Gene Symbol: Ptprz1
Description: protein tyrosine phosphatase, receptor type Z1
Alias: PTPzeta-A, PTPzeta-B, PTPzeta-S, Ptpz, RPTPbeta, receptor-type tyrosine-protein phosphatase zeta, 3F8 chondroitin sulfate proteoglycan, 3H1 keratan sulfate proteoglycan, 6B4 proteoglycan, PTP zeta, R-PTP-zeta, protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Species: rat
Products:     Ptprz1

Top Publications

  1. Tanaka M, Maeda N, Noda M, Marunouchi T. A chondroitin sulfate proteoglycan PTPzeta /RPTPbeta regulates the morphogenesis of Purkinje cell dendrites in the developing cerebellum. J Neurosci. 2003;23:2804-14 pubmed
    PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ..
  2. Hayashi N, Oohira A, Miyata S. Synaptic localization of receptor-type protein tyrosine phosphatase zeta/beta in the cerebral and hippocampal neurons of adult rats. Brain Res. 2005;1050:163-9 pubmed
    ..These results demonstrate that RPTPzeta/beta is localized mainly at the postsynaptic membrane of pyramidal neurons in adult cerebral cortex and hippocampus. ..
  3. Grumet M, Milev P, Sakurai T, Karthikeyan L, Bourdon M, Margolis R, et al. Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue. J Biol Chem. 1994;269:12142-6 pubmed
  4. Nishiwaki T, Maeda N, Noda M. Characterization and developmental regulation of proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta isoforms. J Biochem. 1998;123:458-67 pubmed
    Protein tyrosine phosphatase zeta (PTPzeta/RPTPbeta) is a receptor-like protein tyrosine phosphatase specifically expressed in the brain...
  5. Maeda N, Nishiwaki T, Shintani T, Hamanaka H, Noda M. 6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM). J Biol Chem. 1996;271:21446-52 pubmed
    A major chondroitin sulfate proteoglycan in the brain, 6B4 proteoglycan/phosphacan, corresponds to the extracellular region of a receptor-like protein-tyrosine phosphatase, PTPzeta/RPTPbeta...
  6. Maeda N, Noda M. 6B4 proteoglycan/phosphacan is a repulsive substratum but promotes morphological differentiation of cortical neurons. Development. 1996;122:647-58 pubmed
    b>6B4 proteoglycan/phosphacan is one of the major phosphate-buffered saline-soluble chondroitin sulfate proteoglycans of the brain...
  7. Peles E, Nativ M, Campbell P, Sakurai T, Martinez R, Lev S, et al. The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. Cell. 1995;82:251-60 pubmed
    ..The interaction between contactin and RPTP beta may generate unidirectional or bidirectional signals during neural development. ..
  8. Maurel P, Rauch U, Flad M, Margolis R, Margolis R. Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase. Proc Natl Acad Sci U S A. 1994;91:2512-6 pubmed
    ..We therefore conclude that the 3H1 chondroitin/keratan sulfate proteoglycan and the 3F8 chondroitin sulfate proteoglycan represent glycosylation and possible extracellular splicing variants of a receptor-type protein ..
  9. Milev P, Friedlander D, Sakurai T, Karthikeyan L, Flad M, Margolis R, et al. Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules. J Cell Biol. 1994;127:1703-15 pubmed

More Information


  1. Qi M, Ikematsu S, Maeda N, Ichihara Tanaka K, Sakuma S, Noda M, et al. Haptotactic migration induced by midkine. Involvement of protein-tyrosine phosphatase zeta. Mitogen-activated protein kinase, and phosphatidylinositol 3-kinase. J Biol Chem. 2001;276:15868-75 pubmed
  2. Garwood J, Heck N, Reichardt F, Faissner A. Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth. J Biol Chem. 2003;278:24164-73 pubmed
    ..Hence, the identification of this novel isoform of phosphacan/receptor protein tyrosine phosphatase-beta provides a new component in cell-cell and cell-extracellular matrix signaling events in which these proteins have been implicated. ..
  3. Liu Y, Shang D, Akatsuka S, Ohara H, Dutta K, Mizushima K, et al. Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway. Am J Pathol. 2007;171:1978-88 pubmed
    ..At the common chromosomal region of amplification (4q22) in rat RCCs, we found ptprz1, a tyrosine phosphatase (also known as protein tyrosine phosphatase zeta or receptor tyrosine phosphatase beta) ..
  4. Chow J, Fujikawa A, Shimizu H, Suzuki R, Noda M. Metalloproteinase- and gamma-secretase-mediated cleavage of protein-tyrosine phosphatase receptor type Z. J Biol Chem. 2008;283:30879-89 pubmed publisher
    ..This is the first evidence of the metalloproteinase-mediated processing of a receptor-like protein-tyrosine phosphatase in the central nervous system. ..
  5. Okamoto M, Sakiyama J, Mori S, Kurazono S, Usui S, Hasegawa M, et al. Kainic acid-induced convulsions cause prolonged changes in the chondroitin sulfate proteoglycans neurocan and phosphacan in the limbic structures. Exp Neurol. 2003;184:179-95 pubmed
  6. Naffah Mazzacoratti M, Argañaraz G, Porcionatto M, Scorza F, Amado D, Silva R, et al. Selective alterations of glycosaminoglycans synthesis and proteoglycan expression in rat cortex and hippocampus in pilocarpine-induced epilepsy. Brain Res Bull. 1999;50:229-39 pubmed
    ..The receptor of protein tyrosine phosphatase beta (RPTPbeta) is a chondroitin sulphate proteoglycan which plays an important role in neural morphogenesis and axon guidance ..
  7. Fukada M, Fujikawa A, Chow J, Ikematsu S, Sakuma S, Noda M. Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization. FEBS Lett. 2006;580:4051-6 pubmed
    ..PTN), a natural ligand for protein tyrosine phosphatase receptor type Z (Ptprz) (also called PTPzeta/RPTPbeta), inactivates Ptprz through oligomerization and increases the tyrosine phosphorylation of substrates for Ptprz, G ..
  8. Deepa S, Carulli D, Galtrey C, Rhodes K, Fukuda J, Mikami T, et al. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. J Biol Chem. 2006;281:17789-800 pubmed
    ..A comparison of the brain and spinal cord ECM with respect to CSPGs indicated that the PNNs in both parts of the CNS have the same composition. ..
  9. Maurel P, Meyer Puttlitz B, Flad M, Margolis R, Margolis R. Nucleotide sequence and molecular variants of rat receptor-type protein tyrosine phosphatase-zeta/beta. DNA Seq. 1995;5:323-8 pubmed
  10. Haunsø A, Ibrahim M, Bartsch U, Letiembre M, Celio M, Menoud P. Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice. Brain Res. 2000;864:142-5 pubmed
    ..These results on mice lacking tenascin-R substantiate previously reported in vitro interactions between tenascin-R and phosphacan and neurocan. ..
  11. Thomaidou D, Coquillat D, Meintanis S, Noda M, Rougon G, Matsas R. Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells. J Neurochem. 2001;78:767-78 pubmed
    ..These results identify F3 and NCAM receptors on SC as potential mediators of signalling occurring between axons and glial cells during peripheral nerve development and regeneration. ..
  12. Inatani M, Honjo M, Otori Y, Oohira A, Kido N, Tano Y, et al. Inhibitory effects of neurocan and phosphacan on neurite outgrowth from retinal ganglion cells in culture. Invest Ophthalmol Vis Sci. 2001;42:1930-8 pubmed
  13. Reinehr S, Reinhard J, Wiemann S, Stute G, Kuehn S, Woestmann J, et al. Early remodelling of the extracellular matrix proteins tenascin-C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model. J Cell Mol Med. 2016;20:2122-2137 pubmed publisher
    ..We conclude that remodelling of tenascin-C and phosphacan occurred shortly after immunization, already before RGC loss. We assume that both ECM molecules represent early indicators of neurodegeneration. ..
  14. Vitellaro Zuccarello L, Mazzetti S, Madaschi L, Bosisio P, Fontana E, Gorio A, et al. Chronic erythropoietin-mediated effects on the expression of astrocyte markers in a rat model of contusive spinal cord injury. Neuroscience. 2008;151:452-66 pubmed
  15. Milev P, Monnerie H, Popp S, Margolis R, Margolis R. The core protein of the chondroitin sulfate proteoglycan phosphacan is a high-affinity ligand of fibroblast growth factor-2 and potentiates its mitogenic activity. J Biol Chem. 1998;273:21439-42 pubmed
  16. Kurazono S, Okamoto M, Sakiyama J, Mori S, Nakata Y, Fukuoka J, et al. Expression of brain specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the developing and adult hippocampus of Ihara's epileptic rats. Brain Res. 2001;898:36-48 pubmed
  17. Ranjan M, Hudson L. Regulation of tyrosine phosphorylation and protein tyrosine phosphatases during oligodendrocyte differentiation. Mol Cell Neurosci. 1996;7:404-18 pubmed
    ..lineage, with both precursor cells and oligodendrocytes expressing four major phosphatase transcripts: PTP alpha, PTP zeta, PTP sigma, and PTP gamma...
  18. Hayashi N, Mizusaki M, Kamei K, Harada S, Miyata S. Chondroitin sulfate proteoglycan phosphacan associates with parallel fibers and modulates axonal extension and fasciculation of cerebellar granule cells. Mol Cell Neurosci. 2005;30:364-77 pubmed
    ..These results indicate that phosphacan around parallel fibers may be the repulsive substratum for adhesion and extension of granule cells and promote the fasciculation of parallel fibers. ..
  19. Sango K, Oohira A, Ajiki K, Tokashiki A, Horie M, Kawano H. Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro. Exp Neurol. 2003;182:1-11 pubmed
    ..Taking these findings together, it is plausible that both CS-PGs expressed in the cultured neurons may play a role in the modulation of attachment, survival, and neurite regeneration. ..
  20. Li J, Tullai J, Yu W, Salton S. Regulated expression during development and following sciatic nerve injury of mRNAs encoding the receptor tyrosine phosphatase HPTPzeta/RPTPbeta. Brain Res Mol Brain Res. 1998;60:77-88 pubmed
    Three major isoforms of the receptor protein tyrosine phosphatase HPTPzeta/RPTPbeta (RPTPzeta/beta) have been previously identified, two with identical transmembrane and intracellular catalytic domains that differ by virtue of a long ..
  21. Okamoto M, Sakiyama J, Kurazono S, Mori S, Nakata Y, Nakaya N, et al. Developmentally regulated expression of brain-specific chondroitin sulfate proteoglycans, neurocan and phosphacan, in the postnatal rat hippocampus. Cell Tissue Res. 2001;306:217-29 pubmed
  22. Robles Y, Vivas Mejia P, Ortiz Zuazaga H, Felix J, Ramos X, PENA DE ORTIZ S. Hippocampal gene expression profiling in spatial discrimination learning. Neurobiol Learn Mem. 2003;80:80-95 pubmed
    ..We suggest that statistically valid gene expression profiles generated with cDNA microarrays may provide important insights as to the cellular and molecular events subserving learning and memory processes in the brain. ..
  23. Forostyak S, Homola A, Turnovcova K, Svitil P, Jendelova P, Sykova E. Intrathecal delivery of mesenchymal stromal cells protects the structure of altered perineuronal nets in SOD1 rats and amends the course of ALS. Stem Cells. 2014;32:3163-72 pubmed publisher
  24. Davies J, Tang X, Denning J, Archibald S, Davies S. Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries. Eur J Neurosci. 2004;19:1226-42 pubmed
  25. Asai H, Yokoyama S, Morita S, Maeda N, Miyata S. Functional difference of receptor-type protein tyrosine phosphatase zeta/beta isoforms in neurogenesis of hippocampal neurons. Neuroscience. 2009;164:1020-30 pubmed publisher
    ..Thus, the present study demonstrates that two transmembranous RPTPzeta isoforms have different functions for regulating dendritogenesis and synaptogenesis. ..
  26. Matsui F, Kakizawa H, Nishizuka M, Hirano K, Shuo T, Ida M, et al. Changes in the amounts of chondroitin sulfate proteoglycans in rat brain after neonatal hypoxia-ischemia. J Neurosci Res. 2005;81:837-45 pubmed
    ..Because intensified immunostaining for neurocan and neuroglycan C was not observed, unmasking seems to be specific to phosphacan among these three chondroitin sulfate proteoglycans. ..
  27. Katoh Semba R, Matsuda M, Watanabe E, Maeda N, Oohira A. Two types of brain chondroitin sulfate proteoglycan: their distribution and possible functions in the rat embryo. Neurosci Res. 1998;31:273-82 pubmed
    The distribution of neurocan-like and 6B4 proteoglycan-like immunoreactivities in the rat embryo was investigated from gestational days 10.5-15...
  28. Matsui F, Kawashima S, Shuo T, Yamauchi S, Tokita Y, Aono S, et al. Transient expression of juvenile-type neurocan by reactive astrocytes in adult rat brains injured by kainate-induced seizures as well as surgical incision. Neuroscience. 2002;112:773-81 pubmed
  29. Lamprianou S, Chatzopoulou E, Thomas J, Bouyain S, Harroch S. A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Proc Natl Acad Sci U S A. 2011;108:17498-503 pubmed publisher
    ..Overall, these results implicate the PTPRZ/CNTN1 complex as a previously unknown modulator of oligodendrogenesis. ..
  30. Fujikawa A, Fukada M, Makioka Y, Suzuki R, Chow J, Matsumoto M, et al. Consensus substrate sequence for protein-tyrosine phosphatase receptor type Z. J Biol Chem. 2011;286:37137-46 pubmed publisher
    ..Expectedly, we verified that Ptprz efficiently dephosphorylates paxillin at this site in cells. Our study thus provides key insights into the molecular basis for the substrate recognition of Ptprz. ..
  31. Engel M, Maurel P, Margolis R, Margolis R. Chondroitin sulfate proteoglycans in the developing central nervous system. I. cellular sites of synthesis of neurocan and phosphacan. J Comp Neurol. 1996;366:34-43 pubmed
  32. Fujikawa A, Chow J, Shimizu H, Fukada M, Suzuki R, Noda M. Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z. J Biochem. 2007;142:343-50 pubmed
    Protein tyrosine phosphatase receptor type Z (Ptprz/PTPzeta/RPTPbeta) is a receptor-like protein tyrosine phosphatase (RPTP) preferentially expressed in the brain...
  33. Carmichael S, Archibeque I, Luke L, Nolan T, Momiy J, Li S. Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. Exp Neurol. 2005;193:291-311 pubmed
    ..This region may be a growth-promoting zone after stroke. ..
  34. Marchionini D, Lehrmann E, Chu Y, He B, Sortwell C, Becker K, et al. Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease. Brain Res. 2007;1147:77-88 pubmed
    ..Thus, PTN was identified as a factor that plays a role in the nigrostriatal system during development and in response to disease, and may therefore be useful for neuroprotection or reconstruction of the DA system. ..
  35. Maeda N, Noda M. Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration. J Cell Biol. 1998;142:203-16 pubmed
    ..a specific ligand of protein tyrosine phosphatase zeta (PTPzeta)/receptor-like protein tyrosine phosphatase beta (RPTPbeta) expressed in the brain as a chondroitin sulfate proteoglycan...
  36. Tamura H, Fukada M, Fujikawa A, Noda M. Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP. Neurosci Lett. 2006;399:33-8 pubmed
    ..These results suggest that Ptprz plays a critical role in memory formation by modulating Rho GTPase activity through dephosphorylation at Y1105 on p190 RhoGAP. ..
  37. Hayashi N, Miyata S, Yamada M, Kamei K, Oohira A. Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase beta and phosphacan. Neuroscience. 2005;131:331-48 pubmed
    Receptor-type protein-tyrosine phosphatase beta (RPTPbeta) and its spliced variant phosphacan are major components of chondroitin sulfate proteoglycans in the CNS...
  38. Fujiwara K, Horiguchi K, Maliza R, Tofrizal A, Batchuluun K, Ramadhani D, et al. Expression of the heparin-binding growth factor midkine and its receptor, Ptprz1, in adult rat pituitary. Cell Tissue Res. 2015;359:909-14 pubmed publisher this study, we investigate whether MK and its receptor, protein tyrosine phosphatase receptor-type Z (Ptprz1), are present in the adult rat pituitary...
  39. Fujikawa A, Nagahira A, Sugawara H, Ishii K, Imajo S, Matsumoto M, et al. Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma. Sci Rep. 2016;6:20473 pubmed publisher
    ..Therefore, selective inhibition of PTPRZ represents a promising approach for glioma therapy. ..
  40. Milev P, Meyer Puttlitz B, Margolis R, Margolis R. Complex-type asparagine-linked oligosaccharides on phosphacan and protein-tyrosine phosphatase-zeta/beta mediate their binding to neural cell adhesion molecules and tenascin. J Biol Chem. 1995;270:24650-3 pubmed
  41. Kawachi H, Fujikawa A, Maeda N, Noda M. Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system. Proc Natl Acad Sci U S A. 2001;98:6593-8 pubmed
    ..the yeast substrate-trapping system, to identify substrates for protein tyrosine phosphatases zeta (PTPzeta/RPTPbeta)...
  42. Bekku Y, Rauch U, Ninomiya Y, Oohashi T. Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS. J Neurochem. 2009;108:1266-76 pubmed publisher
    ..Our results revealed that brevican plays a crucial role in determining the specialization of the hyaluronan-binding nodal matrix assemblies in large diameter nodes. ..
  43. Meyer Puttlitz B, Junker E, Margolis R, Margolis R. Chondroitin sulfate proteoglycans in the developing central nervous system. II. Immunocytochemical localization of neurocan and phosphacan. J Comp Neurol. 1996;366:44-54 pubmed
  44. Jones L, Margolis R, Tuszynski M. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol. 2003;182:399-411 pubmed
    ..Optimization of strategies to reduce CSPG expression to enhance regeneration may need to target several different family members over an extended period following injury. ..
  45. Wilson M, Snow D. Chondroitin sulfate proteoglycan expression pattern in hippocampal development: potential regulation of axon tract formation. J Comp Neurol. 2000;424:532-46 pubmed
    ..These findings implicate CSPG in the regulation of axon trajectory and fasciculation during hippocampal axon tract formation. ..
  46. Kurazono S, Okamoto M, Mori S, Matsui H. Recombinant core protein fragment of phosphacan, a brain specific chondroitin sulfate proteoglycan, promote excitotoxic cell death of cultured rat hippocampal neurons. Neurosci Lett. 2001;304:169-72 pubmed
    ..These results suggest that proteolytic degradation of phosphacan and resultant core protein fragments may contribute to neuronal degeneration of hippocampal neurons in various neuropathological conditions. ..
  47. Garwood J, Schnädelbach O, Clement A, Schutte K, Bach A, Faissner A. DSD-1-proteoglycan is the mouse homolog of phosphacan and displays opposing effects on neurite outgrowth dependent on neuronal lineage. J Neurosci. 1999;19:3888-99 pubmed
    ..This indicates that DSD-1-PG/mouse phosphacan can have opposing effects on the process of neurite outgrowth dependent on neuronal lineage. ..
  48. Kaspiris A, Chronopoulos E, Grivas T, Vasiliadis E, Khaldi L, Lamprou M, et al. Effects of mechanical loading on the expression of pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in a rat spinal deformity model. Cytokine. 2016;78:7-15 pubmed publisher
    ..Collectively, PTN and RPTPβ/ζ are expressed in spinal deformities caused by mechanical loading, and their expression depends on the type and severity of the applied strain. ..