Rad51

Summary

Gene Symbol: Rad51
Description: RAD51 recombinase
Alias: RGD1563603, DNA repair protein RAD51 homolog 1, RAD51 homolog
Species: rat
Products:     Rad51

Top Publications

  1. Baumann P, Benson F, West S. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell. 1996;87:757-66 pubmed
    The human testis Rad51 protein, a structural homolog of E. coli RecA, binds single- and double-stranded DNA and exhibits DNA-dependent ATPase activity. Using circular ssDNA and linear dsDNA (3...
  2. Liu N, Lamerdin J, Tebbs R, Schild D, Tucker J, Shen M, et al. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Mol Cell. 1998;1:783-93 pubmed
    ..of these genes and sequence alignments reveal that XRCC2 and XRCC3 are members of an emerging family of Rad51-related proteins that likely participate in homologous recombination to maintain chromosome stability and repair ..
  3. Chen J, Silver D, Walpita D, Cantor S, Gazdar A, Tomlinson G, et al. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell. 1998;2:317-28 pubmed
    ..Like BRCA1 and RAD51, BRCA2 relocates to PCNA+ replication sites following exposure of S phase cells to hydroxyurea or UV irradiation...
  4. Libby B, Reinholdt L, Schimenti J. Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice. Proc Natl Acad Sci U S A. 2003;100:15706-11 pubmed
    ..Homozygotes of both sexes are sterile due to meiotic arrest caused by defects in chromosome synapsis. Notably, RAD51 protein does not load onto Mei1 mutant meiotic chromosomes, suggesting that there is a defect in either ..
  5. Kneitz B, Cohen P, Avdievich E, Zhu L, Kane M, Hou H, et al. MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev. 2000;14:1085-97 pubmed
    ..Although meiosis is initiated in Msh4 mutant male and female mice, as indicated by the chromosomal localization of RAD51 and COR1 during leptonema/zygonema, the chromosomes fail to undergo normal pairing...
  6. Pellegrini L, Yu D, Lo T, Anand S, Lee M, Blundell T, et al. Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature. 2002;420:287-93 pubmed
    The breast cancer susceptibility protein BRCA2 controls the function of RAD51, a recombinase enzyme, in pathways for DNA repair by homologous recombination...
  7. Moens P, Chen D, Shen Z, Kolas N, Tarsounas M, Heng H, et al. Rad51 immunocytology in rat and mouse spermatocytes and oocytes. Chromosoma. 1997;106:207-15 pubmed
    On the assumption that Rad51 protein plays a role in early meiotic chromosomal events, we examine the location and time of appearance of immuno-reactive Rad51 protein in meiotic prophase chromosomes...
  8. Kovalenko O, Golub E, Bray Ward P, Ward D, Radding C. A novel nucleic acid-binding protein that interacts with human rad51 recombinase. Nucleic Acids Res. 1997;25:4946-53 pubmed
    ..system, we isolated a cDNA encoding a novel human protein, named Pir51, that strongly interacts with human Rad51 recombinase. Analysis in vitro confirmed the interaction between Rad51 and Pir51...
  9. Haaf T, Raderschall E, Reddy G, Ward D, Radding C, Golub E. Sequestration of mammalian Rad51-recombination protein into micronuclei. J Cell Biol. 1999;144:11-20 pubmed
    The mammalian Rad51 protein is involved in homologous recombination and in DNA damage repair...

More Information

Publications67

  1. Dosanjh M, Collins D, Fan W, Lennon G, Albala J, Shen Z, et al. Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. Nucleic Acids Res. 1998;26:1179-84 pubmed
    The yeast and human RAD51 genes encode strand-transfer proteins that are thought to be involved in both recombinational repair of DNA damage and meiotic recombination...
  2. Benson F, Stasiak A, West S. Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. EMBO J. 1994;13:5764-71 pubmed
    ..A human gene that shares homology with Escherichia coli recA (and its yeast homologue RAD51) has been cloned from a testis cDNA library, and its 37 kDa product (hRad51) purified to homogeneity...
  3. Lipkin S, Moens P, Wang V, Lenzi M, Shanmugarajah D, Gilgeous A, et al. Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet. 2002;31:385-90 pubmed
    ..Mlh3(-/-) spermatocytes reach metaphase before succumbing to apoptosis, but oocytes fail to complete meiosis I after fertilization. Our results show that Mlh3 has an essential and distinct role in mammalian meiosis. ..
  4. Kovalenko O, Wiese C, Schild D. RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. Nucleic Acids Res. 2006;34:5081-92 pubmed
    Many interacting proteins regulate and/or assist the activities of RAD51, a recombinase which plays a critical role in both DNA repair and meiotic recombination...
  5. Stark J, Pierce A, Oh J, Pastink A, Jasin M. Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol. 2004;24:9305-16 pubmed
    ..We observed an inverse relationship between HDR and SSA when RAD51 or BRCA2 was impaired, i.e., HDR was reduced but SSA was increased...
  6. Shivji M, Mukund S, Rajendra E, Chen S, Short J, Savill J, et al. The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange. Proc Natl Acad Sci U S A. 2009;106:13254-9 pubmed publisher
    The breast and ovarian cancer suppressor BRCA2 controls the enzyme RAD51 during homologous DNA recombination (HDR) to preserve genome stability...
  7. Li M, Peakman M, Golub E, Reddy G, Ward D, Radding C, et al. Rad51 expression and localization in B cells carrying out class switch recombination. Proc Natl Acad Sci U S A. 1996;93:10222-7 pubmed
    b>Rad51 is a highly conserved eukaryotic homolog of the prokaryotic recombination protein RecA, which has been shown to function in both recombinational repair of DNA damage and meiotic recombination in yeast...
  8. Loree J, Koturbash I, Kutanzi K, Baker M, Pogribny I, Kovalchuk O. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Int J Radiat Biol. 2006;82:805-15 pubmed
    ..The possible cellular repercussions of the observed changes in relationship to breast carcinogenesis are discussed. ..
  9. Wang A, Kim T, Wagner J, Conti B, Lach F, Huang A, et al. A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. Mol Cell. 2015;59:478-90 pubmed publisher
    ..Here, we report a de novo heterozygous T131P mutation in RAD51/FANCR, the key recombinase essential for homologous recombination, in a patient with Fanconi anemia-like phenotype...
  10. Gudmundsdottir K, Lord C, Witt E, Tutt A, Ashworth A. DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells. EMBO Rep. 2004;5:989-93 pubmed
    ..cancer susceptibility gene implicated in the repair of double-strand breaks by homologous recombination with RAD51. BRCA2 associates with a 70-amino-acid protein, DSS1, but the functional significance of this interaction has ..
  11. Kwan K, Moens P, Wang J. Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta. Proc Natl Acad Sci U S A. 2003;100:2526-31 pubmed
    ..pachytene, and that there is a time lag between the appearance of chromosome-bound DNA topoisomerase III beta and Rad51, a protein known to be involved in an early step of homologous recombination...
  12. Kumar R, Bourbon H, de Massy B. Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 2010;24:1266-80 pubmed publisher
  13. Kuroda K, Hibi D, Ishii Y, Takasu S, Kijima A, Matsushita K, et al. Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats. Mutagenesis. 2014;29:27-36 pubmed publisher
    ..mRNA and/or protein expression levels of homologous recombination (HR) repair-related genes (Rad51, Rad18 and Brip1), but not nonhomologous end joining-related genes, were increased in response to OTA in a dose-..
  14. Yang L, Tan X, Yang Z, Li Q, Miao X. [Expression of RAD51 and MAX in pancreatic cancer rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010;35:146-51 pubmed publisher
    ..pancreatic cancer induced by 7,12-dimethyl-benzathracene (DMBA) in SD rats, and to detect the expression levels of RAD51 and Myc-associated factor X (MAX) and their effect on carcinogenesis of rat pancreas...
  15. Chu W, Payne M, Beli P, Hanada K, Choudhary C, Hickson I. FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51. Nat Commun. 2015;6:5931 pubmed publisher
    ..Here we report that the central player in HR, RAD51, is ubiquitylated by the SCF(FBH1) complex...
  16. Jakubowska A, Gronwald J, Menkiszak J, Gorski B, Huzarski T, Byrski T, et al. The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers. Cancer Epidemiol Biomarkers Prev. 2007;16:270-5 pubmed
    ..These findings suggest that the effect of the RAD51 C allele is an important risk modifier for malignancies occurring on a background of BRCA1 mutations...
  17. Heyer W, Ehmsen K, Liu J. Regulation of homologous recombination in eukaryotes. Annu Rev Genet. 2010;44:113-39 pubmed publisher
    ..Here, we review the factors and mechanistic stages of recombination that are subject to regulation and suggest that recombination achieves flexibility and robustness by proceeding through metastable, reversible intermediates. ..
  18. Soper S, van der Heijden G, Hardiman T, Goodheart M, Martin S, de Boer P, et al. Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev Cell. 2008;15:285-97 pubmed publisher
    ..This study demonstrates that MAEL, a nuage component, is indispensable for the silencing of TEs and identifies the initiation of meiosis as an important step in TE control in the male germline. ..
  19. Ishishita S, Matsuda Y, Kitada K. Genetic evidence suggests that Spata22 is required for the maintenance of Rad51 foci in mammalian meiosis. Sci Rep. 2014;4:6148 pubmed publisher
    ..Meiotic nodules are the sites of double-stranded DNA break repair. Rpa is a single-stranded DNA-binding protein, and Rad51 is a protein that assists in the repair of DNA double strand breaks...
  20. Esashi F, Galkin V, Yu X, Egelman E, West S. Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat Struct Mol Biol. 2007;14:468-74 pubmed
    The human breast cancer susceptibility gene BRCA2 is required for the regulation of RAD51-mediated homologous recombinational repair...
  21. Davies O, Pellegrini L. Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats. Nat Struct Mol Biol. 2007;14:475-83 pubmed
    BRCA2 has an essential function in DNA repair by homologous recombination, interacting with RAD51 via short motifs in the middle and at the C terminus of BRCA2...
  22. Cherry S, Adelman C, Theunissen J, Hassold T, Hunt P, Petrini J. The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol. 2007;17:373-8 pubmed
    ..Thus, our findings implicate the Mre11 complex in meiotic DNA repair and synapsis in mammals and indicate that the complex may contribute to the establishment of normal sex-specific differences in meiosis...
  23. Gal I, Kimmel G, Gershoni Baruch R, Papa M, Dagan E, Shamir R, et al. A specific RAD51 haplotype increases breast cancer risk in Jewish non-Ashkenazi high-risk women. Eur J Cancer. 2006;42:1129-34 pubmed
    ..in determining familial breast cancer risk in addition to BRCA1/2 are mostly unknown, one strong candidate is RAD51. Jewish non-Ashkenazi women at high-risk for breast/ovarian cancer and ethnically matched controls were genotyped ..
  24. Bischof O, Kim S, Irving J, Beresten S, Ellis N, Campisi J. Regulation and localization of the Bloom syndrome protein in response to DNA damage. J Cell Biol. 2001;153:367-80 pubmed
    ..Our findings suggest that BLM is part of a dynamic nuclear matrix-based complex that requires PML and functions during G2 in undamaged cells and recombinational repair after DNA damage. ..
  25. Antoniou A, Sinilnikova O, Simard J, Leone M, Dumont M, Neuhausen S, et al. RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. Am J Hum Genet. 2007;81:1186-200 pubmed
    b>RAD51 is an important component of double-stranded DNA-repair mechanisms that interacts with both BRCA1 and BRCA2...
  26. Wesoly J, Agarwal S, Sigurdsson S, Bussen W, Van Komen S, Qin J, et al. Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol. 2006;26:976-89 pubmed
    Homologous recombination is a versatile DNA damage repair pathway requiring Rad51 and Rad54...
  27. Simandlova J, Zagelbaum J, Payne M, Chu W, Shevelev I, Hanada K, et al. FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. J Biol Chem. 2013;288:34168-80 pubmed publisher
    ..A key player in HR is RAD51, the eukaryotic ortholog of bacterial RecA protein...
  28. Kim T, Ko J, Hu L, Kim S, Bishop A, Vijg J, et al. RAD51 mutants cause replication defects and chromosomal instability. Mol Cell Biol. 2012;32:3663-80 pubmed publisher
    b>RAD51 is important for restarting stalled replication forks and for repairing DNA double-strand breaks (DSBs) through a pathway called homology-directed repair (HDR)...
  29. Lovren F, Pan Y, Quan A, Singh K, Khan R, Gupta N, et al. BRCA1 shields vascular smooth muscle cells from oxidative stress. J Thorac Cardiovasc Surg. 2014;147:1946-55, 1955.e1 pubmed publisher
    ..X levels, greater RAD51 foci, and decreases in blood pressure...
  30. Ganesan S, Bhattacharya P, Keating A. 7,12-Dimethylbenz[a]anthracene exposure induces the DNA repair response in neonatal rat ovaries. Toxicol Appl Pharmacol. 2013;272:690-6 pubmed publisher
    ..Additionally, DMBA (12.5 nM and 1 ?M) increased levels of mRNA encoding Atm, Xrcc6, Brca1 and Rad51. In contrast, Parp1 mRNA was decreased on d4 and increased on d8 of DMBA exposure, while PARP1 protein increased ..
  31. Badie S, Escandell J, Bouwman P, Carlos A, Thanasoula M, Gallardo M, et al. BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat Struct Mol Biol. 2010;17:1461-9 pubmed publisher
    ..protein BRCA2 is a key component of the homologous recombination pathway of DNA repair, acting as the loader of RAD51 recombinase at sites of double-strand breaks...
  32. Yuan J, Chen J. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Proc Natl Acad Sci U S A. 2013;110:10640-5 pubmed publisher
    The RAD51 recombinase plays a central role in homologous recombination (HR), which is critical for repair of DNA double-strand breaks, maintenance of genomic stability, and prevention of developmental disorders and cancer...
  33. Tarasenko N, Cutts S, Phillips D, Inbal A, Nudelman A, Kessler Icekson G, et al. Disparate impact of butyroyloxymethyl diethylphosphate (AN-7), a histone deacetylase inhibitor, and doxorubicin in mice bearing a mammary tumor. PLoS ONE. 2012;7:e31393 pubmed publisher
    ..with Dox increased tumor levels of ?H2AX, the marker for DNA double-strand breaks and decreased the expression of Rad51, a protein needed for DNA repair...
  34. Nowacka Zawisza M, Brys M, Romanowicz Makowska H, Kulig A, Krajewska W. Genetic instability in the RAD51 and BRCA1 regions in breast cancer. Cell Mol Biol Lett. 2007;12:192-205 pubmed
    ..The RAD51 and BRCA1 proteins are involved in the repair of double-strand DNA breaks by homologous recombination...
  35. Vinson R, Hales B. Expression of base excision, mismatch, and recombination repair genes in the organogenesis-stage rat conceptus and effects of exposure to a genotoxic teratogen, 4-hydroperoxycyclophosphamide. Teratology. 2001;64:283-91 pubmed
    ..After exposure to 4-OOHCPA for 24 hr, XRCC1 and RAD57 expression decreased in yolk sac, whereas only RAD51 transcripts decreased in the embryo...
  36. Auranen A, Song H, Waterfall C, Dicioccio R, Kuschel B, Kjaer S, et al. Polymorphisms in DNA repair genes and epithelial ovarian cancer risk. Int J Cancer. 2005;117:611-8 pubmed
    ..studies from 3 countries were genotyped for 13 single nucleotide polymorphisms (SNP) in 6 genes (BRCA1, NBS1, RAD51, RAD52, XRCC2 and XRCC3) involved in homologous recombination of DNA double strand breaks...
  37. Parplys A, Zhao W, Sharma N, Groesser T, Liang F, Maranon D, et al. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 2015;43:9817-34 pubmed publisher
    ..Here, we demonstrate that NUCKS1 shares extensive sequence homology with RAD51AP1 (RAD51 associated protein 1), suggesting that these two proteins are paralogs...
  38. Wan L, Han J, Liu T, Dong S, Xie F, Chen H, et al. Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair. Proc Natl Acad Sci U S A. 2013;110:10646-51 pubmed publisher
    ..SPIDR independently interacts with BLM and RAD51 and promotes the formation of a BLM/RAD51-containing complex of biological importance...
  39. Park J, Yoo H, Kim B, Park R, Choi S, Kim Y. Identification of a novel human Rad51 variant that promotes DNA strand exchange. Nucleic Acids Res. 2008;36:3226-34 pubmed publisher
    b>Rad51 plays a key role in the repair of DNA double-strand breaks through homologous recombination, which is the central process in the maintenance of genomic integrity...
  40. Bennett B, Knight K. Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. J Cell Biochem. 2005;96:1095-109 pubmed
    b>Rad51-catalyzed homologous recombination is an important pathway for repair of DNA double strand breaks and maintenance of genome integrity in vertebrate cells...
  41. Sun X, Brieño Enríquez M, Cornelius A, Modzelewski A, Maley T, Campbell Peterson K, et al. FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma. 2016;125:237-52 pubmed publisher
  42. Martin R, Orelli B, Yamazoe M, Minn A, Takeda S, Bishop D. RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. Cancer Res. 2007;67:9658-65 pubmed
    ..Here, we show that overexpression of the homologous recombinase RAD51 in a DT40 BRCA1Delta/Delta mutant rescues defects in proliferation, DNA damage survival, and homologous ..
  43. Sage J, Gildemeister O, Knight K. Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. J Biol Chem. 2010;285:18984-90 pubmed publisher
    ..b>Rad51 is the central catalyst of HR in all eukaryotes, and to this point studies of human Rad51 have focused exclusively ..
  44. Robertson R, Moses D, Kwon Y, Chan P, Chi P, Klein H, et al. Structural transitions within human Rad51 nucleoprotein filaments. Proc Natl Acad Sci U S A. 2009;106:12688-93 pubmed publisher
    b>Rad51 is a core component of the eukaryotic homologous recombination machinery and is responsible for key mechanistic steps during strand invasion...
  45. Tryndyak V, Kovalchuk O, Muskhelishvili L, Montgomery B, Rodriguez Juarez R, Melnyk S, et al. Epigenetic reprogramming of liver cells in tamoxifen-induced rat hepatocarcinogenesis. Mol Carcinog. 2007;46:187-97 pubmed
    ..The accumulation of tamoxifen-induced DNA lesions was accompanied by the decreased level of Rad51, Ku70, and DNA polymerase beta (Polbeta) proteins that play a crucial role in maintenance of genomic stability...
  46. Holloway J, Sun X, Yokoo R, Villeneuve A, Cohen P. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. J Cell Biol. 2014;205:633-41 pubmed publisher
  47. Berkowitz K, Sowash A, Koenig L, Urcuyo D, Khan F, Yang F, et al. Disruption of CHTF18 causes defective meiotic recombination in male mice. PLoS Genet. 2012;8:e1002996 pubmed publisher
    ..Repair of DNA double-strand breaks is delayed and incomplete; both RAD51 and ?H2AX persist in prophase I. In addition, MLH1 foci are decreased in pachynema...
  48. Khoury Haddad H, Guttmann Raviv N, Ipenberg I, Huggins D, Jeyasekharan A, Ayoub N. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc Natl Acad Sci U S A. 2014;111:E728-37 pubmed publisher
    ..Consistent with an upstream role in DDR, KDM4D knockdown disrupts the damage-induced recombinase Rad51 and tumor protein P53 binding protein foci formation...
  49. Yang F, Eckardt S, Leu N, McLaughlin K, Wang P. Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. J Cell Biol. 2008;180:673-9 pubmed publisher
    ..mutant spermatocytes, DNA double-strand breaks (DSBs) are formed, but localization of the recombination proteins RAD51 and DMC1 to meiotic chromosomes is severely impaired...
  50. Eijpe M, Offenberg H, Jessberger R, Revenkova E, Heyting C. Meiotic cohesin REC8 marks the axial elements of rat synaptonemal complexes before cohesins SMC1beta and SMC3. J Cell Biol. 2003;160:657-70 pubmed
    ..We propose that REC8 then provides cohesion. RAD51 and/or DMC1 coimmunoprecipitates with REC8, suggesting that REC8 may also provide a basis for assembly of ..
  51. Finsterbusch F, Ravindranathan R, Dereli I, Stanzione M, Tränkner D, Toth A. Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. PLoS Genet. 2016;12:e1006393 pubmed publisher
    ..DNA ends at break sites are resected. The resultant 3-prime single-stranded DNA overhangs recruit RAD51 and DMC1 recombinases that promote the invasion of homologous duplex DNAs by the resected DNA ends...
  52. Guiraldelli M, Eyster C, Wilkerson J, Dresser M, Pezza R. Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. PLoS Genet. 2013;9:e1003383 pubmed publisher
    ..We propose that initial steps of recombination are sufficient to support homology recognition, pairing, and initial chromosome synapsis and that HFM1 is required to form normal numbers of COs and to complete synapsis. ..
  53. Moldovan G, Madhavan M, Mirchandani K, McCaffrey R, Vinciguerra P, D Andrea A. DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol. 2010;30:1088-96 pubmed publisher
    ..Our data indicate that this novel polymerase-helicase complex participates in homologous recombination repair and is essential for cellular protection against DNA cross-links. ..
  54. Chipitsyna G, Slonina D, Siddiqui K, Peruzzi F, Skorski T, Reiss K, et al. HIV-1 Tat increases cell survival in response to cisplatin by stimulating Rad51 gene expression. Oncogene. 2004;23:2664-71 pubmed
    ..Examination of several proteins involved in the control of DNA repair showed elevated levels of Rad51, a key regulator of homologous recombination in cells expressing Tat...
  55. Wong J, Alon N, McKerlie C, Huang J, Meyn M, Buchwald M. Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum Mol Genet. 2003;12:2063-76 pubmed
    ..However, the localization of Rad51, Brca1, Fancd2 and Mlh1 appeared normal on Fanca(tm1Hsc) homozygous meiotic chromosomes...
  56. Herrán Y, Gutiérrez Caballero C, Sanchez Martin M, Hernandez T, Viera A, Barbero J, et al. The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility. EMBO J. 2011;30:3091-105 pubmed publisher
    ..Thus, our results provide in vivo evidence that RAD21L is essential for male fertility and in females for the maintenance of fertility during natural aging. ..
  57. Nowacka Zawisza M, Brys M, Romanowicz Makowska H, Kulig A, Krajewska W. Dinucleotide repeat polymorphisms of RAD51, BRCA1, BRCA2 gene regions in breast cancer. Pathol Int. 2008;58:275-81 pubmed publisher
    ..This is mediated via regulation of RAD51 during homologous recombination...
  58. Ameziane N, May P, Haitjema A, van de Vrugt H, van Rossum Fikkert S, Ristic D, et al. A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51. Nat Commun. 2015;6:8829 pubmed publisher
    ..Ala293Thr (NM_002875) missense mutation in one allele of the homologous recombination DNA repair gene RAD51 in an FA-like patient...