Gene Symbol: Rab7a
Description: RAB7A, member RAS oncogene family
Alias: Rab7, ras-related protein Rab-7a, RAB7, member RAS oncogene family, ras-related protein BRL-RAS, ras-related protein p23
Species: rat
Products:     Rab7a

Top Publications

  1. Meresse S, Gorvel J, Chavrier P. The rab7 GTPase resides on a vesicular compartment connected to lysosomes. J Cell Sci. 1995;108 ( Pt 11):3349-58 pubmed
    Rab GTPases belong to the Ras GTPase superfamily and are key regulators of membrane traffic. Among them, rab7 has been localized on late endosomes of NRK cells but its function remains unknown...
  2. Zhao H, Laitala Leinonen T, Parikka V, Vaananen H. Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption. J Biol Chem. 2001;276:39295-302 pubmed
    ..Here we show that Rab7, a small GTPase that is associated with late endosomes, is highly expressed and is predominantly localized at the ..
  3. Stein M, Feng Y, Cooper K, Welford A, Wandinger Ness A. Human VPS34 and p150 are Rab7 interacting partners. Traffic. 2003;4:754-71 pubmed
    ..b>Rab7 is required for late endosomal transport and here we establish that the phosphatidylinositol 3'-kinase hVPS34 and ..
  4. Spinosa M, Progida C, De Luca A, Colucci A, Alifano P, Bucci C. Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease. J Neurosci. 2008;28:1640-8 pubmed publisher
    ..Recently, four missense mutations in the small GTPase Rab7 associated with the Charcot-Marie Tooth type 2B phenotype have been identified...
  5. Feng Y, Press B, Wandinger Ness A. Rab 7: an important regulator of late endocytic membrane traffic. J Cell Biol. 1995;131:1435-52 pubmed
    Rab5 and rab7 proteins belong to a superfamily of small molecular weight GTPases known to be associated with early and late endosomes, respectively...
  6. Ceresa B, Bahr S. rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome. J Biol Chem. 2006;281:1099-106 pubmed
    ..We examined the role of the small molecular weight guanine nucleotide-binding protein (G-protein) rab7 as a regulator of the distal stages of the endocytic pathway...
  7. Bains M, Zaegel V, Mize Berge J, Heidenreich K. IGF-I stimulates Rab7-RILP interaction during neuronal autophagy. Neurosci Lett. 2011;488:112-7 pubmed publisher
    ..In this report, we identify Rab7 as an IGF-I regulated target during neuronal autophagy...
  8. Saxena S, Bucci C, Weis J, Kruttgen A. The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA. J Neurosci. 2005;25:10930-40 pubmed
    ..The regulation of the endosomal trafficking of TrkA is so far unknown. Because the endosome-associated GTPase Rab7 coimmunoprecipitated with TrkA, we examined whether the endosomal trafficking of TrkA might be under the control of ..
  9. Mehrpour M, Esclatine A, Beau I, Codogno P. Overview of macroautophagy regulation in mammalian cells. Cell Res. 2010;20:748-62 pubmed publisher

More Information


  1. Zhan L, Chen S, Li K, Liang D, Zhu X, Liu L, et al. Autophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats. Cell Death Dis. 2017;8:e2949 pubmed publisher
    Autophagy disruption leads to neuronal damage in hypoxic-ischemic brain injury. Rab7, a member of the Rab GTPase superfamily, has a unique role in the regulation of autophagy...
  2. Song P, Trajkovic K, Tsunemi T, Krainc D. Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway. J Neurosci. 2016;36:2425-37 pubmed publisher
    ..in the endocytic pathway in Parkin-deficient cells, we found that Parkin regulates the levels and activity of Rab7 by promoting its ubiquitination on lysine 38 residue...
  3. Mamo A, Jules F, Dumaresq Doiron K, Costantino S, Lefrancois S. The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting. Mol Cell Biol. 2012;32:1855-66 pubmed publisher
    ..we show that the retromer recruitment machinery is also affected by CLN5 depletion, as we found less loaded Rab7, which is required to recruit retromer...
  4. Rak A, Pylypenko O, Niculae A, Pyatkov K, Goody R, Alexandrov K. Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. Cell. 2004;117:749-60 pubmed
    ..The crystal structures of the REP-1 protein in complex with monoprenylated or C-terminally truncated Rab7 proteins revealed that Rab7 interacts with the Rab binding platform of REP-1 via an extended interface involving ..
  5. Zhang K, Fishel Ben Kenan R, Osakada Y, Xu W, Sinit R, Chen L, et al. Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling. J Neurosci. 2013;33:7451-62 pubmed publisher
    ..Genetic analysis of human CMT2B patients has revealed four missense point mutations in Rab7, a small GTPase that regulates late endosomal/lysosomal pathways, but the exact pathological mechanism remains ..
  6. BasuRay S, Mukherjee S, Romero E, Wilson M, Wandinger Ness A. Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling. PLoS ONE. 2010;5:e15351 pubmed publisher
    Missense mutants in the late endosomal Rab7 GTPase cause the autosomal dominant peripheral neuropathy Charcot-Marie-Tooth disease type 2B (CMT2B)...
  7. Yu T, Calvo L, Anta B, L pez Benito S, L pez Bellido R, Vicente Garc a C, et al. In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J Neurosci. 2014;34:6098-106 pubmed publisher
    ..Our results indicate that the ubiquitination of the TrkA neurotrophin receptor plays a critical role in NGF-mediated functions, such as neuronal survival and sensitivity to pain...
  8. Fernández B, Fdez E, Gomez Suaga P, Gil F, Molina Villalba I, Ferrer I, et al. Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A. Autophagy. 2016;12:1487-506 pubmed publisher
    ..by altered intralysosomal iron handling is abrogated in the presence of an NAADP antagonist or when inhibiting RAB7A activity...
  9. Harrison M, Hung C, Liu T, Christiano R, Walther T, Burd C. A mechanism for retromer endosomal coat complex assembly with cargo. Proc Natl Acad Sci U S A. 2014;111:267-72 pubmed publisher
    ..that membrane recruitment of retromer is mediated by bivalent recognition of an effector of PI3K, SNX3, and the RAB7A GTPase, by the VPS35 retromer subunit...
  10. Lizaso A, Tan K, Lee Y. ?-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation. Autophagy. 2013;9:1228-43 pubmed publisher
    ..a marked increase in the autophagy-targeted LDs for lysosomal degradation, which is dependent on the LD-associated RAB7 as evidenced by the use of both shRNA-mediated RAB7 knockdown and a dominant-negative RAB7 mutant...
  11. Wang T, Hong W. RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment. Biochem Biophys Res Commun. 2006;350:413-23 pubmed
    RILP is emerging as a key regulator of late endocytic pathway by functioning as a downstream effector of activated Rab7 and Rab34, while ESCRT-I-->ESCRT-II-->ESCRT-III machinery acts in sorting proteins to the multivesicular body (..
  12. Bucci C, Frunzio R, Chiariotti L, Brown A, Rechler M, Bruni C. A new member of the ras gene superfamily identified in a rat liver cell line. Nucleic Acids Res. 1988;16:9979-93 pubmed
    ..The BRL-ras gene is present in single copy in the rat genome and is ubiquitously expressed at high levels in all tissues and cell lines examined. ..
  13. Morvan J, Köchl R, Watson R, Collinson L, Jefferies H, Tooze S. In vitro reconstitution of fusion between immature autophagosomes and endosomes. Autophagy. 2009;5:676-89 pubmed
    ..This fusion and maturation requires proteins also involved in endosome maturation such as Rab7. However, it is not known if there are molecular requirements unique to AVi-endosome fusion...
  14. Caillet M, Janvier K, Pelchen Matthews A, Delcroix Genête D, Camus G, Marsh M, et al. Rab7A is required for efficient production of infectious HIV-1. PLoS Pathog. 2011;7:e1002347 pubmed publisher
    ..virological tests and RNA interference targeting Rab proteins, we demonstrate that the late endosome-associated Rab7A is required for HIV-1 propagation...
  15. Ha S, Park S, Han C, Nguyen M, Kim S. Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol. 2012;32:4846-60 pubmed publisher
    ..This study demonstrates for the first time that MLN64 plays a key role in LeTx/caspase-1-induced mitochondrial dysfunction...
  16. Seaman M, Harbour M, Tattersall D, Read E, Bright N. Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. J Cell Sci. 2009;122:2371-82 pubmed publisher
    ..In this study we show that the VPS35/29/26 complex interacts with the small GTPase Rab7 and requires Rab7 for its recruitment to the endosome...
  17. Qin Y, Deng Y, Ricketts C, Srikantan S, Wang E, Maher E, et al. The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function. Hum Mol Genet. 2014;23:2428-39 pubmed publisher
    ..Our data map the tumor-suppressive properties of TMEM127 to modulation of mTOR function in the endolysosome, a feature that may contribute to both pheochromocytoma and RCC pathogenesis. ..
  18. Schaheen B, Dang H, Fares H. Derlin-dependent accumulation of integral membrane proteins at cell surfaces. J Cell Sci. 2009;122:2228-39 pubmed publisher
  19. Sun Y, Buki K, Ettala O, Vääräniemi J, Vaananen H. Possible role of direct Rac1-Rab7 interaction in ruffled border formation of osteoclasts. J Biol Chem. 2005;280:32356-61 pubmed
    b>Rab7 has been shown to regulate the late steps of the endocytic pathway. In bone-resorbing osteoclasts, it is involved in formation of the ruffled border, which is a late endosomal-like compartment in the plasma membrane...
  20. Follett J, Bugarcic A, Yang Z, Ariotti N, Norwood S, Collins B, et al. Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces ?-Synuclein Aggregation. J Biol Chem. 2016;291:18283-98 pubmed publisher
  21. Mousa S, Shaqura M, Khalefa B, Zöllner C, Schaad L, Schneider J, et al. Rab7 silencing prevents ?-opioid receptor lysosomal targeting and rescues opioid responsiveness to strengthen diabetic neuropathic pain therapy. Diabetes. 2013;62:1308-19 pubmed publisher
    ..This study investigated whether enhanced Rab7-mediated lysosomal targeting of peripheral sensory neuron ?-opioid receptors (MORs) is responsible for diminished ..
  22. Yuasa K, Yamagami S, Nagahama M, Tsuji A. Trafficking of cGMP-dependent protein kinase II via interaction with Rab11. Biochem Biophys Res Commun. 2008;374:522-6 pubmed publisher
    ..These data indicate that Rab11b is necessary for the trafficking of cGK-II and that the cGMP/cGK-II signaling pathway is closely related to Rab11b recycling pathway. ..
  23. Lin W, Yang C, Li L, Yi Y, Chen K, Lin Y, et al. Lysosomal targeting of phafin1 mediated by Rab7 induces autophagosome formation. Biochem Biophys Res Commun. 2012;417:35-42 pubmed publisher
    ..of phafin1 provides lysosomal targeting signature and the ability to induce autophagy that is mediated by Rab7 signaling...
  24. Sender V, Moulakakis C, Stamme C. Pulmonary surfactant protein A enhances endolysosomal trafficking in alveolar macrophages through regulation of Rab7. J Immunol. 2011;186:2397-411 pubmed publisher
    ..In this article, we show that SP-A specifically and transiently enhances the protein expression of endogenous Rab7 and Rab7b, but not Rab5 and Rab11, in primary AM from rats and mice...
  25. Tsuji A, Sugyo A, Ogiu T, Sagara M, Kimura T, Ishikawa A, et al. Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines. Genomics. 2005;86:271-9 pubmed
    ..We mapped seven positional candidate genes, Bmp10, Gpr73, Gp9, Cnbp, Copg, Rab7, and Rpn1, to an approximately 1.2-Mb region located between loci D4Got85 and D4Got148 on chromosome 4...
  26. Mayer P, Huang N, Dewey C, Dries D, Zhang H, Yu G. Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2. J Biol Chem. 2010;285:40387-96 pubmed publisher
    ..In HeLa cells, in addition to Golgi, Nmnat2 localizes to Rab7-containing late endosomes...
  27. Guo Z, Wu Y, Das D, Delon C, Cramer J, Yu S, et al. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J. 2008;27:2444-56 pubmed publisher
    ..RabGGTase in complex with phosphoisoprenoids as well as with the prenylated peptides that mimic the C terminus of Rab7 GTPase...
  28. Geetha T, Wooten M. TrkA receptor endolysosomal degradation is both ubiquitin and proteasome dependent. Traffic. 2008;9:1146-56 pubmed publisher
    ..Taken together, our results reveal the existence of a novel proteasome-dependent step in receptor degradation. ..
  29. Fossale E, Wolf P, Espinola J, Lubicz Nawrocka T, Teed A, Gao H, et al. Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis. BMC Neurosci. 2004;5:57 pubmed
    ..Moreover, these deficiencies are likely to be early events in the JNCL disease process and may particularly impact neuronal survival. ..
  30. Yamaguchi H, Nakagawa I, Yamamoto A, Amano A, Noda T, Yoshimori T. An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. PLoS Pathog. 2009;5:e1000670 pubmed publisher
    ..Expression of a dominant-negative form of Rab7 or RNAi-mediated knockdown of Rab7 prevented the initial formation of small GcAV structures...
  31. Mascia A, Gentile F, Izzo A, Mollo N, De Luca M, Bucci C, et al. Rab7 Regulates CDH1 Endocytosis, Circular Dorsal Ruffles Genesis, and Thyroglobulin Internalization in a Thyroid Cell Line. J Cell Physiol. 2016;231:1695-708 pubmed publisher
    b>Rab7 regulates the biogenesis of late endosomes, lysosomes, and autophagosomes. It has been proposed that a functional and physical interaction exists between Rab7 and Rac1 GTPases in CDH1 endocytosis and ruffled border formation...
  32. Pavlos N, Gr Nborg M, Riedel D, Chua J, Boyken J, Kloepper T, et al. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. J Neurosci. 2010;30:13441-53 pubmed publisher
    ..Finally, we demonstrate that selective modulation of the GTP/GDP switch mechanism of Rab27b impairs SV recycling, suggesting that Rab27b, probably in concert with Rab3s, is involved in SV exocytosis...
  33. Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand Brustel Y. A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic. Proc Natl Acad Sci U S A. 2001;98:1637-42 pubmed
    ..We propose that Rabip4, an effector of Rab4, controls early endosomal traffic possibly by activating a backward transport step from recycling to sorting endosomes. ..
  34. Wasano K, Hirakawa Y. Lamellar bodies of rat alveolar type 2 cells have late endosomal marker proteins on their limiting membranes. Histochemistry. 1994;102:329-35 pubmed