Genomes and Genes
Gene Symbol: Ptpre
Description: protein tyrosine phosphatase, receptor type, E
Alias: PTPepsilon, receptor-type tyrosine-protein phosphatase epsilon, R-PTP-epsilon, protein tyrosine phosphatase epsilon, protein tyrosine phosphatase epsilon-like 1, protein tyrosine phosphatase epsilon-like 2, protein tyrosine phosphatase, receptor type, epsilon
- Aga Mizrachi S, Brutman Barazani T, Jacob A, Bak A, Elson A, Sampson S. Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle. Endocrinology. 2008;149:605-14 pubmed..In this study, we examined the possibility that cytosolic PTPepsilon (cytPTPepsilon) is involved in IR signaling. Studies were performed on L6 skeletal muscle cells...
- Nakamura K, Mizuno Y, Kikuchi K. Molecular cloning of a novel cytoplasmic protein tyrosine phosphatase PTP epsilon. Biochem Biophys Res Commun. 1996;218:726-32 pubmedWe have isolated a cDNA of a novel cytoplasmic variant of the protein tyrosine phosphatase epsilon (PTP epsilon) from rat spleen cDNA library. Its deduced amino acid sequence of 642 residues was 94...
- Elson A, Leder P. Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. Proc Natl Acad Sci U S A. 1995;92:12235-9 pubmed..PTP epsilon-cytoplasmic is therefore the initial example to our knowledge of a nontransmembranal protein-tyrosine phosphatase that contains two tandem of catalytic domains. ..
- Gil Henn H, Volohonsky G, Toledano Katchalski H, Gandre S, Elson A. Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. Oncogene. 2000;19:4375-84 pubmedTwo protein forms of tyrosine phosphatase epsilon (PTPepsilon) are known - receptor-like (tm-PTPepsilon) and non receptor-like (cyt-PTPepsilon), with each form possessing unique tissue-specific expression patterns, subcellular ..
- Nakagawa Y, Aoki N, Aoyama K, Shimizu H, Shimano H, Yamada N, et al. Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver. Zoolog Sci. 2005;22:169-75 pubmed..In this study, we showed that receptor-type PTPepsilon (PTP epsilonM) dephosphorylated IR in rat primary hepatocytes and tyrosines 972, 1158, 1162 and 1163 were ..
- Nakagawa Y, Yamada N, Shimizu H, Shiota M, Tamura M, Kim Mitsuyama S, et al. Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src. Biochem Biophys Res Commun. 2004;325:314-9 pubmed..in ECs lacking endogenous PTPepsilonC, indicating the biological significance of selective expression of PTPepsilon isoforms in the vasculature...
- Akimoto M, Mishra K, Lim K, Tani N, Hisanaga S, Katagiri T, et al. Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses. Scand J Immunol. 2009;69:401-11 pubmed publisher..Here, we show that protein tyrosine phosphatase epsilon (PTPepsilon; Ptpre) plays key regulatory roles during mast-cell activation mediated by the high-..
- Shimizu H, Nakagawa Y, Murakami C, Aoki N, Kim Mitsuyama S, Miyazaki H. Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2010;299:C1144-52 pubmed publisher..Therefore, PTP?M negatively regulates PDGFR?-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis, and PTP?M may be involved in diabetes-accelerated atherosclerosis. ..
- Tanuma N, Nakamura K, Kikuchi K. Distinct promoters control transmembrane and cytosolic protein tyrosine phosphatase epsilon expression during macrophage differentiation. Eur J Biochem. 1999;259:46-54 pubmedWe have recently isolated two cDNAs encoding two forms of transmembrane and cytosolic protein tyrosine phosphatase epsilon (PTPepsilon). In this study, the 5' end of the rat PTPepsilon gene was isolated and characterized...
- Toledano Katchalski H, Tiran Z, Sines T, Shani G, Granot Attas S, den Hertog J, et al. Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon. Mol Cell Biol. 2003;23:5460-71 pubmed..Furthermore, dimerization can be mediated by the D2 domain and does not strictly require the presence of PTP extracellular domains. ..
- Kappert K, Sparwel J, Sandin A, Seiler A, Siebolts U, Leppanen O, et al. Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis. Arterioscler Thromb Vasc Biol. 2006;26:2644-51 pubmed..The findings thus suggest, in general terms, reactivation of oxidized PTPs as a novel antirestenotic strategy. ..