Gene Symbol: Rassf5
Description: Ras association domain family member 5
Alias: Maxp1, Nore1, ras association domain-containing protein 5, Ras association (RalGDS/AF-6) domain family member 5, new ras effector 1, novel ras effector 1, protein interacting with guanine nucleotide exchange factor
Species: rat
Products:     Rassf5

Top Publications

  1. Katagiri K, Ueda Y, Tomiyama T, Yasuda K, Toda Y, Ikehara S, et al. Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1. Immunity. 2011;34:24-38 pubmed publisher
    RAPL (an alternative spliced form of Rassf5) is a critical Ras-related protein1 (Rap1) effector that regulates lymphocyte adhesion...
  2. Nakamura T, Yasuda S, Nagai H, Koinuma S, Morishita S, Goto A, et al. Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase. Genes Cells. 2013;18:1020-31 pubmed publisher
    ..Furthermore, Nore1A depletion reduced the number of cells without axons. These results indicate that specific activation of Rap1B contributes to neuronal polarization via interaction with RalA and Nore1A in addition to PI3-kinase. ..
  3. Vos M, Martinez A, Ellis C, Vallecorsa T, Clark G. The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung. J Biol Chem. 2003;278:21938-43 pubmed
    ..We now show that the Ras effector Nore1, which is structurally related to RASSF1, can also mediate a Ras-dependent apoptosis...
  4. Hwang E, Ryu K, Pääkkönen K, Güntert P, Cheong H, Lim D, et al. Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway. Proc Natl Acad Sci U S A. 2007;104:9236-41 pubmed
    ..The Mst1 SARAH domain interacts with its homologous domain of Rassf1 and Rassf5 (also known as Nore1) by forming a heterodimer that mediates the apoptosis process...
  5. Shinmura K, Tao H, Nagura K, Goto M, Matsuura S, Mochizuki T, et al. Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma. Lung Cancer. 2011;71:19-27 pubmed publisher
  6. Gezginci Oktayoglu S, Bolkent S. Ras signaling in NGF reduction and TNF-?-related pancreatic ? cell apoptosis in hyperglycemic rats. Apoptosis. 2012;17:14-24 pubmed publisher
    ..Here, we aimed to investigate the possible role of apoptotic Ras effectors RASSF1 and NORE1 in NGF reduction and TNF-?-related ? cell apoptosis in streptozotocin (STZ)-induced hyperglycemic rats...
  7. Lee D, Park S, Sung K, Park J, Lee S, Park S, et al. Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1. EMBO Rep. 2012;13:163-9 pubmed publisher
    The Ras effector NORE1 is frequently silenced in primary adenocarcinomas, although the significance of this silencing for tumorigenesis is unclear...
  8. Yao R, Wang Y, You M. Chromosome mapping and sequence variation of the murine Ras effector gene Nore1. Cytogenet Cell Genet. 2001;95:126-8 pubmed