Gene Symbol: rat8
Description: interferon induced transmembrane protein 3
Alias: DSPA2b, rat8, interferon-induced transmembrane protein 3, dispanin subfamily A member 2b, interferon-inducible protein variant 10
Species: rat
Products:     rat8

Top Publications

  1. Chan Y, Huang I, Farzan M. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE. 2012;7:e34508 pubmed publisher
    ..We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections. ..
  2. Brass A, Huang I, Benita Y, John S, Krishnan M, Feeley E, et al. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243-54 pubmed publisher
    ..Collectively this work identifies a family of antiviral restriction factors that mediate cellular innate immunity to at least three major human pathogens...
  3. Weidner J, Jiang D, Pan X, Chang J, Block T, Guo J. Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J Virol. 2010;84:12646-57 pubmed publisher
    ..Collectively, our work sheds light on the mechanisms by which tetherin and IFITM3 restrict infection with rhabdoviruses and possibly other pathogenic viruses. ..
  4. Huang I, Bailey C, Weyer J, Radoshitzky S, Becker M, Chiang J, et al. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011;7:e1001258 pubmed publisher
    ..They further show that IFITM proteins differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. ..
  5. Daido H, Zhou M, Gomez Sanchez E, Gomez Sanchez C. Interferon-inducible genes in the rat adrenal gland and vascular smooth muscle cells. Mol Cell Endocrinol. 2003;200:81-7 pubmed
    ..We found the Rat8 gene, which has been reported to be similar to human interferon-inducible genes, as well as two similar genes, No...
  6. Zucchi I, Prinetti A, Scotti M, Valsecchi V, Valaperta R, Mento E, et al. Association of rat8 with Fyn protein kinase via lipid rafts is required for rat mammary cell differentiation in vitro. Proc Natl Acad Sci U S A. 2004;101:1880-5 pubmed
    We previously identified rat8 in the pathway involved in epithelial cell differentiation that occurs in the rat mammary gland at pregnancy when tubules and alveoli are formed...
  7. Ropolo A, Tomasini R, Grasso D, Dusetti N, Cerquetti M, Iovanna J, et al. Cloning of IP15, a pancreatitis-induced gene whose expression inhibits cell growth. Biochem Biophys Res Commun. 2004;319:1001-9 pubmed
    ..In conclusion, we identified a new interferon-inducible gene that is activated early in pancreas with pancreatitis and whose expression inhibits cell growth. ..
  8. El Tanani M, Jin D, Campbell F, Johnston P. Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression. Oncogene. 2010;29:752-62 pubmed publisher
    ..This work has shown for the first time that IFITM3 physically interacts with OPN and reduces OPN mRNA expression, which mediates cell adhesion, cell invasion, colony formation in soft agar and metastasis in a rat model system. ..
  9. Lau S, Yuen M, Kou C, Au K, Zhou J, Tsui S. Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes. J Cell Biochem. 2012;113:841-7 pubmed publisher
    ..Finally, interferon-? and -? were demonstrated to inhibit DNA synthesis during H9C2 cell differentiation. Our results indicated interferons are potentially involved in the differentiation and cell proliferation during heart development. ..

More Information


  1. Zhang Z, Liu J, Li M, Yang H, Zhang C. Evolutionary dynamics of the interferon-induced transmembrane gene family in vertebrates. PLoS ONE. 2012;7:e49265 pubmed publisher
    ..Because primates have experienced a long history of viral infection, such rapid expansion and positive selection suggests that the evolution of primate IR-IFITM genes is associated with broad-spectrum antiviral activity...
  2. Li K, Markosyan R, Zheng Y, Golfetto O, Bungart B, Li M, et al. IFITM proteins restrict viral membrane hemifusion. PLoS Pathog. 2013;9:e1003124 pubmed publisher
    ..Our study provides novel insight into the understanding of how IFITM protein family restricts viral membrane fusion and infection...
  3. Mikedis M, Downs K. Widespread but tissue-specific patterns of interferon-induced transmembrane protein 3 (IFITM3, FRAGILIS, MIL-1) in the mouse gastrula. Gene Expr Patterns. 2013;13:225-39 pubmed publisher
  4. Chesarino N, McMichael T, Hach J, Yount J. Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination. J Biol Chem. 2014;289:11986-92 pubmed publisher
    ..Overall, these results suggest that modification of Tyr(20) may serve in a cellular checkpoint controlling IFITM3 trafficking and degradation and demonstrate the complexity of posttranslational regulation of IFITM3. ..
  5. Rackham O, Langley S, Oates T, Vradi E, Harmston N, Srivastava P, et al. A Bayesian Approach for Analysis of Whole-Genome Bisulfite Sequencing Data Identifies Disease-Associated Changes in DNA Methylation. Genetics. 2017;205:1443-1458 pubmed publisher