Gene Symbol: rat8
Description: interferon induced transmembrane protein 3
Alias: DSPA2b, rat8, interferon-induced transmembrane protein 3, dispanin subfamily A member 2b, interferon-inducible protein variant 10
Chan Y, Huang I, Farzan M. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE. 2012;7:e34508 pubmed publisher
..We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections. ..
Brass A, Huang I, Benita Y, John S, Krishnan M, Feeley E, et al
. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243-54 pubmed publisher
..Collectively this work identifies a family of antiviral restriction factors that mediate cellular innate immunity to at least three major human pathogens...
Weidner J, Jiang D, Pan X, Chang J, Block T, Guo J. Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. J Virol. 2010;84:12646-57 pubmed publisher
..Collectively, our work sheds light on the mechanisms by which tetherin and IFITM3 restrict infection with rhabdoviruses and possibly other pathogenic viruses. ..
Huang I, Bailey C, Weyer J, Radoshitzky S, Becker M, Chiang J, et al
. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011;7:e1001258 pubmed publisher
..They further show that IFITM proteins differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. ..
Daido H, Zhou M, Gomez Sanchez E, Gomez Sanchez C. Interferon-inducible genes in the rat adrenal gland and vascular smooth muscle cells. Mol Cell Endocrinol. 2003;200:81-7 pubmed
..We found the Rat8 gene, which has been reported to be similar to human interferon-inducible genes, as well as two similar genes, No...
Zucchi I, Prinetti A, Scotti M, Valsecchi V, Valaperta R, Mento E, et al
. Association of rat8 with Fyn protein kinase via lipid rafts is required for rat mammary cell differentiation in vitro. Proc Natl Acad Sci U S A. 2004;101:1880-5 pubmed
We previously identified rat8 in the pathway involved in epithelial cell differentiation that occurs in the rat mammary gland at pregnancy when tubules and alveoli are formed...
Ropolo A, Tomasini R, Grasso D, Dusetti N, Cerquetti M, Iovanna J, et al
. Cloning of IP15, a pancreatitis-induced gene whose expression inhibits cell growth. Biochem Biophys Res Commun. 2004;319:1001-9 pubmed
..In conclusion, we identified a new interferon-inducible gene that is activated early in pancreas with pancreatitis and whose expression inhibits cell growth. ..
El Tanani M, Jin D, Campbell F, Johnston P. Interferon-induced transmembrane 3 binds osteopontin in vitro: expressed in vivo IFITM3 reduced OPN expression. Oncogene. 2010;29:752-62 pubmed publisher
..This work has shown for the first time that IFITM3 physically interacts with OPN and reduces OPN mRNA expression, which mediates cell adhesion, cell invasion, colony formation in soft agar and metastasis in a rat model system. ..
Lau S, Yuen M, Kou C, Au K, Zhou J, Tsui S. Interferons induce the expression of IFITM1 and IFITM3 and suppress the proliferation of rat neonatal cardiomyocytes. J Cell Biochem. 2012;113:841-7 pubmed publisher
..Finally, interferon-? and -? were demonstrated to inhibit DNA synthesis during H9C2 cell differentiation. Our results indicated interferons are potentially involved in the differentiation and cell proliferation during heart development. ..