Genomes and Genes
Gene Symbol: Rac2
Description: Rac family small GTPase 2
Alias: ras-related C3 botulinum toxin substrate 2, RAS-related C3 botulinum substrate 2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
- Tao W, Filippi M, Bailey J, Atkinson S, Connors B, Evan A, et al. The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization. Blood. 2002;100:1679-88 pubmed..Here we report that the TRQQKRP motif of Rac2 located near the C-terminus, a region of sequence disparity among Rac proteins, is essential for complementation of ..
- Gakidis M, Cullere X, Olson T, Wilsbacher J, Zhang B, Moores S, et al. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004;166:273-82 pubmed..Thus, Vav proteins play an essential role coupling beta2 to Rho GTPases and regulating multiple integrin-induced events important in leukocyte adhesion and phagocytosis. ..
- Tian Y, Autieri M. Cytokine expression and AIF-1-mediated activation of Rac2 in vascular smooth muscle cells: a role for Rac2 in VSMC activation. Am J Physiol Cell Physiol. 2007;292:C841-9 pubmed..use of a bacterial two-hybrid screen, we identified a molecular interaction between AIF-1 and the small GTPase, Rac2, which was verified by pull-down and colocalization experiments...
- Lawson C, Donald S, Anderson K, Patton D, Welch H. P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. J Immunol. 2011;186:1467-76 pubmed publisher..P1V1) double-deficient cells also showed the strongest reduction in fMLF-stimulated activation of Rac1 and Rac2. This reduction in Rac activity may be sufficient to cause the defects observed in fMLF-stimulated P1V1 neutrophil ..