Gene Symbol: Rab35
Description: RAB35, member RAS oncogene family
Alias: ras-related protein Rab-35
Rahajeng J, Giridharan S, Cai B, Naslavsky N, Caplan S. MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. Traffic. 2012;13:82-93 pubmed publisher
..First, we demonstrate that Rab35 is a MICAL-L1-binding partner in vivo...
Kobayashi H, Fukuda M. Rab35 regulates Arf6 activity through centaurin-?2 (ACAP2) during neurite outgrowth. J Cell Sci. 2012;125:2235-43 pubmed publisher
..Although Rab35 and Arf6 were independently reported to regulate the same cellular events, including endocytic recycling, ..
Etoh K, Fukuda M. Structure-function analyses of the small GTPase Rab35 and its effector protein centaurin-Î²2/ACAP2 during neurite outgrowth of PC12 cells. J Biol Chem. 2015;290:9064-74 pubmed publisher
The small GTPase Rab35 is a molecular switch for membrane trafficking that regulates a variety of cellular events...
Pavlos N, Gr Nborg M, Riedel D, Chua J, Boyken J, Kloepper T, et al
. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. J Neurosci. 2010;30:13441-53 pubmed publisher
..Finally, we demonstrate that selective modulation of the GTP/GDP switch mechanism of Rab27b impairs SV recycling, suggesting that Rab27b, probably in concert with Rab3s, is involved in SV exocytosis...
Sheehan P, Zhu M, Beskow A, Vollmer C, Waites C. Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway. J Neurosci. 2016;36:8668-86 pubmed publisher
..proteins and that the endosomal sorting complex required for transport (ESCRT) machinery and SV-associated GTPase Rab35 are key elements of this use-dependent degradative pathway...
Chevallier J, Koop C, Srivastava A, Petrie R, Lamarche Vane N, Presley J. Rab35 regulates neurite outgrowth and cell shape. FEBS Lett. 2009;583:1096-101 pubmed publisher
Recent studies have identified Rab35 in the endocytic pathway and as a regulator of cytokinesis; however its molecular mechanisms are currently unknown...
Kobayashi H, Etoh K, Fukuda M. Rab35 is translocated from Arf6-positive perinuclear recycling endosomes to neurite tips during neurite outgrowth. Small Gtpases. 2014;5:e29290 pubmed publisher
Small GTPase Rab35 is a key regulator of neurite outgrowth, and its activation dramatically enhances nerve growth factor (NGF)-induced neurite outgrowth...
Kobayashi H, Fukuda M. Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth. J Cell Sci. 2013;126:2424-35 pubmed publisher
..Here we report a molecular link between two gatekeepers for endocytic recycling, the molecular switch Rab35 and the molecular scissors EHD1, that is mediated by two distinct Rab35 effectors during neurite outgrowth of PC12 ..
Miyamoto Y, Yamamori N, Torii T, Tanoue A, Yamauchi J. Rab35, acting through ACAP2 switching off Arf6, negatively regulates oligodendrocyte differentiation and myelination. Mol Biol Cell. 2014;25:1532-42 pubmed publisher
..However, their intracellular signalings remain elusive. We show that Rab35 and its effector, ACAP2, a GTPase-activating protein that switches off Arf6 activity, negatively regulate ..