Genomes and Genes
Gene Symbol: Rasd2
Description: RASD family, member 2
Alias: Rhes, GTP-binding protein Rhes, SE6C, ras homolog enriched in striatum
- Subramaniam S, Sixt K, Barrow R, Snyder S. Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science. 2009;324:1327-30 pubmed publisher..We report that the small guanine nucleotide-binding protein Rhes, which is localized very selectively to the striatum, binds physiologically to mHtt...
- Mealer R, Murray A, Shahani N, Subramaniam S, Snyder S. Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy. J Biol Chem. 2014;289:3547-54 pubmed publisher..We previously reported that the striatal-specific protein Rhes binds mHtt and enhances its cytotoxicity...
- Chan S, Monks L, Gao H, Deaville P, Morgan N. Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell. Br J Pharmacol. 2002;136:31-6 pubmed..Using these antisera in an expression cloning strategy we have identified a monomeric GTP-binding protein, Rhes, as a potential target for regulation by imidazoline ligands...
- Bang S, Steenstra C, Kim S. Striatum specific protein, Rhes regulates AKT pathway. Neurosci Lett. 2012;521:142-7 pubmed publisherThe Rhes/RASD2 GTPase complex is involved in dopamine D1/D2 receptor-mediated signaling and behavior. This GTP binding protein belongs to the RAS superfamily, along with Dexras1/RASD1, and is primarily expressed in the striatum...