Gene Symbol: Rab3gap2
Description: RAB3 GTPase activating non-catalytic protein subunit 2
Alias: RGD1311518, rab3 GTPase-activating protein non-catalytic subunit, RAB3 GTPase activating protein subunit 2, RAB3-GAP150, rab3 GTPase-activating protein 150 kDa subunit, rab3-GAP p150, rab3-GAP regulatory subunit
Nagano F, Sasaki T, Fukui K, Asakura T, Imazumi K, Takai Y. Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein. J Biol Chem. 1998;273:24781-5 pubmed
..When p150 and p130 were co-expressed in the cells, the subcellular localization of each protein did not change. These results indicate that p150 is the noncatalytic subunit of Rab3 GAP. ..
Lee N, Weinstock K, Kirkness E, Earle Hughes J, Fuldner R, Marmaros S, et al
. Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment. Proc Natl Acad Sci U S A. 1995;92:8303-7 pubmed
Nagano F, Kawabe H, Nakanishi H, Shinohara M, Deguchi Tawarada M, Takeuchi M, et al
. Rabconnectin-3, a novel protein that binds both GDP/GTP exchange protein and GTPase-activating protein for Rab3 small G protein family. J Biol Chem. 2002;277:9629-32 pubmed
..These results indicate that rabconnectin-3 serves as a scaffold molecule for both Rab3 GEP and GAP on synaptic vesicles. ..
Gerondopoulos A, Bastos R, Yoshimura S, Anderson R, Carpanini S, Aligianis I, et al
. Rab18 and a Rab18 GEF complex are required for normal ER structure. J Cell Biol. 2014;205:707-20 pubmed publisher
..Disease-associated point mutations of conserved residues in either the Rab3GAP1 (T18P and E24V) or Rab3GAP2 (R426C) subunits result in loss of the Rab18 GEF and membrane-targeting activities...
Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, et al
. RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. Autophagy. 2014;10:2297-309 pubmed publisher
..Employing C. elegans and human primary fibroblasts, we show that RAB3GAP1 and RAB3GAP2, which are components of the TBC domain-free RAB3GAP complex, influence protein aggregation and affect autophagy ..