Gene Symbol: Rad23b
Description: RAD23 homolog B, nucleotide excision repair protein
Alias: UV excision repair protein RAD23 homolog B, RAD23b homolog
Sugasawa K, Ng J, Masutani C, Iwai S, van der Spek P, Eker A, et al
. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol Cell. 1998;2:223-32 pubmed
..After this subpathway-specific initial lesion detection, XPA may function as a common damage verifier and adaptor to the core of the NER apparatus. ..
Vinson R, Hales B. Nucleotide excision repair gene expression in the rat conceptus during organogenesis. Mutat Res. 2001;486:113-23 pubmed
..Exposure of the conceptus to a teratogen, 4-OOHCPA, induced malformations without affecting NER transcript levels. Thus, NER gene expression in the conceptus was unresponsive to regulation by DNA alkylation. ..
Ng J, Vermeulen W, van der Horst G, Bergink S, Sugasawa K, Vrieling H, et al
. A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Genes Dev. 2003;17:1630-45 pubmed
..These findings resolve the primary function of RAD23 in repair and reveal a novel DNA-damage-dependent regulation mechanism of DNA repair in eukaryotes, which may be part of a more global damage-response circuitry. ..
Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondoh J, et al
. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J Biol Chem. 2001;276:18665-72 pubmed
..CEN2 has been shown to play an important role in centrosome duplication. Thus, those findings suggest that the XPC-CEN2 interaction may reflect coupling of cell division and NER. ..
Ng J, Vrieling H, Sugasawa K, Ooms M, Grootegoed J, Vreeburg J, et al
. Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. Mol Cell Biol. 2002;22:1233-45 pubmed
..This function may involve regulation of protein stability via the ubiquitin/proteasome pathway and is not or only in part compensated for by mHR23A. ..
Sugasawa K, Akagi J, Nishi R, Iwai S, Hanaoka F. Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning. Mol Cell. 2009;36:642-53 pubmed publisher
..Our results dissect the intricate molecular mechanism of NER and provide insights into a strategy for mammalian cells to survey large genomes to detect DNA damage. ..
Masutani C, Sugasawa K, Yanagisawa J, Sonoyama T, Ui M, Enomoto T, et al
. Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J. 1994;13:1831-43 pubmed
..All RAD23 derivatives share a ubiquitin-like N-terminus. The nature of the XP-C defect implies that the complex exerts a unique function in the genome-overall repair pathway which is important for prevention of skin cancer. ..
Li X, Demartino G. Variably modulated gating of the 26S proteasome by ATP and polyubiquitin. Biochem J. 2009;421:397-404 pubmed publisher
..Our results suggest that modulated gating of the proteasome may be an important element of the mechanism of proteolysis of polyubiquitylated proteins. ..
Compe E, Egly J. TFIIH: when transcription met DNA repair. Nat Rev Mol Cell Biol. 2012;13:343-54 pubmed publisher
..In this way, studies of TFIIH have revealed tight molecular connections between transcription and DNA repair and have helped to define the concept of 'transcription diseases'. ..