Rab10

Summary

Gene Symbol: Rab10
Description: RAB10, member RAS oncogene family
Alias: Ac1075, ras-related protein Rab-10, ras-related protein rab10
Species: rat
Products:     Rab10

Top Publications

  1. Sano H, Eguez L, Teruel M, Fukuda M, Chuang T, Chavez J, et al. Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell Metab. 2007;5:293-303 pubmed
    ..Here we show that Rab10 functions as a downstream target of AS160 in the insulin-signaling pathway that regulates GLUT4 translocation in ..
  2. Babbey C, Ahktar N, Wang E, Chen C, Grant B, Dunn K. Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2006;17:3156-75 pubmed
    b>Rab10, a protein originally isolated from Madin-Darby Canine Kidney (MDCK) epithelial cells, belongs to a family of Rab proteins that includes Rab8 and Rab13...
  3. Schuck S, Gerl M, Ang A, Manninen A, Keller P, Mellman I, et al. Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells. Traffic. 2007;8:47-60 pubmed
    ..To identify more of the molecular machinery involved, we investigated the function of the small GTPase Rab10 in polarized epithelial Madin-Darby canine kidney cells...
  4. English A, Voeltz G. Rab10 GTPase regulates ER dynamics and morphology. Nat Cell Biol. 2013;15:169-78 pubmed publisher
    We have identified Rab10 as an ER-specific Rab GTPase that regulates ER structure and dynamics...
  5. Klip A, Sun Y, Chiu T, Foley K. Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation. Am J Physiol Cell Physiol. 2014;306:C879-86 pubmed publisher
    ..Finally, we illustrate how actin filaments interact with myosin 1c and ?-Actinin4 to promote vesicle tethering as preamble to fusion with the membrane...
  6. Xu X, Deng C, Liu Y, He M, Peng J, Wang T, et al. MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development. Cell Res. 2014;24:576-94 pubmed publisher
    Axon development requires membrane addition from the intracellular supply, which has been shown to be mediated by Rab10-positive plasmalemmal precursor vesicles (PPVs)...
  7. Chen Y, Holcomb C, Moore H. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. Proc Natl Acad Sci U S A. 1993;90:6508-12 pubmed
    ..In mammals, Rab8 and Rab10 are the two small GTP-binding proteins identified so far that are closest to SEC4, an essential gene product ..
  8. Chen Y, Wang Y, Zhang J, Deng Y, Jiang L, Song E, et al. Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol. 2012;198:545-60 pubmed publisher
    ..TIRF) microscopy and an insulin-responsive aminopeptidase (IRAP)-pHluorin fusion assay, we demonstrated that Rab10 directly facilitated GSV translocation to and docking at the PM...
  9. Elferink L, Anzai K, Scheller R. rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain. J Biol Chem. 1992;267:5768-75 pubmed
    ..related to members of the rab3 subfamily, whereas two others are assigned as the rat homologs of canine rab8 and rab10. Four additional clones, rab12, rab13, rab14, and rab15, revealed unique sequences and are new members of the rab ..

More Information

Publications18

  1. Gerondopoulos A, Bastos R, Yoshimura S, Anderson R, Carpanini S, Aligianis I, et al. Rab18 and a Rab18 GEF complex are required for normal ER structure. J Cell Biol. 2014;205:707-20 pubmed publisher
    ..Micro syndrome is therefore a disease characterized by direct loss of Rab18 function or loss of Rab18 activation at the ER by its GEF Rab3GAP. ..
  2. Babbey C, Bacallao R, Dunn K. Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. Am J Physiol Renal Physiol. 2010;299:F495-506 pubmed publisher
    b>Rab10, a mammalian homolog of the yeast Sec4p protein, has previously been associated with endocytic recycling and biosynthetic membrane transport in cultured epithelia and with Glut4 translocation in adipocytes...
  3. Larance M, Ramm G, James D. The GLUT4 code. Mol Endocrinol. 2008;22:226-33 pubmed
    ..Many are now taking on this challenge. ..
  4. Wang T, Liu Y, Xu X, Deng C, Wu K, Zhu J, et al. Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization. Dev Cell. 2011;21:431-44 pubmed publisher
    ..Interestingly, Lgl1 interacted with and activated Rab10, a small GTPase that mediates membrane protein trafficking, by releasing GDP dissociation inhibitor (GDI) from ..
  5. Kaddai V, Le Marchand Brustel Y, Cormont M. Rab proteins in endocytosis and Glut4 trafficking. Acta Physiol (Oxf). 2008;192:75-88 pubmed publisher
  6. Zaid H, Antonescu C, Randhawa V, Klip A. Insulin action on glucose transporters through molecular switches, tracks and tethers. Biochem J. 2008;413:201-15 pubmed publisher
  7. Cao Z, Li C, Higginbotham J, Franklin J, Tabb D, Graves Deal R, et al. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol Cell Proteomics. 2008;7:1651-67 pubmed publisher
    ..b>Rab10 and myosin IIA were identified as core machinery, and Na(+)/K(+)-ATPase alpha1 was identified as an additional ..
  8. Watson R, Pessin J. GLUT4 translocation: the last 200 nanometers. Cell Signal. 2007;19:2209-17 pubmed
    ..Future work will focus on identifying the key insulin targets that regulate the GLUT4 docking/fusion processes. ..
  9. Liu Y, Xu X, Chen Q, Wang T, Deng C, Song B, et al. Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development. Nat Commun. 2013;4:2005 pubmed publisher
    ..This process is believed to be regulated by directed membrane trafficking of Rab10-containing post-Golgi carriers. However, the mechanisms underlying the biogenesis of these carriers remain unclear...