Rbbp4

Summary

Gene Symbol: Rbbp4
Description: RB binding protein 4, chromatin remodeling factor
Alias: histone-binding protein RBBP4, retinoblastoma binding protein 4
Species: rat
Products:     Rbbp4

Top Publications

  1. Verreault A, Kaufman P, Kobayashi R, Stillman B. Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell. 1996;87:95-104 pubmed
    ..Our data suggest that CAC is a key intermediate of the de novo nucleosome assembly pathway and that the p48 subunit participates in other aspects of histone metabolism. ..
  2. Roche A, Bassett B, Samant S, Hong W, Blobel G, Svensson E. The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex. J Mol Cell Cardiol. 2008;44:352-60 pubmed
    ..Together, these results demonstrate the importance of FOG-2/MTA/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG Repression Motif and the NuRD complex. ..
  3. Herz H, Garruss A, Shilatifard A. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci. 2013;38:621-39 pubmed publisher
  4. Basta J, Rauchman M. The nucleosome remodeling and deacetylase complex in development and disease. Transl Res. 2015;165:36-47 pubmed publisher
    ..Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape. These advances have the potential to lead to new therapeutic approaches to birth defects and cancer. ..
  5. Barak O, Lazzaro M, Lane W, Speicher D, Picketts D, Shiekhattar R. Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J. 2003;22:6089-100 pubmed
    ..Furthermore, we show that hNURF potentiates neurite outgrowth in cell culture. Taken together, our data suggess a role for an ISWI complex in neuronal growth. ..
  6. Cai L, Rothbart S, Lu R, Xu B, Chen W, Tripathy A, et al. An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Mol Cell. 2013;49:571-82 pubmed publisher
    ..Collectively, our data suggest that PCL recognition of H3K36me3 promotes intrusion of PRC2 complexes into active chromatin regions to promote gene silencing and modulate the chromatin landscape during development. ..
  7. Beyea J, Olson D, Harvey S. Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression. Dev Dyn. 2005;234:404-12 pubmed
    ..of mouse GH, as were the concentrations of beta subunit G-protein calponin 2, beta-5 tubulin, retinoblastoma binding protein 4, and fetuin A...
  8. Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, et al. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009;28:2763-76 pubmed publisher
    ..These findings may shed new light on the EGFR-related breast carcinogenesis and might offer a potential new target for breast cancer therapy. ..
  9. Pasini D, Cloos P, Walfridsson J, Olsson L, Bukowski J, Johansen J, et al. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature. 2010;464:306-10 pubmed publisher
    ..Thus, these results demonstrate that JARID2 is essential for the binding of PcG proteins to target genes and, consistent with this, for the proper differentiation of embryonic stem cells and normal development. ..

More Information

Publications12

  1. Ma P, Lin S, Bartolomei M, Schultz R. Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Biol Reprod. 2010;83:1027-35 pubmed publisher
    ..Taken together, our results support a role for MTA2 within the NuRD complex in genomic imprinting. ..
  2. Sun J, Chen H, Davie J. Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J Biol Chem. 2007;282:33227-36 pubmed
    ..We provide evidence that unmodified HDAC2 is associated with the coding region of transcribed genes, whereas phosphorylated HDAC2 is primarily recruited to promoters. ..
  3. Ballaré C, Lange M, Lapinaite A, Martin G, Morey L, Pascual G, et al. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012;19:1257-65 pubmed publisher
    ..These findings show that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells. ..