Gene Symbol: Rad23a
Description: RAD23 homolog A, nucleotide excision repair protein
Alias: UV excision repair protein RAD23 homolog A
Sugasawa K, Ng J, Masutani C, Maekawa T, Uchida A, van der Spek P, et al
. Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol Cell Biol. 1997;17:6924-31 pubmed
..Furthermore, both rhHR23 proteins function in a defined NER system reconstituted with purified proteins, indicating direct involvement of hHR23 proteins in the DNA repair reaction via interaction with XPC. ..
Ng J, Vermeulen W, van der Horst G, Bergink S, Sugasawa K, Vrieling H, et al
. A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Genes Dev. 2003;17:1630-45 pubmed
..These findings resolve the primary function of RAD23 in repair and reveal a novel DNA-damage-dependent regulation mechanism of DNA repair in eukaryotes, which may be part of a more global damage-response circuitry. ..
Bingol B, Wang C, Arnott D, Cheng D, Peng J, Sheng M. Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spines. Cell. 2010;140:567-78 pubmed publisher
..Our findings reveal a scaffolding role of postsynaptic CaMKIIalpha in activity-dependent proteasome redistribution, which is commensurate with the great abundance of CaMKIIalpha in synapses. ..
Laco M, Cortes L, Travis S, Paulson H, Rego A. Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3. PLoS ONE. 2012;7:e43563 pubmed publisher
..Based on our results we propose a model where ataxin-3 normally functions with its interactors to specify the cellular fate of ubiquitinated proteins. ..
Raasi S, Pickart C. Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains. J Biol Chem. 2003;278:8951-9 pubmed
..Here we show that contrary to prediction from this model, the effect of human Rad23A on the degradation of polyubiquitinated substrates catalyzed by purified proteasomes is exclusively inhibitory...
Li G, Elder R, Dubrovsky L, Liang D, Pushkarsky T, Chiu K, et al
. HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome. PLoS ONE. 2010;5:e11371 pubmed publisher
..These findings suggest that Vpr-proteasome interaction might counteract certain host restriction factor(s) to stimulate viral replication in non-dividing cells. ..
Tan X, Liang R, Chuang S. hHR23A is required to control the basal turnover of Chk1. Cell Signal. 2015;27:2304-13 pubmed publisher