retinol with human CRBP1. J Struct Biol. 2017;197:330-339 pubmed publisher
    Four cellular retinol-binding protein (CRBP) types (CRBP1,2,3,4) are encoded in the human genome...
  5. Xu L, Song C, Ni M, Meng F, Xie H, Li G. Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXR?-induced ?-catenin degradation. Int J Biochem Cell Biol. 2012;44:612-9 pubmed publisher
    ..Retinoid signaling plays very important roles in skeletal development. CRBP1 (cellular retinol binding protein 1), a key component of retinoid signaling pathway, is known to take part in vitamin A metabolism and ..
  6. Kiser P, Golczak M, Maeda A, Palczewski K. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012;1821:137-51 pubmed publisher
    ..This article is part of a Special Issue entitled: Retinoid and Lipid Metabolism. ..
  7. Franzoni L, Cavazzini D, Rossi G, Lücke C. New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers. J Lipid Res. 2010;51:1332-43 pubmed publisher
    The main retinol carriers in the cytosol are the cellular retinol-binding proteins types I and II (CRBP-I and CRBP-II), which exhibit distinct tissue distributions...
  8. Careri M, Elviri L, Mangia A, Zagnoni I, Torta F, Cavazzini D, et al. Mass spectrometry techniques for detection of ligand-dependent changes in the conformational flexibility of cellular retinol-binding protein type I localized by hydrogen/deuterium exchange. Rapid Commun Mass Spectrom. 2006;20:1973-80 pubmed
  9. Franzoni L, Lücke C, Perez C, Cavazzini D, Rademacher M, Ludwig C, et al. Structure and backbone dynamics of Apo- and holo-cellular retinol-binding protein in solution. J Biol Chem. 2002;277:21983-97 pubmed
    ..The solution structure and backbone dynamics of rat cellular retinol-binding protein type I (CRBP) in the apo- and holo-form have been determined and compared using multidimensional high resolution NMR ..

More Information


  1. Eriksson U, Das K, Busch C, Nordlinder H, Rask L, Sundelin J, et al. Cellular retinol-binding protein. Quantitation and distribution. J Biol Chem. 1984;259:13464-70 pubmed
  2. Sherman D, Lloyd R, Chytil F. Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA. Proc Natl Acad Sci U S A. 1987;84:3209-13 pubmed
    Cellular retinol-binding protein (CRBP) may be an important mediator of vitamin A action. We report here the identification of a cDNA clone corresponding to the rat CRBP gene...
  3. Lu J, Cistola D, Li E. Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility. J Mol Biol. 2003;330:799-812 pubmed
    Cellular retinol-binding protein I (CRBP I) and cellular retinol-binding protein II (CRBP II) are closely homologous proteins that play distinct roles in the maintenance of vitamin A homeostasis...
  4. Cia D, Bonhomme B, Azaïs Braesco V, Cluzel J, Doly M. Uptake and esterification of vitamin A by RCS rat retinal pigment epithelial cells in primary culture. Vision Res. 2004;44:247-55 pubmed
    ..Retinoids were analyzed by high-performance liquid chromatography. The cellular retinol-binding protein type I (CRBP-I) was assessed by Western blotting. Before supplementation with ROL, RE were lower in RCS rats...
  5. Li L, Yu M, Zhang H, Zhao J, Wu D, Wu Y. [The role of cellular retinol-binding protein-1 on pulmonary structural remodeling after rat myocardial infarction]. Zhonghua Yi Xue Za Zhi. 2012;92:1862-4 pubmed
    To observe the expression of cellular retinol-binding protein-1 (CRBP-1) in pulmonary tissues after rat myocardial infarction (MI) and uncover the role of CRBP-1 on the pulmonary structural remodeling...
  6. Cowan S, Newcomer M, Jones T. Crystallographic studies on a family of cellular lipophilic transport proteins. Refinement of P2 myelin protein and the structure determination and refinement of cellular retinol-binding protein in complex with all-trans-retinol. J Mol Biol. 1993;230:1225-46 pubmed
    P2 myelin protein (P2) and cellular retinol binding protein (CRBP) are members of a family of cellular lipophilic transport proteins. P2 has been refined at a resolution of 2...
  7. Matt N, Schmidt C, Dupé V, Dennefeld C, Nau H, Chambon P, et al. Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development. Dev Dyn. 2005;233:167-76 pubmed
    ..We show that, during development, ROL and retinyl ester levels are decreased in CRBP type 1 (CRBP1) -deficient embryos and fetuses by 50% and 80%, respectively...
  8. Everts H, Sundberg J, Ong D. Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat. Exp Cell Res. 2005;308:309-19 pubmed
    ..a system of retinoic acid (RA) synthesis in the cycling rat uterus consisting of cellular retinol binding protein (Crbp), epithelial retinol dehydrogenase (eRoldh), retinal dehydrogenase 2 (Aldh1a2), and cellular retinoic acid binding ..
  9. Levin M, Li E, Ong D, Gordon J. Comparison of the tissue-specific expression and developmental regulation of two closely linked rodent genes encoding cytosolic retinol-binding proteins. J Biol Chem. 1987;262:7118-24 pubmed
    Cellular retinol-binding protein (CRBP) and cellular retinol-binding protein II (CRBP II) are two highly homologous cytoplasmic proteins that bind all-trans-retinol...
  10. Huang J, Possin D, Saari J. Localizations of visual cycle components in retinal pigment epithelium. Mol Vis. 2009;15:223-34 pubmed
    ..CRALBP and CRBP1 were distributed throughout the RPE cell, where they could mediate diffusion of retinoids between apical processes and somata. ..
  11. Sundelin J, Anundi H, Trägårdh L, Eriksson U, Lind P, Ronne H, et al. The primary structure of rat liver cellular retinol-binding protein. J Biol Chem. 1985;260:6488-93 pubmed
    The complete amino acid sequence of a cellular retinol-binding protein (CRBP) has been determined for the first time...
  12. Rask L, Anundi H, Böhme J, Eriksson U, Ronne H, Sege K, et al. Structural and functional studies of vitamin A-binding proteins. Ann N Y Acad Sci. 1981;359:79-90 pubmed
  13. Napoli J. Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta. 2012;1821:152-67 pubmed publisher
    ..This article is part of a Special Issue entitled: Retinoid and Lipid Metabolism. ..
  14. Van Beneden K, van Grunsven L, Geers C, Pauwels M, Desmouliere A, Verbeelen D, et al. CRBP-I in the renal tubulointerstitial compartment of healthy rats and rats with renal fibrosis. Nephrol Dial Transplant. 2008;23:3464-71 pubmed publisher
    Cellular retinol-binding protein I (CRBP-I), a member of the intracellular lipid-binding protein (iLBP) superfamily, is a specific marker of quiescent stellate cells in the healthy human liver...
  15. Kastner P, Lawrence H, Waltzinger C, Ghyselinck N, Chambon P, Chan S. Positive and negative regulation of granulopoiesis by endogenous RARalpha. Blood. 2001;97:1314-20 pubmed
    ..Thus, the block in granulopoiesis exerted by RARalpha fusion proteins expressed in APL cells may correspond to an amplification of a normal function of unliganded RARalpha. ..
  16. Cvetkovic D, Williams S, Hamilton T. Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer. Clin Cancer Res. 2003;9:1013-20 pubmed
    ..Our findings suggest that the loss of CRBP1 expression contributes to the ovarian cancer oncogenesis via altered vitamin A metabolism. ..