Rab1a

Summary

Gene Symbol: Rab1a
Description: RAB1A, member RAS oncogene family
Alias: Ac2-048, Rab1, Rab1r, ras-related protein Rab-1A, RAB1, member RAS oncogene family
Species: rat
Products:     Rab1a

Top Publications

  1. Preisinger C, Körner R, Wind M, Lehmann W, Kopajtich R, Barr F. Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling. EMBO J. 2005;24:753-65 pubmed
    ..These findings identify a Plk1-dependent signalling mechanism potentially linking Golgi structure and cell cycle control, but suggest that this may not be a cell cycle checkpoint in the classical sense. ..
  2. Beard M, Satoh A, Shorter J, Warren G. A cryptic Rab1-binding site in the p115 tethering protein. J Biol Chem. 2005;280:25840-8 pubmed
    ..At the cis-side of the Golgi, the Rab1 GTPase binds directly to each of three coiled-coil proteins: p115, GM130, and as now shown, Giantin...
  3. Diao A, Frost L, Morohashi Y, Lowe M. Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner. J Biol Chem. 2008;283:6957-67 pubmed publisher
    ..The interaction between GM130 and the small GTPase Rab1 is also inhibited by p115 binding...
  4. Mukhopadhyay A, Nieves E, Che F, Wang J, Jin L, Murray J, et al. Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles. J Cell Sci. 2011;124:765-75 pubmed publisher
    ..Several Rab GTPases, including Rab1a, were found...
  5. Wang C, Yoo Y, Fan H, Kim E, Guan K, Guan J. Regulation of Integrin ? 1 recycling to lipid rafts by Rab1a to promote cell migration. J Biol Chem. 2010;285:29398-405 pubmed publisher
    b>Rab1a is a member of the Rab family of small GTPases with a well characterized function in the regulation of vesicle trafficking from the endoplasmic reticulum to the Golgi apparatus and within Golgi compartments...
  6. Dong N, Zhu Y, Lu Q, Hu L, Zheng Y, Shao F. Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses. Cell. 2012;150:1029-41 pubmed publisher
    ..Specific inactivation of Rab1 by VirA/EspG disrupts ER-to-Golgi trafficking. S...
  7. Ishida M, Ohbayashi N, Maruta Y, Ebata Y, Fukuda M. Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes. J Cell Sci. 2012;125:5177-87 pubmed publisher
    ..transport by expressing 60 different constitutive active (and negative) mutants, and succeeded in identifying Rab1A, originally described as a Golgi-resident Rab, as a prime candidate...
  8. Haas A, Yoshimura S, Stephens D, Preisinger C, Fuchs E, Barr F. Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells. J Cell Sci. 2007;120:2997-3010 pubmed
    ..TBC1D20 is the ER-localized GAP for Rab1, and is the only GAP blocking the delivery of secretory cargo from the ER to the cell surface...
  9. Yin H, Li Q, Qian G, Wang Y, Li Y, Wu G, et al. Rab1 GTPase regulates phenotypic modulation of pulmonary artery smooth muscle cells by mediating the transport of angiotensin II type 1 receptor under hypoxia. Int J Biochem Cell Biol. 2011;43:401-8 pubmed publisher
    Previous studies have demonstrated that Rab1 is involved in the export of angiotensin II (Ang II) type 1 receptor (AT1R) to the cell surface in endothelial cells and cardiomyocytes...

More Information

Publications20

  1. Cussac D, Leblanc P, L Heritier A, Bertoglio J, Lang P, Kordon C, et al. Rho proteins are localized with different membrane compartments involved in vesicular trafficking in anterior pituitary cells. Mol Cell Endocrinol. 1996;119:195-206 pubmed
    ..They were found in both membrane and cytosolic fractions. Rab1 and rab2 were localized in both Golgi and endoplasmic reticulum (ER) membranes, while rab4 and rab6 were found in ..
  2. Hyvola N, Diao A, McKenzie E, Skippen A, Cockcroft S, Lowe M. Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases. EMBO J. 2006;25:3750-61 pubmed
    ..Strongest interaction is seen with Golgi-associated rab1 and rab6 and endosomal rab5...
  3. Huang W, Wu G, Wang G. Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas. Vis Neurosci. 2009;26:443-52 pubmed publisher
    The Ras-like Rab1 and Rab6 GTPases modulate protein traffic along the early secretory pathway and are involved in the regulation of maturation of rhodopsin in the outer retina...
  4. Liu X, Wang Z, Yang Y, Li Q, Zeng R, Kang J, et al. Rab1A mediates proinsulin to insulin conversion in ?-cells by maintaining Golgi stability through interactions with golgin-84. Protein Cell. 2016;7:692-6 pubmed publisher
  5. Loh E, Peter F, Subramaniam V, Hong W. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus. J Cell Sci. 2005;118:1209-22 pubmed
    ..We also show that Bet3 acts after COPII but before Rab1, alpha-SNAP and the EGTA-sensitive stage during ER-Golgi transport...
  6. Fischer J, Weide T, Barnekow A. The MICAL proteins and rab1: a possible link to the cytoskeleton?. Biochem Biophys Res Commun. 2005;328:415-23 pubmed
    The small GTPase rab1 plays a role in vesicle trafficking between ER and the Golgi complex. Recently, MICAL-1 was identified as new rab1 interacting protein...
  7. Touchot N, Chardin P, Tavitian A. Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library. Proc Natl Acad Sci U S A. 1987;84:8210-4 pubmed
    ..of the ras superfamily, we screened a rat brain cDNA library with these probes and isolated four genes, denoted rab1, -2, -3, and -4, encoding proteins homologous to the yeast YPT protein...
  8. Li Y, Wang G, Lin K, Yin H, Zhou C, Liu T, et al. Rab1 GTPase promotes expression of beta-adrenergic receptors in rat pulmonary microvascular endothelial cells. Int J Biochem Cell Biol. 2010;42:1201-1209 pubmed publisher
    It is known that Rab1 regulates the expression and function of beta-adrenoceptors (beta-ARs) in many cells. However, the effect of these changes in rat pulmonary microvascular endothelial cells (RPMVECs) is not known...
  9. Pavlos N, Gr Nborg M, Riedel D, Chua J, Boyken J, Kloepper T, et al. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. J Neurosci. 2010;30:13441-53 pubmed publisher
    ..Finally, we demonstrate that selective modulation of the GTP/GDP switch mechanism of Rab27b impairs SV recycling, suggesting that Rab27b, probably in concert with Rab3s, is involved in SV exocytosis...
  10. Zenner H, Yoshimura S, Barr F, Crump C. Analysis of Rab GTPase-activating proteins indicates that Rab1a/b and Rab43 are important for herpes simplex virus 1 secondary envelopment. J Virol. 2011;85:8012-21 pubmed publisher
    ..We identified that TBC1D20 and RN-tre and their partner Rabs, Rab1a/b and Rab43, respectively, are important for virion assembly...
  11. Krijnse Locker J, Parton R, Fuller S, Griffiths G, Dotti C. The organization of the endoplasmic reticulum and the intermediate compartment in cultured rat hippocampal neurons. Mol Biol Cell. 1995;6:1315-32 pubmed
    ..We also analyzed the location of rab1, rab2, p58, the KDEL receptor, and beta-subunit of coatomer...