Rab27b

Summary

Gene Symbol: Rab27b
Description: RAB27B, member RAS oncogene family
Alias: ras-related protein Rab-27B
Species: rat
Products:     Rab27b

Top Publications

  1. Arimura N, Kimura T, Nakamuta S, Taya S, Funahashi Y, Hattori A, et al. Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Dev Cell. 2009;16:675-86 pubmed publisher
    ..However, the transport mechanism remains largely unknown. Here, we show that the Slp1/Rab27B/CRMP-2 complex directly links TrkB to Kinesin-1, and that this association is required for the anterograde ..
  2. Pavlos N, Gr Nborg M, Riedel D, Chua J, Boyken J, Kloepper T, et al. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. J Neurosci. 2010;30:13441-53 pubmed publisher
    ..immunoblotting and fluorescence microscopy, we have determined the exocytotic (Rab3a, Rab3b, Rab3c, and Rab27b) and endocytic (Rab4b, Rab5a/b, Rab10, Rab11b, and Rab14) Rab machinery of SVs...
  3. Westbroek W, Lambert J, De Schepper S, Kleta R, Van Den Bossche K, Seabra M, et al. Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. Pigment Cell Res. 2004;17:498-505 pubmed
    ..of functional Rab27a in melanocytes of this Griscelli patient is partially compensated by the up-regulation of Rab27b, a homologue of Rab27a...
  4. Kukimoto Niino M, Sakamoto A, Kanno E, Hanawa Suetsugu K, Terada T, Shirouzu M, et al. Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases. Structure. 2008;16:1478-90 pubmed publisher
    ..Mutations that disrupt the Rab27A/Slac2-a interaction cause human Griscelli syndrome. The other Rab27 isoform, Rab27B, also binds all of the known effectors of Rab27A...
  5. Chen D, Guo J, Miki T, Tachibana M, Gahl W. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. Biochem Mol Med. 1997;60:27-37 pubmed
    ..We isolated the complete cDNAs of two rab isoforms, rab27a and rab27b, from human melanoma cells and melanocytes, Rab27a is the human homolog of a rat megakaryocyte rab called ram p25...
  6. Chen X, Li C, Izumi T, Ernst S, Andrews P, Williams J. Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Biochem Biophys Res Commun. 2004;323:1157-62 pubmed
    ..Here we report the identification of Rab27b through this proteomics study and validate its role in granule function...
  7. Kondo H, Shirakawa R, Higashi T, Kawato M, Fukuda M, Kita T, et al. Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets. J Biol Chem. 2006;281:28657-65 pubmed
    ..Taken together, Rab27 is maintained in the active status in unstimulated platelets, which could function to keep dense granules in a preparative status for secretion. ..
  8. Imai A, Yoshie S, Nashida T, Shimomura H, Fukuda M. Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells. Arch Biochem Biophys. 2006;455:127-35 pubmed
    ..Our results suggest that the Noc2/Rab27 complex is an important constituent of the early stages of IPR-stimulated amylase release. ..
  9. Ejlerskov P, Christensen D, Beyaie D, Burritt J, Paclet M, Gorlach A, et al. NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages. J Biol Chem. 2012;287:4835-52 pubmed publisher

More Information

Publications13

  1. Kierszenbaum A, Tres L, Rivkin E, Kang Decker N, van Deursen J. The acroplaxome is the docking site of Golgi-derived myosin Va/Rab27a/b- containing proacrosomal vesicles in wild-type and Hrb mutant mouse spermatids. Biol Reprod. 2004;70:1400-10 pubmed
    ..We suggest that nucleopodes develop at a site where a keratin 5-deficient acroplaxome may not withstand tension forces operating during spermatid nuclear shaping. ..
  2. Imai A, Yoshie S, Nashida T, Shimomura H, Fukuda M. The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. J Cell Sci. 2004;117:1945-53 pubmed
    ..We show that Rab27B, a closely related isoform of Rab27A that regulates lysosome-related granule exocytosis in cytotoxic T lymphocytes,..
  3. Ostrowski M, Carmo N, Krumeich S, Fanget I, Raposo G, Savina A, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2010;12:19-30; sup pp 1-13 pubmed publisher
    ..Among these, Rab27a and Rab27b were found to function in MVE docking at the plasma membrane...
  4. Shen Y, Gu Y, Su W, Zhong J, Jin Z, Gu X, et al. Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes. Neurosci Bull. 2016;32:331-40 pubmed publisher
    ..Here, we demonstrated that a small GTPase, Rab27b, is involved in PLP trafficking in oligodendrocytes...