Ptk2

Summary

Gene Symbol: Ptk2
Description: protein tyrosine kinase 2
Alias: FAK, FRNK, p125FAK, focal adhesion kinase 1, FADK 1, PTK2 protein tyrosine kinase 2, focal adhesion kinase-related nonkinase, pp125FAK
Species: rat
Products:     Ptk2

Top Publications

  1. Hoshina N, Tezuka T, Yokoyama K, Kozuka Hata H, Oyama M, Yamamoto T. Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth. Genes Cells. 2007;12:1245-54 pubmed
    ..Using mass spectrometric analysis, we identified focal adhesion kinase (FAK) as a tyrosine-phosphorylated protein in the rat-derived CG4 oligodendrocyte cell line...
  2. Jiang X, Sinnett Smith J, Rozengurt E. Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Cell Signal. 2007;19:1000-10 pubmed
    A rapid increase in the tyrosine phosphorylation of the non-receptor tyrosine kinase FAK is a prominent early event in fibroblasts stimulated by a variety of signaling molecules...
  3. Golubovskaya V, Finch R, Cance W. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J Biol Chem. 2005;280:25008-21 pubmed
    Focal adhesion kinase (FAK) is a nonreceptor kinase that is overexpressed in many types of tumors and associates with multiple cell surface receptors and intracellular signaling proteins through which it can play an important role in ..
  4. Hagel M, George E, Kim A, Tamimi R, Opitz S, Turner C, et al. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol. 2002;22:901-15 pubmed
    ..display abnormal focal adhesions, reduced cell migration, inefficient localization of focal adhesion kinase (FAK), and reduced fibronectin-induced phosphorylation of FAK, Cas, and mitogen-activated protein kinase...
  5. Schlaepfer D, Mitra S. Multiple connections link FAK to cell motility and invasion. Curr Opin Genet Dev. 2004;14:92-101 pubmed
    ..In this review, we highlight recent findings that place focal adhesion kinase (FAK) in an important receptor-proximal position in the regulation of growth factor and integrin-stimulated cell ..
  6. Wu X, Suetsugu S, Cooper L, Takenawa T, Guan J. Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem. 2004;279:9565-76 pubmed
    N-WASP is a member of the WASP family of proteins that regulate actin cytoskeleton remodeling. FAK is a cytoplasmic tyrosine kinase implicated in integrin signaling during cell migration...
  7. Judson P, He X, Cance W, Van Le L. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer. 1999;86:1551-6 pubmed
    Focal adhesion kinase (FAK) is a tyrosine kinase that is important to such key functions such as cell adhesion, motility, and invasion...
  8. Xia H, Nho R, Kahm J, Kleidon J, Henke C. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. J Biol Chem. 2004;279:33024-34 pubmed
    ..Here we show that in response to collagen contraction focal adhesion kinase (FAK) is dephosphorylated...
  9. Boutahar N, Guignandon A, Vico L, Lafage Proust M. Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation. J Biol Chem. 2004;279:30588-99 pubmed
    ..CS rapidly and time-dependently promoted phosphorylation of both ERK2 at Tyr-187 and focal adhesion kinase (FAK) at Tyr-397 and Tyr-925, leading to the activation of the Ras/Raf/MEK pathway...
  10. Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner D, et al. Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res. 2003;92:300-7 pubmed
    The nonreceptor tyrosine kinase focal adhesion kinase (FAK) is a point of convergence for signals from extracellular matrix, soluble factors, and mechanical stimuli...

Detail Information

Publications61

  1. Hoshina N, Tezuka T, Yokoyama K, Kozuka Hata H, Oyama M, Yamamoto T. Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth. Genes Cells. 2007;12:1245-54 pubmed
    ..Using mass spectrometric analysis, we identified focal adhesion kinase (FAK) as a tyrosine-phosphorylated protein in the rat-derived CG4 oligodendrocyte cell line...
  2. Jiang X, Sinnett Smith J, Rozengurt E. Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Cell Signal. 2007;19:1000-10 pubmed
    A rapid increase in the tyrosine phosphorylation of the non-receptor tyrosine kinase FAK is a prominent early event in fibroblasts stimulated by a variety of signaling molecules...
  3. Golubovskaya V, Finch R, Cance W. Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53. J Biol Chem. 2005;280:25008-21 pubmed
    Focal adhesion kinase (FAK) is a nonreceptor kinase that is overexpressed in many types of tumors and associates with multiple cell surface receptors and intracellular signaling proteins through which it can play an important role in ..
  4. Hagel M, George E, Kim A, Tamimi R, Opitz S, Turner C, et al. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol. 2002;22:901-15 pubmed
    ..display abnormal focal adhesions, reduced cell migration, inefficient localization of focal adhesion kinase (FAK), and reduced fibronectin-induced phosphorylation of FAK, Cas, and mitogen-activated protein kinase...
  5. Schlaepfer D, Mitra S. Multiple connections link FAK to cell motility and invasion. Curr Opin Genet Dev. 2004;14:92-101 pubmed
    ..In this review, we highlight recent findings that place focal adhesion kinase (FAK) in an important receptor-proximal position in the regulation of growth factor and integrin-stimulated cell ..
  6. Wu X, Suetsugu S, Cooper L, Takenawa T, Guan J. Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem. 2004;279:9565-76 pubmed
    N-WASP is a member of the WASP family of proteins that regulate actin cytoskeleton remodeling. FAK is a cytoplasmic tyrosine kinase implicated in integrin signaling during cell migration...
  7. Judson P, He X, Cance W, Van Le L. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer. 1999;86:1551-6 pubmed
    Focal adhesion kinase (FAK) is a tyrosine kinase that is important to such key functions such as cell adhesion, motility, and invasion...
  8. Xia H, Nho R, Kahm J, Kleidon J, Henke C. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. J Biol Chem. 2004;279:33024-34 pubmed
    ..Here we show that in response to collagen contraction focal adhesion kinase (FAK) is dephosphorylated...
  9. Boutahar N, Guignandon A, Vico L, Lafage Proust M. Mechanical strain on osteoblasts activates autophosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 tyrosine sites involved in ERK activation. J Biol Chem. 2004;279:30588-99 pubmed
    ..CS rapidly and time-dependently promoted phosphorylation of both ERK2 at Tyr-187 and focal adhesion kinase (FAK) at Tyr-397 and Tyr-925, leading to the activation of the Ras/Raf/MEK pathway...
  10. Ilic D, Kovacic B, McDonagh S, Jin F, Baumbusch C, Gardner D, et al. Focal adhesion kinase is required for blood vessel morphogenesis. Circ Res. 2003;92:300-7 pubmed
    The nonreceptor tyrosine kinase focal adhesion kinase (FAK) is a point of convergence for signals from extracellular matrix, soluble factors, and mechanical stimuli...
  11. Yin H, Wang L, Huo Y, Peng X, Xia C, Tang C. Activated focal adhesion kinase involved in adhesion and migration of vascular smooth muscle cells stimulated by fibronectin. Chin Med J (Engl). 2002;115:494-7 pubmed
    To study the effects of focal adhesion kinase (FAK) phosphorylation on smooth muscle cells (SMCs) adhesion and migration stimulated by fibronectin...
  12. Hu M, Fan M, Zhen J, Lin J, Wang Q, Lv Z, et al. FAK contributes to proteinuria in hypercholesterolaemic rats and modulates podocyte F-actin re-organization via activating p38 in response to ox-LDL. J Cell Mol Med. 2017;21:552-567 pubmed publisher
    Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase that regulates cell adhesion, proliferation and differentiation...
  13. Koshman Y, Engman S, Kim T, Iyengar R, Henderson K, Samarel A. Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration. Cardiovasc Res. 2010;85:571-81 pubmed publisher
    Focal adhesion kinase (FAK) and its autonomously expressed, C-terminal inhibitor FAK-related non-kinase (FRNK), are important regulators of vascular smooth muscle cell (VSMC) spreading and migration...
  14. Prakash S, Paylor R, Jenna S, Lamarche Vane N, Armstrong D, Xu B, et al. Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum Mol Genet. 2000;9:477-88 pubmed
    ..These results suggest that ARHGAP6 has two independent functions: one as a GAP with specificity for RhoA and the other as a cytoskeletal protein that promotes actin remodeling. ..
  15. Torsoni A, Marin T, Velloso L, Franchini K. RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2005;289:H1488-96 pubmed
    Focal adhesion kinase (FAK) has been shown to be activated in cardiac myocytes exposed to mechanical stress. However, details of how mechanical stimuli induce FAK activation are unknown...
  16. Boyanapalli M, Lahoud O, Messiaen L, Kim B, Anderle de Sylor M, Duckett S, et al. Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt. Biochem Biophys Res Commun. 2006;340:1200-8 pubmed
    ..These novel findings provide insight into possible signaling mechanisms of Nf1 and suggest that together Nf1 and Cav-1 may coordinately regulate cell growth and differentiation. ..
  17. Finnemann S. Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. EMBO J. 2003;22:4143-54 pubmed
    ..This study identifies a key role for focal adhesion kinase (FAK) in RPE phagocytosis...
  18. Zhang B, Luo Q, Chen Z, Shi Y, Ju Y, Yang L, et al. Increased nuclear stiffness via FAK-ERK1/2 signaling is necessary for synthetic mechano-growth factor E peptide-induced tenocyte migration. Sci Rep. 2016;6:18809 pubmed publisher
    ..factor (MGF) C-terminal E-domain with 25 amino acids (MGF-C25E) promotes rat tenocyte migration through the FAK-ERK1/2 signaling pathway...
  19. Guido M, Clemente C, Moretti A, Barbeiro H, Debbas V, Caldini E, et al. Small interfering RNA targeting focal adhesion kinase prevents cardiac dysfunction in endotoxemia. Shock. 2012;37:77-84 pubmed publisher
    ..Cardiovascular instability is a major cause of death in patients with sepsis. Focal adhesion kinase (FAK) is a potential mediator of cardiomyocyte responses to oxidative and mechanical stress...
  20. Lee K, Park J, Lee S, Lim H, Park H. PPARdelta activation inhibits angiotensin II induced cardiomyocyte hypertrophy by suppressing intracellular Ca2+ signaling pathway. J Cell Biochem. 2009;106:823-34 pubmed publisher
    ..Previous studies have implicated the activation of focal adhesion kinase (FAK) in the progress of cardiomyocyte hypertrophy...
  21. Lal H, Verma S, Smith M, Guleria R, Lu G, Foster D, et al. Stretch-induced MAP kinase activation in cardiac myocytes: differential regulation through beta1-integrin and focal adhesion kinase. J Mol Cell Cardiol. 2007;43:137-47 pubmed
    ..FAK signaling was disrupted by infecting NRVM with adenovirus expressing FAK-related non-kinase (FRNK). Western blot analysis was used to assess the phosphorylation of MAP kinases...
  22. Samarin S, Koch S, Ivanov A, Parkos C, Nusrat A. Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells. Biochem Biophys Res Commun. 2010;391:394-400 pubmed publisher
    ..cell-matrix adhesion of coronin-deficient cells correlated with hyperphosphorylation of focal adhesion kinase (FAK) and paxillin, and an increase in number of focal adhesions and their redistribution at the cell periphery...
  23. Shen T, Park A, Alcaraz A, Peng X, Jang I, Koni P, et al. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol. 2005;169:941-52 pubmed
    Focal adhesion kinase (FAK) is a critical mediator of signal transduction by integrins and growth factor receptors in a variety of cells including endothelial cells (ECs)...
  24. Dwane S, Durack E, O Connor R, Kiely P. RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK. Cell Signal. 2014;26:9-18 pubmed publisher
    ..In focal adhesions, RACK1 is required for the regulation of FAK activity and for integrating a wide array of cellular signalling events including the integration of growth factor ..
  25. Flinder L, Wierød L, Rosseland C, Huitfeldt H, Skarpen E. FAK regulates Cdk2 in EGF-stimulated primary cultures of hepatocytes. J Cell Physiol. 2013;228:1304-13 pubmed publisher
    In this study, we report a novel role of FAK as a regulator of Cdk2 in anchorage-dependent primary cultured hepatocytes. In response to EGF, we found that S-phase entry was reduced upon FAK inhibition...
  26. Flinder L, Timofeeva O, Rosseland C, Wierød L, Huitfeldt H, Skarpen E. EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase. J Cell Physiol. 2011;226:2267-78 pubmed publisher
    ..Another important regulator of cell spread is focal adhesion kinase (FAK), a coordinator of integrin and growth factor signaling...
  27. Holzapfel K, Neuhofer W, Bartels H, Fraek M, Beck F. Role of focal adhesion kinase (FAK) in renal ischaemia and reperfusion. Pflugers Arch. 2007;455:273-82 pubmed
    Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays important roles in cell migration, cell proliferation and cell survival...
  28. Liu L, Jiang H, Zhang X, Zhao D. [Effect of Salvia miltiorrhiza monomer IH764-3 on MMP-13 and TIMP-1 by downregulating the expression of focal adhesion kinase in hepatic stellate cell stimulated by H2O2]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007;23:482-6 pubmed
    ..of IH764-3 on the expression of MMP-13 and TIMP-1 by H2O2-stimulated hepatic stellate cell and the alteration of FAK during this process. The expression of MMP-13 and FAK mRNA was examined by RT-PCR...
  29. Walsh K, Zhang J. Regulation of cardiac volume-sensitive chloride channel by focal adhesion kinase and Src kinase. Am J Physiol Heart Circ Physiol. 2005;289:H2566-74 pubmed
    ..FAK-related nonkinase (FRNK) is an endogenous cardiac protein, which functions as an inhibitor of FAK...
  30. Klimová Z, Bráborec V, Maninová M, Cáslavský J, Weber M, Vomastek T. Symmetry breaking in spreading RAT2 fibroblasts requires the MAPK/ERK pathway scaffold RACK1 that integrates FAK, p190A-RhoGAP and ERK2 signaling. Biochim Biophys Acta. 2016;1863:2189-200 pubmed publisher
    ..Since cell adhesion activates both ERK and p190A-RhoGAP signaling this constitutes a spatially confined incoherent feed-forward signaling circuit. ..
  31. Graham Z, Qin W, Harlow L, Ross N, Bauman W, Gallagher P, et al. Focal adhesion kinase signaling is decreased 56 days following spinal cord injury in rat gastrocnemius. Spinal Cord. 2016;54:502-9 pubmed publisher
    ..resulted in significantly lower levels of total and phosphorylated FAK, cSrc and p70S6k, and a trend for increased FRNK protein expression...
  32. Heerkens E, Quinn L, Withers S, Heagerty A. ? Integrins mediate FAK Y397 autophosphorylation of resistance arteries during eutrophic inward remodeling in hypertension. J Vasc Res. 2014;51:305-14 pubmed publisher
    ..In order to investigate the role of focal adhesion kinase (FAK) activation in this process, the level of FAK Y397 autophosphorylation was studied in small blood vessels from ..
  33. Xu F, Tao T, Wang X, Li Y, Song D, Liu M, et al. Cytosolic calreticulin inhibits microwave radiation-induced microvascular endothelial cell injury through the integrin-focal adhesion kinase pathway. Microcirculation. 2014;21:717-29 pubmed publisher
    ..Correlation analysis revealed that integrin-? expression or FAK phosphorylation was positively associated with cytosolic CRT expression...
  34. Wong E, Lee W, Cheng C. Secreted Frizzled-related protein 1 (sFRP1) regulates spermatid adhesion in the testis via dephosphorylation of focal adhesion kinase and the nectin-3 adhesion protein complex. FASEB J. 2013;27:464-77 pubmed publisher
    ..in vivo delayed spermiation, which was accompanied by down-regulation of phosphorylated (p)-focal adhesion kinase (FAK)-Tyr(397) and retention of nectin-3 adhesion protein at the apical ES...
  35. Bianchi M, De Lucchini S, Vietri M, Villa Moruzzi E. Reciprocally interacting domains of protein phosphatase 1 and focal adhesion kinase. Mol Cell Biochem. 2005;272:85-90 pubmed
    ..Among the FAK deletion mutants, only the C-terminal domain (684-1053, also known as FRNK) pulled-down a significant amount of PP1...
  36. Dahmani S, Rouelle D, Gressens P, Mantz J. The effects of lidocaine and bupivacaine on protein expression of cleaved caspase 3 and tyrosine phosphorylation in the rat hippocampal slice. Anesth Analg. 2007;104:119-23 pubmed
    ..We have previously shown that lidocaine increases the phosphorylation of focal adhesion kinase (FAK, a nonreceptor tyrosine kinase playing a role in neuronal plasticity and cell death)...
  37. von Sengbusch A, Gassmann P, Fisch K, Enns A, Nicolson G, Haier J. Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids. Am J Pathol. 2005;166:585-96 pubmed
    ..Reduced expression of FAK or its endogenous inhibition by FAK-related non-kinase (FRNK) interfered with early adhesion events to extracellular matrix components under flow conditions...
  38. Gabriel B, zur Hausen A, Stickeler E, Dietz C, Gitsch G, Fischer D, et al. Weak expression of focal adhesion kinase (pp125FAK) in patients with cervical cancer is associated with poor disease outcome. Clin Cancer Res. 2006;12:2476-83 pubmed
    The pp125 focal adhesion kinase (FAK) plays a pivotal role in tumor cell signaling. FAK expression has been linked to tumor cell invasion and metastasis, but data on cervical cancer are inconclusive...
  39. Cerna J, Cerecedo D, Ortega A, Garcia Sierra F, Centeno F, Garrido E, et al. Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion. J Mol Biol. 2006;362:954-65 pubmed
    ..that the PC12 cell beta1-integrin adhesion complex is composed of beta1-integrin, talin, paxillin, alpha-actinin, FAK and actin...
  40. Liu Y, Zhang G, Hou X, Xu T. Two types of calcium channels regulating activation of proline-rich tyrosine kinase 2 induced by transient brain ischemia in rat hippocampus. Neurosci Lett. 2003;348:127-30 pubmed
    ..The results suggested that Pyk2 was activated after transient brain ischemia and reperfusion, and it might play an important role in mediating post-ischemic signal transduction events. ..
  41. Grisaru Granovsky S, Salah Z, Maoz M, Pruss D, Beller U, Bar Shavit R. Differential expression of protease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples. Int J Cancer. 2005;113:372-8 pubmed
    ..In parallel, we analyzed the expression pattern of alphavbeta5 integrin and of activated focal adhesion kinase (FAK), a major focal contact protein, in these tissues...
  42. Menashi E, Loftus J. Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myocytes. Cell Tissue Res. 2009;337:243-55 pubmed publisher
    The related cytoplasmic non-receptor tyrosine kinases Pyk2 (proline-rich tyrosine kinase 2) and FAK (focal adhesion kinase) have been implicated in phenylephrine-induced G-protein-coupled receptor-mediated signaling mechanisms leading to ..
  43. Viglino C, Montessuit C. A Role for Focal Adhesion Kinase in the Stimulation of Glucose Transport in Cardiomyocytes. J Cell Biochem. 2017;118:670-677 pubmed publisher
    ..We determined whether Focal Adhesion Kinase (FAK) activity is required for stimulation of glucose transport in cardiomyocytes, and whether FAK downregulation ..
  44. Wong C, Xia W, Lee N, Mruk D, Lee W, Cheng C. Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes. Endocrinology. 2005;146:1192-204 pubmed
    ..For instance, the protein levels of beta1-integrin, Tyr-phosphorylated focal adhesion kinase (p-FAK), and c-Src were induced during the T suppression-induced germ cell loss and recovery, implicating that these ..
  45. Toutant M, Costa A, Studler J, Kadaré G, Carnaud M, Girault J. Alternative splicing controls the mechanisms of FAK autophosphorylation. Mol Cell Biol. 2002;22:7731-43 pubmed
    Focal adhesion kinase (FAK) is activated following integrin engagement or stimulation of transmembrane receptors...
  46. Shi Z, Wang H, Tarbell J. Heparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagen. PLoS ONE. 2011;6:e15956 pubmed publisher
    ..Inhibition or knockdown of focal adhesion kinase (FAK) also attenuated or blocked flow-induced ERK1/2 activation, MMP-13 expression, and cell motility...
  47. Hu X, Wei L, Taylor T, Wei J, Zhou X, Wang J, et al. Hypoxic preconditioning enhances bone marrow mesenchymal stem cell migration via Kv2.1 channel and FAK activation. Am J Physiol Cell Physiol. 2011;301:C362-72 pubmed publisher
    ..1 channel acts as a promoter for focal adhesion kinase (FAK) activation and cell motility, the present investigation tested the hypothesis that HP treatment can increase BMSC ..
  48. Li J, Xie D. Cleavage of focal adhesion kinase (FAK) is essential in adipocyte differentiation. Biochem Biophys Res Commun. 2007;357:648-54 pubmed
    ..Focal adhesion kinase (pp125FAK), a widely expressed non-receptor tyrosine kinase in integrin signaling, has been reported to participate in ..
  49. Samarakoon R, Chitnis S, Higgins S, Higgins C, Krepinsky J, Higgins P. Redox-induced Src kinase and caveolin-1 signaling in TGF-?1-initiated SMAD2/3 activation and PAI-1 expression. PLoS ONE. 2011;6:e22896 pubmed publisher
    ..TGF-?1-initiated Src-dependent caveolin-1(Y14) phosphorylation is a critical event in Rho-ROCK-mediated suppression of nuclear PPM1A levels maintaining, thereby, SMAD2/3-dependent transcription of the PAI-1 gene. ..
  50. Stanzione R, Picascia A, Chieffi P, Imbimbo C, Palmieri A, Mirone V, et al. Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression. Lab Invest. 2001;81:51-9 pubmed
    ..In this study, we demonstrate that Pyk2 is expressed only in normal epithelial prostate tissue and in benign prostatic hyperplasia, whereas its expression progressively declines with an increasing grade of malignancy of prostate cancer. ..
  51. Lahlou H, Sanguin Gendreau V, Zuo D, Cardiff R, McLean G, Frame M, et al. Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A. 2007;104:20302-7 pubmed
    Elevated expression and activation of the focal adhesion kinase (FAK) occurs in a large proportion of human breast cancers...
  52. Maeda N, Bydlowski S, Lopes A. Increased tyrosine phosphorylation of platelet proteins including pp125(FAK) suggests endogenous activation and aggregation in pulmonary hypertension. Clin Appl Thromb Hemost. 2005;11:411-5 pubmed
    ..proteins were analyzed in resting platelets after reaction with anti-phosphotyrosine, anti-pp60(s-src), anti-pp125(FAK), and anti-alphaIIbbeta3 antibodies...
  53. Jones G, Stewart G. Nuclear import of N-terminal FAK by activation of the FcepsilonRI receptor in RBL-2H3 cells. Biochem Biophys Res Commun. 2004;314:39-45 pubmed
    As FAK integrates membrane receptor signalling, yet is also found in the nucleus, we investigated whether nuclear FAK is regulated by membrane receptor activation...
  54. Fu M, Rao R, Sudhakar D, Hogue C, Rutta Z, Morales S, et al. Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src. PLoS ONE. 2011;6:e19945 pubmed publisher
    ..In endometrial cancer cells, the focal adhesion kinase (FAK)/Src pathway appears to regulate migration as measured through wound healing assays...
  55. Han M, Wen J, Zheng B, Liu Z, Chen Y. Blockade of integrin beta3-FAK signaling pathway activated by osteopontin inhibits neointimal formation after balloon injury. Cardiovasc Pathol. 2007;16:283-90 pubmed
    ..pathway by which OPN is involved in neointimal formation, we focused on integrin beta3-focal adhesion kinase (FAK) upon VSMC migration...
  56. Tosoni D, Cestra G. CAP (Cbl associated protein) regulates receptor-mediated endocytosis. FEBS Lett. 2009;583:293-300 pubmed publisher
    ..Thus, we suggest that CAP may coordinate the function of dynamin with the regulation of the actin cytoskeleton during endocytosis. ..
  57. Russell J, Koeslag D, Manickavel V, Amy R, Dolphin P. Effects of advancing age and severe food restriction on pathological processes in the insulin resistant JCR:LA-corpulent rat. Diabetes Res. 1990;15:53-62 pubmed
    ..The food restriction throughout life up to 12 months of age, however, did inhibit the development of advanced myocardial lesions. ..
  58. Cheng Z, Zhu Q, Dee R, Opheim Z, Mack C, Cyr D, et al. Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth. J Biol Chem. 2017;292:2065-2079 pubmed publisher
    ..PE), a well known hypertrophic agonist, suppresses autophagy and that activation of focal adhesion kinase (FAK) is necessary for PE-stimulated autophagy suppression and subsequent initiation of hypertrophic growth...
  59. DiMichele L, Hakim Z, Sayers R, Rojas M, Schwartz R, Mack C, et al. Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth. Circ Res. 2009;104:1201-8 pubmed publisher
    ..We previously showed that the C terminus of FAK is expressed as a separate protein termed FAK-related nonkinase (FRNK) in a smooth muscle cell-selective fashion and that FRNK functions to buffer FAK-dependent signals...
  60. Speert D, Konkle A, Zup S, Schwarz J, Shiroor C, Taylor M, et al. Focal adhesion kinase and paxillin: novel regulators of brain sexual differentiation?. Endocrinology. 2007;148:3391-401 pubmed
    ..Focal adhesion kinase (FAK) and paxillin, both members of the focal adhesion complex family of proteins, were significantly elevated in the ..
  61. Mansour H, de Tombe P, Samarel A, Russell B. Restoration of resting sarcomere length after uniaxial static strain is regulated by protein kinase Cepsilon and focal adhesion kinase. Circ Res. 2004;94:642-9 pubmed
    ..were infected with an Adv encoding a dominant-negative inhibitor of focal adhesion kinase (FAK) (Adv-GFP-FRNK). Adv-GFP-FRNK also prevented resting sarcomere length recovery, whereas a control Adv encoding only GFP did not...