Ptprc

Summary

Gene Symbol: Ptprc
Description: protein tyrosine phosphatase, receptor type, C
Alias: CD45, L-CA, Lca, RT7, T200, receptor-type tyrosine-protein phosphatase C, T200 glycoprotein, leucocyte common antigen, leukocyte common antigen A, leukocyte common antigen B, protein tyrosine phosphatase, receptor-type, c polypeptide
Species: rat
Products:     Ptprc

Top Publications

  1. Kishihara K, Penninger J, Wallace V, Kundig T, Kawai K, Wakeham A, et al. Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell. 1993;74:143-56 pubmed
    The transmembrane tyrosine phosphatase CD45 is expressed in multiple isoforms on all nucleated hematopoietic cells, resulting from alternative splicing of variable exons...
  2. Kong Y, Kishihara K, Yoshida H, Mak T, Nomoto K. Generation of T cells with differential responses to alloantigens in CD45 exon 6-deficient mice. J Immunol. 1995;154:5725-35 pubmed
    We characterized the CD45+ population in the CD45 exon 6-deficient mice and addressed a question as to whether the T cells keep responsive properties to alloantigens...
  3. Harp J, Davis B, Ewald S. Inhibition of T cell responses to alloantigens and polyclonal mitogens by Ly-5 antisera. J Immunol. 1984;133:10-5 pubmed
    ..The results are discussed in light of a possible functional role of Ly-5 molecules in immune processes. ..
  4. Li T, Ramirez K, Palacios R. Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ. 1996;7:107-14 pubmed
  5. Symons A, Barclay A. Molecular basis of antigenic differences between the RT7 alleles of rat CD45. Immunogenetics. 2000;51:747-50 pubmed
  6. Krasteva G, Canning B, Hartmann P, Veres T, Papadakis T, Mühlfeld C, et al. Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U S A. 2011;108:9478-83 pubmed publisher
    ..This identifies brush cells as cholinergic sensors of the chemical composition of the lower airway luminal microenvironment that are directly linked to the regulation of respiration...
  7. Morikawa K, Oseko F, Morikawa S. The role of CD45 in the activation, proliferation and differentiation of human B lymphocytes. Int J Hematol. 1991;54:495-504 pubmed
    We examined the role of CD45 antigen in human B cell function, using the anti-CD45 antibody, T29/33...
  8. Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, et al. Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton. J Immunol. 2014;192:771-81 pubmed publisher
    ..The spectrin cytoskeleton influences cell spreading and surface expression of TCR/CD3 and the leukocyte phosphatase CD45. We found higher cell spreading and enhanced surface expression of TCR/CD3 and CD45 in GBP-1 silenced T cells that ..
  9. Irles C, Symons A, Michel F, Bakker T, van der Merwe P, Acuto O. CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling. Nat Immunol. 2003;4:189-97 pubmed
    The transmembrane phosphatase CD45 regulates both Lck activity and T cell receptor (TCR) signaling. Here we have tested whether the large ectodomain of CD45 has a role in this regulation...

More Information

Publications73

  1. Shahinian A, Pfeffer K, Lee K, Kundig T, Kishihara K, Wakeham A, et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science. 1993;261:609-12 pubmed
    ..Thus, CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist. ..
  2. Byth K, Conroy L, Howlett S, Smith A, May J, Alexander D, et al. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J Exp Med. 1996;183:1707-18 pubmed
    The CD45 transmembrane glycoprotein has been shown to be a protein phosphotyrosine phosphatase and to be important in signal transduction in T and B lymphocytes...
  3. Ng L, Sutherland A, Newton R, Qian F, Cachero T, Scott M, et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol. 2004;173:807-17 pubmed
    ..Thus, BAFF-R is important not only for splenic B cell maturation, but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T cells. ..
  4. Ait Azzouzene D, Caucheteux S, Tchang F, Wantyghem J, Moutier R, Langkopf A, et al. Transgenic major histocompatibility complex class I antigen expressed in mouse trophoblast affects maternal immature B cells. Biol Reprod. 2001;65:337-44 pubmed
    ..5, compared to 22% in the (3.83 Tg female x Fvb) control group. This deletion might contribute to the process of maternal tolerance of the conceptus. ..
  5. Xu W, Tao H, Liu Y, Jiang C. [The state of SHP-1 and CD45 in lymphocyte under high partial pressure of oxygen]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005;21:15-8 pubmed
    To explore the function state of protein tyrosine phosphatase (PTP) SHP-1 and CD45 under high partial pressure of oxygen (Po2) in lymphocyte...
  6. Thomas M, Barclay A, Gagnon J, Williams A. Evidence from cDNA clones that the rat leukocyte-common antigen (T200) spans the lipid bilayer and contains a cytoplasmic domain of 80,000 Mr. Cell. 1985;41:83-93 pubmed
    The leukocyte-common antigen (L-CA or T200) includes a family of lymphoid and myeloid cell surface glycoproteins with apparent molecular weights from 180,000 to 240,000...
  7. Bachmann M, Kundig T, Speiser D, McKall Faienza K, Kishara K, Mak T, et al. T-cell-independent antiviral B cell responses in CD45-deficient mice. Cell Immunol. 1997;175:12-5 pubmed
    b>CD45 is expressed on all B cells and has been reported to be essential for their B cell receptor mediated stimulation...
  8. Ogilvy S, Louis dit Sully C, Cooper J, Cassady R, Alexander D, Holmes N. Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice. J Immunol. 2003;171:1792-800 pubmed
    The protein tyrosine phosphatase CD45 is expressed as a series of isoforms whose tissue and differentiation stage specificity is broadly conserved in evolution...
  9. Nemeth M, Curtis D, Kirby M, Garrett Beal L, Seidel N, Cline A, et al. Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood. 2003;102:1298-306 pubmed
    ..We conclude that down-regulation of Hmgb3 protein levels is an important step for myeloid and B-cell differentiation. ..
  10. Hojyo S, Miyai T, Fujishiro H, Kawamura M, Yasuda T, Hijikata A, et al. Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. Proc Natl Acad Sci U S A. 2014;111:11786-91 pubmed publisher
    ..Our data suggest that ZIP10 functions as a positive regulator of CD45R to modulate the BCR signal strength, thereby setting a threshold for BCR signaling in humoral immune responses. ..
  11. Coombe D, Watt S, Parish C. Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate. Blood. 1994;84:739-52 pubmed
    ..Using this approach the beta 2 integrin, Mac-1, and CD45, a receptor-type tyrosine phosphatase, were identified as molecules on the A4 cell surface that bind 3T3 cells...
  12. Irie Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001;409:349-54 pubmed
    ..The transmembrane PTPase CD45 is a key regulator of antigen receptor signalling in T and B cells...
  13. de Dios I, Ramudo L, Alonso J, Recio J, Garcia Montero A, Manso M. CD45 expression on rat acinar cells: involvement in pro-inflammatory cytokine production. FEBS Lett. 2005;579:6355-60 pubmed
    b>CD45 transduces activation signals in inflammatory cells. We investigate CD45 expression on pancreatic acinar cells and examine its role in the inflammatory response which these cells have also shown under certain circumstances...
  14. Ferkowicz M, Starr M, Xie X, Li W, Johnson S, Shelley W, et al. CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development. 2003;130:4393-403 pubmed
  15. Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim K, et al. GATA-3 is required for early T lineage progenitor development. J Exp Med. 2009;206:2987-3000 pubmed publisher
    ..Thus, GATA-3 is required for the cell-autonomous development of the earliest characterized thymic T cell progenitors. ..
  16. Carlyle J, Jamieson A, Gasser S, Clingan C, Arase H, Raulet D. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc Natl Acad Sci U S A. 2004;101:3527-32 pubmed
    ..Remarkably, Ocil/Clr-b is frequently down-regulated on mouse tumor cell lines, indicating a role for this receptor-ligand system in a new form of "missing self-recognition" of tumor cells. ..
  17. Welham S, Clark A, Salter A. A novel liver specific isoform of the rat LAR transcript is expressed as a truncated isoform encoded from a 5'UTR located within intron 11. BMC Mol Biol. 2009;10:30 pubmed publisher
    ..In summary, we describe a novel, liver specific, truncated isoform of the LAR transcript transcribed under the control of an intronic promoter, potentially representing a previously unidentified modulator of hepatic insulin signalling. ..
  18. Cheng A, Rowley B, Pao W, Hayday A, Bolen J, Pawson T. Syk tyrosine kinase required for mouse viability and B-cell development. Nature. 1995;378:303-6 pubmed
  19. Hanaoka K, Fujita N, Lee S, Seimiya H, Naito M, Tsuruo T. Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells. Cancer Res. 1995;55:2186-90 pubmed
    ..Partial amino acid sequences of the purified M(r) 168,000 protein were identical to those of CD45, a transmembrane tyrosine phosphatase...
  20. Roach T, Slater S, Koval M, White L, Cahir McFarland E, Okumura M, et al. CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr Biol. 1997;7:408-17 pubmed
    ..Src family kinases are activated upon integrin-mediated adhesion. In lymphocytes, CD45 is a leukocyte-specific transmembrane protein tyrosine phosphatase that activates Src family kinases associated ..
  21. Cyster J, Healy J, Kishihara K, Mak T, Thomas M, Goodnow C. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature. 1996;381:325-8 pubmed
    ..To analyse factors that determine the extent of B-cell negative selection, we crossed CD45-deficient mice with mice carrying immunoglobulin transgenes specific for hen egg lysozyme (HEL)...
  22. Kong Y, Kishihara K, Sumichika H, Nakamura T, Kaneko M, Nomoto K. Differential requirements of CD45 for lymphocyte development and function. Eur J Immunol. 1995;25:3431-6 pubmed
    b>CD45 exon 6-deficient mice show a profound block of thymocyte development at a transitional differentiation step from immature CD4+ CD8+ to mature single-positive cells...
  23. Park H, Staehling Hampton K, Appleby M, Brunkow M, Habib T, Zhang Y, et al. A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity. J Exp Med. 2008;205:2899-913 pubmed publisher
  24. Wang R, Wan Q, Kozhaya L, Fujii H, Unutmaz D. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLoS ONE. 2008;3:e2705 pubmed publisher
    ..These findings reveal a novel cell surface molecule-mediated regulatory mechanism, with implications for modulating aberrant immune responses. ..
  25. Rupec R, Jundt F, Rebholz B, Eckelt B, Weindl G, Herzinger T, et al. Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity. 2005;22:479-91 pubmed
    ..In summary, we show that cell-fate decisions leading to a premalignant hematopoietic disorder can be initiated by nonhematopoietic cells with inactive I kappa B alpha. ..
  26. Felberg J, Lefebvre D, Lam M, Wang Y, Ng D, Birkenhead D, et al. Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation. J Biol Chem. 2004;279:3455-62 pubmed
    b>CD45 is a transmembrane, two-domain protein-tyrosine phosphatase expressed exclusively in nucleated hematopoietic cells...
  27. Bakker T, Piperi C, Davies E, Merwe P. Comparison of CD22 binding to native CD45 and synthetic oligosaccharide. Eur J Immunol. 2002;32:1924-32 pubmed
    ..One protein that carries such N-glycans is CD45. In this study we used surface plasmon resonance to perform thermodynamic and kinetic analysis of CD22 binding to ..
  28. Baker M, Gamble J, Tooze R, Higgins D, Yang F, O Brien P, et al. Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice. EMBO J. 2000;19:4644-54 pubmed
    The CD45 tyrosine phosphatase lowers T-cell antigen receptor signalling thresholds by its positive actions on p56(lck) tyrosine kinase function...
  29. Kina T, Ikuta K, Takayama E, Wada K, Majumdar A, Weissman I, et al. The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br J Haematol. 2000;109:280-7 pubmed
    ..TER-119+ cells in adult bone marrow expressed significant levels of CD45 but not myeloid (Mac-1, Gr-1) or B-cell (B220) markers...
  30. Fisher C, Pineault N, Brookes C, Helgason C, Ohta H, Bodner C, et al. Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. Blood. 2010;115:38-46 pubmed publisher
  31. Turner M, Mee P, Costello P, Williams O, Price A, Duddy L, et al. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature. 1995;378:298-302 pubmed
    ..Finally, we show that Syk is not required for signalling through the IL-2 and G-CSF receptors. ..
  32. Barclay A, Jackson D, Willis A, Williams A. Lymphocyte specific heterogeneity in the rat leucocyte common antigen (T200) is due to differences in polypeptide sequences near the NH2-terminus. EMBO J. 1987;6:1259-64 pubmed
    The leucocyte-common antigen (L-CA, T200 or CD45) consists of a family of heavily glycosylated glycoproteins of apparent Mr 180,000-240,000 which are restricted to lymphoid and myeloid cells...
  33. McCall M, Shotton D, Barclay A. Expression of soluble isoforms of rat CD45. Analysis by electron microscopy and use in epitope mapping of anti-CD45R monoclonal antibodies. Immunology. 1992;76:310-7 pubmed
    The CD45 or leucocyte-common antigens are encoded by a single gene but can be found in various forms due to alternative splicing of three exons near the 5' end of the gene...
  34. Haidl I, Ng D, Rothenberger S, Johnson P, Jefferies W. Detection of restricted isoform expression and tyrosine phosphatase activity of CD45 in murine dendritic cells. Eur J Immunol. 1995;25:3370-4 pubmed
    b>CD45 is a cell surface transmembrane tyrosine phosphatase. It is expressed as distinct protein isoforms via alternative splicing of exons 4, 5 and 6...
  35. Bohdanova O, Kuz menko L, Morhaienko O, Ostapchenko L. [Peculiarities of dephosphorylation reaction catalyzed by purified protein tyrosine phosphatase CD45 from thymocytes of intact and exposed to ionising radiation rats]. Ukr Biokhim Zh (1999). 2006;78:127-31 pubmed
    This paper is devoted to analysis of parameters of catalytical activity of CD45, the major transmembrane proteintyrosine phosphatase (PTP-ase) of the lymphocytes, isolated from plasma membranes of thymocytes of control and 0...
  36. Erlandsson L, Licence S, Gaspal F, Lane P, Corcoran A, Martensson I. Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo. Eur J Immunol. 2005;35:1969-76 pubmed
    ..As a consequence of the absence of both receptors, the peripheral B cell pool is severely depleted, resulting in atypical splenic B cell structures and reduced serum Ig levels. ..
  37. Balamuth F, Brogdon J, Bottomly K. CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. J Immunol. 2004;172:5887-92 pubmed
    ..These studies suggest that CD4 coreceptor function is regulated not only through its known signaling function, but also by posttranslational lipid modifications which regulate localization of CD4 in lipid rafts. ..
  38. Luo H, Yu G, Tremblay J, Wu J. EphB6-null mutation results in compromised T cell function. J Clin Invest. 2004;114:1762-73 pubmed
    ..Further downstream, in the absence of EphB6, ZAP-70 activation, LAT phosphorylation, the association of PLCgamma1 with SLP-76, and p44/42 MAPK activation were diminished. Thus, we have shown that EphB6 is pivotal in T cell function. ..
  39. Wiest D, Ashe J, Howcroft T, Lee H, Kemper D, Negishi I, et al. A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity. 1997;6:663-71 pubmed
    ..The developmental arrest is due to the inability of CD4+ CD8+ thymocytes to propagate TCR signals in the absence of ZAP-70 kinase activity despite tyrosine phosphorylation of TCR-associated ZAP-70 molecules. ..
  40. Matsuzaki J, Tsuji T, Chamoto K, Takeshima T, Sendo F, Nishimura T. Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo. Cell Immunol. 2003;224:98-105 pubmed
    ..Thus, we initially demonstrated that anti-Gr-1 mAb might become a good tool to investigate a precise role for memory-type CD8(+) T cells in vivo. ..
  41. Yada S, Kishihara K, Kong Y, Nomoto K. Differential requirements of CD45 protein tyrosine phosphatase for cytolytic activities and intrathymic and extrathymic development of intestinal intraepithelial lymphocytes. J Immunol. 1998;161:2208-16 pubmed
    b>CD45 is a transmembrane protein tyrosine phosphatase essential for Ag receptor-mediated signaling in both T and B cells...
  42. Davidson W, Roths J, Holmes K, Rudikoff E, Morse H. Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice. J Immunol. 1984;133:1048-56 pubmed
    ..This suggests that factors other than defective IL 2 production and polyclonal B cell activation are required for the development of fulminant autoimmune disease...
  43. Mee P, Turner M, Basson M, Costello P, Zamoyska R, Tybulewicz V. Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice. Eur J Immunol. 1999;29:2923-33 pubmed
    ..TCR-mediated signals that determine these selection processes are only partly understood. The CD45 tyrosine phosphatase has been shown to be important for signal transduction through the TCR, but there has been ..
  44. Pani G, Siminovitch K, Paige C. The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. J Exp Med. 1997;186:581-8 pubmed
    The cytosolic SHP-1 and transmembrane CD45 protein tyrosine phosphatases (PTP) play critical roles in regulating signal transduction via the B cell antigen receptor (BCR). These PTPs differ, however, in their effects on BCR function...
  45. Gartlan K, Belz G, Tarrant J, Minigo G, Katsara M, Sheng K, et al. A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity. J Immunol. 2010;185:3158-66 pubmed publisher
    ..Therefore, in the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37(-/-) or Tssc6(-/-) mice, demonstrating a complementary role for these two molecules in cellular immunity...
  46. Wang L, Wang X, Chen J, Yang Z, Yu L, Hu L, et al. Activation of protein serine/threonine phosphatase PP2C? efficiently prevents liver fibrosis. PLoS ONE. 2010;5:e14230 pubmed publisher
    ..Moreover, our study might provide the first evidence for the role of PP2C family members in the fibrotic disease. ..
  47. Takai T, Ono M, Hikida M, Ohmori H, Ravetch J. Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice. Nature. 1996;379:346-9 pubmed
    ..Exploiting this property offers new therapeutic opportunities for the treatment of allergic and autoimmune disorders. ..
  48. Jacobsen M, Schweer D, Ziegler A, Gaber R, Schock S, Schwinzer R, et al. A point mutation in PTPRC is associated with the development of multiple sclerosis. Nat Genet. 2000;26:495-9 pubmed
    ..Here we investigated the role of a point mutation in the gene (PTPRC) encoding protein-tyrosine phosphatase, receptor-type C (also known as CD45) in the heterozygous state in the ..
  49. Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol. 2009;10:1252-9 pubmed publisher
    ..Our data show a critical role for microRNA in T(H)-17 differentiation and the pathogenesis of multiple sclerosis. ..
  50. Katagiri T, Ogimoto M, Hasegawa K, Mizuno K, Yakura H. Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J Biol Chem. 1995;270:27987-90 pubmed
    It has been well established that protein-tyrosine phosphatase CD45 is critically involved in the regulation of initial tyrosine phosphorylation and effector functions of T and B cells...
  51. Burns C, Sakaguchi K, Appella E, Ashwell J. CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases. J Biol Chem. 1994;269:13594-600 pubmed
    Previous analyses have suggested that the CD45 tyrosine phosphatase activates src family tyrosine kinases p56lck and p59fyn by dephosphorylating regulatory COOH-terminal residues...
  52. Simpson S, Mizoguchi E, Allen D, Bhan A, Terhorst C. Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur J Immunol. 1995;25:2618-25 pubmed
    ..In light of these findings, we propose that infiltrating CD4+, but not CD8+ T cells are central to the inflammation observed in the intestinal mucosa in IL-2null colitis. ..
  53. Scaglione B, Salerno E, Balan M, Coffman F, Landgraf P, Abbasi F, et al. Murine models of chronic lymphocytic leukaemia: role of microRNA-16 in the New Zealand Black mouse model. Br J Haematol. 2007;139:645-57 pubmed
    ..Future studies utilizing the NZB mouse could ascertain the role of environmental triggers, such as low dose radiation and organic chemicals in the augmentation of a pre-existing propensity to develop CLL. ..
  54. Negishi I, Motoyama N, Nakayama K, Senju S, Hatakeyama S, Zhang Q, et al. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature. 1995;376:435-8 pubmed
    ..Natural killer cell function was intact in the absence of ZAP-70. These data suggest that ZAP-70 is a central signalling molecule during thymic selection for CD4 and CD8 lineage. ..
  55. Kawai K, Kishihara K, Molina T, Wallace V, Mak T, Ohashi P. Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice. J Exp Med. 1995;181:345-9 pubmed
    To determine whether p56lck protein tyrosine kinase and CD45 protein tyrosine phosphatase are involved in the signal transduction during intrathymic differentiation of gamma/delta T cells, we have examined the development of T cells ..
  56. Chin C, Sachs J, Engelman D. Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. FEBS Lett. 2005;579:3855-8 pubmed
    ..Studies of two RPTPs, CD45 and PTPalpha, have provided strong evidence that dimerization leads to inactivation of the receptors, and that the ..
  57. Fujiwara H, Kikutani H, Suematsu S, Naka T, Yoshida K, Tanaka T, et al. The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci U S A. 1994;91:6835-9 pubmed
    ..Germinal center formation after immunization and in vitro proliferative response of B cells were not affected in mutant mice. However, antigen-specific IgE-mediated enhancement of antibody responses was severely impaired. ..
  58. Symons A, Cooper D, Barclay A. Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1. Glycobiology. 2000;10:559-63 pubmed
    ..that galectin-1 interacts with the heavily glycosylated, transmembrane, protein phosphotyrosine phosphatase CD45. The interaction of galectin-1 with purified lymphocyte cell surface proteins was studied using surface plasmon ..
  59. Schenten D, Egert A, Pasparakis M, Rajewsky K. M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood. 2006;107:4849-56 pubmed
    ..Thus, M17 is dispensable for the GC reaction, and its potential function in the pathogenesis of DLBCL remains elusive. ..
  60. Shenoi H, Seavitt J, Zheleznyak A, Thomas M, Brown E. Regulation of integrin-mediated T cell adhesion by the transmembrane protein tyrosine phosphatase CD45. J Immunol. 1999;162:7120-7 pubmed
    The transmembrane protein tyrosine phosphatase CD45 is required for Ag receptor signal transduction in lymphocytes. Recently, a role for CD45 in the regulation of macrophage adhesion has been demonstrated as well...
  61. Tchilian E, Wallace D, Wells R, Flower D, Morgan G, Beverley P. A deletion in the gene encoding the CD45 antigen in a patient with SCID. J Immunol. 2001;166:1308-13 pubmed
    ..We report here that a homozygous 6-bp deletion in the gene encoding CD45 (PTPRC, gene map locus 1q31-32), which results in a loss of glutamic acid 339 and tyrosine 340 in the first fibronectin ..
  62. Tonks N, Charbonneau H, Diltz C, Fischer E, Walsh K. Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase. Biochemistry. 1988;27:8695-701 pubmed
    It has been proposed on the basis of amino acid sequence homology that the leukocyte common antigen CD45 represents a family of catalytically active, receptor-linked protein tyrosine phosphatases [Charbonneau, H., Tonks, N. K., Walsh, K...
  63. Shivtiel S, Lapid K, Kalchenko V, Avigdor A, Goichberg P, Kalinkovich A, et al. CD45 regulates homing and engraftment of immature normal and leukemic human cells in transplanted immunodeficient mice. Exp Hematol. 2011;39:1161-1170.e1 pubmed publisher
    ..We report that the pan-leukocyte CD45 phosphatase plays an essential role in trafficking and repopulation of the bone marrow by immature human CD34(+) ..
  64. Zhou Z, Penn M, Forudi F, Zhou X, Tarakji K, Topol E, et al. Administration of recombinant P-selectin glycoprotein ligand Fc fusion protein suppresses inflammation and neointimal formation in Zucker diabetic rat model. Arterioscler Thromb Vasc Biol. 2002;22:1598-603 pubmed
    ..Immunohistochemistry revealed that P-selectin was intensely expressed and that CD45-positive leukocyte infiltration was significantly increased after arterial injury...