Rasd2

Summary

Gene Symbol: Rasd2
Description: RASD family, member 2
Alias: Rhes, GTP-binding protein Rhes, SE6C, ras homolog enriched in striatum
Species: rat
Products:     Rasd2

Top Publications

  1. Vargiu P, Morte B, Manzano J, Perez J, de Abajo R, Gregor Sutcliffe J, et al. Thyroid hormone regulation of rhes, a novel Ras homolog gene expressed in the striatum. Brain Res Mol Brain Res. 2001;94:1-8 pubmed
    ..work we describe the thyroid hormone regulation of a novel Ras homolog which we have named Rhes (Ras homolog enriched in striatum)...
  2. Vargiu P, De Abajo R, Garcia Ranea J, Valencia A, Santisteban P, Crespo P, et al. The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. Oncogene. 2004;23:559-68 pubmed
    The Ras homolog enriched in striatum, Rhes, is the product of a thyroid hormone-regulated gene during brain development...
  3. Falk J, Vargiu P, Foye P, Usui H, Perez J, Danielson P, et al. Rhes: A striatal-specific Ras homolog related to Dexras1. J Neurosci Res. 1999;57:782-8 pubmed
    ..to members of the Ras-like GTP-binding protein family; thus, we have chosen the name Rhes, for Ras homolog enriched in striatum. The human homolog was found in a genomic sequence from human chromosome 22q13...
  4. Spano D, Branchi I, Rosica A, Pirro M, Riccio A, Mithbaokar P, et al. Rhes is involved in striatal function. Mol Cell Biol. 2004;24:5788-96 pubmed
    ..Among these, the Rhes gene, encoding a small GTP-binding protein, is predominantly expressed in the striatal region of the brain...
  5. Harrison L, LaHoste G. Rhes, the Ras homolog enriched in striatum, is reduced under conditions of dopamine supersensitivity. Neuroscience. 2006;137:483-92 pubmed
    ..The Ras Homolog Enriched in Striatum (Rhes) is expressed in brain areas that receive dopaminergic input, and here we test whether ..
  6. Hill C, Goddard A, Ladds G, Davey J. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. Cell Physiol Biochem. 2009;23:1-8 pubmed publisher
    Ras homologue enriched in striatum (Rhes) is a small monomeric G protein which functions in a variety of cellular processes, including attenuation of G protein-coupled receptor (GPCR) signalling...
  7. Errico F, Santini E, Migliarini S, Borgkvist A, Centonze D, Nasti V, et al. The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons. Mol Cell Neurosci. 2008;37:335-45 pubmed
    b>Rhes is a small GTP-binding protein prominently localized in the striatum...
  8. Harrison L, LaHoste G, Ruskin D. Ontogeny and dopaminergic regulation in brain of Ras homolog enriched in striatum (Rhes). Brain Res. 2008;1245:16-25 pubmed publisher
    b>Rhes is one of several signaling molecules preferentially expressed in the striatum. This GTP-binding protein affects dopamine-mediated signaling and behavior...
  9. Quintero G, Spano D, LaHoste G, Harrison L. The Ras homolog Rhes affects dopamine D1 and D2 receptor-mediated behavior in mice. Neuroreport. 2008;19:1563-6 pubmed publisher
    ..Here we have used mutant mice to test whether Rhes (Ras homolog enriched in striatum) is involved in D1 and D2 dopamine receptor-mediated behaviors...

More Information

Publications13

  1. Subramaniam S, Sixt K, Barrow R, Snyder S. Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science. 2009;324:1327-30 pubmed publisher
    ..We report that the small guanine nucleotide-binding protein Rhes, which is localized very selectively to the striatum, binds physiologically to mHtt...
  2. Mealer R, Murray A, Shahani N, Subramaniam S, Snyder S. Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy. J Biol Chem. 2014;289:3547-54 pubmed publisher
    ..We previously reported that the striatal-specific protein Rhes binds mHtt and enhances its cytotoxicity...
  3. Chan S, Monks L, Gao H, Deaville P, Morgan N. Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell. Br J Pharmacol. 2002;136:31-6 pubmed
    ..Using these antisera in an expression cloning strategy we have identified a monomeric GTP-binding protein, Rhes, as a potential target for regulation by imidazoline ligands...
  4. Bang S, Steenstra C, Kim S. Striatum specific protein, Rhes regulates AKT pathway. Neurosci Lett. 2012;521:142-7 pubmed publisher
    The Rhes/RASD2 GTPase complex is involved in dopamine D1/D2 receptor-mediated signaling and behavior. This GTP binding protein belongs to the RAS superfamily, along with Dexras1/RASD1, and is primarily expressed in the striatum...