Pygl

Summary

Gene Symbol: Pygl
Description: phosphorylase, glycogen, liver
Alias: glycogen phosphorylase, liver form, liver glycogen phosphorylase
Species: rat

Top Publications

  1. ncbi Identification of a mutation in liver glycogen phosphorylase in glycogen storage disease type VI
    S Chang
    Laboratory of Genetic Disease Research and Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 7:865-70. 1998
  2. ncbi Structural relationships among regulated and unregulated phosphorylases
    J L Buchbinder
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143, USA
    Annu Rev Biophys Biomol Struct 30:191-209. 2001
  3. ncbi Evidence against glycogen cycling of gluconeogenic substrates in various liver preparations
    Keld Fosgerau
    Pharmacological Research 2, MedChem Research, Hepatic Biochemistry, Discovery Management, Novo Nordisk A S, Novo Nordisk Park, DK 2760 Maaloev, Denmark
    J Biol Chem 277:28648-55. 2002
  4. ncbi Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase
    Roger R Gomis
    Departament de Bioquimica i Biologia Molecular and the Institut de Recerca Biomèdica de Barcelona Parc Cientific de Barcelona, Universitat de Barcelona, Barcelona E 08028, Spain
    J Biol Chem 278:9740-6. 2003
  5. ncbi Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis
    Susan Aiston
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, UK
    Eur J Biochem 270:2773-81. 2003
  6. ncbi Defect in glucokinase translocation in Zucker diabetic fatty rats
    Yuka Fujimoto
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Am J Physiol Endocrinol Metab 287:E414-23. 2004
  7. ncbi Regulation of rat hepatocyte function by P2Y receptors: focus on control of glycogen phosphorylase and cyclic AMP by 2-methylthioadenosine 5'-diphosphate
    C Jane Dixon
    The Cell Signaling Laboratory, Leicester School of Pharmacy, The Hawthorn Building, De Montfort University, Leicester LE1 9BH, United Kingdom
    J Pharmacol Exp Ther 311:334-41. 2004
  8. ncbi Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures
    Pnina Boer
    Felsenstein Medical Research Institute, Tel Aviv University, Tel Aviv, Israel
    Nucleosides Nucleotides Nucleic Acids 23:1235-9. 2004
  9. ncbi Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species
    Sandra M Lelli
    Salud Humana y Medio Ambiente DIMXSA, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Ciudad Autonoma de Buenos Aires, Argentina
    Toxicology 216:49-58. 2005
  10. ncbi Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors
    Alan M Birch
    AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK
    Bioorg Med Chem Lett 17:394-9. 2007

Scientific Experts

  • Zoltan Gregus
  • K Fosgerau
  • J L Buchbinder
  • Alan M Birch
  • Darya Zibrova
  • Sandra M Lelli
  • Pnina Boer
  • C Jane Dixon
  • Yuka Fujimoto
  • Roger R Gomis
  • Susan Aiston
  • Rüdiger Streicher
  • Rolf Grempler
  • Stefan G Kauschke
  • S Chang
  • Leonor C San Martín de Viale
  • Marta B Mazzetti
  • Oded Sperling
  • Masakazu Shiota
  • Tania E Webb
  • E Patrick Donahue
  • John F Hall
  • Michael R Boarder
  • Matthew P Coghlan
  • Mar Garcia-Rocha
  • Juan C Ferrer
  • Loranne Agius
  • Cristián Favre
  • Joan J Guinovart
  • Josep M FernAndez-Novell
  • J P Schellens
  • C A Francomano
  • L G Biesecker
  • M J Rosenberg
  • H Morton
  • K R Herrick
  • D Mayer
  • H Vreeling-Sindelarova
  • R J Van den Munckhof
  • W M Frederiks
  • A Carabaza
  • R C Tait
  • K Schiebel
  • F A Gorin
  • L N Johnson
  • E A Park
  • M M Crerar
  • K Satoh
  • S Osawa
  • B E Froman
  • E Pekel
  • G Seelmann-Eggebert
  • J J Guinovart
  • S Baqué
  • C J Ciudad
  • K E Matthews
  • A Gomez-Munoz
  • T Glaser
  • I Letsch
  • J W Hudson
  • K Sato
  • B A Horwitz
  • D E Housman
  • R H Chiu
  • P Hales
  • D N Brindley
  • M J Sancho
  • E S David
  • G L Johnson
  • T B Miller
  • G B Golding
  • P Seth
  • A McDonough
  • J S Stern

Detail Information

Publications26

  1. ncbi Identification of a mutation in liver glycogen phosphorylase in glycogen storage disease type VI
    S Chang
    Laboratory of Genetic Disease Research and Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 7:865-70. 1998
    ..Linkage analysis was performed using genetic markers flanking the liver glycogen phosphorylase gene ( PYGL ), which was suspected to be the cause of the disorder on biochemical grounds...
  2. ncbi Structural relationships among regulated and unregulated phosphorylases
    J L Buchbinder
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94143, USA
    Annu Rev Biophys Biomol Struct 30:191-209. 2001
    ..Phosphorylation, though common to both the yeast and mammalian enzymes, occurs at different sites and activates the enzymes by surprisingly different mechanisms...
  3. ncbi Evidence against glycogen cycling of gluconeogenic substrates in various liver preparations
    Keld Fosgerau
    Pharmacological Research 2, MedChem Research, Hepatic Biochemistry, Discovery Management, Novo Nordisk A S, Novo Nordisk Park, DK 2760 Maaloev, Denmark
    J Biol Chem 277:28648-55. 2002
    ..Taken together, these data also suggest that inhibition of glycogen phosphorylase may prove beneficial in the treatment of type 2 diabetes...
  4. ncbi Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase
    Roger R Gomis
    Departament de Bioquimica i Biologia Molecular and the Institut de Recerca Biomèdica de Barcelona Parc Cientific de Barcelona, Universitat de Barcelona, Barcelona E 08028, Spain
    J Biol Chem 278:9740-6. 2003
    ..We hypothesize that Glc-6-P has a major role in glycogen metabolism not only by determining the activation state of GS but also by controlling its subcellular distribution in the hepatocyte...
  5. ncbi Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis
    Susan Aiston
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, The Medical School, Newcastle upon Tyne, UK
    Eur J Biochem 270:2773-81. 2003
    ..Selective inactivation of phosphorylase can mimic insulin stimulation of hepatic glycogen synthesis...
  6. ncbi Defect in glucokinase translocation in Zucker diabetic fatty rats
    Yuka Fujimoto
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    Am J Physiol Endocrinol Metab 287:E414-23. 2004
    ..The unresponsiveness of hepatic glucose flux to the rise in plasma glucose and insulin seen in prediabetic ZDF rats was associated with impaired GK translocation...
  7. ncbi Regulation of rat hepatocyte function by P2Y receptors: focus on control of glycogen phosphorylase and cyclic AMP by 2-methylthioadenosine 5'-diphosphate
    C Jane Dixon
    The Cell Signaling Laboratory, Leicester School of Pharmacy, The Hawthorn Building, De Montfort University, Leicester LE1 9BH, United Kingdom
    J Pharmacol Exp Ther 311:334-41. 2004
    ....
  8. ncbi Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures
    Pnina Boer
    Felsenstein Medical Research Institute, Tel Aviv University, Tel Aviv, Israel
    Nucleosides Nucleotides Nucleic Acids 23:1235-9. 2004
    ....
  9. ncbi Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species
    Sandra M Lelli
    Salud Humana y Medio Ambiente DIMXSA, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Ciudad Autonoma de Buenos Aires, Argentina
    Toxicology 216:49-58. 2005
    ....
  10. ncbi Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors
    Alan M Birch
    AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK
    Bioorg Med Chem Lett 17:394-9. 2007
    ..X-ray crystallographic data are presented, showing an unexpected variety of binding orientations at the dimer interface site...
  11. ncbi Glutathione-dependent reduction of arsenate by glycogen phosphorylase responsiveness to endogenous and xenobiotic inhibitors
    Zoltan Gregus
    Department of Pharmacology and Pharmacotherapy, Toxicology Section, University of Pecs, Medical School, Szigeti ut 12, H 7624 Pecs, Hungary
    Toxicol Sci 100:44-53. 2007
    ..It was also shown that a GPa-rich extract of rat liver contained GSH-dependent As(V)-reducing activity that was inhibited by specific GPIs, suggesting that the liver-type GPa can also catalyze reduction of As(V)...
  12. ncbi Electron microscopical study of a cytosolic enzyme in unfixed cryostat sections: demonstration of glycogen phosphorylase activity in rat liver and heart tissue
    J P Schellens
    Department of Cell Biology and Histology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Histochem J 27:609-14. 1995
    ....
  13. ncbi Characterization of the 5' flanking region of the gene encoding rat liver glycogen phosphorylase
    K R Herrick
    Department of Neurology, University of California, Davis 95616 8647
    Gene 126:203-11. 1993
    ..region encompassing 800 bp of the promoter-regulatory region and exon 1 of the gene (LGP) encoding rat liver glycogen phosphorylase has been isolated and characterized...
  14. ncbi The nucleotide sequence of rat liver glycogen phosphorylase cDNA
    K Schiebel
    Deutsches Krebsforschungszentrum, Abteilung Cytopathologie, Heidelberg, Germany
    Biochim Biophys Acta 1130:349-51. 1992
    The nucleotide sequence of a cDNA coding for rat liver glycogen phosphorylase has been determined...
  15. ncbi Glycogen phosphorylase: control by phosphorylation and allosteric effectors
    L N Johnson
    Laboratory of Molecular Biophysics, University of Oxford, England
    FASEB J 6:2274-82. 1992
    ..The allosteric mechanism of activation of phosphorylase by phosphorylation may be relevant to other enzymes although it is now known that other mechanisms such as electrostatic steric blocking mechanisms also exist...
  16. ncbi Glycogen phosphorylase isoenzymes from hepatoma 3924A and from a non-tumorigenic liver cell line. Comparison with the liver and brain enzymes
    D Mayer
    Abteilung Cytopathologie, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    Biochem J 282:665-73. 1992
    ....
  17. ncbi Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes
    A Carabaza
    Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Spain
    FEBS Lett 296:211-4. 1992
    ....
  18. ncbi The gene encoding rat liver glycogen phosphorylase contains multiple polyadenylation signal sequences
    B E Froman
    Department of Neurology, University of California, Davis 95616
    Gene 109:269-74. 1991
    ..Polyadenylation site selection does not appear to be regulated in a tissue-specific fashion. The relative steady-state L-GP mRNA levels in the different types of adipose tissues were comparable to, or exceeded transcript levels in liver...
  19. ncbi Isolation of partial cDNAs for rat liver and muscle glycogen phosphorylase isozymes
    S Osawa
    FEBS Lett 202:282-8. 1986
    ..Rather, the phosphorylase isozymes probably evolved for tissue-specific transcriptional regulation of the genes in liver and muscle...
  20. ncbi Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively
    T Glaser
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Genomics 5:510-21. 1989
    ..The genes encoding muscle, liver, and brain phosphorylases (Pygm, Pygl, and Pygb) are assigned to mouse chromosomes 19, 12, and 2, respectively...
  21. ncbi Rapid activation of glycogen phosphorylase by steroid hormones in cultured rat hepatocytes
    A Gomez-Munoz
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Biochem J 262:417-23. 1989
    ..These results may explain some of the pharmacological effects of sex steroids, and also might contribute to the physiological actions of glucocorticoids...
  22. ncbi Studies on the expression and evolution of the glycogen phosphorylase gene family in the rat
    M M Crerar
    Department of Biology, York University, North York, Ont, Canada
    Genome 30:582-90. 1988
    ..Differences in the relative rates of change of the three isozymes were observed and this may reflect different constraints on their evolution perhaps related to their functional roles and (or) tissue-specific expression...
  23. ncbi Glycogen-binding protein components of rat tissues
    K Satoh
    Biochem Biophys Res Commun 96:28-33. 1980
  24. ncbi Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes
    Darya Zibrova
    Department of Metabolic Diseases Research, Boehringer Ingelheim Pharma GmbH and Co KG, Birkendorfer Strasse 65, D 88397 Biberach an der Riss, Germany
    Biochem J 412:359-66. 2008
    ....