Gene Symbol: Rab11b
Description: RAB11B, member RAS oncogene family
Alias: ras-related protein Rab-11B
Species: rat
Products:     Rab11b

Top Publications

  1. Balse E, El Haou S, Dillanian G, Dauphin A, Eldstrom J, Fedida D, et al. Cholesterol modulates the recruitment of Kv1.5 channels from Rab11-associated recycling endosome in native atrial myocytes. Proc Natl Acad Sci U S A. 2009;106:14681-6 pubmed publisher
    ..This process could be a major mechanism for the tuning of cardiac electrical properties and might contribute to the understanding of cardiac effects of lipid-lowering drugs. ..
  2. Zhao H, Ettala O, Vaananen H. Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins. Biochem Biophys Res Commun. 2002;293:1060-5 pubmed
    ..Rab1B, rab4B, rab5C, rab7, rab9, rab11B, and rab35 were identified from rat osteoclasts in this study...
  3. Hong W, Amara S. Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB J. 2013;27:2995-3007 pubmed publisher
  4. Schlierf B, Fey G, Hauber J, Hocke G, Rosorius O. Rab11b is essential for recycling of transferrin to the plasma membrane. Exp Cell Res. 2000;259:257-65 pubmed
    ..The Rab11 subfamily consists of two highly conserved members, Rab11a and Rab11b. Rab11a has been localized both to the pericentriolar recycling endosome and to the trans-Golgi network and ..
  5. Yuasa K, Yamagami S, Nagahama M, Tsuji A. Trafficking of cGMP-dependent protein kinase II via interaction with Rab11. Biochem Biophys Res Commun. 2008;374:522-6 pubmed publisher
    ..proteins that are involved in cGMP/cGK-II signaling, we performed yeast two-hybrid screening and identified Rab11b as a cGK-II-interacting protein that regulates the slow-recycling pathway...
  6. Zhao Z, Sagare A, Ma Q, Halliday M, Kong P, Kisler K, et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015;18:978-87 pubmed publisher
    ..Thus, PICALM regulates Aβ BBB transcytosis and clearance, which has implications for Aβ brain homeostasis and clearance therapy. ..
  7. Khvotchev M, Ren M, Takamori S, Jahn R, Sudhof T. Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis. J Neurosci. 2003;23:10531-9 pubmed
    ..b>Rab11b, which is enriched in brain, had the strongest effect...
  8. Scapin S, Carneiro F, Alves A, Medrano F, Guimarães B, Zanchin N. The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform. J Struct Biol. 2006;154:260-8 pubmed
    ..The Rab11 subfamily members, comprising Rab11a, Rab11b, and Rab25, act in recycling of proteins from the endosomes to the plasma membrane, in transport of molecules from ..
  9. Takamori S, Holt M, Stenius K, Lemke E, Gr Nborg M, Riedel D, et al. Molecular anatomy of a trafficking organelle. Cell. 2006;127:831-46 pubmed publisher

More Information


  1. Silvis M, Bertrand C, Ameen N, Golin Bisello F, Butterworth M, Frizzell R, et al. Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells. Mol Biol Cell. 2009;20:2337-50 pubmed publisher
    ..Western blotting of immunoisolated Rab11a or Rab11b vesicles revealed localization of endogenous CFTR within both compartments...
  2. Oehlke O, Martin H, Osterberg N, Roussa E. Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts. J Cell Physiol. 2011;226:638-51 pubmed publisher
    ..The results show that Rab11b is expressed in salivary ducts and exhibits a significantly higher co-localization with V-ATPase than Rab11a and ..
  3. Beaumont K, Hamilton N, Moores M, Brown D, Ohbayashi N, Cairncross O, et al. The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. Traffic. 2011;12:627-43 pubmed publisher
    ..Our findings reveal new functions for RE and Rab17 in pigmentation through a distal step in the process of melanosome release via filopodia. ..
  4. Lamothe S, Zhang S. The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11. J Biol Chem. 2013;288:15075-84 pubmed publisher
    ..These results show that SGK enhances the expression level of mature hERG channels by inhibiting Nedd4-2 as well as by promoting Rab11-mediated hERG recycling. ..
  5. Sugawara K, Shibasaki T, Mizoguchi A, Saito T, Seino S. Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis. Genes Cells. 2009;14:445-56 pubmed publisher
    ..In the present study, we examined the roles of Rab11B and its effectors in insulin secretion in pancreatic beta-cells...