Rac2

Summary

Gene Symbol: Rac2
Description: Rac family small GTPase 2
Alias: ras-related C3 botulinum toxin substrate 2, RAS-related C3 botulinum substrate 2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Species: rat
Products:     Rac2

Top Publications

  1. Yang F, Kapur R, King A, Tao W, Kim C, Borneo J, et al. Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity. 2000;12:557-68 pubmed
    Mast cells generated from Rac2-deficient (-/-) mice demonstrated defective actin-based functions, including adhesion, migration, and degranulation...
  2. Ingram D, Hiatt K, King A, Fisher L, Shivakumar R, Derstine C, et al. Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. J Exp Med. 2001;194:57-69 pubmed
    ..Using a genetic intercross between Nf1(+/)- and Rac2(-)(/)- mice, we now provide genetic evidence to support a biochemical model where hyperactivation of the ..
  3. Cheng G, Diebold B, Hughes Y, Lambeth J. Nox1-dependent reactive oxygen generation is regulated by Rac1. J Biol Chem. 2006;281:17718-26 pubmed
    ..A model is presented comparing activation by regulatory subunits of Nox1 versus gp91(phox) (Nox2) in which Rac1 activation provides a major trigger that acutely activates Nox1-dependent ROS generation. ..
  4. Zhang H, Sun C, Glogauer M, Bokoch G. Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J Immunol. 2009;183:2718-28 pubmed publisher
    Rac1 and Rac2, members of the small Rho GTPase family, play essential roles in coordinating directional migration and superoxide production during neutrophil responses to chemoattractants...
  5. Abe D, Kubota T, Morozumi T, Shimizu T, Nakasone N, Itagaki M, et al. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. J Periodontal Res. 2011;46:345-53 pubmed publisher
  6. Wang J, Ma S, Tao R, Xia L, Liu L, Jiang Y. Gene expression profile changes in rat dorsal horn after sciatic nerve injury. Neurol Res. 2017;39:176-182 pubmed publisher
    ..Among them, 160 were specific in adult group (e.g. CCL2, NF-?B1 and RAC2); 9 were specific in young group (e.g. ILF3 and LYVE1); and 41 were common in both two groups (e.g...
  7. Razzouk S, Lieberherr M, Cournot G. Rac-GTPase, osteoclast cytoskeleton and bone resorption. Eur J Cell Biol. 1999;78:249-55 pubmed
    The members of the Rho-GTPase subfamily, Rac1 and Rac2, are intimately involved in the organization of the cytoskeleton, and the p21-activated kinases or PAKs are targets of these proteins...
  8. Ambruso D, Knall C, Abell A, Panepinto J, Kurkchubasche A, Thurman G, et al. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Proc Natl Acad Sci U S A. 2000;97:4654-9 pubmed
    ..b>Rac2, which constitutes >96% of the Rac in neutrophils, is a member of the Rho family of GTPases that regulates the ..
  9. Yu H, Leitenberg D, Li B, Flavell R. Deficiency of small GTPase Rac2 affects T cell activation. J Exp Med. 2001;194:915-26 pubmed
    b>Rac2 is a hematopoietic-specific GTPase acting as a molecular switch to mediate both transcriptional activation and cell morphological changes. We have examined the effect of Rac2 deficiency during T cell activation...

More Information

Publications14

  1. Tao W, Filippi M, Bailey J, Atkinson S, Connors B, Evan A, et al. The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization. Blood. 2002;100:1679-88 pubmed
    ..Here we report that the TRQQKRP motif of Rac2 located near the C-terminus, a region of sequence disparity among Rac proteins, is essential for complementation of ..
  2. Gakidis M, Cullere X, Olson T, Wilsbacher J, Zhang B, Moores S, et al. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004;166:273-82 pubmed
    ..Thus, Vav proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis. ..
  3. Tian Y, Autieri M. Cytokine expression and AIF-1-mediated activation of Rac2 in vascular smooth muscle cells: a role for Rac2 in VSMC activation. Am J Physiol Cell Physiol. 2007;292:C841-9 pubmed
    ..use of a bacterial two-hybrid screen, we identified a molecular interaction between AIF-1 and the small GTPase, Rac2, which was verified by pull-down and colocalization experiments...
  4. Accetta D, Syverson G, Bonacci B, Reddy S, Bengtson C, Surfus J, et al. Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia. J Allergy Clin Immunol. 2011;127:535-538.e1-2 pubmed publisher
  5. Lawson C, Donald S, Anderson K, Patton D, Welch H. P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. J Immunol. 2011;186:1467-76 pubmed publisher
    ..P1V1) double-deficient cells also showed the strongest reduction in fMLF-stimulated activation of Rac1 and Rac2. This reduction in Rac activity may be sufficient to cause the defects observed in fMLF-stimulated P1V1 neutrophil ..