Gene Symbol: Rab4a
Description: RAB4A, member RAS oncogene family
Alias: Rab4, ras-related protein Rab-4A, Ras-related small GTP binding protein 4
Species: rat
Products:     Rab4a

Top Publications

  1. Cormont M, Tanti J, Zahraoui A, Van Obberghen E, Tavitian A, Le Marchand Brustel Y. Insulin and okadaic acid induce Rab4 redistribution in adipocytes. J Biol Chem. 1993;268:19491-7 pubmed
    ..Rab3B, Rab3C, Rab4, and Rab8 were detected, but Rab3A was not...
  2. Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand Brustel Y. A FYVE-finger-containing protein, Rabip4, is a Rab4 effector involved in early endosomal traffic. Proc Natl Acad Sci U S A. 2001;98:1637-42 pubmed
    The small GTPase Rab4 is implicated in endocytosis in all cell types, but also plays a specific role in some regulated processes...
  3. Li L, Omata W, Kojima I, Shibata H. Direct interaction of Rab4 with syntaxin 4. J Biol Chem. 2001;276:5265-73 pubmed
    In the present study, we examined the possible interaction between Rab4 and syntaxin 4, both having been implicated in insulin-induced GLUT4 translocation...
  4. Zaid H, Antonescu C, Randhawa V, Klip A. Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem J. 2008;413:201-15 pubmed publisher
  5. Watson R, Pessin J. GLUT4 translocation: the last 200 nanometers. Cell Signal. 2007;19:2209-17 pubmed
    ..Future work will focus on identifying the key insulin targets that regulate the GLUT4 docking/fusion processes. ..
  6. Roosterman D, Cottrell G, Schmidlin F, Steinhoff M, Bunnett N. Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases. J Biol Chem. 2004;279:30670-9 pubmed
    ..NK1R translocated from superficial early endosomes to recycling endosomes containing Rab4a and Rab11a, and Rab11aS25N inhibited NK1R recycling...
  7. Potokar M, Lacovich V, Chowdhury H, Kreft M, Zorec R. Rab4 and Rab5 GTPase are required for directional mobility of endocytic vesicles in astrocytes. Glia. 2012;60:594-604 pubmed publisher
    b>Rab4 and Rab5 GTPases are key players in the regulation of endocytosis. Although their role has been studied intensively in the past, it is still unclear how they regulate vesicle mobility...
  8. Peng H, Chen G, Hsieh M, Lai C, Huang Y, Lin T. Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund's adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats. Pain. 2012;153:2380-92 pubmed publisher
    ..kinase 1 (SGK1) and downstream glutamate receptor interacting protein (GRIP)-associated protein-1 (GRASP-1)/Rab4-dependent GluR1-containing ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) recycling play a ..
  9. Kuijl C, Pilli M, Alahari S, Janssen H, Khoo P, Ervin K, et al. Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria. EMBO J. 2013;32:713-27 pubmed publisher
    ..Here, we identify Nischarin as a novel dual effector that can interact with members of Rac and Rab GTPase (Rab4, Rab14 and Rab9) families at different endosomal compartments...

More Information


  1. Ricort J, Tanti J, Cormont M, Van Obberghen E, Le Marchand Brustel Y. Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states. FEBS Lett. 1994;347:42-4 pubmed
    Insulin-induced Glut 4 and Rab4 movements were studied in two insulin-resistant states. In adipocytes from streptozotocin diabetic rats, the amount of Glut 4 was decreased by 60%...
  2. Zahraoui A, Touchot N, Chardin P, Tavitian A. Complete coding sequences of the ras related rab 3 and 4 cDNAs. Nucleic Acids Res. 1988;16:1204 pubmed
  3. Shibata H, Omata W, Kojima I. Insulin stimulates guanine nucleotide exchange on Rab4 via a wortmannin-sensitive signaling pathway in rat adipocytes. J Biol Chem. 1997;272:14542-6 pubmed
    b>Rab4, a member of the Rab family of Ras-related small GTP-binding proteins, has been shown to be associated with GLUT4-containing vesicles and implicated in the insulin action on glucose transport in rat adipocytes...
  4. Verges M, Havel R, Mostov K. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Proc Natl Acad Sci U S A. 1999;96:10146-51 pubmed
  5. Cussac D, Leblanc P, L Heritier A, Bertoglio J, Lang P, Kordon C, et al. Rho proteins are localized with different membrane compartments involved in vesicular trafficking in anterior pituitary cells. Mol Cell Endocrinol. 1996;119:195-206 pubmed
    ..Rab1 and rab2 were localized in both Golgi and endoplasmic reticulum (ER) membranes, while rab4 and rab6 were found in fractions enriched with Golgi and plasma membranes, implicating these proteins in the ..
  6. Etzion S, Etzion Y, DeBosch B, Crawford P, Muslin A. Akt2 deficiency promotes cardiac induction of Rab4a and myocardial ?-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010;49:931-40 pubmed publisher
    ..Expression profiling of akt2(-/-) myocardium revealed that Rab4a, a GTPase involved in glucose transporter 4 translocation and ?-adrenergic receptor (?AR) recycling to the plasma ..
  7. Hoogenraad C, Popa I, Futai K, Martinez Sanchez E, Sanchez Martinez E, Wulf P, et al. Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. PLoS Biol. 2010;8:e1000283 pubmed publisher
    ..Here, we identify GRIP-associated protein-1 (GRASP-1) as a neuron-specific effector of Rab4 and key component of the molecular machinery that coordinates recycling endosome maturation in dendrites...
  8. Martínez Turrillas R, Del Rio J, Frechilla D. Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs. Biochem Biophys Res Commun. 2007;353:750-5 pubmed
    ..Paroxetine increased the interaction of GluR1 with Rab4A, and desipramine markedly increased the interaction of GluR1 with SAP97...
  9. Liu W, Yuen E, Yan Z. The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex. J Biol Chem. 2010;285:6101-8 pubmed publisher
    ..This enhancing effect of corticosterone is through a mechanism dependent on Rab4, the small GTPase-controlling receptor recycling between early endosome and plasma membrane...
  10. Kaddai V, Gonzalez T, Keslair F, Gremeaux T, Bonnafous S, Gugenheim J, et al. Rab4b is a small GTPase involved in the control of the glucose transporter GLUT4 localization in adipocyte. PLoS ONE. 2009;4:e5257 pubmed publisher
    Endosomal small GTPases of the Rab family, among them Rab4a, play an essential role in the control of the glucose transporter GLUT4 trafficking, which is essential for insulin-mediated glucose uptake...
  11. Chichger H, Braza J, Duong H, Stark M, Harrington E. Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. Am J Physiol Lung Cell Mol Physiol. 2015;309:L700-9 pubmed publisher
    ..barrier integrity is vital in neovascularization, we sought to elucidate the role for endosome proteins p18 and Rab4, Rab7, and Rab9 in the process of vessel formation within the pulmonary vasculature...
  12. Schindler C, Chen Y, Pu J, Guo X, Bonifacino J. EARP is a multisubunit tethering complex involved in endocytic recycling. Nat Cell Biol. 2015;17:639-50 pubmed publisher
    ..Depletion of syndetin or syntaxin 6 delays recycling of internalized transferrin to the cell surface. These findings implicate EARP in canonical membrane-fusion events in the process of endocytic recycling. ..
  13. Touchot N, Chardin P, Tavitian A. Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library. Proc Natl Acad Sci U S A. 1987;84:8210-4 pubmed
    ..Amino acid homology scores with YPT range from 75% for rab1 to 37% for rab4, whereas the homologies with p21 ras and other ras-related proteins are approximately equal to 30%, and homologous ..
  14. Yuasa K, Yamagami S, Nagahama M, Tsuji A. Trafficking of cGMP-dependent protein kinase II via interaction with Rab11. Biochem Biophys Res Commun. 2008;374:522-6 pubmed publisher
    ..These data indicate that Rab11b is necessary for the trafficking of cGK-II and that the cGMP/cGK-II signaling pathway is closely related to Rab11b recycling pathway. ..
  15. Kaddai V, Le Marchand Brustel Y, Cormont M. Rab proteins in endocytosis and Glut4 trafficking. Acta Physiol (Oxf). 2008;192:75-88 pubmed publisher
  16. Eathiraj S, Pan X, Ritacco C, Lambright D. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature. 2005;436:415-9 pubmed
  17. Huber S, Scheidig A. High resolution crystal structures of human Rab4a in its active and inactive conformations. FEBS Lett. 2005;579:2821-9 pubmed
    The Ras-related human GTPase Rab4a is involved in the regulation of endocytosis through the sorting and recycling of early endosomes...
  18. Nashida T, Yoshie S, Imai A, Shimomura H. Co-localization of rab4 with endocytosis-related proteins in the rat parotid glands. Arch Histol Cytol. 2003;66:45-52 pubmed
    ..We investigated the localization of Rab4 in the rat parotid glands by Western blotting and light-microscopic immunohistochemistry...
  19. Han S, Park D, Park S, Hong S. Identification of Rab6 as an N-ethylmaleimide-sensitive fusion protein-binding protein. Biochem J. 2000;352 Pt 1:165-73 pubmed
    ..Furthermore, we found that Rab3 and Rab4 can also associate with NSF and stimulate its ATPase activity...
  20. Sherman L, Hirshman M, Cormont M, Le Marchand Brustel Y, Goodyear L. Differential effects of insulin and exercise on Rab4 distribution in rat skeletal muscle. Endocrinology. 1996;137:266-73 pubmed
    ..The purpose of this study was to determine if Rab4, a small GTP binding protein that has been implicated in the insulin-stimulated translocation of GLUT4 in adipose ..
  21. Uphues I, Kolter T, Goud B, Eckel J. Insulin-induced translocation of the glucose transporter GLUT4 in cardiac muscle: studies on the role of small-molecular-mass GTP-binding proteins. Biochem J. 1994;301 ( Pt 1):177-82 pubmed
    ..of microsomal membranes with a panel of antisera against rab GTP-binding proteins indicated the presence of rab4A, with a molecular mass of 24 kDa, whereas rab1A, rab2 and rab6 were not observed...
  22. Uphues I, Kolter T, Goud B, Eckel J. Failure of insulin-regulated recruitment of the glucose transporter GLUT4 in cardiac muscle of obese Zucker rats is associated with alterations of small-molecular-mass GTP-binding proteins. Biochem J. 1995;311 ( Pt 1):161-6 pubmed
    ..addition to the translocation of GLUT4, insulin was found to promote the movement of the small GTP-binding protein rab4A from the cytosol (decrease to 61 +/- 13% of control) to the plasma membrane (increase to 177 +/- 19% of control) ..
  23. Mruk D, Lau A, Sarkar O, Xia W. Rab4A GTPase catenin interactions are involved in cell junction dynamics in the testis. J Androl. 2007;28:742-54 pubmed
    ..In this report, we show that Rab4A associates with adherens junction signaling proteins in the testis...